Professor XIA, Jiang（夏江教授） – Department of Chemistry, The Chinese University of Hong Kong

Professor

Fellow of the Royal Society of Chemistry

Room 360 Science Centre

(852) 3943 6165

(852) 2603 5057

jiangxia@cuhk.edu. hk

Prof. Xia’s Research Group

0000-0001-8112-7625

Education

1999	B.Sc.	Nanjing University
2002	M.S.	Nanjing University
2006	Ph.D.	Stanford University

Position

Since 2021.8	Professor, Department of Chemistry, Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong
2015-2021	Associate Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong
2015-2021	Associate Professor, Department of Chemistry, The Chinese University of Hong Kong
2009-2014	Assistant Professor, The Chinese University of Hong Kong
2007-2008	Research Associate, Howard Hughes Medical Institute
2007-2008	Postdoctoral scholar, California Institute of Technology

Research Interests

Bioorganic chemistry, chemical and synthetic biology

We apply chemistry to biomedicine (Chem4BioMed) with a focus on immunotherapies and tissue engineering.

Immunotherapies
a. Antibody conjugates
b. Immune cell engineering
c. mRNA immunotherapies
Design and engineering of molecular coacervate/condensates based on liquid-liquid phase separation to deliver mRNA
Tissue engineering to treat degenerative disease
a. Collagen materials for skin regeneration and diabetic foot ulcers
b. Exosomes and hydrogel biomaterials for osteoarthritis

Recent publications

The full publication list can be found here (link) or at Google Scholar.

1	Cheng, K., Zhang, F.; Zou, J.-H.; Lei, X.-L.; Xie, X.-T.; Guo, Y.-B.; Wang, G.-P.; Liu, B.; Zhao, Y.-D.; Xia, J.; Fan, J.-X.* Peptide-functionalized membrane camouflage for endogenous H2S-induced photothermal immunotherapy of orthotopic colorectal cancer. Nat. Comm.. 2025, accepted.
2	Cheng, K.; Zhang, F.; Bao, Y.; Xu, Z.; Kong, H.; Yuan, D.; Zheng, Z.; Zhao, Y.-D.; Xia, J. Curcumin coacervates for supramolecular-interaction-responsive cytosolic siRNA delivery to enhance pyroptosis. Theranostics 2025, doi.org/10.7150/thno.121865.
3	Bao, Y.; Xia, J. Phase-separated coacervates of low-molecular-weight compounds for cytosolic delivery and disease treatment. J. Am. Chem. Soc. Au 2025, doi.org/10.1021/jacsau.5c01164 (invited review)
4	Xu, X.; Xu, L.; Wen, C.; Zhang, Y.; Xia, J.; Liang, Y.* Engineering bacterial membrane vesicles: A new paradigm in biomedical innovation. Coord. Chem. Rev. 2025, 542, 216895. (review)
5	Xing, Z.; Zhang, X.; Zhao, C.; Zhang, L.; Qian, S.; Chu, Y.; Yang, W.; Wang, Y.; Xia, J.; Wang, J. Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia. Acta Biomater. 2025, 200, 400-415.
6	Chen, H. †; Xu, Z†.; Bao, Y. †; Shiri, F. †; Yuan, D.; Hu, Y.; Li, B.; Zeng, B.; Li, X.; Kong, H.; Wang, Z.; Lau, W. C.-Y.; Lin, Z.; Xia, J. Bioorthogonal reaction of o-quinone with furan-2(3h)-one for site-selective tyrosine conjugation and construction of bispecific antibody complexes. Adv. Sci. 2025, 12, 2417260.
7	Bao, Y.†; Xu, Z.†; Cheng, K.; Li, X.; Chen, F.; Yuan, D.; Zhang, F.; Audrey Run-yu Che, A. R.-Y.; Zeng, X.; Zhao, Y.-D.; Xia, J.* Staudinger reaction-responsive coacervates for cytosolic antibody delivery and TRIM21-mediated protein degradation. J. Am. Chem. Soc. 2025, 147, 3830-3839.
8	Kong, H.†; Xie, X.†; Bao, Y.; Zhang, F.; Bian, L.; Cheng, K.; Zhao, Y.-D.; Xia, J.* Phase-separated spiropyran coacervates as dual-wavelength-switchable reactive oxygen generators. Angew. Chem. Int. Ed. 2025, 64, e202419538.
9	Zhang, L.; Chen, Y.; Feng, D.; Xing, Z.; Wang, Y.; Bai, Y.; Shi, D.; Li, H.; Fan, X.; Xia, J.; Wang, J. Recombinant collagen microneedles for transdermal delivery of antibacterial copper-DNA nanoparticles to treat skin and soft tissue infections. J. Controll. Release 2025, 379, 191-201.
10	Chen, H.;† Bao, Y;† Li, X.; Chen, F.; Sugimura, R.; Zeng, X.; Xia, J.* Cell surface engineering by phase-separated coacervates for antibody display and targeted cancer cell therapy. Angew. Chem. Int. Ed. 2024, 63, e202410566.
11	11. Xu, X.; Xu, L.; Wang, J.; Wen, C.; Xia, J.; Zhang, Y.; Liang, Y.* Bioinspired cellular membrane-derived vesicles for mRNA delivery. Theranostics 2024, 14, 3246-3266. (review).
12	Li, B.; Yuan, D.; Chen, H.; Wang, X.; Liang, Y.; Wong, C.T.T.; Xia, J. Site-selective antibody-lipid conjugates for surface functionalization of red blood cells and targeted drug delivery. J. Controll. Release 2024, 370, 302-309.
13	Zhang, H.; Yan, W.; Wang, J.; Xie, S.; Tao, W. A.; Lee, C.-W.; Zhang, X.; Zhang, G.; Liu, Y.; Wei, D.; Hu, J.; Liu, H.; Liu, F.; Nie, Y.; Chen, X.; Xu, H.; Xia, J.; Wang, S.* Surface functionalization of exosomes for chondrocyte-targeted siRNA delivery and cartilage regeneration. J. Controll. Release 2024, 369, 493-505.
14	Han, Y.; Jiang, H.; Huang, C.; Wu, X.; Ouyang, Y.; Chen, H.; Lan, D.; Wang, Y.; Zheng, B.; Xia, J.* Enzymatic Interfacial Conversion of Acylglycerols in Pickering Emulsions Stabilized by Hydrogel Microparticles. J. Colloid Interface Sci. 2024, 661, 228-236.
15	Pan, X.; Ye, F.; Ning, P.; Zhang, Z.; Li, X.; Zhang, B.; Wang, Q.; Chen, G.; Gao, W.; Qiu, C.; Wu, Z.; Li, J.; Zhu, L.; Xia, J.; Gong, K.; Du, Y.* Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov. 2023, 9, 118.
16	Liu, M.†, Wu, C. †,* Wang, R.; Qiu, J.; She, Z.; Qu, J.; Xia, J.* Modulating Liquid-Liquid Phase Separation of Nck Adaptor Protein against Enteropathogenic Escherichia coli Infection ACS Cent. Sci. 2023, 9, 2358-2368.
17	Chen, H.; Wong, H.-C. F.; Qiu, J.; Li, B.; Yuan, D.; Kong, H.; Bao, Y.; Zhang, Y.; Xu, Z.; Tse, Y.-L. S.; Xia, J. Site-Selective Tyrosine Reaction for Antibody-Cell Conjugation and Targeted Immunotherapy Adv. Sci. 2023, 11, 2305012.
18	Bao, Y.; Chen, H.; Xu, Z.; Gao, J.; Jiang, L.; Xia, J.* Photo-Responsive Phase-Separating Fluorescent Molecules for Intracellular Protein Delivery Angew. Chem. Int. Ed. 2023, 62, e202307045.
19	Xu, L.†; Xu, X.†; Liang, Y.; Wen, C.; Ouyang, K.; Huang, J.; Xiao, Y.; Deng, X.; Xia, J.; Duan, L. Osteoclast-Targeted Delivery of Anti-miRNA Oligonucleotides by Red Blood Cell Extracellular Vesicles. J. Controll. Release 2023, 358, 259-272.
20	Yuan, D.†; Zhang, Y.†; Lim, K. H.; Leung, S. K. P.; Yang, X.; Liang, Y.; Lau, W. C. Y.; Chow, K. T.; Xia, J.** Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes. J. Am. Chem. Soc. 2022,144, 18494-18503.
21	Wang, Y.†; Liu, M.†; Wei, Q.; Wu, W.; He, Y.; Gao, J.; Zhou, R.; Jiang, L.; Qu, J.; Xia, J.* Phase-Separated Multienzyme Compartmentalization for Terpene Biosynthesis in a Prokaryote. Angew. Chem. Int. Ed. 2022, e202203909.
22	Liang, Y.; Duan, L.; Lu, J.; Xia, J.* Engineering exosomes for targeted drug delivery Theranostics 2021, 11, 3183-3195.
23	Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.; Li, Y.Q.; Xia, J.* Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism. Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268.
24	Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.; Wang, D.; Xia, J.* Chondrocyte-targeted microRNA delivery by engineered exosomes toward a cell-free osteoarthritis therapy. ACS Appl. Mater. Interfaces 2020, 12, 36938–36947.
25	Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L.; He, S.; Qu, J.; Au, S. W-N.; Kang, B. H.; Lau, W. C. Y.; Deng, Z.; Xia, J., Liu, T.. Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux. Nat. Commun. 2019, 10, 4248.