Emeritus Professor
B.Sc., Ph.D.
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Publons: https://publons.com/researcher/271635/po-sing-leung/
ORCID: https://orcid.org/0000-0001-8074-3178
- Pancreatic islet cell biology and diabetes.
- Pancreatic progenitor cell and islet development.
- Novel agents/drugs for treating diabetes and pancreatic cancer.
- Yang, B.C., & Leung, P.S. (2020). Irisin is a positive regulator for ferroptosis in pancreatic cancer. Molecular Therapy: Oncolytics,18, 457- 466.
- Wu, S.Y., Liang, J., Yang, B., & Leung, P.S. (2019). SIRT1 activation promotes β-cell regeneration by activating endocrine progenitor cells via AMPK signalling-mediated fatty acid oxidation. Stem Cells, 37, 1416-1428.
- Wang, Y., Xie, T., Zhang, D., & Leung, P.S. (2019). GPR120 protects lipotoxicity-induced pancreatic beta-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation in mice. Clinical Science, 133, 101-116.
- Chan, K.Y., Wang, Y., Ng, K.W., & Leung, P.S. (2018). Na+/H+ exchanger 3 blockade ameliorates type 2 diabetes mellitus via inhibition of SGLT1-mediated glucose absorption in the small intestine. Diabetes, Obesity & Metabolism, 20, 709-717.
- Zhang, D., Xie, T., & Leung, P.S. (2018). Irisin ameliorates glucolipotoxicity-associated beta-cell dysfunction and apoptosis via AMPK sigaling and anti-inflammatory actions. Cellular Physiology & Biochemistry, 51, 924-937.
- Li, Y.T., Cheng, T.W., Zhang, D., & Leung, P.S. (2017). Identification and functional implications of sodium/myo-inositol cotransporter-1 in pancreatic beta-cells and type 2 diabetes mellitus. Diabetes, 66, 1258-1271.
- Zhang, D., So, W.Y., Wang, Y., Wu, S.Y., Cheng, Q., & Leung, P.S. (2017). Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states. Clinical Science, 131, 247-260.
- Liang, J., Wu, S.Y., Zhang, D., Wang, L., Leung, K.K., & Leung, P.S. (2016). NADPH oxidase-dependent reactive oxygen species stimulate beta-cell regeneration through differentiation of endocrine progenitors in murine pancreas. Antioxidants and Redox Signaling, 24, 419-433.
- Cheng, T.W., Chen, L., Li, Y.T., Mayoux E., & Leung, P.S. (2016). The effects of empagliflozin, an SGLT2 inhibitor, on pancreatic β-cell mass and glucose homeostasis in type 1 diabetes. PLoS One, 11, e0147391.
- So, W.Y., & Leung, P.S. (2016). Fibroblast growth factor 21 as an emerging therapeutic target for type 2 diabetes mellitus. Medicinal Research Reviews, 36, 672-704.
- So, W.Y., Cheng, Q., Xu, A., Lam, S.L., & Leung, P.S. (2015). Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice. Cell Death and Disease, 6, e1707.
- Chen, L., So, W.Y., Li, S.Y.T., Cheng, Q., Boucher, B.J., & Leung, P.S. (2015). Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets. Molecular and Cellular Endocrinology, 404, 56-66.
- Wang, L., Liang, J., & Leung, P.S. (2015). The ACE2/Ang-(1-7)/Mas axis regulates the development of pancreatic endocrine cells in mouse embryos. PLoS One, 10, e0128216.
- Leung, K.K., Liang, J., Zhao, S., Chan, W.Y., & Leung, P.S. (2014). Angiotensin II type 2 receptor regulates the development of pancreatic endocrine cells in mouse embryos. Developmental Dynamics, 243, 415-427.
- So, W.Y., Cheng, Q., Chen, L., Evans-Molina, E., Xu, A., Lam, S.L., & Leung, P.S. (2013). High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor gamma signaling. Diabetes, 62, 3751-3759.
- Cheng, Q., Boucher, B.J., & Leung, P.S. (2013). Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin-angiotensin system in mice. Diabetologia, 56, 553-562.
- Leung, K.K., Liang, J., Ma, M.T., & Leung, P.S. (2012). Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation. Stem Cells, 30, 525-536.
- Cheng, Q., Li, Y.C., Boucher, B.J., & Leung, P.S. (2011). A novel role for vitamin D: modulation of expression and function of the local renin-angiotensin system in mouse pancreatic islets. Diabetologia, 54, 2077-2081.
- Leung, P.S., & Chan, Y.C. (2009). Role of oxidative stress in pancreatic inflammation. Antioxidants and Redox Signaling, 11, 135-165.
- Wong, T.P., Debnam, E.S., & Leung, P.S. (2007). Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal border membrane. Journal of Physiology, 584, 613-623.
- Chu, K.Y., & Leung, P.S. (2007). Angiotensin II type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic β-cell function in young type 2 diabetic mice. Antioxidants and Redox Signaling, 9, 869-878.
- Chu, K.Y., Lau, T., Carlsson, P.O., & Leung, P.S. (2006). AT1 receptor blockade improves β-cell function and glucose tolerance in mouse model of type 2 diabetes. Diabetes, 55, 367-374.
- Leung, P.S., Srai, S.K., Mascarenhas, M., Churchill, L.J., & Debnam, E.S. (2005). Increased duodenal iron transport in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression. Gut, 54, 1391-1395.
- Lau, T., Carlsson, P.O., & Leung, P.S. (2004). Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets. Diabetologia, 47, 240-248.