School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

Prof AU Chak Leung Simon

simonau


Senior Lecturer

B.Sc., M.Phil., Ph.D.

Telephone: 3943 6813

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:  610G Choh-Ming Li Basic Medical Sciences Building, CUHK

 

 

 

 

 

 

Biography

Prof AU Chak Leung (歐澤樑) graduated from the Faculty of Science, The University of Hong Kong with a BSc (First Class Honours) degree in Biological Sciences and obtained his MPhil degree under the supervision of Prof Patrick Y.D. Wong in the Department of Physiology, Faculty of Medicine, The University of Hong Kong. He was awarded the Commonwealth Scholarship to pursue his PhD degree in the Department of Anatomy, Faculty of Medicine, Monash University under the supervision of Prof David M. de Kretser. He joined the Department of Physiology, The Chinese University of Hong Kong in February 1983, where he served as a lecturer and later as an Associate Professor. He joined the Hong Kong Society of Endocrinology, Metabolism and Reproduction as a member when it was founded in 1983, and he later held various positions as Council Member, Honorary Secretary, Vice-President and President. He is currently a senior lecturer in the School of Biomedical Sciences. He is an experienced teacher and has served in various capacities in curriculum design and course/programme administration, including as the Year Coordinator of MBChB Programme (2010-2020). He received twenty “Teacher of the Year Award” (2000-2004, 2009-2021), the “Master Teacher Award” in 2004 from the Faculty of Medicine, and the Vice-Chancellor’s Exemplary Teaching Award in 2012. His current research interest is on student assessments in teaching and learning.

  1. Teaching of general physiology, endocrine and reproductive physiology, cardiovascular physiology (electrocardiography)
  2. Research in male reproductive physiology (epididymal function), reproductive endocrinology (inhibin), blood supply to reproductive organs (vascular control and angiogenesis)
  3. Research in medical education/student assessments (item analysis, standard setting)
  1. Au SCL (2018) Relating item analyses of multiple-choice questions (MCQ) to the test score and pass/fail determination. An International Association for Medical Education (AMEE) 2018 Conference, Basal, Switzerland; Abstract 4EE10.
  2. Au SCL (2017) Studies on applying modified Cohen method of standard setting to assessments in a preclinical year. An International Association for Medical Education (AMEE) 2017 Conference, Helsinki, Finland; Abstract 4DD11.
  3. Wong CM, Au CL, Tsang SY, Lau CW, Yao XQ, Cai ZW, Chung ACK. (2017) Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aortas. Brit J Pharmacol 174(8): 718-733.
  4. Gao DY, Zhang BL, Leung MCT, Au SCL, Wong PYD, Shum WWC. (2017) Coupling of TRPV6 and TMEM16A in epithelial principal cells of the rat epididymis". J Gen Physiol 148(2): 161-182.
  5. Tian XY, Wong WT, Leung FP, Zhang Y, Wang Y, Lee HK, Ng CF, Chen ZY, Yao XQ, Au CL, Lau CW, Vanhoutte PM, Cooke JP, Huang Y. (2012) Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2a impairs endothelial function in renovascular hypertensive rats. Antioxid Redox Signal 16: 363-373.
  6. Wong SL, Lau CW, Wong WT, Xu A, Au CL, Ng CF, Ng SMS, Gollasch M, Yao XQ, Huang Y. (2011) Pivotal role of protein kinase Cδ in angiotensin II-induced endothelial cyclooxygenase-2 expression. A Link to vascular inflammation. Arterioscler Thromb Vasc Biol 31: 1169-1176.
  7. Lau KH, Chow AW, Au CL, Ko WH. (2011) Differential inhibitory effects of CysLT(1) receptor antagonists on P2Y(6) receptor-mediated signaling and ion transport in human bronchial epithelia. PLoS One vol. 6 no.7, pp. e22363 (13 pages).
  8. Lee YL, Liu Y, Ng PY, Lee KF, Au CL, Ng EH, Ho PC, Yeung WS (2008) Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation. Human Reprod 23: 894-903.
  9. Leung FP, Yung LM, Leung HS, Au CL, Yao XQ, Vanhoutte PM, Laher I, Huang Y (2007) Therapeutic concentrations of raloxifene augment nitric oxide-dependent coronary artery dilatation in vitro. Brit J Pharmacol 152: 223-229.
  10. Cheung LW, Au SC, Cheung AN, Ngan HY, Tombran-Tink J, Auersperg N, Wong AS (2006) Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells. Endocrinology 147: 4179-4191
  11. Lo ACY, Fung MK, Au CL, Chan TS, Sauer B, Chung SS, Chung SK (2004) Transgenic mice over-expressing endothelin-1 in testis transactivated by a Cre/loxP system showed decreased testicular capillary blood flow. Transgenic Res 13:119-34.
  12. Ko WH, Au CL, Yip CY (2003) Multiple purinergic receptors lead to intracellular calcium increases in cultured rat Sertoli cells. Life Sci 72: 1519-1535.
  13. Au CL, Canny BJ, Farnworth PG, Giraud AS (1997) Bombesin regulation of adrenocorticotropin release. Peptides 18: 995-1000
  14. Au CL, Chung HS, Pang HC, Chan LF (1996) Human chorionic gonadotrophin (hCG)-induced endothelial cell proliferation in adult rat testes and its dependence on the presence of Leydig cells. J Physiol 494: 81P.
  15. Au CL, Affandi B, Rogers PAW (1994) Immunohistochemical staining of von Willebrand factor in endometrium of women during the first year of Norplant use. Contraception 50: 477-489.
  16. Critchley HOD, Bailey DA, Au CL, Affandi B, Rogers PAW (1993) Immunohistochemical sex steroid receptor distribution in endometrium from long-term subdermal levonorgestrel users and during the normal menstrual cycle. Human Reprod 8: 1632-1639.
  17. Au CL, Rogers PAW (1993) Immunocytochemical determinations of changes in von Willebrand factor levels in endometrium of normal women during the menstrual cycle. Human Reprod 8: 17-23.
  18. Au CL, Robertson DM, de Kretser DM (1987) Changes of testicular inhibin after a single episode of heating. Endocrinology 120: 973-977.
  19. Au CL, Robertson DM, de Kretser DM (1986) Measurement of inhibin and an index of inhibin production by rat testes during postnatal development. Biol. Reprod 35: 37-43.
  20. Au CL, Robertson DM and de Kretser DM (1985) Effects of hypophysectomy and subsequent FSH and testosterone treatment on inhibin production by adult rat testes. J Endocrinol 105: 1-6.
  21. Au CL, Robertson DM and de Kretser DM (1983) In vitro bioassay of testicular inhibin in normal and bilaterally cryptorchid rats. Endocrinology 112: 239-244.
  22. Wong PYD, Au CL, Bedford JM (1982) Biology of the scrotum. II. Suppression by abdominal temperature of transepithelial ion and water transport in the cauda epididymidis. Biol Reprod 26: 683-689.
  23. Au CL, Wong PYD (1980) Luminal acidification by the perfused rat cauda epididymidis. J Physiol 309: 419-427.
  24. Wong PYD, Au CL, Ngai HK (1978) Electrolyte and water transport in the rat cauda epididymis: Its possible role in sperm maturation. Int. J Androl Suppl 2: 608-628.
  25. Au CL, Ngai HK, Yeung CH, Wong PYD (1978) Effect of adrenalectomy and hormone replacement on sodium and water transport in the perfused rat cauda epididymidis. J Endocrinol 77: 265-266.
  1. Teaching Development and Learning Enhancement Grant (TDLEG) for 2016-19 Triennium, CUHK [Co-I; 01-Jan-17]: “Application of Augmented Reality (AR) and Virtual Reality (VR) for Teaching Multidisciplinary Topics in Biomedical Sciences” (HK$496,980).
  2. Courseware Development Grant (CDG) for 2011-12, CUHK [PI; 02-2011 to 6-2013]: “Development of WebCT-based Courseware for the teaching and self-assessment study of electrocardiogram (ECG) in the medical physiology course” (HK$50,000)
2020 - 2021 Teacher of the Year Award (MBChB Year 2)
2020 - 2021 Teacher of the Year Award (MBChB Year 3)
2019 - 2020 Teacher of the Year Award (MBChB Year 2)
2019 - 2020 Teacher of the Year Award (MBChB Year 3)
2018 - 2019 Teacher of the Year Award (MBChB Year 2)
2017 - 2018 Teacher of the Year Award (MbChB Year 3)
2016 - 2017 Teacher of the Year Award (MbChB Year 3)
2015 - 2016 Teacher of the Year Award (MbChB Year 3)
2014 - 2015 Teacher of the Year Award (MbChB Year 3)
2013 - 2014 Teacher of the Year Award (MBChB Year 2)
2012 - 2013 Teacher of the Year Award (MBChB Year 1)
2012 Vice-Chancellor’s Exemplary Teaching Award
2011 - 2012 Teacher of the Year Award (MBChB Year 1)
2010 - 2011 Teacher of the Year Award (MBChB Year 1)
2009 - 2010 Teacher of the Year Award (MBChB Year 1)
2008 - 2009 Teacher of the Year Award (MBChB Year 1)
2004 Master Teacher Award
2003 - 2004 Teacher of the Year Award (MBChB Year 3)
2002 - 2003 Teacher of the Year Award (MBChB Year 2)
2001 - 2002 Teacher of the Year Award (MBChB Year 2)
2000 - 2001 Teacher of the Year Award (MBChB Year 2)
1999 - 2000 Teacher of the Year Award (MBChB Year 2)
1989 C.Y. Kwan Endowment Fund for Staff Development, CUHK
1980 - 1983 Commonwealth Scholarship
1979 Hong Kong Swire Cathay Pacific Travelling Award
1978 - 1979 Hong Kong Swire Scholarship