Prof. LAU Bik San Clara

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  4. Prof. LAU Bik San Clara
  • Address:
    (Office): Room 305, Science Centre East Block
  • Phone:
    (Office): (852) 3943 6109
  • Fax: (852) 2603 5248
  • Email: claralau@cuhk.edu.hk

Biography

Professor Clara Lau is the Associate Director of the Institute of Chinese Medicine at The Chinese University of Hong Kong. She also serves as the Associate Director of the State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants (The Chinese University of Hong Kong). She has a courtesy appointment as Associate Professor at the School of Chinese Medicine, CUHK and has served as Deputy Program Director/Program Director (2005-2015) of a part-time MSc in Chinese Medicines and Herbal Drugs. With BPharm and PhD in Pharmacy (Pharmacognosy) from King’s College London, University of London, United Kingdom, she has a continuous interest in medicinal plants (western herbals and traditional Chinese herbal medicines) and has over 26 years' experience in natural products research. She currently serves as member of ChP-USP Advisory Group on Monographs for Traditional Chinese Medicine Ingredients and Products; Acting Secretary General and Executive Council Member of The Consortium for Globalization of Chinese Medicine (CGCM); President-Elect, Secretary General and Executive Committee Member of the Board of Directors for Good Practice in Traditional Chinese Medicine Research Association (GP-TCM RA); Council member and Associate Chief Executive of Modernized Chinese Medicine International Association (MCMIA); Advisor for Chinese Medicine Council of Hong Kong on Registration of Proprietary Chinese Medicines; Associate Editor of “Journal of Traditional and Complementary Medicine (eJTCM)”, Consulting Editor of “Pharmacological Research”, and Editorial Board member of journals “Phytomedicine”, “Scientific Reports”, “Journal of Natural Products”, “Journal of Ethnopharmacology”, “Journal of Pharmacy and Pharmacology” and “Integrative Medicine Research”.

Research Interests

( 1 ) Study of herbs and natural products with potential anti-cancer activities; discovery and development of anti-angiogenic natural products; evaluation of anti-tumor and anti-metastatic activities of natural compounds; research on adjuvant potentials of Chinese herbal extracts in cancer management.

( 2 ) Study of anti-diabetic and diabetic foot ulcer healing activities of medicinal herbs.

( 3 ) Investigation of beneficial herb-drug interactions.

Representative Publications

(over 250 SCI journal articles, 9 book chapters) *Corresponding author
  1. Yue GGL, Chan YY, Liu W, Gao S, Wong CW, Lee JKM, Lau KM, Lau CBS* (2021). Effectiveness of Scutellaria barbata water extract on inhibiting colon tumor growth and metastasis in tumor-bearing mice. Phytotherapy Research 35, 361-373.
  2. Li M, Yue GGL, Luo L, Tsui SKW, Fung KP, Ng SSM, Lau CBS* (2021). Turmeric is therapeutic in vivo on patient-derived colorectal cancer xenografts: inhibition of growth, metastasis and tumor recurrence. Frontiers in Oncology 10, 574827.
  3. Yue GGL, Liang XX, Li XL, Lee JKM, Gao S, Kwok HF, Lau CBS*, Xiao WL (2020). Immunomodulatory and antitumor bioactive labdane diterpenoids from Leonurus japonicus. Journal of Pharmacy and Pharmacology 72, 1657-1665.
  4. Yue GGL, Gao S, Lee JKM, Chan YY, Wong ECW, Zheng T, Li XX, Shaw PC, Simmonds MSJ, Lau CBS* (2020). A natural flavone tricin from grains can alleviate tumor growth and lung metastasis in colorectal tumor mice. Molecules 25(16), 3730.
  5. Cheung MK, Yue GGL, Tsui KY, Gomes AJ, Kwan HS, Chiu PWY, Lau CBS* (2020). Discovery of an interplay between the gut microbiota and esophageal squamous cell carcinoma in mice. American Journal of Cancer Research 10(8), 2409-2427.
  6. Wu XX, Yue GGL, Dong JR, Lam CWK, Wong CK, Qiu MH, Lau CBS* (2020). Actein inhibits tumor growth and metastasis in HER2-positive breast tumor bearing mice via suppressing AKT/mTOR and Ras/Raf/MAPK signaling pathways. Frontiers in Oncology 10, 854.
  7. Cheung MK, Yue GGL, Chiu PWY, Lau CBS* (2020). A review of the effects of natural compounds, medicinal plants and mushrooms on the gut microbiota in colitis and cancer. Frontiers in Pharmacology 11, 744
  8. Dong J, Yue GGL, Lee JKM, Lau CBS*, Qiu M (2020). Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum. Medicinal Chemistry Research 29, 549-555.
  9. Safavi F, Farimani MM, Golalipour M, Leung PC, Lau KM, Kwok HF, Wong CW, Bayat H, Lau CBS* (2019). Investigations on the wound healing properties of Onosma dichroantha Boiss root extracts. South African Journal of Botany 125, 344-352.
  10. Yue GGL, Li L, Lee JKM, Kwok HF, Wong ECW, Li M, Fung KP, Yu J, Chan AWH, Chiu PWY, Lau CBS* (2019). Multiple modulatory activities of Andrographis paniculata on immune responses and xenograft growth in esophageal cancer preclinical models. Phytomedicine 60, 152886.
  11. Lau KM, Yue GGL, Chan YY, Kwok HF, Gao S, Wong CW, Lau CBS* (2019). A review on the immunomodulatory activity of Acanthopanax senticosus and its active components. Chinese Medicine 14, 25.
  12. Yue GGL, Wong LS, Leung HW, Gao S, Tsang JYS, Lin ZX, Law BKB, Tse GMK, Lau CBS* (2019). Is Danggui safe to be taken by breast cancer patients? - A skepticism finally answered by comprehensive preclinical evidence. Frontiers in Pharmacology 10, 706.
  13. Lau CBS*, Yue GGL, Lau KM, Chan YY, Shaw PC, Kwok HF, Wong LS (2019). Method establishment for upgrading chemical markers in Pharmacopoeia to bioactive markers for biological standardization of traditional Chinese medicine. Journal of Traditional and Complementary Medicine 9, 179-183.
  14. Yue GGL, Wong LS, Leung HW, Gao S, Tsang JYS, Lin ZX, Tse GMK, Lau CBS* (2019). Evaluation of the safety profiles of estrogenic Chinese herbal medicines in breast cancer. Phytomedicine 56, 103-117.
  15. Yue GGL, Lee JKM, Chan BCL, Kwok HF, Hoi SWH, Sze DMY, Fung KP, Leung PC, Lau CBS* (2018). An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model. Chinese Medicine 13, 64.
  16. Li M, Yue GGL, Tsui SKW, Fung KP, Lau CBS* (2018). Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo. Phytomedicine 46, 131-141.
  17. Leung HW, Ko CH, Yue GGL, Herr I, Lau CBS* (2018). The natural agent 4-vinylphenol targets metastasis and stemness features in breast cancer stem-like cells. Cancer Chemotherapy and Pharmacology 82, 185-197.
  18. Wat E, Wang Y, Chan K, Law HW, Koon CM, Lau KM, Leung PC, Yan C, Lau CBS* (2018). An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome. Phytomedicine 42, 112-125.
  19. Li L, Yue GGL, Lee JKM, Wong ECW, Fung KP, Yu J, Lau CBS*, Chiu PWY (2018). Gene expression profiling reveals the potential mechanisms underlying the anti-tumor and anti-metastasis effects of Andrographis paniculata in esophageal cancer. Phytotherapy Research 32, 1388-1396.
  20. Li M, Yue GGL, Song LH, Huang MB, Lee JKM, Tsui SKW, Fung KP, Tan NH, Lau CBS* (2018). Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway. Biochemical Pharmacology 150, 191-201.
  21. Zhou X, Yue GGL, Tsui SKW, Pu J, Fung KP, Lau CBS* (2018). Elaborating the role of natural products on the regulation of autophagy and their potentials in breast cancer therapy. Current Cancer Drug Targets 18, 239-255.
  22. Zhou X, Yue GGL, Chan AML, Tsui SKW, Fung KP, Sun H, Pu J, Lau CBS* (2017). Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer. Biochemical Pharmacology 142, 58-70.
  23. Li P, Yue GGL, Kwok HF, Long CL, Lau CBS*, Kennelly EJ (2017). Using Ultra-Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry-Based Chemometrics for the identification of anti-angiogenic bioflavonoids from edible Garcinia species. Journal of Agricultural and Food Chemistry 65, 8348-8355.
  24. Wat E, Ng CF, Koon CM, Zheng C, Gao S, Tomlinson B, Lau CBS* (2017). The adjuvant value of Herba Cistanches when used in combination with statin in murine models. Scientific Reports 7, 9391.
  25. Ko CH, Yue GGL, Gao S, Luo KW, Siu WS, Shum WT, Shiu HT, Lee JKM, Li G, Leung PC, Evdokiou A and Lau CBS* (2017). Evaluation of the combined use of metronomic zoledronic acid and Coriolus versicolor in intratibial breast cancer mouse model. Journal of Ethnopharmacology 204, 77-85.
  26. Li L, Yue GGL, Lee JKM, Wong ECW, Fung KP, Yu J, Lau CBS*, Chiu PWY (2017). The adjuvant value of Andrographis paniculata in metastatic esophageal cancer treatment – from preclinical perspectives. Scientific Reports 7(1), 854.
  27. Chan KM, Yue GGL, Li P, Wong ECW, Lee JKM, Kennelly EJ, Lau CBS* (2017). Screening and analysis of potential anti-tumor components from the stipe of Ganoderma sinense using high-performance liquid chromatography/time-of-flight mass spectrometry with multivariate statistical tool. Journal of Chromatography A 1487, 162-167.
  28. Li M, Song LH, Yue GGL, Lee JKM, Zhao LM, Li L, Zhou X, Tsui SKW, Ng SSM, Fung KP, Tan NH, Lau CBS* (2017). Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species. Scientific Reports 7, 42176.
  29. Zhou X, Yue GGL, Liu M, Zuo Z, Lee JKM, Li M, Tsui SKW, Fung KP, Sun H, Pu J, Lau CBS* (2016). Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling. Oncotarget 7(50), 82820-82835.
  30. Ng WL, Lau KM, Lau CBS, Shing TKM (2016). Palladium-catalyzed arylation of carbasugars enables the discovery of potent and selective SGLT2 inhibitors. Angewandte Chemie International Edition 55, 13818-13821.
  31. Yue GGL, Xie S, Lee JKM, Kwok HF, Gao S, Nian Y, Wu XX, Wong CK, Qiu MH, Lau CBS* (2016). New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment. Scientific Reports 6, 35263.
  32. Yue GGL, Kwok HF, Lee JKM, Jiang L, Wong ECW, Gao S, Wong HL, Lin L, Chan KM, Leung PC, Fung KP, Zuo Z, Lau CBS* (2016). Combined therapy using bevacizumab and turmeric ethanolic extract (with absorbable curcumin) exhibited beneficial efficacy in colon cancer mice. Pharmacological Research 111, 43-57.
  33. Wat E, Ng CF, Koon CM, Wong ECW, Tomlinson B, Lau CBS* (2016). The protective effect of Herba Cistanches on statin-induced myotoxicity in vitro. Journal of Ethnopharmacology 190, 68-73.
  34. Yue GGL, Lee JKM, Li L, Chan KM, Wong ECW, Chan JYW, Fung KP, Lui VWY, Chiu PWY, Lau CBS* (2015). Andrographis paniculata elicits anti-invasion activities by suppressing TM4SF3 gene expression and by anoikis-sensitization in esophageal cancer cells. American Journal of Cancer Research 5(12), 3570-3587.
  35. Tam JCW, Ko CH, Lau KM, To MH, Kwok HF, Siu WS, Lau CP, Chan WY, Leung PC, Fung KP, Lau CBS* (2015). Enumeration and functional investigation of endothelial progenitor cells in neovascularization of diabetic foot ulcer rats with a Chinese 2-herb formula. Journal of Diabetes 7, 718-728.
  36. Leung HW, Wang Z, Yue GGL, Zhao SM, Lee JKM, Fung KP, Leung PC, Lau CBS*, Tan NH (2015). Cyclopeptide RA-V inhibits cell adhesion and invasion in both estrogen receptor positive and negative breast cancer cells via PI3K/AKT and NF-κB signaling pathways. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853, 1827-1840.
  37. Lau CBS*, Yue GGL, Fung KP, Tan NH, Leung PC (2015). The potential role of Chinese herbal medicines in cancer management. Science Jan 16 “The Art and Science of Traditional Medicine, Part 2: Multidisciplinary approaches for studying traditional medicine” Vol. 347, no. 6219, pg.337, S45-S47.