School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

Prof WANG Dan Michelle


Wang_Dan_MichelleAssistant Professor

 

Telephone:   3943 0681

Email:   This email address is being protected from spambots. You need JavaScript enabled to view it.

Address:

  Room 422A, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

ORCID: https://orcid.org/0000-0002-5934-9085

 

 

 

Biography

Prof. WANG Dan (王丹) completed her B.S and M.S in Dental Medicine from Sun Yat-Sen University, obtained her Ph.D. from the Dental School of University of Pittsburgh, and pursued postdoctoral training at Stanford University. In Aug 2022, she assumed the position of Assistant Professor at CUHK with appointments in the School of Biomedical Sciences (SBS), the Institute for Tissue Engineering and Regenerative Medicine (iTERM), and Department of Orthopaedics & Traumatology (ORT; by courtesy). She also serves as a Principal Investigator at CNRM, InnoHK center located at Hong Kong Science Park.

Prof. Wang has extensive training that spans across diverse disciplines, including basic and pre-clinical research, as well as her medical practice. Her diverse background has expanded the frontiers of biomedical knowledge and advanced patient care. In her current research program at CUHK, Prof. Wang and her team focus on elucidating the synergistical contributions of cell microenvironmental features, such as extracellular matrix (ECM), substrate stiffness, mechanical loading, during tendon development, regeneration, and the pathogenesis of diseases. This knowledge will be applied towards the development of innovative therapeutics and the engineering of novel biomaterials for musculoskeletal tissue regeneration. Prof. Wang has secured local and national research support and her work has been published in prestigious journals such as Advanced Functional Materials, Biomaterials, NPG Asia Materials, Bioactive Materials, Stem Cell Research & Therapy, as well as in book chapters. 

 

  1. ECM biology and ECM-based biomaterial development: Investigating cell and ECM interactions and developing ECM-mimetic biomaterials for tendon repair.
  2. Exosome-based cell free therapy: Advancing large-scale production of stem cell-derived exosome technologies for tendon repair.
  3. Materiomics: A high-throughput, transcriptome-informed approach for tailored, predictable, highly efficient biomaterial design.
  1. Kwan, K.Y.C, Ng, K.W.K., Zhu, C., Rao, Y., QI, S., TUAN, R.S., Ker, D. F.E., & Wang, D.* (2023). Effect of Aging on Tendon Biology, Biomechanics and Implications for Treatment Approaches. International Journal of Molecular Sciences. International Journal of Molecular Sciences , 24(20):15183. 2022 Impact factor: 6.208.
  2. Rao, Y., Zhu, C., Suen, H.C., Huang, S., Liao, J., Ker, D. F.E., TUAN, R.S., & Wang, D.* (2022). Tenogenic Induction of Human Adipose-derived Stem Cells by Soluble Tendon Extracellular Matrix: Composition and Transcriptomic Analyses. Stem Cell Research & Therapy, 13(1):380, Impact factor: 8.088.
  3. Wang, D., Zhang, X., Ng, K.W., Rao, Y., Wang, C., Gharaibeh, B., Lin, S., Abrams , G., Safran, M., Cheung, E., Campbell, P., Weiss L., & Yang, Y.P. (2022). Growth and Differentiation Factor-7 Immobilized, Mechanically Strong Quadrol-Hexamethylene Diisocyanate-Methacrylic Anhydride Polyurethane Polymer for Tendon Repair and Regeneration. Acta Biomaterialia, 154:108, Impact factor: 9.7.
  4. Liu, H.*, Shen, Y.*, Zhao, B., Poon, E.H., Qi, S., Ker, D.F.E., Billiar, T.R., Cooper, G.M., Xu, Y.*, & Wang, D.* (2022). Short-term Administration of the HIV Protease Inhibitor Saquinavir Improves Skull Bone Healing with Enhanced Osteoclastogenesis. Plastic and Reconstructive Surgery, 150(6):1264e-1274e, Impact factor: 5.169.
  5. Wang, D.*, Ker, D.F.E.*, Ng, K.W., L, K., Gharaibeh, B., Safran, M., Cheung, E., Campbell, P., Weiss .E, & Yang, Y.P. (2021). Combinatorial Mechanical-Gradation and Growth Factor-Biopatterning Strategy to Spatially Control Bone-Tendon-like Cell Differentiation and Tissue Formation. Nature Publishing Group Asia Materials, 13: 26. Impact factor:: 10.481.
  6. Wang, D.*, Zhang, X.*, Huang, S.T., Liu, Y., Fu, S.C., Mak, K.L., Blocki, A.M., Yung, S.H., Tuan, R.S., & Ker, D.F.E. (2021). Engineering Multi-Tissue Units for Regenerative Medicine: Bone-Tendon-Muscle Units of the Rotator Cuff. Biomaterials, 120789, Impact factor: 12.479.
  7. Wang, D., Pun, C.C.M., Huang, S., Tang, T.C.M., Ho, K.K.W., Rothrauff, B.B., Yung, P.S.H., Blocki, A.M., Ker, E.D.F., & Tuan, R.S. (2020). Tendon-derived extracellular matrix induces mesenchymal stem cell tenogenesis via an integrin/transforming growth factor-β crosstalk-mediated mechanism. Federation of American Societies for Experimental Biology Journal, 34(6):8172-8186. Impact factor: 5.191.
  8. Wang, D., Gilbert, J.R., Zhang, X., Zhao, B.K., Ker, D.F.E., & Cooper, G.M. (2020). Long Bone versus Calvarial Bone: Development, Structure, Healing and Tissue Engineering Strategies. Tissue Engineering Part B, 26(1):46-63. Impact factor: 6.089.
  9. Ker, D.F.E., Wang, D., Sharma, S., Zhang, B., Passarelli, B., Neff, N., Li, C., Maloney, W., Quake, S., & Yang, Y.P. (2018). Identifying deer antler uhrf1 proliferation and s100a10 mineralization genes using comparative RNA-seq. Stem Cell Research & Therapy, 9(1), 292, Impact factor: 6.832.
  10. Ker, D.F.E.*, Wang, D.*, Behn, A.W., Wang, E.T.H., Zhang, X., Zhou, B.Y., Mercado-Pagán, A.E., Kim, S., Kleimeyer, J., Gharaibeh, B., Shanjani, Y., Nelson, D., Safran, M., Cheung, E., Campbell, P., & Yang, Y.P. (2018). Functionally graded, bone- and tendon-like polyurethane for rotator cuff repair. Advanced Functional Materials , 28(20):1707107. Impact factor: 18.808.

    * Co-first author
  1. GRF, RGC 14118620 [Principal Investigator]: “Development of tendon extracellular matrix-based approach for functional tendon repair”.
  2. GRF, RGC 14121121 [Principal Investigator]: “Tendon extracellular matrix (ECM): identification of pro-tenogenic components and engineering of an ECM-mimetic biomaterial for tendon repair”.
  3. HMRF, HMRF 07180686 [Principal Investigator]: “Bone allograft revitalization via immunomodulatory and pro-regenerative strategies for enhanced fracture repair”.
  4. ITF Tier 3, ITC No. ITS/333/18 [Principal Investigator]: “Developmentally-inspired biomaterials for tendon repair”.
  5. The Chinese University of Hong Kong, CUHK Direct grant, 2018.092 [Principal Investigator]: “Development of QHM Polyurethane Hydrogel for Soft Tissue Repair”.
  6. General Program of NSFC 2017, 81771035 [Principal Investigator]: “Investigating the role of HMGB1/TLR4-mediated osteoclastogenesis in allograft remodeling”.
  7. Young Scientists of China of NSFC, 8102141 [Principal Investigator]: “Cell necrosis promotes bone regeneration by virtue of an inflammatory response through TLR4 signal pathway”.