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Garlic

E-mail: eugene.chan@cuhk.edu.hk


ORCID: 0000-0002-1463-6005


Administrative support: Ms Connie Poon

Consultation by Appointment: (852) 3505-2839



Dr. CHAN Yu Hin, Eugene
陳宇軒醫生

  • Associate Professor (Clinical), Department of Paediatrics

MBBS (HK), MD (HKU), DCH (HK), DCH (International), FHKCPaed, FHKAM (Paed), FRCPCH (UK)

Research Team: Nephrology (Childhood Kidney Disease)

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Biography

Prof. Eugene Chan is currently a Clinical Associate Professor at the Department of Paediatrics of the Chinese University of Hong Kong. He works in the Paediatric Nephrology Centre of Hong Kong Children’s Hospital, which is the designated, territory-wide referral centre in Hong Kong.


Prof. Chan dedicates his research in the field of paediatric glomerular disease, in particular childhood nephrotic syndrome and lupus nephritis. His team focuses to unravel the underlying disease pathogenesis and advance patient care in these conditions. He is also interested in research related to chronic kidney disease, peritoneal dialysis and onco-nephrology. Over the past few years, he has established an international collaborative research network on novel therapy in nephrotic syndrome, involving over 30 paediatric nephrology centres in Asia, Europe, North America and Oceania. His team has identified the impact of rituximab dosing regimen and maintenance immunosuppression on disease remission in complicated steroid-dependent nephrotic syndrome (Kidney Int 2020, J Am Soc Nephrol 2022). The team has also found that anti-CD20 could serve as a rescue therapy in steroid-resistant nephrotic syndrome that is not responsive to calcineurin inhibitors (Kidney Int 2024). His works have been published in top peer-reviewed nephrology journals including Kidney International and the Journal of the American Society of Nephrology. Findings of studies have led to changes in treatment recommendations in international guidelines published by the International Pediatric Nephrology Association (IPNA) and KDIGO.


He serves as a Co-Chair (Webinar) in the Professional Education Committee of the International Pediatric Nephrology Association and has contributed significantly to medical education in advancing global kidney care for children. He also works as an Associate Editor in Kidney International and a Section Editor in Pediatric Nephrology. Locally, he is a Council Member of the Hong Kong Paediatric Nephrology Society.


In recognition of his research and clinical contribution to the field of paediatric nephrology, he has received several international and local honours. He received the prominent Renee Habib Young Investigator Award from IPNA and the Young Nephrologist Award from the International Society of Nephrology, highlighting his exceptional achievement in advancing patient care. Other achievements include Young Investigator Award from the Asian Pacific Society of Nephrology, Young Achiever Award from the Hospital Authority, as well as Distinguished Young Fellow and Gold Medal for Best Original Research from the Hong Kong Academy of Medicine.

Research Interests

  • Paediatric Nephrology

  • Childhood nephrotic syndrome

  • Lupus nephritis and other paediatric glomerular disease

  • Kidney failure and dialysis

  • Onconephrology


Honorary Appointments 

  • Honorary Associate Consultant, Paediatric Nephrology Centre, Hong Kong Children’s Hospital


Professional Service  

Editorship

  • Associate Editor, Kidney International

  • Section Editor, Pediatric Nephrology

  • Editorial Board Member, Frontiers in Pediatrics (Pediatric Nephrology)

  • Editorial Board Member, Frontiers in Nephrology (Nephrology)

Others

  • Co-chair (webinar), Professional Education Committee, International Pediatric Nephrology Association

  • Junior Council, Asian Pediatric Nephrology Association

  • Founding faculty, Clinician Scientist Academy, International Pediatric Nephrology Association

  • Board Member, International Pediatric Continuous Renal Replacement Therapy (pCRRT)

  • Council member, Hong Kong Paediatric Nephrology Society

  • Scientific Organising Committee, World Congress of Nephrology 2025


Awards and Honours

  • Renee Habib Young Investigator Award, International Pediatric Neprhology Association, 2025

  • Best Abstract Award, International Chinese Congress of Nephrology, 2024

  • Outstanding HKCH Staff Research Award, Hong Kong Children’s Hospital, 2024

  • Young Investigator Award, Asia Pacific Society of Nephrology, 2024

  • Distinguished Young Fellow, Hong Kong Academy of Medicine, 2023

  • Awardee for International Society of Nephrology, Kidney International Fellowship, 2023

  • Fellow, International Society of Nephrology (FISN), 2023

  • Silver Medal, Best Original Research, Hong Kong Academy of Medicine, 2022

  • Best Paediatric Research of the Year, UK Kidney Week, 2022

  • Young Achiever Award, Hospital Authority, 2022

  • Young Outstanding Staff, Hong Kong Children’s Hospital, 2022

  • Gold Medal, Best Original Research, Hong Kong Academy of Medicine, 2020

  • Young Nephrologist Award, International Society of Nephrology, 2019

  • Outstanding Staff and Team Award, Hospital Authority, 2017

  • Eugenia Lee Education Scholarship, Hong Kong Kidney Foundation, 2013


Grant record

1. Health and Medical Research Fund (2025), Food and Health Bureau, HKSAR. – HKD 1,476,360

2. Hong Kong Society of Nephrology 45th Anniversary Research Grant (2024). HKD 300,000

3. HKAM-HKGI Research Excellence Grant in Genomic Medicine (2024). HKD 249,791



Selected Publications

  1. Chan EYh, Yap DY, Tullus K et al. An international, multi-center study evaluated rituximab therapy in childhood steroid-resistant nephrotic syndrome. Kidney Int. 2024 Oct 10:S0085-2538(24)00700-2. doi: 10.1016/j.kint.2024.09.011. Epub ahead of print. [IF=14.8]

  2. Chan EY, Yap HK, Tullus K et al. Long-Term Efficacy and Safety of Repeated Rituximab to Maintain Remission in Idiopathic Childhood Nephrotic Syndrome: An International Study. J Am Soc Nephrol. 2022 Jun;33(6):1193-1207. doi: 10.1681/ASN.2021111472. [IF=14.9]

  3. Chan EY, Webb H, Tullus K et al. Both the rituximab dose and maintenance immunosuppression in steroid-dependent/frequently-relapsing nephrotic syndrome have important effects on outcomes. Kidney Int. 2020 Feb;97(2):393-401. doi: 10.1016/j.kint.2019.09.033. [IF=19.6]

  4. Chan EY, Boyer O. Levamisole in childhood idiopathic nephrotic syndrome: new promises, and advocacy for global access. Kidney Int. 2024 May;105(5):932-934. doi: 10.1016/j.kint.2024.01.030. [IF=19.6]

  5. Chan EY, Yap DY, Ma AL et al. Renal relapse in children and adolescents with childhood-onset lupus nephritis: a 20-year study. Rheumatology (Oxford). 2023 Aug 26:kead447. doi: 10.1093/rheumatology/kead447 [IF=7.04]

  6. Chan EY, Parekh R, Tullus K et al. The use of rituximab in childhood idiopathic nephrotic syndrome. Clin J Am Soc Nephrol. 2023 Apr 1;18(4):533-548. doi: 10.2215/CJN.08570722. [IF=10.7]

  7. Chan EY, Leung D, Lau YL et al. Humoral and Cellular Immunogenicity and Safety of 3-Dose Inactivated COVID-19 Vaccine in Young Children Less Than 5 Years With Kidney Diseases. Kidney Int Rep. 2023 Aug 19;8(10):2177-2179. doi: 10.1016/j.ekir.2023.08.012. [IF=5.7]

  8. Chan EY, Yap DYH, Ma AL et al. Long-term outcomes of children and adolescents with biopsy-proven childhood-onset lupus nephritis. Kidney International Reports, 2022. Kidney Int Rep. 2022 Oct 21;8(1):141-150. DOI: https://doi.org/10.1016/j.ekir.2022. [IF=5.7]

  9. Chan EY, Ma AL, Yap DY et al. Long-term outcomes with rituximab as add-on therapy in severe childhood-onset lupus nephritis. Pediatr Nephrol. 2023 Jun 26. doi: 10.1007/s00467-023-06025-6. [IF=3.6]

  10. Malakasioti G, Chan EY, Tullus K et al. A multicenter retrospective study of calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene variants. Kidney Int. 2023 May;103(5):962-972. doi: 10.1016/j.kint.2023.02.022. [IF=19.6] (25 of 39 authors)

  11. Ma AL, Leung D, Chan EY et al. Antibody responses to 2 doses of mRNA COVID-19 vaccine in pediatric patients with kidney diseases. Kidney Int. 2022 May;101(5):1069-1072. (Impact factor 18.998) doi: 10.1016/j.kint.2022.01.035. [IF=19.6] (3 of 14 authors)

  12. Marlais M, Chan EY, Tullus K et al. Clinical Factors and Adverse Kidney Outcomes in Children With ANCA-Associated Glomerulonephritis. Am J Kidney Dis. 2022 Jul 7:S0272-6386(22)00772-7. [IF=13.2] (15 out of 60 authors)

  13. Borzych-Dużałka D, Chan EYH, Schaefer F, Warady BA et al. Best Practice of Peritoneal Dialysis-Associated Gram-Negative Peritonitis in Children: Insights from the International Pediatric Peritoneal Dialysis Network Registry. Kidney Int Rep. 2024 Mar 28;9(6):1654-1663. doi: 10.1016/j.ekir.2024.03.031. [IF=5.7]

  14. Chan EY, Borzych-Duzalka D, Warady et al. Colostomy in children on chronic peritoneal dialysis (A work from the International Pediatric Peritoneal Dialysis Network). Pediatr Nephrol. 2020 Jan;35(1):119-126. doi: 10.1007/s00467-019-04372-x. [IF=3.7]


Book Chapters

  1. Chan EYH, Boyer O, K Tullus. Pediatric Glomerular Disease. Nephrology Self-assessment tool (NephSAP) 2024, an official educational material published by the American Society of Nephrology.

  2. Chan EYH, Ma ATL, Lai WM. Development of Paediatric Nephrology in Hong Kong for “Progress in Pediatrics in Guangdong”, 2023 edition.

  3. Ma ATL, Chan EYH, Lai WM. End stage kidney disease in children. Integrated systemic nephrology, 4thedition. The University of Hong Kong

  4. Chan EYH, Warady BA. Acquired cystic kidney disease. Pediatric Dialysis Case Studies – A practical guide to patient care. Springer, 2017. ISBN 978-3-319-55147-0

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