Prof. XUE, Yang
Research Assistant Professor, Department of Biomedical Engineering, CUHK
E-mail: yangxue@cuhk.edu.hk
Location: MMW405
About
Yang joined the Department of Biomedical Engineering (BME), The Chinese University of Hong Kong (CUHK) as Research Assistant Professor in 2024. Before joining BME, she was a Postdoctoral Fellow at the Department of Chemistry, CUHK for 4 years. During her study at Sichuan University for Bachelor of Engineering in Pharmaceutical Engineering, she secured several University-level and national-level scholarships, such as the “Sheng Huaxi” First-class Scholarship (National-level 1%). She then furthered her studies and obtained a PhD degree at the Department of Chemistry, CUHK.
Professional Education and Training
2020-2024 Postdoctoral Fellow, Department of Chemistry, The Chinese University of Hong Kong
2016-2020 PhD in Chemistry, Department of Chemistry, The Chinese University of Hong Kong
2012-2016 Bachelor of Engineering in Pharmaceutical Engineering, Sichuan University
Research Interest
Development of advanced strategies to modulate and detect cell-cell interactions and to facilitate cell-based immunotherapy;
Development of multifunctional nanosystems for targeted cancer therapy;
Development of novel supramolecular and bioorthogonal approaches for various biomedical applications.
HONORS & AWARDS
2019 Certificate of Excellence in Professional Development Course for Teaching Assistants
2015 Second-class Scholarship of Sichuan University
2014 National Scholarship
2014 “Sheng Huaxi” First-class Scholarship
Selected Publications
1. Xue, E. Y.; Lee, A. C. K.; Ng, D. K. P.* Promotion and Detection of Cell−Cell Interactions through a Bioorthogonal Approach. J. Am. Chem. Soc. 2024, 146, 17334−17347. (Supplementary Cover)
2. Xue, E. Y.; Yang, C.; Zhou, Y.; Ng, D. K. P.* A Bioorthogonal Antidote Against the Photosensitivity after Photodynamic Therapy. Adv. Sci. 2023, 2306207.
3. Xue, E. Y.;# Kang, F.;# Zhou, Y.; Ng, D. K. P.* Design and Synthesis of a NAD(P)H:Quinone Oxidoreductase 1-Activatable Photosensitiser for Controlled Photodynamic Therapy. Chem. Commun. 2023, 59, 7056−7059.
4. Xiong, J.;# Xue, E. Y.;# Wu, Q.; Lo, P.-C.;* Ng, D. K. P.* A Tetrazine-Responsive Isonitrile-Caged Photosensitiser for Site-Specific Photodynamic Therapy. J. Controlled Release 2023, 353, 663−674.
5. Durán-Sampedro, G.;# Xue, E. Y.;# Moreno-Simoni, M.; Paramio, C.; Torres, T.;* Ng, D. K. P.;* de la Torre, G.* Glycosylated BODIPY-Incorporated Pt(II) Metallacycles for Targeted and Synergistic Chemo-Photodynamic Therapy. J. Med. Chem. 2023, 66, 3448−3459.
6. Liu, S.; Ma, J.; Xue, E. Y.; Wang, S.; Zheng, Y.; Ng, D. K. P.;* Wang, A.;* Zheng, N.* Polymeric Phthalocyanine-Based Nanosensitizers for Enhanced Photodynamic and Sonodynamic Therapies. Adv. Healthcare. Mater. 2023, 12, 2300481.
7. Xiong, J.; Xue, E. Y.; Ng, D. K. P.* Synthesis, Cellular Uptake, and Photodynamic Activity of Oligogalactosyl Zinc(II) Phthalocyanines. ChemPlusChem, 2023, 88, e202200285 with a front cover in that issue and a Cover Profile, ChemPlusChem, 2023, 88, e202200406.
8. Xue, E. Y.; Yang, C.; Fong, W.-P.; Ng, D. K. P.* Site-Specific Displacement-Driven Activation of Supramolecular Photosensitizing Nanoassemblies for Antitumoral Photodynamic Therapy. ACS Appl. Mater. Interfaces 2022, 14, 14903−14915.
9. Casellas, N. M.; Dai, G.; Xue, E. Y.; Vicente-Arana, M. J.; Ng, D. K. P.;* Torres, T.;* García-Iglesias, M.* Porphyrin-Based Supramolecular Nanofibres as a Dynamic and Activatable Photosensitiser for Photodynamic Therapy. Biomater. Sci. 2022, 10, 3259−3267.
10. Casellas, N. M.;# Dai, G.;# Xue, E. Y.; Fonseca, A.; Ng, D. K. P.;* García-Iglesias, M.;* Torres, T.* A Self-Assembled Subphthalocyanine-Based Nanophotosensitiser for Photodynamic Therapy. Chem. Commun. 2022, 58, 669−672.
11. Xue, E. Y.; Shi, W.-J.; Fong, W.-P.; Ng, D. K. P.* Targeted Delivery and Site-Specific Activation of β-Cyclodextrin-Conjugated Photosensitizers for Photodynamic Therapy through a Supramolecular Bio-Orthogonal Approach. J. Med. Chem. 2021, 64, 15461–15476.
12. Xue, E. Y.; Wong, R. C. H.; Wong, C. T. T.; Fong, W.-P.; Ng, D. K. P.* Synthesis and Biological Evaluation of an Epidermal Growth Factor Receptor-Targeted Peptide-Conjugated Phthalocyanine-Based Photosensitiser. RSC adv. 2019, 9, 20652−20662.
