Located at the Sir Y K Pao Centre for Cancer of the Prince of Wales Hospital, the State Key Laboratory of Oncology in South China (Partner Laboratory in The Chinese University of Hong Kong) is built on the solid foundation of CUHK’s long-established partnership with Sun Yat-sen University in cancer research and the backing of a strong clinical base and support of the Hospital Authority and the Food and Health Bureau of Hong Kong. Besides, there is a long tradition of cancer research and care in the local community. CUHK’s Hong Kong Cancer Institute was established in 1990. The investigators of the SKL are a multi-disciplinary group of clinical and basic cancer researchers from CUHK and Sun Yat-sen University, who have conducted research investigating the molecular genetics, signalling pathways, clinical diagnostics and novel therapeutic developments of cancers common in the region, in particular nasopharyngeal cancer, liver cancer and gastric cancer. The SKL has entered into collaborations with over 20 top cancer centres in the world, including MD Anderson of Texas University, Mayo Clinic in Minnesota and Johns Hopkins University of the US, Oxford University of the UK, and Fudan University and Peking University of China.