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Research




Ongoing and recently completed studies

Lifestyle modification programme for HIV-infected individuals with non-alcoholic fatty liver disease: A randomized controlled trial.

Eating behaviours, diet quality and gastrointestinal symptoms in children with autism spectrum disorders and typically developing children: a case-control study.

Sulfur Amino Acids as Risk Factors for Obesity and Related Morbidities in Older Chinese People.

Effects of exercise and nutrition supplementation in community-dwelling older Chinese people with sarcopenia: a randomized controlled trial.

A randomized controlled trial examining the effectiveness of a lifestyle intervention in reducing gestational diabetes mellitus in high risk Chinese pregnant women in Hong Kong.


 


Publications

Selected Publications

Cardiovascular disease, blood pressure and stroke

Ruth Chan, Blanche Yu, Jason Leung, Jenny Shun-Wah Lee, Jean Woo. Association of dietary patterns with serum high-sensitivity C-reactive protein level in community-dwelling older adults. Clinical Nutrition ESPEN 2019 Jun; 31: 38-47.

Ruth Chan, Forrest Yau, Blanche Yu, Jean Woo. The role of dietary patterns in the contribution of cardiorespiratory fitness in community-dwelling older Chinese adults in Hong Kong. J Am Med Dir Assoc 2019; 20(5), 558-563.

Chi-Ho Lee, Ruth S. M. Chan, Helen Y. L. Wan, Yu-Cho Woo, Chloe Y. Y. Cheung, Carol H. Y. Fong, Bernard M. Y. Cheung, Tai-Hing Lam, Edward Janus, Jean Woo, Karen S. L. Lam. Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese — A 22-Years Population-Based Prospective Study. Nutrients 2018 Nov 4; 10(11).

Woo J, Yu WM, Chan RSM, Leung J. Influence of dietary patterns and inflammatory markers on atherosclerosis using ankle brachial index as a surrogate. J Nutr Health Aging 2018; 22(5): 619-626.

Obesity

Cheung LTF, Chan RSM, Ko GTC, Lau ESH, Chow FCC, Kong APS. Diet quality is inversely associated with obesity in Chinese adults with type 2 diabetes. Nutr J 2018; Jul 3;17(1):63.

Chan DFY, So HK, Hui SCN, Chan RSM, Li AM, Sea MM, Chu WCW, Chan M, Woo J, and Nelson EAS. Dietitian-led lifestyle modification programme for obese Chinese adolescents with nonalcoholic fatty liver disease: A randomized controlled study. Int J Obesity 2018; 42(9):1680-1690.

A.W.Y. Leung, R.S.M. Chan, M.M.M. Sea, J. Woo. Identifying psychosocial predictors of adherence to lifestyle modification program among Chinese overweight and obese adult participants. Int J Behav Med 2016; 23(Supp 1).

Abraham AA, Chow WC, So HK, Yip BHK, Li AM, Kumta SM, Woo J, Chan SM, Lau EYY, Nelson EAS. Lifestyle intervention using an internet-based curriculum with cell phone reminders among obese Chinese adolescents: a randomized controlled study. PLOS One 2015; 10(5): e0125673.

Osteoporosis and bone-Related Disease

Zhao-min Liu, Jason Leung, Samuel Wong, Carmen Wong, Ruth Chan, Jean Woo. Greater fruit intake was associated with better bone mineral status among Chinese elderly men and women: Results of Hong Kong Mr. Os and Ms. Os Studies. J Am Med Dir Assoc 2015; 16(4), 309-15.

Ruth Chan, Dicken Chan, Jean Woo, Claes Ohlsson, Dan Mellström, Timothy Kwok, Ping Chung Leung. Not All Elderly People Benefit from Vitamin D Supplementation with Respect to Physical Function - Results from the Osteoporatic Fractures in Men Study, Hong Kong. J Am Geriatr Soc 2012; 60(2): 290-295.

Chan R, Leung J, Woo J. No association between dietary vitamin K intake and fracture risk in Chinese community-dwelling older men and women: a prospective study. Calcif Tissue Int 2012; 90(5): 396-403.

Ruth Chan, Dicken Chan, Jean Woo, Claes Ohlsson, Dan Mellström, Timothy Kwok, Pingchung Leung. Serum 25-hydroxyvitamin D, bone mineral density and non-vertebral fracture risk in community-dwelling older men: results from Mr. Os, Hong Kong. Arch Osteoporos 2011, 6(1-2), 21-30.

Chan R, Woo J. The value of vitamin D supplementation in older people. Nutr Ther Metab 2011; 29(1): 8-21.

Muscular and functional outcomes

Liu-Ying Zhu, Ruth Chan, Timothy Kwok, Kenneth Chik-Chi Cheng, Amy Ha, Jean Woo. Effects of exercise and nutrition supplementation in community-dwelling older Chinese people with sarcopenia: a randomized controlled trial. Age Ageing 2018; 48(2): 220-228.

Liu-Ying Zhu, Ruth Chan, Liz Li, Timothy Kwok and Jean Woo. Dietary protein intake pattern and sources and their associations with muscle and physical function measures in older Chinese adults with sarcopenia in Hong Kong. J Aging Res Clin Practice 2018; 7: 75-81.

Ruth Chan, Jason Leung, Jean Woo. A prospective cohort study to examine the association between dietary patterns and sarcopenia in Chinese community-dwelling older people in Hong Kong. J Am Med Dir Assoc 2016; 17(4): 336-42.

Ruth Chan, Jason Leung, Jean Woo. Association between estimated net endogenous acid production and subsequent decline in muscle mass over four years in ambulatory older Chinese people in Hong Kong: a prospective cohort study. J Gerontol A Biol Sci Med Sci 2015 Jul; 70(7): 905-11.

Psychological Health (e.g. cognitive performance, dementia)

Bernice HK Cheung, Ivan CH Ho, Ruth SM Chan, Mandy MM Sea, Jean Woo. Current evidence on dietary pattern and cognitive function. Adv Food Nutr Res 2014; 71: 137-63.

Ruth Chan, Dicken Chan, Jean Woo. A cross sectional study to examine the association between dietary patterns and cognitive impairment in older Chinese people in Hong Kong.  J Nutr Health Aging 2013; 17(9): 757-765.

Kwok TCY, Lam LCW, Sea MMM, Goggins W, Woo J. A randomized controlled trial of dietetic interventions to prevent cognitive decline in old age hostel residents. Eur J Clin Nutr 2012; 66: 1135-1140.

Chan R, Chan D, Woo J, Ohlsson C, Mellström D, Kwok T, Leung PC. Association between serum 25-hydroxyvitamin D and psychological health in older Chinese men in a cohort study. J Affect Disord 2011; 130: 251-259.

Clinical and nutritional assessment (e.g. use of different biomarkers, questionnaire validation)

Ruth Chan, Sin Li, Siu-Wai Choi, Erica Weilan Wang, Jason Leung, Iris Benzie, Mandy Sea, Jean Woo. Effect of Four Different Meal Types on Postprandial Oxidative Stress: A Randomized Crossover Study with Healthy Subjects. Int J Foo Nutri 2016; doi:10.15436/2377-0619.16.985.
Chau PH, Leung AY, Li HL, Sea M, Chan R, Woo J. Development and Validation of Chinese Health Literacy Scale for Low Salt Consumption-Hong Kong Population (CHLSalt-HK). PLOS One 2015; 10(7): e0132303.
Forrest Yau, Ruth Chan, William Goggins, Kay-Tee Khaw, Jean Woo. Examination of the Applicability of the Physical Activity Questionnaire from European Prospective Investigation into Cancer and Nutrition Study in the Hong Kong Chinese Population. Prim Health Care 2012; 2:115. doi:10.4172/2167-1079.100011.

Maternal and child health and nutrition

Vincy Wing-Si Wong, Yuk-Fan Ng, Suk-Mei Chan, Yi-Xiang Su, Kevin Wing-Hin Kwok, Hing-Man Chan, Chi-Leung Cheung, Hang-Wai Lee, Wing-Yiu Pak, Shi-Ying Li and Man-Sau Wong. Positive relationship between consumption of specific fish type and omega-3 polyunsaturated fatty acids in milk of Hong Kong lactation mothers. Brit J Nutr 2019; 12: 1-30.
Ruth Suk-Mei CHAN, Wing-Hung TAM, Ivan Chak-Hang HO, Macy Wai-Chi KWAN, Liz Sin LI, Mandy Man-Mei SEA, Jean WOO. Randomized trial examining effectiveness of lifestyle intervention in reducing gestational diabetes in high risk Chinese pregnant women in Hong Kong. Sci Rep 2018 Sep14; 8(1).
Ruth Chan, Suey Yeung, Cynthia Leung, Sing Kai Lo, Sandra Tsang. Family factors and fruit and vegetable consumption in Chinese preschool children living in Hong Kong. J Child Serv 2018; 13(3/4): 122-133.
Chan KC, Tam WH, Chan MH, Chan RS. Li AM. Vitamin D deficiency among healthy infants in Hong Kong: a pilot study. Hong Kong Med J 2018 Jun; 24 Supp 3(3): 32-35.
Suey Yeung, Ruth Chan, Liz Li, Shirley Leung, Jean Woo. Bottle milk-feeding and its association with food group consumption, growth and socio-demographic characteristics in Chinese young children. Matern Child Nutr 2017; 13(3).
Tam Wing Hung, Chan Ruth Suk-mei, Chan Michael Ho-ming, Yuen Lai Yuk, Li Liz, Sea Mandy Man-mei, Woo Jean. Moderate iodine deficiency among pregnant mothers in Hong Kong – revisit the problem after two decades. Hong Kong Medical Journal 2017;23(6):586-93.

Nonalcoholic fatty liver disease

Wong VW, Wong GL, Chan RS, Shu SS, Cheung BH, Li LS, Chim AM, Chan CK, Leung JK, Chu WC, Woo J, Chan HL. Beneficial effects of lifestyle intervention in non-obese patients with non-alcoholic fatty liver disease. J Hepatol 2018; 69(6): 1349-1356.
Ruth Chan, Vincent Wai-Sun Wong, Winnie Chiu-Wing Chu, Grace Lai-Hung Wong, Liz Sin Li, Jason Leung, Angel Mei-Ling Chim, David Ka-Wai Yeung, Mandy Man-Mei Sea, Jean Woo, Francis Ka-Leung Chan, Henry Lik-Yuen Chan. Diet-quality scores and prevalence of nonalcoholic fatty liver disease: a population study using proton-magnetic resonance spectroscopy. PLOS One 2015; 10(9): e0139310.
Ruth Chan, Vincent Wai-Sun Wong, Winnie Chiu-Wing Chu, Grace Lai-Hung Wong, Liz Sin Li, Jason Leung, Angel Mei-Ling Chim, David Ka-Wai Yeung, Mandy Man-Mei Sea, Jean Woo, Francis Ka-Leung Chan, Henry Lik-Yuen Chan. Higher estimated net endogenous acid production may be associated with increased prevalence of nonalcoholic fatty liver disease in Chinese adults in Hong Kong. PLOS One 2014; 10(4): e0122406.
Vincent Wai-Sun Wong* (co-first author), Ruth Suk-Mei Chan* (co-first author), Grace Lai-Hung Wong, Bernice Ho-Ki Cheung, Winnie Chiu-Wing Chu, David Ka-Wai Yeung, Angel Mei-Ling Chim, Jennifer Wing-Yan Lai, Liz Sin Li, Mandy Man-Mei Sea, Francis Ka-Leung Chan, Joseph Jao-Yiu Sung, Jean Woo, Henry Lik-Yuen Chan. Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial. J Hepatol 2013; 59: 536-542.

Others

Susanna SS Ng, Ruth SM Chan, Jean Woo, Tat-On Chan, Bernice HK Cheung, Mandy MM Sea, Kin-Wang To, Ken KP Chan, Jenny Ngai, Wing-Ho Yip, Fanny WS Ko, David SC Hui. A randomized controlled study to examine the effect of lifestyle modification program in obstructive sleep apnea. Chest 2015; 148(5): 1193-1203.
Wong WC, Wong EL, Li H, You JH, Ho S, Woo J, Hui E. Isoflavones in treating watchful waiting benign prostate hyperplasia: a double-blinded, randomized controlled trial. J Altern Complement Med 2012; 18(1): 54-60.
Woo J, Leung JCS, Wong SYS. Impact of Childhood Experience of Famine on Late Life Health. J Nutr Health Ageing 2010; 14: 91-95.

List of selected publications  
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