Professor TSUI, Chit Gavin（徐哲教授）

Associate Professor

location    Room 162 Science Centre

Phone No.    (852) 3943 6293

Email    gctsui@cuhk.edu.hk

Research Group    Tsui Research Group Website

0000-0003-4824-8745

 

 

 

 

 

 

 

Education and Training

2013–2015 Postdoctoral Fellow Max-Planck-Institut für Kohlenforschung, Germany (with Prof. Benjamin List, Nobel laureate 2021)
2008-2013 Ph.D. University of Toronto, Canada (with Prof. Mark Lautens, Officer of the Order of Canada)
2011 Visiting Scholar Kyoto University, Japan (with Prof. Tamio Hayashi)
2004-2006 M.Sc. University of Guelph, Canada (with Prof. William Tam)
2000-2004 B.Sc. (Hons.) University of Guelph, Canada

 

Professional Positions

2022-present Associate Professor, The Chinese University of Hong Kong, Hong Kong
2015-2022 Assistant Professor, The Chinese University of Hong Kong, Hong Kong

 

Research Interests

  • Organofluorine chemistry
  • Organometallic chemistry
  • Organic synthesis and homogeneous catalysis
  • Asymmetric synthesis
  • Pharmaceutical, agrochemical and material applications

 

Honours and Awards

2019 Asian Core Program Lectureship Award (Taiwan)
2018 Asian Core Program Lectureship Award (Japan)
2017 Asian Core Program Lectureship Award (Singapore)
2017 Asian Core Program Lectureship Award (Korea)
2016 Thieme Chemistry Journals Award
2013 Humboldt-Bayer Research Fellowship for Postdoctoral Researchers

 

 

Research Grants

– RGC General Research Fund 14303823
– RGC General Research Fund 14304421
– RGC General Research Fund 14301820
– RGC Early Career Scheme 24301217
– NSFC/RGC Joint Research Scheme N_CUHK403/20
– PROCORE-France/Hong Kong Joint Research Scheme F-CUHK404/20
– Germany/Hong Kong Joint Research Scheme G-CUHK401/20

 

 

Publications (since independent career)

44 Thermal N-O Bond Heterolysis of TEMPO-CF2CF3 Towards Trifluoroacetylation of Alcohols and Amines. Dong, T.; Tang, Y.; Tsui, G. C.* Org. Chem. Front. 2023, Advance Article.
43 Synthesis of Difluoromethylated Alkenes via Copper-Catalyzed Protodefluorination of β-(Trifluoromethyl)styrenes. Dong, T.; Ye, Y.; Wang, Y.; Cheung, K. P. S.; Tsui, G. C.* Chem. Asian J. 2023, e202300655.
42 Stereoselective Palladium-Catalyzed C–F Bond Alkenylation of Tetrasubstituted gem-Difluoroalkenes via Mizoroki–Heck Reaction. Wang, Y.; Tsui, G. C.* Org. Lett. 2023, 25, 6217-6221.
41 Three-Component Domino Acylation/Trifluoromethylation of Bicyclic Amidines. Luo, Z.; Chen, J.; Li, M.; Tsui, G. C.* Org. Lett. 2023, 25, 5656-5660.
40 Interrupted Click Reaction with CuCF2CF3 Reagent: Synthesis of 5-Pentafluoroethyl 1,2,3-Triazoles. Fu, Z.; Yang, X.; Tsui, G. C.* Org. Lett. 2023, 25, 4945-4949.
39 Palladium-Catalyzed Stereoselective Defluoroborylation of gem-Difluoroalkenes with Unsymmetrical Diboron: Access to Tetrasubstituted Monofluorinated Vinyl–Bdam Derivatives. Luo, Z.; Zong, Y.; Tsui, G. C.* Org. Lett. 2023, 25, 4406-4410.
38 Palladium-Catalyzed Stereoselective Defluorosilylation of gem-Difluoroalkenes for the Synthesis of Tetrasubstituted Monofluorinated Vinylsilanes. Zong, Y.; Luo, Z.; Tsui, G. C.*  Org. Lett. 2023, 25, 2333-2337.
37 Copper-Catalyzed Visible-Light-Induced Allylic Difluoromethylation of Unactivated Alkenes Using Difluoroacetic Acid. Wang, J.; Luo, Z.; Wu, Y.; Tang, Y.; Yang, X.;* Tsui, G. C.* Org. Lett. 2023, 25, 1045-1049.
36 Radical Fluorosulfonyl Heteroarylation of Unactivated Alkenes with Quinoxalin-2(1H)-ones and Related N-Heterocycles. Lin, L.; Wang, P.; Dong, T.; Tsui, G. C.* Liao, S.* Org. Lett. 2023, 25, 1088-1093.
35 Using fluoroform in trifluoromethylation reactions. Luo, Z.; Cahard, D.;* Tsui, G. C.* J. Fluor. Chem, 2023, 266, 110092.
34 Stereoselective Rhodium(I)-Catalyzed C–F Bond Arylation of Tri- and Tetrasubstituted gem-Difluoroalkenes with Boronic Acids. Tan, H.; Zong, Y.; Tang, Y.; Tsui, G. C.* Org. Lett. 2023, 25, 877-882.
33 Rhodium(I)-Catalyzed Defluorinative Coupling of Boronic Acids with Monofluoroalkenes. Zong, Y.; Tang, Y.; Tsui, G. C.* Org. Lett. 2022, 24, 6380-6385.
32 Radical cyclization/bis(pentafluoroethylation) of 1,6-dienes using HCF2CF3-derived CuCF2CF3. Luo, Z.; Tsui, G. C.* Org. Chem. Front. 2022, 9, 4969-4974.
31 Organocatalytic Three-Component Acyldifluoromethylation of Vinylarenes via N-Heterocyclic Carbene-Catalyzed Radical Relay. She, K.; Liang, F.; Wang, H.*; Tsui, G. C.*; Wang, Q.*; Org. Lett. 2022, 24, 4840-4844.
30 Enantioselective Pd-catalyzed dearomative reductive Heck and domino Heck–Suzuki reactions of 2-CF3-indoles. Liang, R.; Chen, J.; Huang, Y.; Yu, Y.; Zhang, H.; Song, Y.; Tsui, G. C.* Chem. Comm. 2022, 58, 6200-6203.
29 Highly Selective C-F Bond Functionalization of Tetrasubstituted gem-Difluoroalkenes and Trisubstituted Monofluoroalkenes Using Grignard Reagents. Wang, Y.; Tang, Y.; Zong, Y.; Tsui, G. C.* Org. Lett. 2022, 24, 4087-4092.
28 New Avenues in Copper-Mediated Trifluoromethylation Reactions Using Fluoroform as the CF3 Source. Yang, X.; Tsui, G. C.* Synlett 2022, 33, A–H.
27 Construction of Carbon-Fluorine Bonds via Copper-Catalyzed/-Mediated Fluorination Reactions. Dong, T.; Tsui, G. C.* Chem. Rec. 2021, 21, 4015–403.
26 Palladium-Catalyzed Stereoselective C−F Bond Vinylation and Allylation of Tetrasubstituted gem-Difluoroalkenes via Stille Coupling: Synthesis of Monofluorinated 1,3- and 1,4-Dienes. Li, M.; Wang, Y.; Tsui, G. C.* Org. Lett. 2021, 23, 8072-8076.
25 Nucleophilic Vinylic Substitution (SNV) of Trisubstituted Monofluoroalkenes for the Synthesis of Stereodefined Trisubstituted Alkenes and Divinyl Ethers. Zong, Y.; Ma, Q.; Tsui, G. C.* Org. Lett. 2021, 23, 6169-6173.
24 Stereoselective Synthesis of Difluorinated 1,3-Dienes via PalladiumCatalyzed C−F Bond Activation of Tetrasubstituted gem-Difluoroalkenes. Wang, Y.; Ma, Q.; Tsui, G. C.* Org. Lett. 2021, 23, 5241-5245.
23. Stereoselective Palladium-Catalyzed Base-Free Suzuki–Miyaura Cross-Coupling of Tetrasubstituted gem-Difluoroalkenes: An Experimental and Computational Study. Wang, Y.; Qi, X.; Ma, Q.; Liu, P.;* Tsui, G. C.* ACS Catal. 2021, 11, 4799-4809.
22. Perfluoroalkylation of Thiosulfonates: Synthesis of Perfluoroalkyl Sulfides. Luo, Z.; Yang, X.; Tsui, G. C.* Org. Lett. 2020, 22, 6155-6159.
21. Palladium-Catalyzed Stereoselective Hydrodefluorination of Tetrasubstituted gem-Difluoroalkenes. Ma, Q.; Liu, C.; Tsui, G. C.* Org. Lett. 2020, 22, 5193-5197.
20. Radical Pentafluoroethylation of Unactivated Alkenes Using CuCF2CF3. Yang, X.; Tsui, G. C.* Org. Lett. 2020, 22, 4562-4567.
19. Stereoselective Palladium‐Catalyzed C−F Bond Alkynylation of Tetrasubstituted gem‐Difluoroalkenes. Ma, Q.; Wang, Y.; Tsui, G. C.* Angew. Chem. Int. Ed. 2020, 59, 11293-11297.
18. Silver-Catalyzed Trifluoromethylalkynylation of Unactivated Alkenes with Hypervalent Iodine Reagents. Yang, X.; Tsui, G. C.* Org. Lett. 2019, 21, ​8625-8629.
17. Trifluoromethylation of Anthraquinones for n-Type Organic Semiconductors in Field Effect Transistors. Zhao, M.; Yang, X.; Tsui, G. C.*; Miao, Q.* J. Org. Chem. 2020, 85, ​44-51.
16. Trifluoromethylation of Unactivated Alkenes with Me3SiCF3 and N-Iodosuccinimide. Yang, X.; Tsui, G. C.* Org. Lett. 2019, 21, 1521-1525.
15. Domino Cyclization/Trifluoromethylation of 2-Alknylphenols for the Synthesis of 3-(Trifluoromethyl)benzofurans and Evaluation of Their Antibacterial and Antifungal Activities. Li, M.; Ye, Y.; He, L.; Hui, M.; Ng, T. B.; Wong, J. H.; Tsui, G. C.* Asian J. Org. Chem. 2019, 8, 702-709.
14. Trifluoromethylation of α-Diazoesters and α-Diazoketones with Fluoroform-Derived CuCF3: Synergistic Effects of Co-Solvent and Pyridine as a Promoter. Ma, Q.; Tsui, G. C.* Org. Chem. Front. 2019, 6, 27-31.
13. Copper-Mediated 1,2-Bis(trifluoromethylation) of Arynes. Yang, X.; Tsui, G. C.* Chem. Sci. 2018, 9, 8871-8875.
12. Domino Cyclization/Trifluoromethylation of 2-Alkynylanilines Using Fluoroform-Derived CuCF3: Synthesis of 3-(Trifluoromethyl)indoles. Ye, Y.; Cheung, K. P. S.; He, L.; Tsui, G. C.* Org. Chem. Front. 2018, 5, 1511-1515.
11. Synthesis of 2-(Trifluoromethyl)indoles via Domino Trifluoromethylation/Cyclization of 2-Alkynylanilines. Ye, Y.; Cheung, K. P. S.; He, L.; Tsui, G. C.* Org. Lett. 2018, 20, 1676-1679.
10. Copper-Mediated Domino Cyclization/Trifluoromethylation of Propargylic N‐Hydroxylamines: Synthesis of 4‐Trifluoromethyl-4- isoxazolines. Wang, Q.; Tsui, G. C.* J. Org. Chem. 2018, 83, 2971-2979.
9. Copper-Mediated Trifluoromethylation-Allylation of Arynes. Yang, X.; Tsui, G. C.* Org. Lett. 2018, 20, 1179-1182.
8. Domino Hydroboration/Trifluoromethylation of Alkynes Using Fluoroform-Derived CuCF3. He, L.; Yang, X.; Tsui, G. C.* J. Org. Chem. 2017, 82, 6192-6201.
7. Copper(I)-Catalyzed Interrupted Click Reaction with TMSCF3: Synthesis of 5-Trifluoromethyl 1,2,3-Triazoles. Cheung, K. P. S.; Tsui, G. C.* Org. Lett. 2017, 19, 2881-2884.
6. Hydroxytrifluoromethylation of Alkenes Using Fluoroform-Derived CuCF3. Yang, X.; He, L.; Tsui, G. C.* Org. Lett. 2017, 19, 2446-2449.
5. Synthesis of Fluorescent Indazoles by Palladium-Catalyzed Benzannulation of Pyrazoles with Alkynes. Kim, O. S.; Jang, J. H.; Kim, H. T.; Han, S. J.; Tsui, G. C.*; Joo, J. M.* Org. Lett. 2017, 19, 1450-1453.
4. Copper-Mediated Domino Cyclization/Trifluoromethylation/Deprotection with TMSCF3: Synthesis of 4-Trifluoromethylpyrazoles. Wang, Q.; He, L.; Li, K. K.; Tsui, G. C.* Org. Lett. 2017, 19, 658-661.
3. Fluoroform-Derived CuCF3 for Trifluoromethylation of Terminal and TMS-Protected Alkynes. He, L.; Tsui, G. C.* Org. Lett. 2016, 18, 2800-2803.
2. Review: Fluoroform, First Update. He, L.; Tsui, G. C., In Encyclopedia of Reagents for Organic Synthesis, Rovis, T. Ed.; Wiley-VCH: Weinheim, 2017.
1. Book chapter: Five-Membered Ring Systems: Furans and Benzofurans. Ke, Z.; Tsui, G. C.*, Peng, X.-S.; Yeung, Y.-Y., In Progress in Heterocyclic Chemistry, Gribble, G. W.; Joule, J. A. Eds.; Elsevier: Oxford, 2016 to present.