| Prof YUNG Shu-hang, Patrick, MH, JP |
| Prof ONG Tim-yun, Michael |
| Prof WONG Ronald Man Yeung |
| Prof LING Ka-kin, Samuel |
| Dr LAW Sheung-wai |
| Dr WONG Wing-yee, Clara |
| Dr HO Ki-wai, Kevin |
| Dr LAM Tsz-ping |
| Prof LEUNG Ping-chung, SBS, OBE, JP |
| Prof CHAN Kai-ming, OBE, JP |
| Prof LEUNG Kwok-sui |
| Prof CHENG Chun-yiu, Jack |
| Prof KUMTA Shekhar Madhukar |
| Prof QIN Ling |
| Prof LI Gang |
| Prof WANG Huating |
| Prof CHEUNG Wing-hoi, Louis |
| Prof LUI Po-yee, Pauline |
| Prof LEE Yuk-wai, Wayne |
| Prof XU Jiankun, Jerry |
| Prof ZHANG Ning |
| Prof LIN Sien |
| Prof CHUI Chun-sing, Elvis |
| Prof TONG Wenxue |
| Prof CHEN Xiaona |
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CONTACT INFORMATION
Office : (852) 3763-6057
Email : xiaonachen@cuhk.edu.hk
ACADEMIC ENGAGEMENT
Postgraduate teaching:
MPhil/PhD in Orthopaedics & Traumatology
ORCID: 0000-0001-6241-811X
ResearcherID: GYI-4886-2022 |
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Professor CHEN Xiaona 陳小娜 |
BSc (ECNU), MSc (ECNU), PhD (CUHK)
Research Assistant Professor of Orthopaedics and Traumatology
矯形外科及創傷學系研究助理教授
BIOGRAPHY
Professor Chen obtained her BSc degree from the School of Life Sciences, East China Normal University (ECNU) in 2006. She continued her study at ECNU, focusing on miRNAs and cancer, and obtained her MSc degree in 2009. She switched to lncRNAs and skeletal muscle related research and obtained her PhD degree in Obstetrics and Gynaecology from the Chinese University of Hong Kong (CUHK) in 2014. She pursued her postdoctoral training in the Department of Orthopaedics and Traumatology of CUHK (2015-2019) and in the Division of Life Science at the Hong Kong University of Science and Technology (2019-2022).
Her research focuses on deciphering the regulatory mechanisms of long non-coding RNA, RNA binding proteins and G-quadruplexes (G4) in modulating gene expression in skeletal muscle stem cells (also known as muscle satellite cells, SC) during muscle regeneration and ageing and her work has been published in Nature Communications, Cell Reports, Cell Discovery etc.
SPECIALISED RESEARCH AREAS
- Gene Regulation in Skeletal Muscle Stem Cells, Muscle Regeneration and Aging
- Biological Regulatory Functions of DNA/RNA G-quadruplexes
- Gene Regulatory Functions of lncRNAs and RNA Binding Proteins
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SELECTED PUBLICATION
| 1. |
Chen X*, Xue G*, Zhao J, Zhang Y, Zhang S, Wang W, Li Y, Yuan J, He L, Chan CY, Liu Y, Chen W, Zhao Y, Hu P, Sun H, Kwok CK, Wang H. Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5' UTR rG4 unwinding and Anp32e translation. Cell Reports. 2022 Jun 7;39(10):110927. IF: 9.995 (* Co-first authors) |
| 2. |
Chen X*, Yuan J*, Xue G, Campanario S, Wang D, Wang W, Mou X, Liew SW, Umar M, Isern J, Zhao Y, He L, Li Y, Mann C, Yu X, Wang L, Perdiguero E, Chen W, Xue Y, Nagamine Y, Kwok CK, Sun H, Muñoz-Cánoves P, Wang H. Translational control by DHX36 binding to 5’UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nature Communications. 2021 Aug 19;12(1):5043. IF: 17.7 (* Co-first authors) |
| 3. |
Chen X, He L, Zhao Y, Li Y, Zhang S, Sun K, So K, Chen F, Zhou L, Lu L, Wang L, Zhu X, Bao X, Esteban MA, Nakagawa S, Prasanth KV, Wu Z, Sun H, Wang H. Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity. Cell Discovery. 2017 Mar 14;3:17002. IF: 38.079 |
| 4. |
He L, Ding Y, Zhao Y, So KK, Peng XL, Li Y, Yuan J, He Z, Chen X, Sun H, Wang H. CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell. Stem Cell Reports. 2021 Oct 12;16(10):2442-2458. IF: 7.29 |
| 5. |
Li Y, Yuan J, Chen F, Zhang S, Zhao Y, Chen X, Lu L, Zhou L, Chu CY, Sun H, Wang H. Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly. Nature Communications. 2020 Jun 1;11(1):2725. IF: 17.7 |
| 6. |
Zhao Y, Zhou J, He L, Sun K, Chen X, Li Y, Bao X, Esteban MA, Sun H and Wang H. MyoD induced enhancer RNA interacts with hnRNPL protein via CAAA motif to activate target gene transcription during myogenic differentiation. Nature Communications. 2019 Dec 19;10(1):5787. IF: 17.7 |
| 7. |
Zhou L, Sun K, Zhao Y, Zhang S, Wang X, Li Y, Lu L, Chen X, Chen F, Bao X, Zhu X, Wang L, Tang LY, Esteban MA, Wang CC, Jauch R, Sun H, Wang H. Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1. Nat Communications. 2015 Dec 11;6:10026. IF: 17.7 |
| 8. |
Wang L, Zhao Y, Bao X, Zhu X, Kwok YK, Sun K, Chen X, Huang Y, Jauch R, Esteban MA, Sun H, Wang H. LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration. Cell Res. 2015 Mar;25(3):335-50. IF: 46.297 |
| 9. |
Lu L, Sun K, Chen X, Zhao Y, Wang L, Zhou L, Sun H, Wang H. Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis. EMBO J. 2013 Oct 2;32(19):2575-88. IF: 14.012 |
| 10. |
Wang L, Zhou L, Jiang P, Lu L, Chen X, Lan H, Guttridge DC, Sun H, Wang H. Loss of miR-29 in myoblasts contributes to dystrophic muscle pathogenesis. Mol Ther. 2012 Jun;20(6):1222-33. IF: 12.9 |
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