Faculty
Paul KS CHAN
Mamie HUI
Margaret IP
Christopher KC LAI
Rita WY NG
Zigui CHEN
Jessie LIANG
Siaw Shi BOON
Xiao YANG
Yun Kit YEOH
Chiu Yeung CHAN
Research, Administrative and Honorary Staff
Elite Alumni Microbiologists
Hospital Staff
Department Photo Album
 
 
 
 
 
 
Faculty > Martin Chi-Wai CHAN
Personal information
Name Martin Chi-Wai CHAN 陳子蔚博士
Academic / Professional Qualifications BSc (1st Hons), MPhil, PhD
Academic title & affiliations Dr.
Department of Microbiology, CUHK
Stanley Ho Centre for Emerging Infectious Diseases, CUHK
Li Ka Shing Institute of Health Sciences, CUHK
Email martin.chan@cuhk.edu.hk
Current Appointments
(Including honorary appointments)		 Assistant Professor, Department of Microbiology, CUHK
Assistant Professor, Stanley Ho Centre for Emerging Infectious Diseases, CUHK
ORCID http://orcid.org/0000-0002-1568-1596
 
Research Interests
Norovirus genomic epidemiology & phylogeography | Norovirus disease-causing mechanism | Human virus discovery | Metagenomic virus diagnostics | Advanced technologies involved: bioinformatics, metagenomic next-generation sequencing, stem-cell—derived enteroids, and CRISPR/Cas9 gene-editing
 
Lab Website
https://www.martinchanlab.hk (latest surveillance statistics, new norovirus sequences, opportunities, and more)
 
Lab Facebook
https://www.facebook.com/martinchanlab
 
Lab Twitter
https://twitter.com/martinchanlab
 
ResearcherID
 
Google Scholar
https://scholar.google.com.hk/citations?user=Zv1WfIAAAAAJ&hl=en
 
Publons
https://publons.com/a/536287/
 
Postgraduate Students
Information for Postgraduate Study in Department of Microbiology
Professional Membership
2018 – now Member, European Society for Clinical Virology
2017 – now Certified Member, EpiCore
2017 – now Member, International Society for Influenza and other Respiratory Virus Diseases
2016 – now Member, European Society of Clinical Microbiology and Infectious Diseases
2016 – now Member, European Society for Virology
2013 – now Member, NoroNet
2012 – now Member, American Society for Virology
2007 – now Member, American Society for Microbiology
 
Professional Service
2018 – now Associate Editor, BMC Infectious Diseases (Springer Nature)
2016 – now Member, Editorial Board, Journal of Virological Methods (Elsevier)
2013 – now Member, Editorial Board, Scientific Reports | Microbiology (Nature Publishing Group)
2013 – 2018 Member, Board of Reviewers, PLOS Currents: Outbreaks (Public Library of Science)
 
Awards
Name of award Best Oral Presentation Award
Date 2017
Place The Lancet-CAMS Health Summit 2017, Beijing, China
 
Name of award Best Free Paper Award
Date 2011
Place 15th Annual Scientific Meeting, The Hong Kong Society for Infectious Diseases, Hong Kong, China
 
Name of award Young Investigator Award
Date 2011
Place XIII International Symposium on Respiratory Viral Infections, Rome, Italy
 
Name of award Best Postgraduate Oral Presentation
Date 2006
Place Faculty Research Day, Faculty of Medicine, CUHK
 
Guest Reviewer for International Journals (34 journals)
Annals of Internal Medicine; Applied and Environmental Microbiology; Archives of Disease in Childhood; BMC Infectious Diseases; BMC Pediatrics; BMC Public Health; BMC Research Notes; Clinical and Experimental Gastroenterology; Clinical Microbiology and Infection; Clinical and Vaccine Immunology; Clinical Infectious Diseases; Diagnostic Microbiology & Infectious Disease; Disease Markers; Emerging Infectious Diseases; Epidemiology and Infection; European Journal of Clinical Microbiology & Infectious Diseases; Frontiers in Medicine; Frontiers in Microbiology; Infection, Genetics and Evolution; Influenza and Other Respiratory Viruses; International Journal of Molecular Sciences; Journal of Applied Microbiology; Journal of Clinical Microbiology; Journal of Clinical Virology; Journal of Infectious Diseases; Journal of Medical Virology; Journal of Virological Methods; Molecular Genetics & Genomic Medicine; mSphere; Pharmacological Research; PLOS ONE; Scientific Reports; Virology Journal; Virus Evolution
 
Research Description

Human noroviruses are a large family of viruses and are leading causes of acute gastroenteritis (AGE) in all age groups worldwide. They have replaced rotavirus as the most common causes of AGE in children. Our research team is committed to studying molecular epidemiology and pathogenesis of human noroviruses. We have established a surveillance system in hospitalized AGE cases in Hong Kong to untangle norovirus genotype distribution among children and adults and to monitor emergence of novel strains. This will form scientific foundation for vaccine strain selection in the region. We are also working on teasing out host interactome of norovirus structural proteins. This will better our understanding on disease-causing mechanism of noroviruses with insights into antiviral drug intervention.

Available research projects: (1) Molecular surveillance of norovirus; (2) Mechanism of new norovirus emergence; (3) Norovirus gastroenteritis and gut virome; and (4) Metagenomic NGS in clinical diagnosis of acute infections.
 
Research Grants (PI capacity)

  GRF (2017/18, 2016/17, 2014/15) and HMRF (2012/13 x2) 

 
Invited State-of-the-Art Lectures
  • Rise of non-GII.4 capsids and GII.P16 polymerase in norovirus gastroenteritis. 7th International Calicivirus Conference,
    13–17 October 2019, Sydney, Australia
 
Invited Lectures
  1. Changing epidemiology of norovirus gastroenteritis in Hong Kong: a tug-of-war between pandemic GII.4 and epidemic non-GII.4 genotypes. Fifth Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE) Symposium, 28 February–1 March 2019, Canmore, Alberta, Canada
  2. Changing epidemiology of norovirus gastroenteritis in Hong Kong: a tug-of-war between GII.4 and non-GII.4 genotypes. Collaboration Research Visit, Osaka Institute of Public Health, 31 October 2018, Osaka, Japan
  3. Metagenomic NGS in virology research. Illumina Hong Kong User Meeting 2017, 21 November 2017, Hong Kong, China.
  4. Changing epidemiology of norovirus gastroenteritis in Hong Kong: a tug-of-war between GII.4 and non-GII.4 genotypes. 1st International Workshop on Gastroenteritis Viruses, Fudan University, 14—15 September 2017, Shanghai, China
  5. Norovirus gastroenteritis: epidemiology, clinical impact, and knowledge gaps. 13th Annual Scientific Meeting, Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, 22 June 2016, Hong Kong, China
  6. Norovirus gastroenteritis: epidemiology, clinical impact, and knowledge gaps. Advances in Medicine 2016, The Chinese University of Hong Kong, 28—29 May 2016, Hong Kong, China
  7. Norovirus surveillance in hospitalized patients, Hong Kong, China. Symposium of Medical Virology, Chinese Medical Association (中华医学会2015年医学病毒学大会), 20—22 November 2015, Shanghai, China
  8. GI involvement of influenza. AoE Flu Seminars, The University of Hong Kong, 9 July 2012, Hong Kong, China
 
Academic Activities and Achievements of Research Students

Jenny Chan (MPhil 2017-2019)

Awards
  • Scholarship (International Student Travel Grant), 7th International Calicivirus Conference, 2019
  • Best Presentation, Joint Graduate Student Seminar, Department of Microbiology, CUHK, 31 May & 2 July 2019
 
 
Publications
  • EID 2019 (4th)
 
Book Chapters
  • Biotech in HK 2019 (2nd)
 
Conference Presentations (as presenting author)
POSTER
  • Norovirus-induced immune response in human intestinal enteroids. 7th International Calicivirus Conference, 13–17 October 2019, Sydney, Australia
  • Establishment of three human intestinal enteroid lines to study human norovirus infection. INFECTION 2019, 10-11 June 2019, Hong Kong, China
 
Training
  • ORGANOIDS: INTESTINAL & LUNG – 2-Day Hands-on Practical Course, 11-12 April 2019, Cambridge, UK
 
Kirsty Kwok (MPhil 2016-2018)
 
Currently a PhD candidate in the Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
 
Awards
  • Best Presentation, Joint Graduate Student Seminar, Department of Microbiology, CUHK, 2 & 4 May 2018
  • Best Presentation, Joint Graduate Student Seminar, Department of Microbiology, CUHK, 16-17 May 2017
 
Publications (after commencement of research study)
  • EID 2019 (2nd), EID 2018 (2nd), EID 2017 (1st), EID 2017 (28th), JID 2017 (15th), GA 2017 (2nd), JCM 2017 (2nd and co-first), CID 2016 (5th)
 
Conference Presentations (as presenting author)
POSTER
  • Rapid re-emergence and geographic transmission dynamics of a recombinant GII.P16-GII.2 norovirus in the winter of 2016/17. Epidemics6, 29 November – 1 December 2017, Sitges, Spain.
  • Metagenomic next-generation viral genome sequencing on clinical samples. INFECTION 2017, 20-21 September 2017, Hong Kong, China.
  • Close genetic relatedness between human and swine hepatitis E viruses in Hong Kong. 6th European Congress of Virology, 19-22 October 2016, Hamburg, Germany.
  • Continuous emergence and disappearance of sub-lineages of norovirus GII.4 Sydney 2012 during 2012-2016 in Hong Kong. 6th European Congress of Virology, 19-22 October 2016, Hamburg, Germany.
 
Publications (71 papers; first-authored, 29 papers; *corresponding author, 9 papers)
GASTROINTESTINAL VIRUSES
Norovirus
  1. [NEW in 2020] Tse EH, Zhang LY, Lau SL, Chan MC*. Genome sequence of a human norovirus GII.4 Hong Kong[P31] variant in Hong Kong, China. Microbiol Resour Announc. 2020. (in press)
  2. Chhabra P, de Graaf M, Parra GI, Chan MC, Green KY, Martella V, Wang Q, White PA, Katayama K, Vennema H, Koopmans MP, Vinjé J. Updated classification of norovirus genogroups and genotypes. J Gen Virol. 2019 (in press) [PubMed]
  3. Chan MC*, Cheung SK, Mohammad KN, Chan JC, Estes MK, Chan PK. Use of human intestinal enteroids to detect human norovirus infectivity. Emerg Infect Dis. 2019 Sep;25(9):1730-1733. [PubMed]
  4. Cheung SK, Kwok K, Zhang LY, Mohammad KN, Lui GC, Lee N, Nelson EA, Lai RW, Leung TF, Chan PK, Chan MC*. Higher viral load of emerging norovirus GII.P16-GII.2 than pandemic GII.4 and epidemic GII.17, Hong Kong, China. Emerg Infect Dis. 2019 Jan;25(1):119-122. [PubMed]
  5. Chan MC, Kwok K, Zhang LY, Mohammad KN, Lee N, Lui GC, Nelson EA, Lai RW, Leung TF, Chan PK. Bimodal seasonality and alternating predominance of norovirus GII.4 and non-GII.4, Hong Kong, China, 2014-2017. Emerg Infect Dis. 2018 Apr;24(4):767-769. [PubMed]
  6. van Beek J, de Graaf M, Al-Hello H, Allen DJ, Ambert-Balay K, Botteldoorn N, Brytting M, Buesa J, Cabrerizo M, Chan M, Cloak F, Bartolo ID, Guix S, Hewitt J, Iritani N, Jin M, Johne R, Lederer I, Mans J, Martella V, Maunula L, McAllister G, Niendorf S, Niesters HG, Podkolzin AT, Poljsak-Prijatelj M, Rasmussen LD, Reuter G, Tuite G, Kroneman A, Vennema H, Koopmans MP; NoroNet. Molecular surveillance of norovirus, 2005-16: an epidemiological analysis of data collected from the NoroNet network. Lancet Infect Dis. 2018 May;18(5):545-553. [PubMed]
  7. Kwok K, Niendorf S, Lee N, Hung TN, Chan LY, Jacobsen S, Nelson EA, Leung TF, Lai RW, Chan PK, Chan MC. Increased detection of emergent recombinant norovirus GII.P16-GII.2 strains in young adults, Hong Kong, China, 2016-2017. Emerg Infect Dis. 2017 Nov;23(11):1852-1855. [PubMed]
  8. Chan MC, Hu Y, Chen H, Podkolzin AT, Zaytseva EV, Komano J, Sakon N, Poovorawan Y, Vongpunsawad S, Thanusuwannasak T, Hewitt J, Croucher D, Collins N, Vinjé J, Pang XL, Lee BE, de Graaf M, van Beek J, Vennema H, Koopmans MP, Niendorf S, Poljsak-Prijatelj M, Steyer A, White PA, Lun JH, Mans J, Hung TN, Kwok K, Cheung K, Lee N, Chan PK. Global spread of norovirus GII.17 Kawasaki 308, 2014-2016. Emerg Infect Dis. 2017 Aug;23(8):1350-1354. [PubMed]
  9. Chan MC, Kwok K, Hung TN, Chan LY, Chan PK. Complete genome sequence of an emergent recombinant GII.P16-GII.2 norovirus strain associated with an epidemic spread in the winter of 2016-17 in Hong Kong, China. Genome Announc. 2017 May 18;5(20). pii: e00343-17. [PubMed]
  10. Doerflinger SY, Weichert S, Koromyslova A, Chan M, Schwerk C, Adam R, Jennewein S, Hansman GS, Schroten H. Human norovirus evolution in a chronically infected host. mSphere. 2017 Mar 29;2(2). pii: e00352-16. [PubMed]
  11. Chan MC, Lee N, Hung TN, Chan LY, Kwok K, Wong RY, Chan PK. Letter to the Editor: Recurrent infections of emergent norovirus GII.17 in an elderly patient. Clin Infect Dis. 2017 Mar;64(5):697-9. [PubMed]
  12. Chan MC, Kwok K, Hung TN, Chan PK. Reduced diagnostic performance of two norovirus antigen enzyme immunoassays for the emergent genogroup II genotype 17 Kawasaki 2014 variant. J Clin Microbiol. 2016 Jun;54(6):1650-1652. [PubMed]
  13. Chan MC, Lee N, Hung TN, Kwok K, Cheung K, Tin EK, Lai RW, Nelson EA, Leung TF, Chan PK. Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014. Nat Commun. 2015 Dec 2;6:10061. doi: 10.1038/ncomms10061 [PubMed]
  14. Chan MC, Hung TN, Kwok K, Chan PK. Complete genome sequence of a novel recombinant GII.Pe_GII.17 norovirus strain from Hong Kong in 2015. Genome Announc. 2015 Nov 12;3(6). pii: e01338-15. [PubMed]
  15. Chen H, Qian F, Xu J, Chan M, Shen Z, Zai S, Shan M, Cai J, Zhang W, He J, Liu Y, Zhang J, Yuan Z, Zhu Z, Hu Y. A novel norovirus GII.17 lineage contributed to adult gastroenteritis in Shanghai, China, during the winter of 2014-2015. Emerg Microbes Infect. 2015 Nov 11:4:e67 [PubMed]
  16. de Graaf M, van Beek J, Vennema H, Podkolzin AT, Hewitt J, Bucardo F, Templeton K, Mans J, Nordgren J, Reuter G, Lynch M, Rasmussen LD, Iritani N, Chan MC, Martella V, Ambert-Balay K, Vinje J, White PA, Koopmans MP. Emergence of a novel GII.17 norovirus – end of the GII.4 era? Euro Surveill. 2015 Jul 2;20(26). pii: 21178 [PubMed]
  17. Chan MC, Leung TF, Chung TW, Kwok AK, Nelson EA, Lee N, Chan PK. Virus genotype distribution and virus burden in children and adults hospitalized for norovirus gastroenteritis, 2012—2014, Hong Kong. Sci Rep. 2015 Jun 17;5:11507. [PubMed]
  18. Chan MC, Leung TF, Kwok AK, Lee N, Chan PK. Characteristics of patients infected with norovirus GII.4 Sydney 2012, Hong Kong, China. Emerg Infect Dis. 2014 Apr;20(4):658-61. [PubMed]
  19. Chan MC*, Chan PK. Complete genome sequence of a novel recombinant human norovirus genogroup II genotype 4 strain associated with an epidemic during summer of 2012 in Hong Kong. Genome Announc. 2013 Jan;1(1):e00140-12. [PubMed]
  20. Chan MC*, Lee N, Ho WS, Law CO, Lau TC, Tsui SK, Sung JJ. Covariation of major and minor viral capsid proteins in norovirus genogroup II genotype 4 strains. J Virol. 2012 Jan;86(2):1227-32. [PubMed]
  21. Chan MC*, Ho WS, Sung JJ. In vitro whole-virus binding of a norovirus genogroup II genotype 4 strain to cells of the lamina propria and Brunner’s glands in the human duodenum. J Virol. 2011 Aug;85(16):8427-30. [PubMed]
  22. Chan MC*, Lee N, Wong RY, Ho WS, Sung JJ. A 75-year-old woman with seasonal influenza A (H3N2) virus infection and diarrhea. J Clin Virol. 2010 Aug;48(4):231-3. [PubMed]
  23. Chan MC, Wong YP, Sung JJ, Leung WK. Letter to the Editor: Histo-blood group antigens and susceptibility to infection with norovirus genogroup II genotype 4. J Infect Dis. 2008 Sep 15;198(6):940. [PubMed]
  24. Lee N, Chan MC, Wong B, Choi KW, Sin W, Lui G, Chan PK, Lai RW, Cockram CS, Sung JJ, Leung WK. Fecal viral concentration and diarrhea in norovirus gastroenteritis. Emerg Infect Dis. 2007 Sep;13(9):1399-401. [PubMed]
  25. Chan MC, Wong YP, Leung WK. Letter to the Editor: Cell culture assay for human noroviruses. Emerg Infect Dis. 2007 Jul;13(7):1117. [PubMed]
  26. Chan MC, Sung JJ, Lam RK, Chan PK, Lee NL, Lai RW, Leung WK. Fecal viral load and norovirus-associated gastroenteritis. Emerg Infect Dis. 2006 Aug;12(8):1278-80. [PubMed]
 
Sapovirus
  1. Chan MC, Sung JJ, Lam RK, Chan PK, Lai RW, Leung WK. Sapovirus detection by quantitative real-time RT-PCR in clinical stool specimens. J Virol Methods. 2006 Jun;134(1-2):146-53. [PubMed]
 
Rotavirus
  1. Yeung KH, Tate JE, Chan CC, Chan MC, Chan PK, Poon KH, Siu SL, Fung GP, Ng KL, Chan IM, Yu PT, Ng CH, Lau YL, Nelson EA. Rotavirus vaccine effectiveness in Hong Kong children. Vaccine. 2016 Sep 22;34(41):4935-42. [PubMed]
  2. Chan MC, Mok HY, Lee TC, Nelson EA, Leung TF, Tam WW, Chan PK. Rotavirus activity and meteorological variations in an Asian subtropical city, Hong Kong, 1995—2009. J Med Virol. 2013 Nov;85(11):2026-33. [PubMed]
 
Hepatitis Virus
  1. Chan MC, Cheng FW, Sze KH, Wong AH, Leung AW, Chan PK, Li CK. Hepatitis B infection acquired after haematopioetic stem cell transplant through horizontal mode. J Med Virol. 2017 Oct;89(10):1882-1884. [PubMed]
  2. Chan MC, Kwok K, Hung TN, Chan PK. Molecular epidemiology and strain comparison between hepatitis E viruses in human sera and pig livers during 2014 to 2016 in Hong Kong. J Clin Microbiol. 2017 May;55(5):1408-1415. [PubMed]
  3. Chan PK, Ngai KL, Lao TT, Wong MC, Cheung T, Yeung AC, Chan MC, Luk SW. Response to booster doses of hepatitis B vaccine among young adults who had received neonatal vaccination. PLOS ONE. 2014 Sep 8;9(9):e107163. [PubMed]
  4. Chiu DM, Chan MC, Yeung AC, Ngai KL, Chan PK. Seroprevalence of hepatitis E virus in Hong Kong, 2008—2009. J Med Virol. 2013 Mar;85(3):459-61. [PubMed]
 
RESPIRATORY VIRUSES
Influenza Virus
  1. Chan MC, Wang MH, Chen Z, Hui DS, Kwok AK, Yeung AC, Liu KM, Yeoh YK, Lee N, Chan PK. Frequent genetic mismatch between vaccine strains and circulating seasonal influenza viruses, Hong Kong, China, 1996-2012. Emerg Infect Dis. 2018 Oct;24(10):1825-1834. [PubMed]
  2. Lee N, Wong CK, Chan MC, Yeung ES, Tam WW, Tsang OT, Choi KW, Chan PK, Kwok A, Lui GC, Leung WS, Yung IM, Wong RY, Cheung CS, Hui DS. Anti-inflammatory effects of adjunctive macrolide treatment in adults hospitalized with influenza: A randomized controlled trial. Antiviral Res. 2017 Aug;144:48-56. [PubMed]
  3. Lee N, Cao B, Ke C, Lu H, Hu Y, Tam CH, Ma RC, Guan D, Zhu Z, Li H, Lin M, Wong RY, Yung IM, Hung TN, Kwok K, Horby P, Hui DS, Chan MC, Chan PK. IFITM3, TLR3, and CD55 genes SNPs and cumulative genetic risks for severe outcomes in Chinese patients with H7N9 / H1N1pmd09 influenza. J Infect Dis. 2017 Jul 1;216(1):97-104. [PubMed]
  4. Lee N, Chan PK, Tam WW, Chan MC, Lui GC, Kwok AK, Ko FW, Ng SS, Yung IM, Wong RY, Hui DS. Virological response to peramivir treatment in adults hospitalised for influenza-associated lower respiratory tract infections. Int J Antimicrob Agents. 2016 Aug;48(2):215-9. [PubMed]
  5. Wong MC, Nelson EA, Leung C, Lee N, Chan MC, Choi KW, Rainer TH, Cheng FW, Wong SY, Lai CK, Lam B, Cheung TH, Leung TF, Chan PK. Ad hoc influenza vaccination during years of significant antigenic drift in a tropical city with 2 seasonal peaks: a cross-sectional survey among health care practitioners. Medicine (Baltimore). 2016 May;95(19):e3359. [PubMed]
  6. Chan PK, Tam WW, Lee TC, Hon KL, Lee N, Chan MC, Mok HY, Wong MC, Leung TF, Lai RW, Yeung AC, Ho WC Nelson EA, Hui DS. Hospitalization incidence, mortality and seasonality of common respiratory viruses over a period of 15 years in a developed subtropical city. Medicine (Baltimore). 2015 Nov;94(46):e2024. [PubMed]
  7. Li TC, Chan MC, Lee N. Clinical implications of antiviral resistance in influenza. Viruses. 2015 Sep;7(9):4929-44. [PubMed]
  8. Chan MC, Lee N, Ngai KL, Leung TF, Chan PK. Clinical and virologic factors associated with reduced sensitivity of rapid influenza diagnostic tests in hospitalized elderly patients and young children. J Clin Microbiol. 2014 Feb;52(2):497-501. [PubMed]
  9. Lee N, Hui DS, Zuo Z, Ngai KL, Lui GC, Wo SK, Tam WW, Chan MC, Wong BC, Wong RY, Choi KW, Sin WW, Lee EL, Tomlinson B, Hayden FG, Chan PK. A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza A and B infections. Clin Infect Dis. 2013 Dec;57(11):1511-9. [PubMed]
  10. Ngai KL, Chan MC, Chan PK. Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A viruses. PLOS One.2013;8(6):e65038. [PubMed]
  11. Lee N, Wong CK, Hui DS, Lee SK, Wong RY, Ngai KL, Chan MC, Chu YJ, Ho AW, Lui GC, Wong BC, Wong SH, Yip SP, Chan PK. Role of human Toll-like receptors in naturally occurring influenza A infections. Influenza Other Respi Viruses. 2013 Sep;7(5):666-75. [PubMed]
  12. Chan MC*, Lee N, Ngai KL, Wong BC, Lee MK, Choi KW, Lai RW, Chan PK. A “pre-seasonal” hospital outbreak of influenza pneumonia caused by the drift variant A/Victoria/361/2011-like H3N2 viruses, Hong Kong, 2011. J Clin Virol. 2013 Mar;56(3):219-25. [PubMed]
  13. Chan PK, Chan MC, Cheung JL, Lee N, Leung TF, Yeung AC, Wong MC, Ngai KL, Nelson EA, Hui DS. Influenza B lineage circulation and hospitalization rates in a subtropical city, Hong Kong, 2000-2010. Clin Infect Dis. 2013 Mar;56(5):677-84. [PubMed]
  14. Chan MC, Lee N, Chan PK, To KF, Wong RY, Law CO, Ngai KL, Sung JJ. Intestinal binding of seasonal influenza A viruses to DC-SIGN+ CD68+ cells. Influenza Other Respi Viruses. 2013 May;7(3):228-30. [PubMed]
  15. Chan MC, Lee N, Lui GC, Ngai KL, Wong RY, Choi KW, Chan PK. Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008-2009. Influenza Other Respi Viruses. 2013 May;7(3):235-9. [PubMed]
  16. Chan MC, Lee N, Chan PK, To KF, Wong RY, Ho WS, Ngai KL, Sung JJ. Seasonal influenza A virus in feces of hospitalized adults. Emerg Infect Dis. 2011 Nov;17(11):2038-42. [PubMed]
  17. Lee N, Wong CK, Chan PK, Chan MC, Wong RY, Lun SW, Ngai KL, Lui GC, Wong BC, Lee SK, Choi KW, Hui DS. Cytokine response patterns in severe pandemic 2009 H1N1 and seasonal influenza among hospitalized adults. PLOS One. 2011;6(10):e26050. [PubMed]
  18. Lee N, Chan PK, Lui GC, Wong BC, Sin WW, Choi KW, Wong RY, Lee EL, Yeung AC, Ngai KL, Chan MC, Lai RW, Yu AW, Hui DS. Complications and outcomes of pandemic 2009 influenza A (H1N1) virus infection in hospitalized adults – how do they differ from those in seasonal influenza? J Infect Dis. 2011 Jun;203(12):1739-47. [PubMed]
  19. Lee N, Chan PK, Wong CK, Wong KT, Choi KW, Joynt GM, Lam P, Chan MC, Wong BC, Lui GC, Sin WW, Wong RY, Lam WY, Yeung AC, Leung TF, So HY, Yu AW, Sung JJ, Hui DS. Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A (H1N1) virus pneumonia. Antivir Ther. 2011 Feb;16(2):237-47. [PubMed]
  20. Chan MC*, Lee N, Chan PK, Leung TF, Sung JJ. Fecal detection of influenza A virus in patients with concurrent respiratory and gastrointestinal symptoms. J Clin Virol. 2009 Jul;45(3):208-11. [PubMed]
 
Respiratory Syncytial Virus
  1. Lee N, Chan MC, Lui GC, Li R, Wong RY, Yung IM, Cheung CS, Chan EC, Hui DS, Chan PK. High viral load and respiratory failure in adults hospitalized for respiratory syncytial virus infections. J Infect Dis. 2015 Oct;212(8):1237-40. [PubMed]
 
Coronavirus
  1. Chan PK, Chan MC. Tracing the SARS-coronavirus. J Thorac Dis. 2013 Aug;5(S2):S118-21. [PubMed]
  2. Chim SS, Tsui SK, Chan KC, Au TC, Hung EC, Tong YK, Chiu RW, Ng EK, Chan PK, Chu CM, Sung JJ, Tam JS, Fung KP, Waye MM, Lee CY, Yuen KY, Lo YM; CUHK Molecular SARS Research Group. Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong. Lancet. 2003 Nov 29;362(9398):1807-8. [PubMed]
 
NEUROLOGICAL VIRUSES
  1. Chan MC, Kwok SW, Chan PK. False-positive PCR detection of cyclovirus Malawi strain VS5700009 in human cerebrospinal fluid. J Clin Virol. 2015 Jul;68:76-8. [PubMed]
 

MICROBIOME
  1. Ho J, Yeoh YK, Barua N, Chen Z, Lui G, Wong SH, Yang X, Chan MC, Chan PK, Hawkey PM, Ip M. Systematic review of human gut resistome studies revealed variable definitions and approaches. Gut Microbes. 2019 (accepted)
  2. Chen Z, Hui PC, Hui M, Yeoh YK, Wong PY, Chan MC, Wong MC, Ng SC, Chan FK, Chan PK. Impact of preservation method and 16S rRNA hypervariable region on gut microbiota profiling. mSystems. 2019 Feb 26;4(1):e00271-18. [PubMed]
  3. Chen Z, Yeoh YK, Hui M, Wong PY, Chan MC, Ip M, Yu J, Burk RD, Chan FK, Chan PK. Diversity of macaque microbiota compared to the human counterparts. Sci Rep. 2018 Oct 22;8(1):15573. [PubMed]
  4. Zuo T, Wong SH, Lam K, Lui R, Cheung K, Tang W, Ching JY, Chan PK, Chan MC, Wu JC, Chan FK, Yu J, Sung JJ, Ng SC. Bacteriophage transfer during fecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome. Gut. 2018 Apr;67(4):634-643. [PubMed]
 
TUMOR VIROLOGY
  1. Chen Z, Ho WC, Boon SS, Law PT, Chan MC, DeSalle R, Burk RD, Chan PK. Ancient evolution and dispersion of human papillomavirus 58 variants. J Virol. 2017 Nov;91(21):e01285-17 [PubMed]
  2. Chan PK, Ho WC, Chan MC, Wong MC, Yeung AC, Chor JS, Hui M. Meta-analysis on prevalence and attribution of human papillomavirus types 52 and 58 in cervical neoplasia worldwide. PLOS ONE. 2014 Sep 17;9(9):e107573. [PubMed]
  3. Zhang C, Park JS, Grce M, Hibbitts S, Palefsky JM, Konno R, Smith-McCune KK, Giovannelli L, Chu TY, Picconi MA, Piña-Sánchez P, Settheetham-Ishida W, Coutlée F, De Marco F, Woo YL, Ho WC, Wong MC, Chirenje MZ, Magure T, Moscicki AB, Sabol I, Fiander AN, Chen Z, Chan MC, Cheung TH, Burk RD, Chan PK. Geographical distribution and risk association of human papillomavirus 52-variant lineages. J Infect Dis. 2014 Nov;210(10):1600-4. [PubMed]
  4. Chan PK, Zhang C, Park JS, Smith-McCune KK, Palefsky JM, Giovannelli L, Coutlée F, Hibbitts S,Konno R, Settheetham-Ishida W, Chu TY, Ferrera A, Picconi MA, De Marco F, Woo YL, Raiol T,Piña-Sánchez P, Bae JH, Wong MC, Chirenje MZ, Magure T, Moscicki AB, Fiander AN, Capra G, Ki EY, Tan Y, Chen Z, Burk RD, Chan MC, Cheung TH, Pim D, Banks L. Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations. Int J Cancer. 2013 Jun;132(11):2528-36. [PubMed]
 
CANCER BIOLOGY
  1. Fu YG, Sung JJ, Wu KC, Bai AH, Chan MC, Yu J, Fan DM, Leung WK. Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J(2) through the downregulation of angiopoietin-1. Cancer Lett. 2006 Nov 18;243(2):246-54. [PubMed]
  2. Leung WK, Chan MC, To KF, Man EP, Ng EK, Chu ES, Lau JY, Lin SR, Sung JJ. H. pylori genotypes and cytokine gene polymorphisms influence the development of gastric intestinal metaplasia in a Chinese population. Am J Gastroenterol. 2006 Apr 1;101(4):714-20. [PubMed]
  3. Fu YG, Sung JJ, Wu KC, Wu HP, Yu J, Chan M, Chan VY, Chan KK, Fan DM, Leung WK. Inhibition of gastric cancer-associated angiogenesis by antisense COX-2 transfectants. Cancer Lett. 2005 Jun 28;224(2):243-52. [PubMed]
 
OTHER VIRUSES/PATHOGENS
  1. Lee P, Yeung AC, Chen Z, Chan MC, Sze KH, Chan PK. Age-specific seroprevalence of dengue infection in Hong Kong. J Med Virol. 2018 Sep;90(9):1427-1430. [PubMed]
  2. Chiang GP, Chen Z, Chan MC, Lee SH, Kwok AK, Yeung AC, Nelson EA, Hon KL, Leung TF, Chan PK. Clinical features and seasonality of parechovirus infection in an Asian subtropical city, Hong Kong. PLOS ONE. 2017 Sep 8;12(9):e0184533. [PubMed]
  3. Leung WK, Chow VC, Chan MC, Ling JM, Sung JJ. Psychrobacter bacteraemia in a cirrhotic patient after the consumption of raw geoduck clam. J Infect. 2006 Jun;52(6):e169-71. [PubMed]
 
Book Chapters
  1. Chan MC and Chan JC. (2019). Human organoids: past, present, and future. In A. Chan (Ed.), Biotechnology in Hong Kong Volume IV (pp. 15-27). New York: United States-China Intellectual Property Institute Inc.
  2. Chan, M et al. (2017).  Structure and genotypes of noroviruses. In P. Chan, H-S. Kwan, & M. Chan (Eds.), The Norovirus: Features, Detection, and Prevention of Foodborne Disease (pp. 51-63). Netherlands: Elsevier.
 
Conference Oral Presentations (as presenting author)
  1. Detection of human pegivirus in blood of immunocompromised children with acute myeloid leukemia. 67th Annual Meeting of the Japanese Society for Virology, 29–31 October 2019, Tokyo, Japan
  2. Metagenomic identification and winter seasonality of picobirnavirus in stool of hospitalized patients with acute gastroenteritis. 22nd European Society for Clinical Virology Annual Meeting, 11–14 September 2019, Copenhagen, Denmark
  3. Norovirus virus-like particles – good surrogates for native virions in binding analyses? 38th Annual American Society for Virology Meeting, 20–24 July 2019, Minneapolis, MN, USA
  4. Genome coverage as a better diagnostic parameter than read count for metagenomic identification of viral pathogens in clinical stool samples. 66th Annual Meeting of the Japanese Society for Virology, 28–30 October 2018, Kyoto, Japan
  5. Use of metagenomic next-generation sequencing in diagnosis of respiratory viruses in a cohort of patients admitted to intensive care unit. 2nd International Meeting on Respiratory Pathogens, 7-9 March 2018, Singapore.
  6. Single-nucleotide polymorphisms of IFITM3, TLR3, CD55, and TLR4 and risk for severe outcomes in patients with influenza A (H7N9) and (H1N1)pdm09 in China: a multicenter cohort study. The Lancet-CAMS Health Summit 2017, 11-12 December 2017, Beijing, China.
  7. Molecular epidemiology of norovirus GII.17 Kawasaki, Hong Kong, China, 2014-2016. Sixth International Calicivirus Conference, 9-13 October 2016, Savannah, Georgia, USA.
  8. Emergence and predominance of a fast-mutating and putatively immune-escaped novel variant of norovirus genogroup II genotype 17 in hospitalized gastroenteritis, 2014-2015, Hong Kong. 10th Asia-Pacific Congress of Medical Virology, 15-18 October 2015, Taipei, Taiwan.
  9. Norovirus GII.4 Sydney 2012 in hospitalized gastroenteritis: admission rate, age distribution, and viral shedding. Fifth International Calicivirus Conference, 12-15 October 2013, Beijing, China
  10. Frequent virus detection in stool of adults hospitalized with seasonal influenza A infection. 15th Annual Scientific Meeting, The Hong Kong Society for Infectious Diseases, 19 March 2011
  11. Fecal viral shedding in adults hospitalized for seasonal influenza A virus infections. XIII International Symposium on Respiratory Viral Infections, 13-16 March 2011, Rome, Italy
  12. Ex vivo support and suppression of human norovirus RNA replication. Third International Calicivirus Conference, 10-13 November 2007, Cancun, Mexico
 
Last updated: 2 January 2020