Professor LAI Bo San Paul    
賴寶山

Professor
MBChB (CUHK), MD (CUHK), FCSHK, FHKAM (Surgery), FRCSEd (Gen), FRCS (Glas), FRACMA, FHKCCM

Hepato-biliary and Pancreatic Surgery
(852) 3505 1496
paullaiadd this for spam@add this for spamcuhk.edu.hk
K-8556-2015
0000-0002-9469-6728

Biography

Prof. Lai graduated from CUHK and joined the department in 1990. He received surgical training in Hong Kong and Edinburgh and specialized in hepato-biliary and pancreatic surgery. Apart from being an active practicing surgeon, teacher for medical students and trainer for surgical trainees, Prof. Lai is actively involved in both clinical and basic scientific research. He is also the editor-in-chief of the journal Surgical Practice and a member of editorial boards of a number of local and international academic journals, such as British Journal of Surgery and Annals of Surgical Oncology.

Prof. Lai served as the Director of the Office of Medical Education (OME) from 2014 to 2019 and the OME served to oversee the MBChB curriculum of the Faculty of Medicine, the Chinese University of Hong Kong.

Prof. Lai has a keen interest in surgical outcome research, quality and risk management, healthcare policy, medico-legal and mediation. He has studied for a master degree in medical law at the University of Northumbria and he is an accredited mediator in Hong Kong under the Hong Kong Mediation Accreditation Association Limited (HKMAAL). He has contributed to training and education of healthcare professionals in various areas and is an experience examiner in the Faculty and College of Surgeons of Hong Kong. He also served as the Vice President (Education and Examination) of the Hong Kong Academy of Medicine from 2021 to 2022.

In the field of hospital administration, Prof. Lai was previously the Honorary Chief of Service in the Department of Surgery at the Prince of Wales Hospital and the Cluster Coordinator for Surgical Services in New Territories East Cluster from 2008 to 2018. He was elected as a fellow of the Royal Australasian College of Medical Administrators, a fellow of the Faculty of Public Health and a fellow of the Hong Kong College of Community Medicine (Administrative Medicine) in 2018. He also served as the Medical Director, Quality & Safety at the CUHK Medical Centre from 2019 to 2022.

Research Interests

• Clinical research in general surgery and hepato-biliary and pancreatic surgery
• Molecular genetics of liver cancer and other cancers
• Hospital administration, quality and risk management
• Surgical outcome research
• Medico-legal study and mediation
• Medical education research

Additional Information

Current positions in the Faculty of Medicine, the Chinese University of Hong Kong:

• Professor, Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery
• Director of the Wong Tze Lam - Hing Tak Centre of Surgical Outcome Research
• Professor (by courtesy), of the School of Biomedical Sciences

Current positions in the Hospital Authority:

• Honorary Consultant HBP Surgeon, Department of Surgery, Prince of Wales Hospital
• Honorary Consultant, New Territories East Cluster, Hospital Authority
• Director, Surgical Outcomes Monitoring & Improvement Program (SOMIP), Hospital Authority Head Office

Current positions in the College of Surgeons of Hong Kong and the Hong Kong Academy of Medicine:

• Editor-in-chief of Surgical Practice (the official journal for the College of Surgeons of Hong Kong)

Selected Publications

1. Lee KF, Chong CN, Wong J, Cheung YS, Wong J, Lai P. Long-term results of laparoscopic hepatectomy versus open hepatectomy for hepatocellular carcinoma: a case-matched analysis. World J Surg. 2011;35(10):2268-2274. doi:10.1007/s00268-011-1212-6
2. Chan AWH, Zhong J, Berhane S, Toyoda H, Cucchetti A, Shi K, Tada T, Chong CCN, Xiang BD, Li LQ, Lai PBS, Mazzaferro V, García-Fiñana M, Kudo M, Kumada T, Roayaie S, Johnson PJ. Development of pre and post-operative models to predict early recurrence of hepatocellular carcinoma after surgical resection. J Hepatol. 2018;69(6):1284-1293. doi:10.1016/j.jhep.2018.08.027
3. Chen J, Chan AW, To KF, Chen W, Zhang Z, Ren J, Song C, Cheung YS, Lai PB, Cheng SH, Ng MH, Huang A, Ko BC. SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling. Hepatology. 2013 Jun;57(6):2287-98. doi: 10.1002/hep.26278. Epub 2013 Apr 26. PMID: 23348706.
4. Yu J, Wu WK, Li X, He J, Li XX, Ng SS, Yu C, Gao Z, Yang J, Li M, Wang Q, Liang Q, Pan Y, Tong JH, To KF, Wong N, Zhang N, Chen J, Lu Y, Lai PB, Chan FK, Li Y, Kung HF, Yang H, Wang J, Sung JJ. Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer. Gut. 2015 Apr;64(4):636-45. doi: 10.1136/gutjnl-2013-306620. Epub 2014 Jun 20. PMID: 24951259; PMCID: PMC4392212.
5. Toyoda H, Lai PB, O'Beirne J, Chong CC, Berhane S, Reeves H, Manas D, Fox RP, Yeo W, Mo F, Chan AW, Tada T, Iñarrairaegui M, Vogel A, Schweitzer N, Chan SL, Sangro B, Kumada T, Johnson PJ. Long-term impact of liver function on curative therapy for hepatocellular carcinoma: application of the ALBI grade. Br J Cancer. 2016 Mar 29;114(7):744-50. doi: 10.1038/bjc.2016.33. PMID: 27022825; PMCID: PMC4984858.
6. Sun K, Jiang P, Chan KC, Wong J, Cheng YK, Liang RH, Chan WK, Ma ES, Chan SL, Cheng SH, Chan RW, Tong YK, Ng SS, Wong RS, Hui DS, Leung TN, Leung TY, Lai PB, Chiu RW, Lo YM. Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5503-12. doi: 10.1073/pnas.1508736112. Epub 2015 Sep 21. PMID: 26392541; PMCID: PMC4603482.
7. Chan AW, Chan SL, Wong GL, Wong VW, Chong CC, Lai PB, Chan HL, To KF. Prognostic Nutritional Index (PNI) Predicts Tumor Recurrence of Very Early/Early Stage Hepatocellular Carcinoma After Surgical Resection. Ann Surg Oncol. 2015 Dec;22(13):4138-48. doi: 10.1245/s10434-015-4516-1. Epub 2015 Mar 24. PMID: 25801356.
8. Søreide K, Hallet J, Matthews JB, Schnitzbauer AA, Line PD, Lai PBS, Otero J, Callegaro D, Warner SG, Baxter NN, Teh CSC, Ng-Kamstra J, Meara JG, Hagander L, Lorenzon L. Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services. Br J Surg. 2020 Sep;107(10):1250-1261. doi: 10.1002/bjs.11670. Epub 2020 Apr 30. PMID: 32350857; PMCID: PMC7267363.
9. Johnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL, O'Beirne J, Fox R, Skowronska A, Palmer D, Yeo W, Mo F, Lai P, Iñarrairaegui M, Chan SL, Sangro B, Miksad R, Tada T, Kumada T, Toyoda H. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. J Clin Oncol. 2015 Feb 20;33(6):550-8. doi: 10.1200/JCO.2014.57.9151. Epub 2014 Dec 15. PMID: 25512453; PMCID: PMC4322258.
10. Jiang P, Chan CW, Chan KC, Cheng SH, Wong J, Wong VW, Wong GL, Chan SL, Mok TS, Chan HL, Lai PB, Chiu RW, Lo YM. Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1317-25. doi: 10.1073/pnas.1500076112. Epub 2015 Feb 2. PMID: 25646427; PMCID: PMC4372002.
11. Liu D, Wong CC, Fu L, Chen H, Zhao L, Li C, Zhou Y, Zhang Y, Xu W, Yang Y, Wu B, Cheng G, Lai PB, Wong N, Sung JJY, Yu J. Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target. Sci Transl Med. 2018 Apr 18;10(437):eaap9840. doi: 10.1126/scitranslmed.aap9840. Erratum in: Sci Transl Med. 2018 Sep 26;10(460): PMID: 29669855.