In this program, we seek to understand the genetic basis of brain development for normal functioning and its dysfunction in developmental and degenerative disorders. We aim to apply novel and generic method applicable to the studying of landscape of gene expression underlying both normal brain development and neurological disorders in animal models and human samples. This will be accomplished by developing platforms for single cell isolation and high throughput transcriptome sequencing, as well as establishment of bioinformatics computing facilities. Two main directions include:

1. Genetic basis of neural circuitry development
2. Genetics of circuitry dysfunction in brain disorders, including rare neurological diseases