Clinical Trials and Precision Medicine
application of systems biology approaches and patient-derived induced pluripotent stem cells to address disease pathogenic mechanisms and drug targeting
Clinical Application of MSCs
An endeavor to investigate the role of hMSCs in regulating hematopoietic stem cell fate and their therapeutic potential to treat lupus nephritis, spinocerebellar ataxia and diabetes in different animal models, and has established clinical trials [...]
Induction of MSC Differentiation by microenvironments and mechanical stimuli for tissue regeneration
Prof. Oscar Lee's research team has been studying on how physical properties of the microenvironments, including three-dimensional spherical spatial boundary conditions, substrate stiffness, and mechanical forces contribute to the regulation of MSC differentiation over the [...]
TGFβ1-Dnmts axis control the hepatic plasticity of MSCs
Transl Res. 2017 Apr;182:61-74.e8. Stem Cell Reports. 2017 Jul 11;9(1):247-263 The irreversibility of developmental processes in mammalian cells has been challenged by rising evidence that de-differentiation of hepatocytes occurs in adult liver. However, the underlying [...]
MSCs Isolation and Hepatic Tissue Engineering
Prof. Oscar Lee's first important research achievement was the discovery of differentiation potential of stem cells from mesodermal origin into hepatocytes of endodermal origin, and being the first to design a novel 2-step protocol to [...]
Clinical Trials and Precision Medicine
Cell-based therapy – Autologous chondrocyte implantation, a patch of cartilage defect made by the patient’s own chondrocytes. Technically, doctors will take a tiny piece of healthy articular cartilage, around 200mg, size like a couple [...]
MSC-based therapies are able to reduce nonalcoholic fatty liver disease
Obesity is an alarming global health problem that results in multiaspect metabolic syndromes in both genders and most age groups. The lack of effective therapies for obesity and its associated metabolic syndrome is an urgent [...]