Professor Dennis Lo
Professor Rossa Chiu
Professor Allen K C Chan
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Hao Sun
Professor Kathy Lui
Professor Peiyong Jiang
Professor Peter Cheung
Professor Jacky Lam
Professor Masashi Yukawa
Professor Chun Kit Choi
Professor Jason Liao
Professor Christopher Lam
Professor Nirmal Panesar
Dr Michael H M Chan
Dr Angel Chan
 
 
 
Peter Cheung 張栢恒
Assistant Professor 助理教授
ppcheung@cuhk.edu.hk
Biography
 
Present Employment:
2022 - Present: Assistant Dean (Research), Faculty of Medicine, The Chinese University of Hong Kong
2021 - Present: Assistant Professor at Department of Chemical Pathology, The Chinese University of Hong Kong
 
Previous Employment:
2018 - 2021: Research Assistant Professor at Department of Chemistry, The Hong Kong University of Science and Technology
2016 - 2018: Research Assistant Professor at Division of Biomedical Engineering, The Hong Kong University of Science and Technology
2015 - 2016: Postdoctoral Fellow at Division of Biomedical Engineering, The Hong Kong University of Science and Technology
2013 - 2015: Research Associate at School of Public Health, University of Hong Kong
 
Academic Qualifications:
2009 - 2013 : Doctor of Philosophy, The University of Hong Kong, Hong Kong, China
2005 - 2007 : Master of Science in Pathology, Western University, London, Ontario, Canada
2001 - 2005 : Bachelor of Science (Honours) in Life Sciences, Queen's University, Kingston, Ontario, Canada (first class honor)
 
Prizes and Awards:
2019: Silver Award, HKUST - Sino One Million Dollar Entrepreneurship Competition
2015: Finalist, Young Scientist Awards
2012: Graduate Student Travel Scholarship, Tech Dragon Limited
2010: Croucher-Butterfield Studentship, Croucher Foundation
 
Leading Grants and Projects:
1. RGC - Collaborative Research Fund
 

CHEUNG Pak Hang Peter (Lead, Principal Coordinator)
  2022 - Present
   
2. RGC - General Research Fund
 

CHEUNG Pak Hang Peter (Lead, Principal Coordinator)
  2018 - Present
   
3. RGC - General Research Fund
 

CHEUNG Pak Hang Peter (Lead, Principal Coordinator)
  2019 - Present
 
Specialised Research Area(s):
Our team's current interests lie in the gene transcription of RNA viruses, with emphasis on influenza and coronaviruses. RNA viruses encode their RNA polymerases to replicate the viral genome. The error-prone transcription process of RNA polymerases is the main driving force for viral genetic diversity essential for adaption to and infection of the host. However, the accuracy of virus transcription must be maintained at a certain threshold for faithful gene expression and protein production. We are interested in understanding the structural basis of how viral polymerases regulate transcription accuracy in RNA viruses and the biological consequences of transcriptional errors during infection by developing a novel genomics platform and using Cryogenic Electron Microscopy (Cryo-EM). These fundamental insights are essential in the basic understanding of gene transcription and virus evolution and the biomedical research for the development of antiviral drugs and vaccines for infectious diseases.
 
Selected publications (*denotes corresponding author):
Au, W. Y. and Cheung, P.P.H.*. Effectiveness of heterologous and homologous COVID-19 vaccine regimens: a living systematic review with network meta-analysis. The British Medical Journal (BMJ), 377: e069989, (2022) [Impact Factor: 93.333]
Au, W. Y., Ye, C., Briner S.L., Suarez, G.D., Han, J., Xu, X., Park, J.G., Brindley, M.A., Martinez-Sobrido*, L., Cheung, P.P.H*. Systematic comparison between BNT162b2 and CoronaVac in the seroprotection against SARS-CoV-2 Alpha, Beta, Gamma, and Delta variants, Journal of Infection, DOI: 10.1016/j.jinf.2022.02.030, (2022) [Impact Factor: 38.637]
Suarez, G.D., Suarez D.A., Tang Y.Y.K., Zhang J.-X., Li, J., Nagl, S., Cheung P.P.H.* Uncovering Mechanisms of RT-LAMP Colorimetric SARS-CoV-2 Detection to Improve Assay Reliability, Analytical Methods, DOI: 10.1039/D1AY01395E (2022) [Impact Factor: 3.532]
Au, W. Y., Cheung, P. P. H.*. Diagnostic performances of common nucleic acid tests for SARS-CoV-2 in hospitals and clinics: a systematic review and meta-analysis. The Lancet Microbe, DOI:10.1016/S2666-5247(21)00214-7 (2021) [Impact Factor: 86.208]
Xu, X., Zhang, L.*, Chu J.T.S., Wang, Y. Chin, A.W.H., Dai, Z., Poon, L.L.M., Cheung, P.P.-H.*, Huang, X.*. A Novel Mechanism of Enhanced Transcription Activity and Fidelity for Influenza A Viral RNA-dependent RNA Polymerase, Nucleic Acids Research, 49 (15), 8796 (2021) [Impact Factor: 19.160]
Wang, Y., Yuan, C., Xu, X., Chong, T.H., Zhang, L., Cheung P.P.H.*, Huang, X.*. The mechanism of action of T-705 as a unique delayed chain terminator on influenza viral polymerase transcription, Biophysical Chemistry, 277, 106652 (2021) [Impact Factor: 3.628]
Zhang, L., Zhang, D., Wang X., Yuan, X., Li, Y., Jia, X., Gao, X., Yen, H.L., Cheung, P.P.*, Huang, X.*, 1’-Ribose Cyano Substitution Allows Remdesivir to Effectively Inhibit both Nucleotide Addition and Proofreading during SARS-CoV-2 Viral RNA Replication, Physical Chemistry Chemical Physics, 23, 5852 (2021) [Impact Factor: 3.945]
Wang, Y.*, Chong, T.H.*, Unarta, I.C.*, Xu, X., Suarez, G.D., Wang, J., Lis, J.T., Huang, X., Cheung, P.P.H.*, EmPC-Seq: Accurate RNA-sequencing and Bioinformatics Platform to Map RNA Polymerases and Remove Background Error, Bio-Protocol, 11, 4 (2021)
Cheung, P.P.H., Jiang, B., Booth, G.T., Chong, T.H., Unartar, I.C., Wang, Y., Suarez, G.D., Wang, J., Lis, J.T., Huang, X., Identifying Transcription Error-Enriched Genomic Loci Using Nuclear Run-On Circular-Sequencing Coupled with Background Error Modeling, Journal of Molecular Biology, S0022-2836(20)30284-9 (2020) [Impact Factor: 6.151]
Tse, K.M., Xu, J., Xu, L., Sheong, F.K., Wang, S., Chow, H.Y., Gao, X., Li, X., Cheung, P.P.H.*, Wang, D.*, Zhang, Y.*, Huang, X*. Intrinsic cleavage of RNA polymerase II adopts a nucleobase-independent mechanism assisted by transcript phosphate, Nature Catalysis, 2, 228-235 (2019) [Impact Factor: 40.706]
Cheung, P.P., Rogozin, I.B., Choy, K.T., Ng, H.Y., Peiris, J.S., and Yen, H.L Comparative mutational analyses of influenza A viruses. RNA 21, 36 (2015) [Impact Factor: 5.636]
Cheung, P.P., Watson, S.J., Choy, K.T., Fun Sia, S., Wong, D.D., Poon, L.L., Kellam, P., Guan, Y., Malik Peiris, J.S., and Yen, H.L. Generation and characterization of influenza A viruses with altered polymerase fidelity. Nature Communications 5, 4794  (2014) [Impact Factor: 17.694]
Cheung, P.P., Leung, Y.H., Chow, C.K., Ng, C.F., Tsang, C.L., Wu, Y.O., Ma, S.K., Sia, S.F., Guan, Y., and Peiris, J.S., Identifying the species-origin of faecal droppings used for avian influenza virus surveillance in wild-birds. Journal of Clinical Virology 46, 90  (2009) [Impact Factor: 14.481]
Wang, L., Chen, J., Zeng, X., Cheung, P.P.H., Zheng, X., Xie, L., Shi, X., Ren, L., Huang, X., Wang, Y. Mechanistic Insights and Rational Design of a Versatile Surface with Cells/Bacteria Recognition Capability via Orientated Fusion Peptides, Advanced Science, 6 (9), 1801827 (2019). [Impact Factor: 17.521]
Lei, J., Sheng, G., Cheung, P.P.H., Wang, S., Li, Y., Gao, X., Zhang, Y., Wang, Y., Huang, X. Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proceedings of the National Academy of Sciences of the United States of America, 116 (3), 845-853, (2019). [Impact Factor: 12.779]
Jiang, L., Cao, S., Cheung, P.P.H., Zheng, X., Leung, C.W.T., Peng, Q., Shuai, Z., Tang, B.Z., Yao, S., Huang, X., Real-Time Monitoring of Hydrophobic Aggregation Reveals a Critical Role of Cooperativity in Hydrophobic Effect, Nature Communications, 8, 15639 (2017) [Impact Factor: 17.521]
Zhang, L., Pardo, F., Unarta, I.C., Cheung, P.P.H., Wang, G., Wang, D., and Huang, X. Elucidation of the Dynamics of Transcription Elongation by RNA Polymerase II using Kinetic Network Models, Accounts of Chemical Research, 49 (4), 687-694 (2016) [Impact Factor: 24.466]
 
 
 
 
The Chinese University of Hong Kong