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In this program, we aim to decipher the fine structure of specific neural circuits in the brain, and how fundamental cellular and intercellular processes occurring in these circuits collectively translate to high-level processes such as sensory perception, motor control, attention, memory formation and decision-making. Cutting-edge technologies, including multi-electrode array recording, in vivo brain imaging, viral neuronal tracing, optogenetic and chemogenetic techniques are employed. Major directions include:
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Circuitry underlying visual and other sensory functions
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Brain circuits of motor control and motor learning
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Neural circuits governing higher cognitive functions
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Representative publications
Mu MD, Geng HY, Rong KL, Peng RC, Wang ST, Geng LT, Qian ZM, Yung WH, Ke Y (2020) A limbic circuitry involved in emotional stress-induced grooming. Nature Communications 2020 May 8;11(1):2261. doi: 10.1038/s41467-020-16203-x
(Press Release)
Cui Q, Li Q, Geng H, Chen L, Ip NY, Ke Y, Yung WH (2018) Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex-nucleus accumbens pathway in mice. Proceedings of the National Academy of Sciences of the USA
May 7, 2018, doi:10.1073/pnas.1717106115
(Press Release)
Li Q, Ko H, Qian ZM, Yan LYC, Chan DCW, Arbuthnott G, Ke Y, Yung WH (2017) Refinement of learned skilled movement representation in motor cortex deep output layer. Nature Communications Jun 9;8:15834. doi: 10.1038/ncomms15834
(Press Release)
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