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Professor Christopher Lam 林偉基
Adjunct Professor 客座教授 |
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Biography |
Professor Lam is at present employed by the Macau University of Science and Technology (MUST), Macao as (1) Chair Professor and Vice Dean of the Faculty of Medicine and (2) Director of Laboratory Medicine at the University Hospital. He took up these appointments upon retiring from The Chinese University of Hong Kong (CUHK) and Prince of Wales Hospital, Hong Kong in 2009. The MUST Faculty of Medicine is a new designation renamed from the previous Faculty of Health Sciences after the university had been granted government approval in March 2019 to establish the first Bachelor of Medicine Bachelor of Surgery (MBBS) program in Macao. |
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Professor Lam obtained his PhD degree in Immunology from the Southampton General Hospital (UK, 1974), and had worked in the Singapore General Hospital (Singapore, 1975-1979) and the Royal Prince Alfred Hospital (Sydney, Australia, 1991-1993) before and after joining CUHK (1983). His other qualifications include Fellow of the Royal Society of Chemistry (UK, 1985), Fellow of the Academy of Clinical Biochemistry (US, 1989), Honorary Fellow of the Hong Kong College of Pathologists (2004), and Honorary Fellow of the Royal College of Pathologists (UK, 2006). He is also qualified as a Hong Kong Government Listed Practitioner of Chinese Medicine (License Number L07700, since 2001). |
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Professor Lam is a general clinical biochemist who has published over 600 papers widely in Allergy and Clinical Immunology, Nephrology, Lipidology, Diabetology and Endocrinology, Infectious Diseases, Toxicology, and Chinese Medicine accruing a total citation number of > 18,000 and an h-index of 67. During the SARS epidemic in 2003, Professor Lam developed a postulate that many acute infections and chronic illnesses are in fact communication diseases caused by cytokine and chemokine aberrations resulting in deranged intercellular communication and intracellular signal transduction. This new concept in laboratory medicine has enhanced understanding of the messenger and message pathology of acute and chronic diseases, with clinical applications in patient care using cytokines and chemokines for monitoring and their antibodies (e.g. anti-TNF antibody) for treatment. For this contribution Professor Lam was conferred the IFCC Distinguished Award in Laboratory Medicine and Patient Care in 2008 (IFCC = International Federation of Clinical Biochemistry). His other honors include the APFCB Silver Jubilee Distinguished Medal and Award bestowed in 2006 (APFCB = Asian and Pacific Federation of Clinical Biochemistry). |
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Professor Lam has been active in local, regional and international services in Clinical Biochemistry. He has served as the Secretary, President, Chief Examiner and Chairman of the Board of Accreditation for the Hong Kong Society of Clinical Chemistry (1987-2001); Secretary and President of APFCB (1994-2004); Executive Board Member (1999-2005) and Vice President cum Chairman of the Awards Committee of IFCC (2009-2011). He has been Visiting Professor in China for (1) the People's Liberation Army General Hospital (301 Hospital) and Postgraduate Medical School (Beijing, since 2000) and (2) Chongqing Medical University (Chongqing, since 2000). His traveling lectureships comprise the Roman Traveling Lectureship of the Australasian Association of Clinical Biochemists (7 state capital cities, 2002), APFCB Traveling Lectureship (8 Asian-Pacific countries, 2006), and IFCC Traveling Lectureship to the EFCC (European Federation of Clinical Chemistry, 2008), for which he presented The Laboratory Medicine of Infectious Diseases and Cybernetics of Cytokines and Chemokines: Pathophysiology and Clinical Applications along a stretch of the River Danube in Croatia, Hungry and the Czech Republic - in exchange for concert tickets for him and his wife in the evenings. |
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Clinical Biochemistry is real-life biochemistry. Professor Lam has recently undertaken a keen research interest into Largo meaning Front Place or Front Square in Portuguese. In Macao there is a largo for every venue: Largo do Senado (front square of the city council), do Bazar (city market), do Cais (pier), do Alfanega (customs and immigration), do Lilau (of the well of old woman), and even do Matadouro (abattoir), just to name a few. Professor Lam believes that there must have been very substantial real-life activities occurring in these largos advancing culture and civilization. They may be folk-dancing and singing, courting and romance, soccer and other sports, or even quarrels and fights, mostly resulting in a happy ending. Being a quiet and modest person, Professor Lam loves to sit smilingly by a largo and observe the world goes by. He is also keen in enrolling into a tuition course of the Portuguese language for enhancing his appreciation of life-style in the local community. |
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February 2022 |
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Recent Publications: |
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Gao X, Chan PKS, Lui GCY, Hui DSC, Chu IMT, Sun XY, Tsang MSM, Chan BCL, Lam CWK, Wong CK. Interleukin 38 ameliorates Poly (I:C) induced lung inflammation: Therapeutic implications in respiratory viral infections. Cell Death & Disease 2021 Jan 7; 12 (1):53. Doi:10.1038/s41419-020-03282-2. |
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Hou TH, Tsang MSM, Chu IMT, Kan LLY, Hon KL, Leung TF, Lam CWK, Wong CK. Skewed inflammation is associated with aberrant interleukin-37 signaling pathway in atopic dermatitis. Allergy 2021 Feb 7; 76:2102-14. |
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Tomlinson B, Lin CH, Chan P, Lam CWK (Co-Corresponding Author). Personalized medicine in lipid-modifying therapy. Personalized Medicine 2021 Feb 10; 18(2): 185-203. |
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Chen RH, Yang LJ, Hamdoun S, Chung S, Zhang KZ, Lam CWK, Guo SL, Xia CL, Law YK, Wong KW. 1,2,3,4,6-Pentagalloyl glucose, a RBD- ACE2 binding inhibitor to prevent SARS-CoV-2 infection. Frontiers in Pharmacology 2021 Mar 4; 12:634176. |
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Tomlinson B, Patil NG, Fok M, Lam CWK (Co-Corresponding Author). Role of PCSK9 inhibitors in patients with familial hypercholesterolemia. Endocrinol Metab Seoul 2021 Apr; 36(2): 279-295. |
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Li Y, Zhang HX, Luo WD, Lam CWK, Wang CY, Bai LP, Wong VKW, Zhang W, Jiang ZH. Profiling ribonucleotide and deoxyribonucleotide pools perturbed by Remdesivir in human bronchial epithelial cells. Front Pharmacol 2021 May 4; 12:647280. |
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Hou TH, Tsang MSM, Kan LLY, Li PT, Chu AMT, Lam CWK, Wong CK. IL-37 targets TSLP-primed basophils to alleviate atopic dermatitis. Int J Mol Sci 2021 (July); 22:7393. |
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Wu XX, Siu WS, Wat CL, Chan CL, Koon CM, Li X, Cheng W, Tsang MSM, Lam CWK, Wong CK. Effects of topical application of a tri-herb formula on inflammatory dry-skin condition in mice with oxazolone-induced atopic dermatitis. Phytomedicine 91 (2021 July 28) 153691. |
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Chan SW, Tomlinson B, Chan P, Lam CWK. The beneficial effects of Ganoderma Iucidum on cardiovascular and metabolic disease risk. Pharm Biol 2021 (August); 59: 1161-71. |
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Tomlinson B, Chan P, Lam CWK. Is there still a role for sulfonylureas in type 2 diabetes? Current Pharmacogenomics and Personalized Medicine (Accepted 21 September 2021). |
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Tomlinson B, Chan P, Lam CWK (Co-Corresponding Author). An overview of alogliptin + pioglitazone for the treatment of type 2 diabetes. Expert Opin Pharmacother 2021 Oct 11:1-14. |
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Tomlinson B, Chow E, Cahn P, Lam CWK (Co-Corresponding Author). An evaluation of the pharmacokinetics of inclisiran in the treatment of atherosclerotic cardiovascular disease. Exp Opin Drug Metab Toxicol. Accepted 2021 Oct 20. |
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Guo X, Leung TF, Wong GWK, Ko WH, Cai MY, Je EJY, Chu IMT, Tsang MSM, Chan BCL, Ling JW, Fan X, Lu LW, Lam CWK, Wong CK. Meteorin-beta/Meteorin-like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma. Cellular & Molecular Immunology accepted 28 October 2021. |
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Tomlinson B, Chan P, Lam CWK (Co-Corresponding Author). The role of sulfonylureas in the treatment of type-2 diabetes. Expert Opin Pharmacother 2021 Nov 10:1-17. |
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Tomlinson B, Patil NG, Fok M, Lam CWK (Co-Corresponding Author). Managing dyslipidemia in patients with type 2 diabetes. Expert Opin Pharmacother 2021 Nov 22 (16): 2221-2234. |
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Ling JW, Chan BCL, Tsang MSM, Gao X, Leung PC, Lam CWK, Hu JM, Wong CK. Current advances in the mechanisms and treatment of dry eye disease: towards anti-inflammatory and immune-modulating therapy and traditional Chinese medicine. Frontiers in Medicine. Accepted December 27, 2021. |
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Li PT, Tsang MSM, Kan LLY, Hou YH, Hon SSM, Chan BCL, Chu IMT, Lam CWK, Leung PC, Wong CK. The immune-modulatory activities of Pentaherbs formula on ovalbumin0induced allergic rhinitis mice via the activation of Th1 and Treg cells and inhibition of Th2 and Th17 cells. Molecules 2021 Dec 31; 27:239. |
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