Faculty
Paul KS CHAN
Mamie HUI
Margaret IP
Christopher KC LAI
Rita WY NG
Zigui CHEN
Jessie LIANG
Siaw Shi BOON
Xiao YANG
Yun Kit YEOH
Chiu Yeung CHAN
Research, Administrative and Honorary Staff
Elite Alumni Microbiologists
Hospital Staff
Department Photo Album
 
 
 
 
 
 
Faculty > Jessie Qiaoyi LIANG
Personal information
Name Jessie Qiaoyi LIANG 梁巧儀
Academic / Professional Qualifications Ph.D. in Oncology, B.S. in Biological Sciences
Academic title & affiliations Dr., Department of Microbiology, CUHK
Email JessieQY@cuhk.edu.hk
Current Appointments
(Including honorary appointments)		 Research Associate Professor
Department of Microbiology, CUHK;
Professor (by courtesy) 研究員(禮任)
Shenzhen Research Institute, CUHK
Member, Center for Gut Microbiota Research, CUHK
 
Research
ORCID ORCID iD iconorcid.org/0000-0001-8496-3442
ResearcherID
Google Scholar  https://scholar.google.com.hk/citations?hl=zh-TW&user=4PZ2D34AAAAJ
Research interest
1.
Microbiome in health and disease
2.
Human endogenous retroviruses
3.
Cancer genomics and epigenetics
4.
Molecular and translational medicine
 
Awards (selected)
05/2019 Poster of Distinction, Digestive Disease Week 2019, San Diego, USA
05/2018 Scientific Accomplishment as an Early Career Investigator, American Gastroenterological Association
10/2017 Health and Medical Research Fund Research fellowship, Food and Health Bureau, Hong Kong
12/2016 State Scientific & Technological Progress Award (SSTPA), Ministry of Science and Technology, China
2015 Women Scientists Award, the 10th International Conference on Genomics (ICG-10) Conference Committee
10/2015 Oral Free Paper Prize, UEG Week 2015, UEG Scientific Committee
05/2015 Travel Award for UEG Week 2015, UEG Scientific Committee
2015 Research Excellence Award 2014-15, Faculty of Medicine, The Chinese University of Hong Kong
10/2014 AACR Travel Prize and Best Poster Award, American Association for Cancer Research,
2012 HK Quality Migrant Admission Scheme Awardee
 

Research Grants (as PI, external competitive)
1. GRF, Hong Kong (01/12/2018-30/11/2021)
Project Title: Regulation of autophagy by the novel tumor suppressor gene GGT7 in gastric cancer
Project code: 14116418
Amount awarded: HKD 965,601
2. HMRF Research Fellowship Scheme (01/10/2017-30/09/2019)
Project Title: Establishing a best panel of stool-based detection for non-invasive colorectal neoplasm screening
Project code: 02160037
Amount awarded: HKD 1,187,488
3. National Nature and Science Foundation of China (01/01/2018-31/12/2021)
Project Title: Functional importance and clinical application of the novel fusion gene DDX5-POLG2 in gastric cancer
Project code: 81773000
Amount awarded: RMB 600,000
4 National Nature and Science Foundation of China (01/01/2013-31/12/2016)
Project Title: Clinical Application of DNA Methylation and Functional Importance of the Novel Gene psiTPTE22-HERV in Gastric Cancer
Project code: 81272304
Amount awarded: RMB 850,000
5. Shenzhen Municipal Science and Technology R&D funding of basic research programs, China (01/01/2013-30/12//2015)
Project Title: Clinical implication and molecular mechanism of a novel tumor suppressor MDGA2 in gastric cancer
Project code: JCYJ20130401151108652
Amount awarded: RMB 300,000
 
Patents:
  1. 2 Granted (ZL201010019380.5; US 10,364,471 B2)
  2. 12 Filed for cancer biomarkers (1 PCT, 3 US, 1 EPO, 3 HK, 1 Taiwan, 3 China)
 
Publications (Representative)
  1. Liang JQ# (corresponding), Li T, Chen YX, Yau TO, Nakatsu G, Chu ESH, Wong S, Szeto CH, Ng SC, Chan FK, Fang JY, Sung JJ, Yu J#. A Novel Fecal Lachnoclostridium Marker for the Non-Invasive Diagnosis of Colorectal Adenoma and Cancer. Gut 2019 Sep 12 DOI 10.1136/gutjnl-2019-318532. (IF2018: 17.943)
    https://gut.bmj.com/content/early/2019/11/27/gutjnl-2019-318532
  2. Liang JQ, Teoh N*, Xu L, Pok S, Li X, Chu ESH, Chiu J, Dong L, Arfianti E, Haigh WG, Yeh MM, Ioannou GN, Sung JJ, Wong N, Farrell G#, Yu J#. Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma by inducing aberrant gene expression in metabolism and mutations in calcium signaling. Nat Commun. 2018 Oct 26;9(1):4490. doi: 10.1038/s41467-018-06931-6. (IF2018: 11.878)
    https://www.nature.com/articles/s41467-018-06931-6
  3. Gou H, Liang JQ*(co-first), Zhang L, Chen H, Zhang Y, Li R, Wang X, Ji J, Tong JH, To KF, Sung JJ, Chan FK, Fang JY, Yu J#. TTPAL promotes colorectal tumorigenesis by stabilizing TRIP6 to activate Wnt/β-catenin signaling. Cancer Res. 2019 Jul 1;79(13):3332-3346. doi: 10.1158/0008-5472.CAN-18-2986. Epub 2019 Apr 24. (IF2018: 8.378)
    https://cancerres.aacrjournals.org/content/early/2019/04/24/0008-5472.CAN-18-2986
  4. Zhang M, Liang JQ#(corresponding), Zheng S#. Expressional activation and functional roles of human endogenous retroviruses in cancers. Rev Med Virol. 2019 Mar;29(2):e2025. doi: 10.1002/rmv.2025. Epub 2019 Jan 6. (IF2018: 3.702)
    https://onlinelibrary.wiley.com/doi/pdf/10.1002/rmv.2025
  5. Liang Q# (corresponding), Chiu J, Chen Y, Huang Y, Higashimori A, Fang J, Brim H, Ashktorab H, Ng SC, SM Ng SSM, Zheng S, Chan FK, Sung JJ, Yu J#. Fecal Bacteria Act as Novel Biomarkers for Non-Invasive Diagnosis of Colorectal Cancer.Clin Cancer Res. 2017 Apr 15;23(8):2061-2070. doi: 10.1158/1078-0432.CCR-16-1599. (IF2018: 8.911)
    http://clincancerres.aacrjournals.org/content/early/2016/10/01/1078-0432.CCR-16-1599.long
  6. Wang K*, Liang Q*(co-first), Li X, Tsoi H, Zhang J, Wang H, Go MY, Chiu PW, Ng EK, Sung JJ, Yu J. MDGA2 is a novel tumor suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome. Gut. 2016 Oct;65(10):1619-31. doi: 10.1136/gutjnl-2015-309276. (IF2018: 17.943)
    https://gut.bmj.com/content/65/10/1619
  7. Shen J*, Tsoi H*, Liang Q*(co-first), Chu ESH, Liu D, Li X, Wong VW, Sung JJ, Yu J. Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma. Oncogene. 2016 Dec 8;35(49):6271-6280. doi: 10.1038/onc.2016.162. (IF2018: 6.634)
    http://www.nature.com/onc/journal/vaop/ncurrent/pdf/onc2016162a.pdf
  8. Yu J*, Feng Q*, Wong SH*, Zhang D*, Liang QY*(co-first), Qin Y, Tang L, Zhao H, Stenvang J, Li Y, Wang X, Xu X, Chen N, Wu WK, Al-Aama J, Nielsen HJ, Kiilerich P, Jensen BA, Yau TO, Lan Z, Jia H, Li J, Xiao L, Lam TY, Ng SC, Cheng AS, Wong VW, Chan FK, Xu X, Yang H, Madsen L, Datz C, Tilg H, Wang J, Brünner N, Kristiansen K, Arumugam M#, Sung JJ#, Wang J#. Metagenomic analysis of fecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut. 2017 Jan;66(1):70-78. doi: 10.1136/gutjnl-2015-309800. (IF2018: 17.943)
    http://gut.bmj.com/content/early/2015/09/25/gutjnl-2015-309800.full.pdf+html
  9. Liang Q, Yao X, Tang S, Zhang J, Yau TO, Li X, Tang CM, Kang W, Lung RW, Li JW, Chan TF, Xing R, Lu Y, Lo KW, Wong N, To KF, Yu C, Chan FK, Sung JJ, Yu J. Integrative Identification of Epstein-Barr Virus-associated Mutations and Epigenetic Alterations in Gastric Cancer. Gastroenterology. 2014 Dec;147(6):1350-1362.e4. doi: 10.1053/j.gastro.2014.08.036. (IF2018: 19.233)
    http://www.sciencedirect.com/science/article/pii/S0016508514010750
  10. Xie X, Liang Q# (corresponding). Establishment of a 10-plex Quantitative Fluorescent-PCR Assay for Rapid Diagnosis of Sex Chromosome Aneuploidies. PLoS One. 2014 Sep;9(9):e106307. doi: 10.1371/journal.pone.0106307. (IF2018: 2.776)
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106307
  11. Yu J*, Liang QY *(co-first), Wang J *, Cheng YD, Cheung KF, Wang SY, Poon TC, Go MY, Tao Q, Chang ZJ, Sung JJ. Zinc-Finger Protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer. Oncogene. 2013 Jan;32(3):307-17. doi: 10.1038/onc.2012.54. (IF2018: 6.634)
    http://www.nature.com/onc/journal/v32/n3/pdf/onc201254a.pdf
  12. Zhao J*, Liang Q*(co-first), Cheung KF, Kang W, Lung RW, Tong JH, To KF, Sung JJ, and Yu J. Genome-wide identification of Epstein-Barr virus-driven promoter methylation profiles of human genes in gastric cancer cells. Cancer. 2013 Jan;119(2):304-12. doi: 10.1002/cncr.27724. (IF2018: 6.102)
    http://olinelibrary.wiley.com/doi/10.1002/cncr.27724/full
  13. Liang Q, Xu Z, Xu R, Wu L, Zheng S. Expression patterns of non-coding spliced transcripts from human endogenous retrovirus HERV-H elements in colon cancer. PLoS One. 2012 Jan;7(1):e29950. doi: 10.1371/journal.pone.0029950. (IF2018: 2.776)
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029950
  14. Liang Q, Ding J, Xu R, Xu Z, Zheng S. The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers. Int J Cancer. 2010 Oct;127(8):1833-43. doi: 10.1002/ijc.25213. (IF2018: 4.982)
    https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijc.25213
  15. Liang Q, Ding J, Xu R, Xu Z, Zheng S. Identification of a novel human endogenous retrovirus and promoter activity of its 5' U3. Biochem Biophys Res Commun. 2009 May;382 (2):470-4. doi: 10.1016/j.bbrc.2009.03.058. (IF2018: 2.705)
    http://www.sciencedirect.com/science/article/pii/S0006291X09005245