黃振國教授

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簡介

黄振國教授於1993年獲得香港中文大學生物化學系免疫學博士學位，其後在美國哈佛醫學院Centre for Biochemical and Biophysical Science and Medicine, Brigham and Women‘s Hospital (1994-1996) 以及哈佛醫學院馬薩諸塞州總醫院胸肺和重症監護中心（1996-1997）進行博士後研究 。返港後, 他於1997年8月至2000年6月委任為香港中文大學化學病理系博士後研究員，2000年7月任科學主任，2001年2月為副教授，2009年8月1日升為教授。分別自2010年至2013年起, 他還被任命為藥用植物應用研究國家重點實驗室(香港中文大學)副主任與中醫中藥研究所所長。

黃教授參與中文大學醫學院和理學院課程教學和大學通識教育。目前，黃教授指導六名博士研究生和一名博士後研究員。他也在香港醫院管理局威爾斯親王醫院診斷臨床化學實驗室擔任名譽科學主任(醫學)。

黃教授曾任香港免疫學會及香港流式細胞學會會長，現任香港免疫學會司庫和英國皇家生物學會院士。

研究簡介

(1) 利用體外，動物和臨床研究中藥(包括多糖肽和小分子)的免疫調節，抗腫瘤和抗過敏活性，最近工作包括免疫調節草本產品的開發。

(2) 闡明細胞間細胞因子/趨化因子網絡和免疫效應細胞的細胞內信號轉導，包括嗜酸性粒細胞，淋巴細胞，肥大細胞，嗜鹼性粒細胞和樹突細胞在過敏性炎症中的免疫病理機制，最近強調模式識別受體介導的先天免疫和損傷性炎症，和使用人源化和基因條件敲除小鼠的動物研究。

(3) 通過國際和部門間合作，對過敏性疾病，自身免疫性疾病，傳染病，糖尿病的免疫病理機制進行臨床研究, 最近著重於具有潛在抗炎應用的調節性細胞因子的轉化醫學。

他在國際期刊和書籍章節 上發表了255篇文獻 (H-index = 50, Web of Science)。

代表性著作

  1. Wong CK, Wong BCK, Chan KCA, Joynt GM, Yap YHY, Lam CWK, Lee N, Lee SS, Cockram CS, Sung JJY, Chan PKS, Lo YMD and Tang JW. Cytokine profile in fatal human immunodeficiency virus-tuberculosis-Epstein-Barr virus-associated hemophagocytic syndrome. Arch Int Med 2007; 167:1901-1903
  2. Lee N*, Wong CK*, (*Equal first author), Chan PKS, Lun SWM, Lui G, Wong B, Hui DSC, Lam CWK, Cockram CS, Choi KW, Yeung ACM , Tang Julian W , Sung JJY . Hypercytokinemia and Hyperactivation of p38 Mitogen-Activated Protein Kinase in Severe Human Influenza A Infections. Clin Infect Dis 2007; 45: 723-731.
  3. Cheung PFY, Wong CK* (*Equal first author), and Lam CWK. Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17F and IL-23: implications for Th17 lymphocyte-mediated allergic inflammation. J Immunol 2008; 180:5625-35
  4. Wong CK, Hu SQ, Cheung PFY and Lam CWK. Thymic Stromal Lymphopoietin Induces Chemotactic and Pro-survival Effects in Eosinophils: Implications in Allergic Inflammation. Am J Respir Cell Mol Biol 2010; 43: 305-15.
  5. Wong CK, Cao J, Yin YB and Lam CWK. IL-17A activation on bronchial epithelial cells and basophils: a novel inflammatory mechanism. Eur Respir J 2010; 35: 883-93.
  6. Wong CK, Chen DP, Tan LS, Li EK, Yin YB, and Lam CW. Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther 2010; 12: R129.
  7. `Chen DP, Wong CK (Equal 1st author, correspondence author), Leung PC, Fung KP, Lau CBS, Lau CP, Li EK, Tam LS, Lam CWK. Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-a-activated human fibroblast-like synoviocytes in rheumatoid arthritis. J Ethnopharmacol 2011; 137:457-468.
  8. Dong J, Wong CK (Equal first author, correspondence author), Cai Z, Jiao D, Chu M and Lam CWK. Amelioration of allergic airway inflammation in mice by regulatory IL-35 through dampening inflammatory dendritic cells. Allergy 2015; 70: 921–932.
  9. Jiao D, Wong CK (equal 1st author, correspondence author), Qiu HN, Dong J, Cai Z, Chu M, Hon KL, Tsang MSM, Lam CWK. NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation. Cell Mol Immunol 2016; 13: 535-550.
  10. Zhu J, Dong J, Ji L, Jiang P, Leung TF, Liu D, Ng LG, Tsang MSM, Jiao D, Lam CWK, Wong CK (correspondence author). Anti-allergic inflammatory activity of interleukin-37 is mediated by novel signaling cascades in human eosinophils. Front Immunol 2018; 9:1445.
  11. Hou T, Sun X, Zhu J, Hon KL, Jiang P, Chu IM, Tsang MS, Lam CW, Zeng H, Wong CK (correspondence author). IL-37 ameliorating allergic inflammation in atopic dermatitis through regulating microbiota and AMPK-mTOR signaling pathway-modulated autophagy mechanism. 2020. Front Immunol 2020; 11: 752.
  12. Sun X, Hou T, Cheung EC, Iu TN, Tam VW, Chu IM, Tsang MS, Chan PK, Lam CW, Wong CK (correspondence author). Anti-inflammatory Mechanisms of the Novel Cytokine Interleukin-38 in Allergic Asthma. Cell Mol Immunol 2020; 17:631–646
  13. Hou T, Tsang MSM, Chu IMT, Kan LL, Hon KL, Leung TF, Lam CWK and Wong CK (correspondence author). Skewed inflammation is associated with aberrant interleukin-37 signaling pathway in atopic dermatitis. Allergy 2021; 76: 2102-2114.
  14. Cai Z, Zhang S, Wu P , Ren Q, Wei P, Hong M, Feng Y, Wong CK (correspondence author), Tang H, Zeng H. A novel potential target of IL-35 regulated JAK/STAT signaling pathway in lupus nephritis. Clin Transl Med 2021; 11:e309.
  15. Gao X, Chan PKS, Lui GCY, Hui DSC, Chu IMT, Sun X, Tsang MSM, Chan BCL, Lam CWK and Wong CK (correspondence author). Interleukin-38 ameliorates Poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections. Cell Death and Disease 2021; 12:53.