O&T, CUHK

Academic Profile

Prof ZHANG Ning

Prof LIN Sien

Prof CHUI Chun-sing, Elvis

Prof TONG Wenxue

Prof CHEN Xiaona

CONTACT INFORMATION

Office : (852) 3505-1559

Email : ningzhang@cuhk.edu.hk

ACADEMIC ENGAGEMENT

Postgraduate teaching:
MPhil/PhD in Orthopaedics & Traumatology

ORCID: 0000-0002-9513-9288

Professor ZHANG Ning 張寧

BSc (SDU), MSc (SJTU), PhD (CUHK)

Assistant Professor of Orthopaedics and Traumatology
矯形外科及創傷學系助理教授

BIOGRAPHY

Professor Zhang received his PhD in the Department of Orthopaedics & Traumatology at the Chinese University of Hong Kong (CUHK). After finishing his postdoctoral training at Stanford University, Department of Orthopaedic Surgery, he joined the Department of Orthopaedics & Traumatology, CUHK as an Assistant Professor in 2023. Professor Zhang has published over 35 peer-reviewed articles. His research topics have been chosen for the final lists of new investigator awards and presentations of podium spotlight sessions at several academic conferences. Professor Zhang also serves as the guest editor and reviewer of several international journals.

As an orthopaedic researcher, Professor Zhang’s interests center on cell-based and tissue-engineering therapeutic strategies for immunomodulation during the regeneration of bone and muscle. He is also interested in and has applied novel techniques in pre-clinical and clinical orthopaedic studies for detecting differential dynamics and changes during the progress. He is passionate about finding new targets and strategies for the diagnosis and treatment of musculoskeletal disorders.

EXPERTISE

Genetic Modification of Cells
Animal Models of Musculoskeletal Disorders
Bone and Muscle Histomorphometry
Mass Cytometry

SPECIALISED RESEARCH AREAS

Cell-based Therapies for Musculoskeletal Disorders
Immunomodulation During the Bone and Muscle Regeneration
Bone-muscle Interactions

SELECTED PUBLICATION

1.	N Zhang, CW Lo, T Utsunomiya, M Maruyama, EE Huang, C Rhee, Q Gao, ZY Yao, SB Goodman. PDGF-BB and IL-4 co-overexpression is a potential strategy to enhance mesenchymal stem cell-based bone regeneration. Stem Cell Research & Therapy. 12 (1), 1-11; 2021.
2.	N Zhang, T Utsunomiya, TH Lin, Y Kohno, M Ueno, M Maruyama, EE Huang, C Rhee, ZY Yao, SB Goodman. Mesenchymal Stem Cells and NF-κB Sensing Interleukin-4 Over-Expressing Mesenchymal Stem Cells Are Equally Effective in Mitigating Particle-Associated Chronic Inflammatory Bone Loss in Mice. Frontiers in Cell and Developmental Biology. 9:757830; 2021.
3.	EE Huang, N Zhang* (co-first author), EA Ganio, HS Shen, XP Li, M Ueno, T Utsunomiya, M Maruyama, Q Gao, N Su, ZY Yao, F Yang, B Gaudillière, SB Goodman. Differential dynamics of bone graft transplantation and mesenchymal stem cell therapy during bone defect healing in a murine critical size defect. Journal of Orthopaedic Translation. 36:64-74. 2022.
4.	H Hirata, N Zhang* (co-first author), M Ueno, D Barati, J Kushioka, HS Shen, M Tsubosaka, M Toya, TH Lin, EE Huang, ZY Yao, JY Wu, S Zwingenberger, F Yang, SB Goodman. Ageing Attenuates Bone Healing by Mesenchymal Stem Cells in a Microribbon Hydrogel with a Murine Long Bone Critical-Size Defect Model. Immunity & Ageing. 19,14; 2022
5.	M Ueno, N Zhang* (co-first author), H Hirata, D Barati, T Utsunomiya, HS Shen, TH Lin, M Maruyama, EE Huang, ZY Yao, JY Wu, S Zwingenberger, F Yang, SB Goodman. Sex Differences in Mesenchymal Stem Cell Therapy with Gelatin-Based Microribbon Hydrogels in a Murine Long Bone Critical-Size Defect Model. Frontiers in bioengineering and biotechnology. 9: 755964; 2021.
6.	T Utsunomiya, N Zhang* (co-first author), TH Lin, Y Kohno, M Ueno, M Maruyama, C Rhee, EE Huang, ZY Yao, SB Goodman. Different effects of intramedullary injection of mesenchymal stem cells during the acute versus chronic inflammatory phase on bone healing in the murine continuous polyethylene particle infusion model. Frontiers in Cell and Developmental Biology. 9, 329; 2021.
7.	G Hu, N Zhang* (co-first author), J Li, J Wang, W Wu, J Li, W Tong, X Zhao, L Dai, XL Zhang. TRAF3 modulates cartilage degradation through its suppression of interleukin 17 signaling. The American Journal of Pathology. 190(8):1701-1712; 2020.
8.	N Zhang, YN Chim, J Wang, RMY Wong, SKH Chow, WH Cheung. Impaired fracture healing in sarco-osteoporotic mice can be rescued by vibration treatment through myostatin suppression. Journal of Orthopaedic Research. 38 (2), 277-287; 2019.
9.	N Zhang, SKH Chow, KS Leung, HH Lee, WH Cheung. An animal model of co-existing sarcopenia and osteoporotic fracture in senescence accelerated mouse prone 8 (SAMP8). Experimental Gerontology. 97: 1-8; 2017.
10.	N Zhang, SKH Chow, KS Leung, WH Cheung. Ultrasound as a stimulus for musculoskeletal disorders. Journal of Orthopaedic Translation. 9:52-59; 2017.