Professor CHU, Chun Ho Jacky （朱俊豪教授）

Research Assistant Professor

location    Room 252 Science Centre

Phone No.    (852) 3943 0818

Email    jackychu@cuhk.edu.hk

0000-0003-3858-3312

 

 

 

 

 

Education

08/2017 – 07/2021 Ph.D. in Chemistry The Chinese University of Hong Kong
09/2013 – 07/2017 B.Sc. (Hons.) in Chemistry, First Class The Chinese University of Hong Kong

 

Position

Since 02/2025 Research Assistant Professor, Department of Chemistry, The Chinese University of Hong Kong
04/2022 – 01/2025 Honorary Research Associate, Department of Chemistry, The University of Hong Kong
04/2024 – 01/2025 Research Manager, Laboratory for Synthetic Chemistry and Chemical Biology, InnoHK@HKU
04/2022 – 04/2024 Postdoctoral Fellow, Laboratory for Synthetic Chemistry and Chemical Biology, InnoHK@HKU
08/2021 – 03/2022 Postdoctoral Fellow, Department of Chemistry, The Chinese University of Hong Kong

 

Research Interests

Development of innovative therapeutic strategies, with a strong emphasis on antibody conjugates, immunotherapy, and photodynamic therapy.

 

Representative Publications

1 Chu, J. C. H.;† Escriche-Navarro, B.;† Xiong, J.;† García-Fernández, A.;* Martínez-Máñez, R.;* Ng, D. K. P.* β-Galactosidase-Triggered Photodynamic Elimination of Senescent Cells with a Boron Dipyrromethene-Based Photosensitizer. Adv. Sci. 2024, 11, e2401012.
2 Ruan, M.-L.; Ni, W.-X.; Chu, J. C. H.; Lam, T.-L.; Law, K.-C.; Zhang, Y.; Yang, G.; He, Y.; Zhang, C.; Fung, Y. M. E.; Liu, T.; Huang, T.; Lok, C.-N.;* Chan, S. L-.F.; Che, C.-M.* Iridium(III) Carbene Complexes as Potent Girdin Inhibitors against Metastatic Cancers. Proc. Natl. Acad. Sci. U.S.A. 2024, 121, e2316615121.
3 Shao, C.; Tang, B.; Chu, J. C. H.; Lau, K. M.; Wong, W.-T.; Che, C.-M.; Tai, W. C. S.;* Wong, W.-T.;* Wong, C. T. T.* Macrophage-Engaging Peptidic Bispecific Antibody (pBsAb) for Immunotherapy via Facile Bioconjugation Strategy. Chem. Sci.  2024, 15, 11272-11278.
4 Tam, L. K. B.; Chu, J. C. H.; Yang, C.; Cheung, P. C. K.; Ng, D. K. P.;* Lo, P.-C.* An Enzyme-Responsive Double-Locked Photodynamic Molecular Beacon for Targeted Photodynamic Anticancer Therapy. J. Am. Chem. Soc.  2023, 145, 7361-7375.
5 Chu, J. C. H.; Wong, C. T. T.; Ng, D. K. P.* Toward Precise Antitumoral Photodynamic Therapy Using a Dual Receptor-Mediated Bioorthogonal Activation Approach. Angew. Chem. Int. Ed. 2023, 62, e202214473.
6 Xiong, J.;† Chu, J. C. H.;† Fong, W.-P.; Wong, C. T. T.;* Ng, D. K. P.* Specific Activation of Photosensitizer with Extrinsic Enzyme for Precisive Photodynamic Therapy. J. Am. Chem. Soc. 2022, 144, 10647-10658.
7 Chu, J. C. H.; Shao, C.; Ha, S. Y. Y.; Fong, W.-P.; Wong, C. T. T.;* Ng, D. K. P.* One-Pot Peptide Cyclisation and Surface Modification of Photosensitiser-Loaded Red Blood Cells for Targeted Photodynamic Therapy. Biomater.  Sci. 2021, 9, 7832-7837.
8 Chu, J. C. H.; Fong, W.-P.; Wong, C. T. T.;* Ng, D. K. P.* Facile Synthesis of Cyclic Peptide-Phthalocyanine Conjugates for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy. J. Med. Chem. 2021, 64, 2064-2076.
9 Chu, J. C. H.; Chin, M. L.; Wong, C. T. T.;* Hui, M.;* Lo, P.-C.;* Ng, D. K. P.* One-Pot Synthesis of a Cyclic Antimicrobial Peptide-Conjugated Phthalocyanine for Synergistic Chemo-Photodynamic Killing of Multidrug-Resistant Bacteria. Adv.  Therap. 2021, 4, 2000204.
10 Chu, J. C. H.; Yang, C.; Fong, W.-P.; Wong, C. T. T.;* Ng, D. K. P.* Facile One-Pot Synthesis of Cyclic Peptide-Conjugated Photosensitisers for Targeted Photodynamic Therapy. Chem. Commun. 2020, 56, 11941-11944.