C.H. Jonathan Choi Research Group

By exploring how nanoparticles interact with the living system across the length scales of organs, tissues, cells, and organelles, we design novel bionanomaterials for treating diseases arisen from various biological locations in vivo.

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Cola and Donna have both received an Outstanding Tutor Award from the Department of Electronic Engineering in recognition of their excellent teaching performance in 2014-2015. Cola will also receive an Outstanding Tutor Award from the Faculty of Engineering in February 2016. Congratulations!
Prof Chad A. Mirkin, a towering figure in the field of nanotechnology, came to CUHK to deliver the 2015 Sunney and Irene Chan Lecture in Chemical Biology. Together with Mr Ben Mirkin, he visited our Bionanotechnology Lab and interacted with our group members.

Prof Choi with Prof Chad Mirkin and Mr Ben Mirkin.

Our group members cheerfully posed with Prof Chad Mirkin and Mr Ben Mirkin.

A Choi group member presented our latest research highlights to Prof Mirkin.

Prof Mirkin delivered the 2015 Sunney and Irene Chan Lecture in Chemical Biology at CUHK.

Invited by Prof. Nam-Joon Cho of Nanyang Technological University, Prof Choi gave a seminar entitled ‘A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells’ at the 2015 International Symposium for Advanced Materials Research (ISAMR 2015) at Sun Moon Lake, Taiwan on August 17, 2015.

Prof Choi presenting his work

Prof Choi and Prof Cho

Kit Choi, Bohan Yin, Cecilia Chan and Samuel Sy are starting their 1st year PhD study here in Bionanotachnology Lab. Welcome! Find out more about them here.

(From left to right) Kit, Bohan, Prof Choi, Cecilia and Samuel

Prof Leaf Huang from the University of North Carolina at Chapel Hill visited the Bionanotechnology Lab and gave a seminar entitled “Lipid Bilayer-Stabilized Calcium Phosphate Nanoparticles for Drug and Gene Delivery” at the Biomedical Engineering Seminar Series. Prof Huang is a towering figure in the field of drug delivery and has pioneered the development of PEGylated liposomes.

Prof Huang and Prof Choi at the Pavilion of Harmony at CUHK

Prof Huang and Prof Choi at the Bionanotechnology Lab

Prof Huang and Choi lab members at the Bionanotechnology Lab

Prof Choi gave a presentation entitled ‘A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells’ at the Revolutionizing Biology and Medicine with Advances in Nanotechnology Workshop at Hunan University on June 23, 2015. This two-day workshop successfully attracted 10-12 leading experts in nanomedicine/ chemical biology from the US and China as well as 40 undergraduate students from Hunan.

[LEFT] Prof Ke ZHANG, Prof Jonathan CHOI & Prof Chad MIRKIN. [RIGHT] Prof Choi and workshop participants.

Prof Choi presenting his recent work.

Workshop group photo.

Prof Choi's postdoctoral work (as a co-first author) entitled “The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates” has been published in Small! GGG! [Abstract & Full Text]
Our work, entitled “A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells”, is now out in JACS! In collaboration with Prof. Liming Bian and his team, we have successfully demonstrated the use of gold@polydopamine nanoprobes to monitor the long-term differentiation events inside stem cells via the sequence-specific detection of microRNA markers. Congratulations to Kit! [Abstract & Full Text]
The Choi group presented their recent work at the Hong Kong International Medical Devices and Supplies Fair, organized by the Hong Kong Trade Development Council (HKTDC) from 18 May to 20 May at the Hong Kong Convention and Exhibition Centre.
Invited by Prof. Anderson Shum from The University of Hong Kong (HKU), Prof Choi gave a seminar entitled ‘A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells’ at the Re-engineering BioMed Engineering Symposium at the Hong Kong Science Park (HKSTP) on May 15, 2015. The symposium was jointly organized by HKU, The City University of Hong Kong, University of Califonia Irvine, and HKSTP.
Invited by Prof Chuan ZHANG of the School of Chemistry and Chemical Engineering at Shanghai Jiao Tong University, Prof Choi gave a seminar entitled ‘Probing the “nano-bio” interactions between DNA-based nanostructures and the cell’. [Abstract]
Invited by Prof Zhen SHEN of the School of Chemistry and Chemical Engineering at Nanjing University, Prof Choi gave a seminar entitled ‘Probing the “nano-bio” interactions between DNA-based nanostructures and the cell’ at the State Key Laboratory of Coordination Chemistry. [Abstract]
Chow Yuk Ho Technology Centre for Innovative Medicine is established by The Chinese University of Hong Kong, to transfer biomedical engineering research into clinical practice. The Choi group is one of the core members in this centre. The opening ceremony was held 30 January, 2015. Over 100 guests from the medical and engineering fields were present.

Chow Yuk Ho Technology Centre for Innovative Medicine opening

[LEFT] Prof Joseph J.Y. Sung, Vice-Chancellor and President of CUHK (right) and Ms Therese P.F. Chow, Solicitor, Notary Public and China Appointed Attesting Officer unveil the plaque of CUHK Chow Yuk Ho Technology Centre for Innovative Medicine; [RIGHT] (From left) Prof Philip W.Y. Chiu, Director of the Chow Yuk Ho Technology Centre for Innovative Medicine, CUHK; Prof Francis K.L. Chan, Dean, Faculty of Medicine, CUHK; Prof T.F. Fok, Pro-Vice-Chancellor and Vice-President, CUHK; Prof Joseph J.Y. Sung, Vice-Chancellor and President, CUHK; Miss Janet Wong, Commissioner for Innovation and Technology; Prof Fanny M.C. Cheung, Pro-Vice-Chancellor and Vice-President, CUHK; and Prof Irwin K.C. King, Associate Dean of the Faculty of Engineering, CUHK.

Chow Yuk Ho Technology Centre for Innovative Medicine opening

Over 100 guests from the medical and engineering fields attend the opening ceremony.

Students from Bina Bangsa School (Indonesia) visited CUHK in early January. Prof Choi was invited to give an admission talk, and encouraged them to pursue their undergraduate and postgraduate studies in CUHK.