| Prof. William K.K. Wu |
| BSc (Hons), MMedSc (Distinction), MPhil, PhD, FRCPath, FRCP (Edin, Lond), FRCPS (Glasg) |
Associate Professor (Non-clinical)
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong
Principal Investigator
State Key Laboratory of Digestive Diseases & Li Ka Shing Institute of Health Sciences
The Chinese University of Hong Kong |
|
Research Interests
Cancer Biology and Genomics; Sepsis and ICU-related Infections; Pain Mechanism; Autophagy; Microbiome; Evolutionary Medicine
Publications:
For details about citations arising from my publications and links to online versions of some of the publications, refer to:
https://www.webofscience.com/wos/author/record/1303603 (Researcher ID: A-3277-2009)
(^equal contribution; *corresponding author)
- Chen H, Zhang X, Su H, Zeng JD, Chan H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV, Chen H (2023) Immune dysregulation and RNA N6-methyladenosine modification in sepsis. Wiley Interdiscip Rev RNA doi: 10.1002/wrna.1764. [Online ahead of print]
- Zhang J, Chen B, Li H, Wang Y, Liu X, Wong KY, Chan WN, Chan AKY, Cheung AHK, Leung KT, Dong Y, Pan Y, Ke H, Liang L, Zhou Z, Xiao J, Wong CC, Wu WKK, Cheng ASL, Ma BBY, Yu J, Lo KW, Kang W, To KF (2023) Cancer-associated fibroblasts potentiate colorectal cancer progression by the crosstalk of IGF2-IGF1R and Hippo-YAP1 signaling pathways. J Pathol doi: 10.1002/path.6033. [Online ahead of print]
- Au-Doung PLW, Chan RH, Wu WKK*, Li Q* (2023) Gut microbiota modulation: Probiotics and prebiotics in GI cancer. In: Microbiome in Gastrointestinal Cancer doi: 10.1007/978-981-19-4492-5. Springer Nature [In press]
- Chan H, Li Q, Wang X, Liu Y, Hu W, Zeng J, Xie, C, Kwong NYK, Ho IHT, Liu X, Chen H, Yu J, Ko H, Chan RCY, Ip M, Gin T, Cheng ASL, Zhang L, Chan MTV*, Wong SH*, Wu WKK* (2022) Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification. Autophagy 18(9):2050-2067.
- Wang X, Hu W, Li X, Huang D, Li Q, Chan H, Zeng JD, Xie C, Chen H, Liu X, Gin T, Wang MH, Cheng ASL, Kang W, To KF, Plewczynski D, Zhang Q, Chen X, Chan DCW, Ko H, Wong SH, Yu J, Chan MTV*, Zhang L*, Wu WKK* (2022) Single-hit inactivation drove tumor suppressor genes out of the X chromosome during evolution. Cancer Res 82(8):1482-1491.
- Wang X, Cheng FTF, Lam TYT, Liu Y, Huang D, Liu X, Chen H, Zhang L, Ali Y, Wang MHT, Yu J, Gin T, Chan MTV*, Wu WKK*, Wong SH (2022) Stress hyperglycemia is associated with an increased risk of subsequent development of diabetes among bacteremic and non-bacteremic patients. Diabetes Care 45(6):1438-1444.
- Sun X, Liu Y, Huang Z, Xu W, Hu W, Yi L, Liu Z, Chan H, Zeng J, Liu X, Chen H, Yu J, Chan FKL, Ng SC, Wong SH, Wang MH, Gin T, Joynt GM, Hui DSC, Zou X, Shu Y, Cheng CHK, Fang S*, Luo H*, Lu J*, Chan MTV*, Zhang L*, Wu WKK* (2022) SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1. Cell Death Differ 29(6):1240-1254.
- Huang D, Wang X, Huang Z, Liu Y, Liu X, Gin T, Wong SH, Yu J, Zhang L, Chan MTV*, Chen H*, Wu WKK* (2022) 3'untranslated regions of tumor suppressor genes evolved specific features to favor cancer resistance. Oncogene 41(23):3278-3288.
- Xu W, Liu Y, Zou X, Luo H, Wu W, Xia J, Chan MTV*, Fang S*, Shu Y*, Wu WKK*, Zhang L* (2022) Hypozincemia in COVID-19 patients correlates with stronger antibody response. Front Immunol 12:785599.
- Sun X, Yu J, Wong SH, Chan MTV*, Zhang L*, Wu WKK* (2022) SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell death. Autophagy 18(9):2246-2248.
- Sun R, Wang X, Sun X, Zhao B, Zhang X, Gong X, Wong SH, Chan MTV, Wu WKK (2022) Emerging roles of long non-coding RNAs in ankylosing spondylitis. Front Immunol13:790924.
- Zeng J, Xie C, Zhang L, Liu X, Chan MTV, Wu WKK*, Chen H* (2022) Host cell antimicrobial responses against Helicobacter pylori infection: from biological aspects to therapeutic strategies. Int J Mol Sci 23(18): 10941.
- Ma X, Wang X, Ma X, Zhang X, Gong X, Sun R, Wong SH, Chan MTV, Wu WKK (2022) An update on the roles of circular RNAs in spinal cord injury. Mol Neurobiol 59(4):2620-2628.
- Xu D, Ma X, Sun C, Han J, Zhou C, Chan MTV, Wu WKK (2022) Circular RNAs in intervertebral disc degeneration: An updated review. Front Mol Biosci 8:781424.
- Devereaux PJ, Marcucci M, Painter TW, Conen D, Lomivorotov V, Sessler DI, Chan MTV, Borges FK, Martínez-Zapata MJ, Wang CY, Xavier D, Ofori SN, Wang MK, Efremov S, Landoni G, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Duceppe E, Ruetzler K, Parlow JL, Tandon V, Fleischmann E, Polanczyk CA, Lamy A, Astrakov SV, Rao M, Wu WKK, Bhatt K, de Nadal M, Likhvantsev VV, Paniagua P, Aguado HJ, Whitlock RP, McGillion MH, Prystajecky M, Vincent J, Eikelboom J, Copland I, Balasubramanian K, Turan A, Bangdiwala SI, Stillo D, Gross PL, Cafaro T, Alfonsi P, Roshanov PS, Belley-Côté EP, Spence J, Richards T, VanHelder T, McIntyre W, Guyatt G, Yusuf S, Leslie K; POISE-3 Investigators (2022) Tranexamic Acid in Patients Undergoing Noncardiac Surgery. N Engl J Med 386(21):1986-1997.
- Cao L, Lou J, Zheng H, Zhao S, Mok CKP, Chan SY, Chan RWY, Chong MKC, Wu WKK, Chen Z, Wong ELY, Chan PKS, Zee BCY, Yeoh EK, Wang MH (2022) Rapid evaluation of COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 variants by analysis of genetic distance.Nat Med 28(8):1715-1722.
- Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau JCN, Chan CCY, Chan DCW, Wong TY, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Lam HHN, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H (2022) Antibody stabilization for thermally accelerated deep immunostaining. Nat Methods 19(9):1137-1146.
- Chen H, Pan Y, Zhou Q, Liang C, Wong CC, Zhou Y, Huang D, Liu W, Zhai J, Gou H, Su H, Zhang X, Xu H Wang Y, Kang W, Wu WKK, Yu J (2022) METTL3 inhibits anti-tumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer. Gastroenterology 163(4):891-907.
- Lam S, Zhang J, Yang K, Chu LC, Zhu W, Tang W, Chan FKL, Chan PKS, Wu WKK, Ng SC (2022) Modulation of gut microbiota impacts diet- and drug-induced alopecia in mice. Gut 71(11):2366-2369.
- Guo CLT, Wong SH, Lau LHS, Lui RNS, Mak JWY, Tang RSY, Yip TCF, Wu WKK, Wong GLH, Chan FKL, Lau JYW, Sung JJY (2022) Timing of endoscopy for acute upper gastrointestinal bleeding: A territory-wide cohort study. Gut 71(8):1544-1550.
- Sugimura N, Li Q, Chu ESH, Lau HCH, Fong W, Liu W Liang C, Nakatsu G, Su ACY, Coker OO, Wu WKK, Chan FKL, Yu J (2022) Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumorigenesis. Gut 71(10):2011-2021.
- Coker OO, Liu C, Wu WKK, Wong SH, Jia W, Sung JJY, Yu J (2022) Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers. Microbiome 10(1):35.
- Yang J, Li Z, Wu WKK, Yu S, Xu Z, Chu Q, Zhang Q (2022) Deep Learning Identifies Explainable Reasoning Paths of Mechanism of Action for Drug Repurposing from Multilayer Biological Network. Brief Bioinform 23(6): bbac469.
- Wang Y, Chen H, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W (2022) MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target. Theranostics 12(15): 6509-6526.
- Zhao L, Zhang X, Zhou Y, Fu K, Lau HCH, Cha TWY, Cheung A, Coker OO, Wei H, Wu WKK, Wong SH, Sung JJY, To KF, Yu J (2022) Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients. Oncogene 41(36):4200-4210.
- Xia X, Zhang Y, Sun R, Wei Y, Li Q, Chong MKC, Wu WKK, Zee BCY, Tang H, Wang MH (2022) A Prism Vote method for individualized risk prediction of traits in genotype data of multi-population. PLoS Genetics 18(10):e1010443.
- Zhang X, Su H, Chen H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV, Chen H (2022) RNA modifications in gastrointestinal cancer: Current status and future perspectives. Biomedicines 10(8):1918.
- Niu JY, Yin IX, Wu WKK, Li QL, Mei ML, Chu CH (2022) Efficacy of the dual-action GA-KR12 peptide for remineralising initial enamel caries: an in vitro study. Clin Oral Investig 26(3):2441-2451.
- Marcucci M, Painter TW, Conen D, Leslie K, Lomivorotov VV, Sessler D, Chan MTV, Borges FK, Martínez Zapata MJ, Wang CY, Xavier D, Ofori SN, Landoni G, Efremov S, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Duceppe E, Ruetzler K, Parlow JL, Tandon V, Wang MK, Fleischmann E, Polanczyk CA, Jayaram R, Astrakov SV, Rao M, VanHelder T, Wu WKK, Cheong CC, Ayad S, Abubakirov M, Kirov M, Bhatt K, de Nadal M, Likhvantsev V, Iglesisas PP, Aguado HJ, McGillion M, Lamy A, Whitlock RP, Roshanov P, Stillo D, Copland I, Vincent J, Balasubramanian K, Bangdiwala SI, Biccard B, Kurz A, Srinathan S, Petit S, Eikelboom J, Richards T, Gross PL, Alfonsi P, Guyatt G, Belley-Cote E, Spence J, McIntyre W, Yusuf S, Devereaux PJ (2022) Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery. Trials 23(1):101.
- Li Q, Hu W, Liu WX, Zhao LY, Huang D, Liu XD, Chan H, Zhang Y, Zeng JD, Coker OO, Kang W, Ng SSM, Zhang L, Wong SH, Gin T, Chan MTV*, Wu JL*, Yu J*, Wu WKK* (2021) Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting beta-galactosidase. Gastroenterology 160(4):1179-1193.e14. [Cover Story]
- Huang D, Wang X, Liu Y, Huang Z, Hu X, Hu W, Li Q, Chan H, Zou Y, Ho IHT, Wang Y, Cheng ASL, Kang W, To KF, Wang MHT, Wong SH, Yu J, Gin T, Zhang Q, Li Z, Shen J, Zhang L, Chan MTV*, Liu X*, Wu WKK* (2021) Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance. Brief Bioinform 22(5):bbab040.
- Li Z, Li X, Shen J*, Tan H, Rong T, Lin Y, Feng E, Chen Z*, Jiao Y, Liu G, Zhang L, Chan MTV, Wu WKK* (2021) Bioinformatic analysis of SMN1-ACE/ACE2 interactions hinted at a potential protective effect of spinal muscular atrophy against COVID-19-induced lung injury. Brief Bioinform 22(2):1291-1296.
- Fang S, Zhang L, Liu Y, Xu W, Wu W, Huang Z, Wang X, Liu H, Sun Y, Zhang R, Peng B, Liu X, Sun X, Yu J, Chan FKL, Ng SC, Wong SH, Wang MHT, Gin T, Joynt GM, Hui DSC*, Feng T*, Wu WKK*, Chan MTV*, Zou X*, Xia J* (2021) Lysosome activation in peripheral blood mononuclear cells and prognostic significance of circulating LC3B in COVID-19. Brief Bioinform 22(2):1466-1475.
- Guo CLT, Kwong TNY, Mak JWY, Zhang L, Lui GCY, Wong GLH, Ip M, Lee SS, Yu J, Sung JJY, Wu WKK#, Wong SH# (2021) Trends in the incidence and clinical outcomes of Clostridioides difficile infection, Hong Kong. Emerg Infect Dis 27(12):3036-3044. (#co-principal investigators)
- Li Z, Huang Z, Li X, Huang C, Shen J*, Li S*, Zhang L, Wong SH, Chan MTV, Wu WKK* (2021) Bioinformatic analyses hinted at augmented T helper 17 cell differentiation and cytokine response as the central mechanism of COVID-19-associated Guillain-Barré syndrome. Cell Prolif 54(5):e13024.
- Xu D, Ma X, Sun C, Han J, Zhou C, Chan MTV, Wu WKK (2021) Emerging roles of circular RNAs in neuropathic pain. Cell Prolif 54(12):e13139.
- Li Z, Li X, Xu D, Chen X, Li S, Zhang L, Chan MTV, Wu WKK (2021) An update on the roles of circular RNAs in osteosarcoma. Cell Prolif 54(1):e12936.
- Li Z, Li X, Shen J, Chan MTV, Wu WKK (2021) Miller Fisher syndrome associated with COVID-19: an up-to-date systematic review. Environ Sci Pollut Res 28(17):20939-20944.
- Yu X, Li L*, Chan MTV, Wu WKK* (2021) Bioinformatic analyses suggest augmented interleukin-17 signalling as the mechanism of COVID‐19-associated herpes zoster. Environ Sci Pollut Res 28(46):65769-65775.
- Liu YZ, Ling L, Wong SH, Wang MHT, Fitzgerald JR, Zou X, Fang S, Liu X, Wang X, Hu W, Chan H, Wang Y, Huang D, Li Q, Wong WT, Choi G, Zou H, Hui DSC, Yu J, Tse G, Gin T, Wu WKK*, Chan MTV*, Zhang L* (2021) Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients. EClinicalMedicine 37:100955.
- Ho IHT, Ng LHL, Cheng X, Gin T, Chan CS, Sun W, Xiao L, Zhang L, Chan MTV, Wu WKK*, Liu X* (2021) Annexin A2 traps mu-opioid receptors in recycling endosomes upon remifentanil-induced internalization. Neurobiol Pain 10:100071.
- Chen B, Chan WN, Mui CW, Liu X, Zhang J, Wang Y, Cheung AHK, Chan AKY, Chan RCK, Leung KT, Dong J, Pan Y, Ke H, Liang L, Zhou Z, Wong CC, Wu WKK, Cheng ASL, Yu J, Lo KW, To KF, Kang W (2021) STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker. Mol Cancer 20(1):147.
- Klionsky DJ, ..., Wu WKK, et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17(1):1-382.
- Zhou J, Lee S, Wang X, Li Y, Wu WKK, Liu T, Cao Z, Zeng DD, Leung KSK, Wai AKC, Wong ICK, Cheung BMY, Zhang Q, Tse G (2021) Development of a multivariable prediction model for severe COVID-19 disease: a population-based study from Hong Kong. NPJ Digit Med 4(1):66.
- Kang X, Zhang R, Kwong TNY, Wu WKK, Sung JJY, Yu J, Lui RNS, Wong SH (2021) Serrated neoplasia in the colorectum: gut microbiota and molecular pathways. Gut Microbes 13(1):1-12.
- Kang W, Zhang J, Huang T, Zhou Y, Wong CC, Chan RCK, Dong Y, Wu F, Zhang B, Wu WKK, Chan MWY, Cheng ASL, Yu J, Wong N, Lo KW, To KF (2021) NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway. Oncogene 40(9):1578-1594.
- Wang MH, Lou J, Cao L, Zhao S, Chan RW, Chan PK, Chan MC, Chong MK, Wu WKK, Wei Y, Zhang H, Zee BC, Yeoh EK (2021) Characterization of key amino acid substitutions and dynamics of the influenza virus H3N2 hemagglutinin. J Infect 83(6):671-677.
- Ouyang Y, Zhu Z, Huang L, Zeng C, Zhang L, Wu WKK, Lu N, Xie C(2021) Research trends on clinical Helicobacter pylori eradication: A bibliometric analysis from 1983 to 2020. Helicobacter 26(5):e12835.
- Zhou J, Sun W, Liu Y, Yang S, Wu S, Wang S, Xiong D, Ho IH, Zhang L, Chan MTV, Wu WKK, Liu X, Xiao L (2021) Clinical characteristics, treatment effectiveness, and predictors of response to pharmacotherapeutic interventions among patients with herpetic-related neuralgia: A retrospective analysis. Pain Ther 10(2):1511-1522.
- Yang J, Xu Z, Wu WKK, Chu Q, Zhang Q (2021) GraphSynergy: network inspired deep learning model for anti-cancer drug combination prediction. J Am Med Inform Assoc 28(11):2336-2345.
- Zhou J, Li H, Chang C, Wu WKK, Wang X, Liu T, Cheung BMY, Zhang Q, Lee S, Tse G (2021) The association between blood pressure variability and hip or vertebral fracture risk: A population-based study. Bone 150:116015.
- Niu JY, Yin IX, Wu WKK, Li QL, Mei ML, Chu CH (2021) Remineralising dentine caries using an artificial antimicrobial peptide: an in vitro study. J Dent 111:103736.
- Niu JY, Yin IX, Wu WKK, Li QL, Mei ML, Chu CH (2021) A novel dual-action antimicrobial peptide for caries management. J Dent 111:103729.
- Cao L, Lou J, Zhao S, Chan RWY, Chan M, Wu WKK, Chong MKC, Zee BCY, Yeoh EK, Wong SYS, Chan PKS, Wang MH (2021) In silico prediction of influenza vaccine effectiveness by sequence analysis. Vaccine 39(7):1030-1034.
- Niu JY, Yin IX, Wu WKK, Li QL, Mei ML, Chu CH (2021) Antimicrobial peptides for the prevention and treatment of dental caries: A concise review. Arch Oral Biol 122:105022.
- Niu JY, Yin IX, Mei ML, Wu WKK, Li QL, Chu CH (2021) The multifaceted roles of antimicrobial peptides in oral diseases. Mol Oral Microbiol 36(3):159-171.
- Lee S, Zhou J, Wong WT, Liu T, Wu WKK, Wong ICK, Zhang QP, Tse G (2021) Glycemic and lipid variability for predicting complications and mortality in diabetes mellitus using machine learning. BMC Endocr Disord 21(1):94.
- Lee S, Zhou J, Leung KSK, Wu WKK, Wong WT, Liu T, Wong ICK, Jeevaratnam K, Zhang Q, Tse G (2021) Development of a predictive risk model for all-cause mortality in diabetic patients in Hong Kong. BMJ Open Diabetes Res Care 9(1):e001950.
- Lau WKW, Chan RCH, Ngan LHM, Wu WKK, Lau BWM (2021) Impact of COVID-19 on pornography use: evidence from big data analyses. PLoS ONE 16(12):e0260386.
- Cao L, Zhao S, Li Q, Ling L, Wu WKK, Zhang L, Lou, J, Chong KC, Chen Z, Wong ELY, Zee BCY, Chan MTV, Chan PKS, Wang MH (2021) A Bayesian method for synthesizing multiple diagnostic outcomes of COVID-19 tests. R Soc Open Sci 8(9):201867.
- Li Z, Zhang X, Ding L, Du K, Yan J, Chan MTV, Wu WKK, Li S (2021) Deep learning approach for guiding three-dimensional computed tomography reconstruction of lower limbs for robotically-assisted total knee arthroplasty. Int J Med Robot 17(5):e2300.
- Chen X, Li Z, Zhang X, Yan J, Song Y, Kong Y, Chan MTV, Wu WKK, Lin J (2021) A new robotically assisted system for total knee arthroplasty: A sheep model study. Int J Med Robot 17(4):e2264.
- Ng YL, Lo CK, Lee KH, Xie X, Kwong TNY, Ip M, Zhang L, Yu J, Sung JJY, Wu WKK, Wong SH, Kwok KW (2021) Development of an open-access and explainable machine learning prediction system to assess the mortality and recurrence risk factors of Clostridioides difficile infection patients. Adv Intell Syst 3(1):2000188.
- Joynt GM, Wu WKK (2020) Understanding COVID-19: What dose viral RNA load really mean? Lancet Infect Dis 20(6):635-636.
- Xia X^, Wu WKK^, Wong SH^, Liu D, Kwong TNY, Nakatsu G, Yan PS, Chuang YM, Chan MWY, Coker OO, Chen Z, Yeoh YK, Zhao L, Wang X, Cheng WY, Chan MTV, Chan PKS, Sung JJY, Wang MH, Yu J (2020) Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer. Microbiome 8(1):108.
- Ho J, Chan H, Liang Y, Liu X, Zhang L, Li Q, Zhang Y, Zeng J, Ugwu FN, Ho IHT, Hu W, Yau JCW, Wong SH, Wong WT, Ling L, Cho CH, Gallo RL, Gin T, Tse G, Yu J, Chan MTV*, Leung CCH*, Wu WKK* (2020) Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. Crit Care 24(1):47.
- Kong KY, Kwong TNY, Chan H, Wong K, Wong SSY, Chaparala AP, Chan RCY, Zhang L, Sung JJY, Yu J, Hawkey PM, Ip M, Wu WKK*, Wong SH* (2020) Biological characteristics associated with virulence in Clostridioides difficile ribotype 002 in Hong Kong. Emerg Microbes Infect 9(1):631-638.
- Wang K, Liu X, Liu Q, Ho IHT, Wei X, Yin T, Zhan Y, Zhang W, Zhang W, Chen B, Gu J, Tan Y, Zhang L, Chan MTV, Wu WKK*, Du B*, Xiao J* (2020) Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells. Cell Death Dis 11(8):611.
- Wu WKK*, Yue J* (2020) Autophagy in host-microbe interactions. Semin Cell Dev Biol 101:1-2.
- Hu W, Chan H, Lu L, Wong KT, Wong SH, Li MX, Gang XZ, Cho CH, Gin T, Chan MTV*, Wu WKK*, Zhang L* (2020) Autophagy in intracellular bacterial infection. Semin Cell Dev Biol 101:41-50.
- Li Z, Li X, Shen J, Zhang L, Chan MTV, Wu WKK (2020) Emerging roles of non-coding RNAs in scoliosis. Cell Prolif 53(2):e12736.
- Ho IHT, Chan MTV, Wu WKK*, Liu X* (2020) Spinal microglia-neuron interactions in chronic pain. J Leuko Biol 108(5):1575-1592.
- Li CKH, Xu Z, Ho J, Lakhani I, Liu Y, Bazoukis G, Liu T, Wong WT, Cheng SH, Chan MTV, Zhang L, Gin T, Wong MCS, Wong I, Wu WKK*, Zhang Q*, Tse G* (2020) Association of NPAC score with survival after acute myocardial infarction. Atherosclerosis 301:30-36.
- Yu X, Wang M, Li L, Zhang L, Chan MTV, Wu WKK (2020) MicroRNAs in atopic dermatitis: a systematic review. J Cell Mol Med 24(11):5966-5972.
- Li Z, Ma J, Lin Y, Shen J, Wu Z, Chan MTV, Wu WKK (2020) Embryonic gene expression altered by maternal exposure to air pollution in rats. Environ Sci Pollut Res 27(25):31699-31705.
- Li Z, Xu D, Chen X, Li S, Chan MTV, Wu WKK (2020) LINC01133: an emerging tumor-associated long non-coding RNA in tumor and osteosarcoma. Environ Sci Pollut Res 27(26):32467-32473.
- Li Z, Huang C, Yang B, Hu W, Chan MTV, Wu WKK (2020) Emerging roles of long non-coding RNAs in osteonecrosis of the femoral head. Am J Transl Res 12(9):5984-5991.
- Wong SH, Teoh JYC, Leung CH, Wu WKK, Yip BHK, Wong MCS, Hui DSC (2020) COVID-19 and public interest in face mask. Am J Resp Crit Care Med 202(3):453-455.
- Coker OO, Wu WKK, Wong SH, Sung JJY, Yu J (2020) Altered gut archaea composition and interaction with bacteria are associated with colorectal cancer. Gastroenterology 159(4):1459-1470.e5.
- Zhang J, Wong CC, Leung KT, Wu F, Zhou Y, Tong JHM, Chan RCK, Li H, Wang Y, Yan H, Liu L, Wu WKK, Chan MWY, Cheng ASL, Yu J, Wong N, Lo KW, To KF, Kang W (2020) FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential. Oncogene 39(43):6647–6663.
- Turan A, Artis AS, Hanline C, Saha P, Masheshwari K, Kurz A, Devereaux PJ, Duceppe E, Patel A, Tiboni M, Ruetzler K, Pearse R, Chan MTV, Wu WKK, Srinathan S, Garg A, Sapsford R, Sessler DI (2020) Preoperative vitamin D concentration and cardiac, renal, and infectious morbidity after noncardiac surgery. Anesthesiology 132(1):121-130.
- Chen Z, Wong PY, Ng CWK, Lan L, Fung S, Li JW, Cai L, Lei P, Mou Q, Wong SH, Wu WKK, Li RJ, Meehan K, Lui VWY, Chow C, Lo WK, Chan ABW, Boon SS, Lau EHL, Yeung Z, Chan KCA, Wong EWY, Cheng ASL, Yu J, Chan PKS, Chan JYK (2020) Intersection between oral microbiota, host gene methylation and patient outcomes in head and neck squamous cell carcinoma. Cancers 12(11): 3425.
- Liu YZ, Chu R, Lee A, Gomersall CD, Zhang L, Gin T, Chan MTV, Wu WKK, Ling L (2020) A surveillance method to identify patients with sepsis from electronic health records in Hong Kong: a single centre retrospective study. BMC Infect Dis 20(1):652.
- Hu W, Zhang L, Wu WKK, Cho CH (2020) Involvement of autophagy in antibacterial actions of vitamin D in Helicobacter pylori infection: abridged secondary publication. Hong Kong Med J 26 Suppl 4:26-28.
- Ho IHT, Liu X, Zou Y, Liu T, Hu W, Chan H, Tian Y, Zhang Y, Li Q, Kou S, Chan CS, Gin T, Cheng C, Wong SH, Yu J, Zhang L, Wu WKK*, Chan MTV* (2019) A novel peptide interfering with proBDNF-sortilin interaction alleviates chronic inflammatory pain. Theranostics 9(6):1651-1665.
- Ho J, Li X, Zhang L, Liang Y, Hu W, Yau JCW, Chan H, Gin T, Chan MTV*, Tse G*, Wu WKK* (2019) Translational genomics in pancreatic ductal adenocarcinoma: a review with re-analysis of TCGA dataset. Semin Cancer Biol 55:70-77.
- Wong SH*, Wu WKK* (2019) Cancer genomics: From benchtop to bedside. Semin Cancer Biol 55:iii-iv.
- Hu W, Zhang L, Li MX, Shen J, Liu XD, Xiao ZG, Wu DL, Ho IHT, Wu JCY, Cheung CKY, Zhang YC, Lau AHY, Ashktorab H, Smoot DT, Fang EF, Chan MTV, Gin T*, Gong W*, Wu WKK*, Cho CH* (2019) Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through PDIA3 receptor in gastric epithelial cells. Autophagy 15(4):707-725.
- Li Z, Li X, Chen X, Li S, Ho IHT, Liu X, Chan MTV, Wu WKK (2019) Emerging roles of long non-coding RNAs in neuropathic pain. Cell Prolif 52(1):e12528.
- Li Z, Chen X, Xu D, Li S, Chan MTV, Wu WKK (2019) Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif 52(6):e12704.
- Chen X, Chan H, Zhang L, Liu X, Ho IHT, Zhang X, Ho J, Hu W, Tian Y, Kou S, Chan CS, Yu J, Wong SH, Gin T, Chan MTV*, Sun X*, Wu WKK* (2019) The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux. J Cell Mol Med 23(6):4290-4300.
- Sun X, Ng TTH, Sham KWY, Zhang L, Chan MTV, Wu WKK*, Cheng CHK* (2019) Bufalin, a traditional Chinese medicine compound, prevents tumour formation in two murine models of colorectal cancer. Cancer Prev Res (Phila) 12(10):653-666.
- Ng TH, Sham KWY, Xie CM, Ng SSM, To KF, Tong JHM Liu WYZ, Zhang L, Chan MTV, Wu WKK*, Cheng CHK* (2019) Eukaryotic elongation factor-2 kinases expression is an independent prognostic factor in colorectal cancer. BMC Cancer 19(1):649.
- NeuroVISION Investigators (2019) Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study. Lancet 394(10203):1022-1029.
- Chan MTV, Wang CY, Seet E, Tam S, Lai HY, Chew EFF, Wu WKK, Cheng BCP, Lam CKM, Short TG, Hui DSC, Chung F; for the Postoperative vascular complications in unrecognized Obstructive Sleep Apnea (POSA) Study Investigators (2019) Association of unrecognized obstructive sleep apnea with postoperative cardiovascular events in patients undergoing major noncardiac surgery. JAMA 321(18):1788-1798.
- Coker OO, Nakatsu G, Dai Z, Wu WKK, Chen Z, Ng SC, Wong SH, Chan FKL, Sung JJY, Yu J (2019) Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer. Gut 68(4):654-662.
- Xing R, Zhou Y, Yu J, Yu Y, Nie YZ, Luo W, Yang C, Xiong T, Wu WKK, Li Z, Bing Y, Lin S, Zhang Y, Hu Y, Li L, Han L, Yang C, Huang S, Huang, S, Zhou R, Li J, Wu K, Fan D, Tang G, Zou J, Zhu Z, Ji J, Fang X, Lu Y (2019) Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer. Nat Commun 10(1):2037.
- Tian Y, Yang B, Qiu W, Hao Y, Zhang Z, Yang B, Li N, Cheng S, Lin Z, Rui YC, Cheung OKW, Yang W, Wu WKK, Cheung YS, Lai PBS, Luo J, Sung JJY, Chen R, Wang HY, Cheng ASL, Yang P (2019) ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy. Nat Commun 10(1):3391.
- Zhang Y, Zhang L, Yang L, Vong CI, Chan KF, Wu WKK, Kwong TNY, Lo NWS, Ip M, Wong SH, Sung JJY, Chiu PWY, Zhang L (2019) Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of C. diff toxins. Sci Adv 5(1):eaau9650.
- Li Z, Li X, Bi J, Chan MTV, Wu WKK, Shen J (2019) Melatonin protected against the detrimental effects of microRNA-363 in a rat model of vitamin A-associated congenital spinal deformities: Involvement of Notch signaling. J Pineal Res 66(3):e12558.
- Wang X, Wu WKK, Gao J, Li Z, Dong B, Lin X, Li Y, Li Y, Gong J, Qi C, Peng Z, Yu J, Shen L (2019) Autophagy inhibition enhances PD-L1 expression in gastric cancer. J Exp Clin Cancer Res 38(1):140.
- Zeng JD, Wu WKK, Wang HY, Li XX (2019) Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer. Pharmacol Res 149:104352.
- Wong J, Chopra J, Chiang LLW, Liu T, Ho J, Wu WKK, Tse G, Wong SH (2019) The role of connexins in gastrointestinal diseases. J Mol Biol 431(4):643-652.
- Li Z, Ho IHT, Li X, Xu D, Wu WKK, Chan MTV Li S, Liu X (2019) Long non-coding RNAs in the spinal cord injury: Novel spotlight. J Cell Mol Med 23(8):4883-4890.
- Li Z, Ma J, Li X, Chan MTV, Wu WKK, Wu Z, Shen J (2019) Aberrantly expressed long non-coding RNAs in air pollution-induced congenital defects. J Cell Mol Med 23(11):7717-7725.
- Li Z, Ma J, Bi J, Guo H, Chan MTV, Wu WKK, Wu Z, Shen J (2019) MicroRNA signature of air pollution exposure-induced congenital defects. J Cell Physiol 234(10):17896-17904.
- Konstantatos AH, Zhong T, Paul E, Tsang S, Tian S, Liu M, Liang Y, Tian Y, Qiao S, Wu WKK, Chan MTV (2019) Effect of cultural background and healthcare environment on postoperative opioid requirement. Can J Anesth 66(3):309-317.
- Li Z, Ma J, Shen J, Chan MTV, Wu WKK, Wu Z (2019) Differentially expressed circular RNAs in air pollution-exposed rat embryos. Environ Sci Pollut Res 26(33):34421-34429.
- Sun R, Xia X, Chong KC, Zee BC, Wu WKK, Wang MH (2019) wtest: an integrated R package for genetic epistasis testing. BMC Med Genomics 12(Suppl 9):180.
- Ren Z, Li Z, Li S, Sheng L, Xu D, Chen X, Wu WKK, Chan MTV, Ho J (2019) Local infiltration with cocktail analgesics during 2 level lumbar spinal fusion surgery: Study protocol of a randomized controlled trial. Medicine (Baltimore) 98(19):e15526.
- Yuan M, Zhang Z, Tse G, Feng X, Korantzopoulos P, Letsas KP, Yan BP, Wu WKK, Zhang H, Li G, Liu T, Xia Y (2019) Association of cancer and the risk of developing atrial fibrillation: A systematic review and meta-analysis. Cardiol Res Pract 2019:8985273.
- Li CKH, Sang T, Chan CP, Gong M, Liu Y, Jesuthasan A, Li G, Liu T, Lam MHS, Wu WKK, Chan MTV, Liu FZ, Chen C, Ho J, Xia Y, Tse G; International Health Informatics Study (IHIS) Network (2019) Anesthesia use in catheter ablation for atrial fibrillation: A systematic review and meta-analysis of observational studies. Heart Asia 11:e011155.
- Ng C, Li H, Wu WKK, Wong SH, Yu J (2019) Genomics and metagenomics of colorectal cancer. J Gastrointest Oncol 10(6):1164-1170
- Kwong TNY, Wu WKK, Wong SH (2019) Reply. Gastroenterology 156(1):292.
- Wang X^, Li X^, Zhang L^, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T*, Chan MTV*, Wu WKK* (2018) Oncogenes expand during evolution to withstand somatic amplification. Ann Oncol 29(11):2254-2260.
- Dai Z^, Coker OO^, Nakatsu G^, Wu WKK^, Zhao L, Chen Z, Chan FKL, Kristiansen K, Sung JJY, Wong SH, Yu J (2018) Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers. Microbiome 6(1):70.
- Li X^, Xu W^, Kang W, Wong SH, Wang M, Zhou Y, Fang X, Zhang X, Yang H, Wong CH, To FK, Chan SL, Chan MTV, Sung JJY, Wu WKK*, Yu J* (2018) Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features. Theranostics 8(6):1740-1751.
- Tian Y, Liu X, Jia M, Yu H, Lichtner P, Shi Y, Meng Z, Kou S, Ho IHT, Jia B, Cheng BCP, Lam CKM, Tsang S, Wong SH, Yu J, Cheng CHK, Gin T#, Wu WKK#, Chen Z#, Chan MTV#; Persistent Pain After Surgery Study Investigators (2018) Targeted genotyping identifies susceptibility locus in brain-derived neurotrophic factor gene for chronic postsurgical pain. Anesthesiology 128(3):587-597. (#joint senior authorship)
- Zhang L^, Hu W^, Cho CH, Chan FK, Yu J, Ross Fitzgerald J, Cheung CK, Xiao ZG, Shen J, Li LF, Li MX, Wu JC, Ling TK, Chan JY, Ko H, Tse G, Ng SC, Yu S, Wang MH, Gin T, Ashktorab H, Smoot DT, Wong SH*, Chan MTV*, Wu WKK* (2018) Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. J Pathol 244(4):432-444.
- Wang X^, Zhang X^, Chu ESH, Chen X, Kang W, Wu F, To KF, Wong VWS, Chang HLY, Chan MTV, Sung JJY, Wu WKK*, Yu J* (2018) Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis. FASEB J 32(1):37-51.
- Li Z^, Jiang C^, Li X^, Wu WKK^, Chen X, Zhu S, Ye C, Chan MTV, Qian W (2018) Circulating microRNA signature of steroid-induced osteonecrosis of the femoral head. Cell Prolif 51(1):e12418.
- Liu T, Shi Y, Chan MTV, Peng G, Zhang Q, Sun X, Zhu Z, Xie Y, Sham KWY, Li J, Liu X, Ho IHT, Gin T, Lu Z, Wu WKK*, Cheng CHK* (2018) Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Transl Psychiatry 8(1):232.
- Wu WKK^, Sun R^, Zuo T^, Tian Y^, Zheng Z, Ho J, Wu JCY, Chan FKL, Chan MTV, Yu J, Wong SH*, Wang MH*, Ng SC* (2018) A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn’s disease in the Chinese population. J Cell Mol Med 22(4):2368-2377.
- Chan H^, Zhao S^, Zhang L, Ho J, Leung CHH, Wong WT, Tian Y, Liu X, Kwong TNY, Chan RCY, Yu SSB, Wang MHT, Tse G*, Wong SH*, Chan MTV*, Wu WKK* (2018) Clostridium difficile toxin B induces autophagic cell death in colonocytes. J Cell Mol Med 22(4):2469-2477.
- Yu X, Zheng H, Chan MTV, Wu WKK (2018) Nova1 acts as an oncogene in melanoma via regulating FOXO3a expression. J Cell Mol Med 22(5):2622-2630.
- Zhang L^, Zhang Y^, Wong SH^, Law PTY, Zhao S, Yu J, Chan MTV*, Wu WKK* (2018) Common deregulation of seven biological processes by microRNAs in gastrointestinal cancers. Sci Rep 8:3287.
- Tse G, Li KHC, Li G, Liu T, Wong SH, Bazoukis G, Wong WT, Chan MTV, Wong MCS, Letsas K, Chan CP, Chan YS, Wu WKK (2018) Higher dispersion measures of conduction and repolarization in type 1 compared to non-type 1 Brugada syndrome patients: an electrocardiographic study from a single centre. Front Cardiovasc Med 5:132.
- Tipoe TL, Wu WKK*, Chung L, Gong M, Dong M, Liu T, Roever L, Ho J, Wong MCS, Chan MTV, Tse G*, Wu JCY*, Wong SH* (2018) Plasminogen activator inhibitor-1 for predicting sepsis severity and mortality outcomes: a systematic review and meta-analysis. Front Immunol 9:1218.
- Tse G, Gong M, Lei M, Wong CW, Bazoukis G, Chan MTV, Wong MCS, Letsas K, Baranchuk AM, Yan GX, Liu T, Wu WKK (2018) Predictive value of Tpeak � Tend indices for adverse outcomes in acquired QT prolongation: a meta-analysis. Front Physiol 9:1226.
- Lee YT, Gong M, Chau A, Wong WT, Bazoukis G, Wong SH, Lampropoulos K, Xia Y, Li G, Wong MCS, Liu T, Wu WKK*, Tse G*; International Health Informatics Study (IHIS) Network (2018) Pentraxin-3 as a marker of sepsis severity and predictor of mortality outcomes: A systematic review and meta-analysis. J Infect 76(1):1-10.
- Li KHC, Gong M, Li G, Baranchuk A, Liu T, Wong MCS, Jesuthasan A, Lai RWC, Lai JCL, Lee APW, Bay�s-Genis A, De la Espriella R, Sanchis J, Wu WKK*, Tse G*, Nu�ez J* (2018) Cancer Antigen-125 and outcomes in acute heart failure: a systematic review and meta-analysis. Heart Asia 10:e011044.
- Yu X, Zheng H, Tse G, Zhang L, Wu WKK (2018) CASC2: an emerging tumor-suppressing long non-coding RNA in human cancers and melanoma. Cell Prolif 51(6):e12506.
- Li Z, Li X, Chen C, Li S, Shen J, Tse G, Chan MTV, Wu WKK (2018) Long non-coding RNAs in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif 51(5):e12483.
- Yu X, Zheng H, Tse G, Chan MTV, Wu WKK (2018) Long non-coding RNAs in melanoma. Cell Prolif 51(4):e12457.
- Li Z, Shen J, Chan MTV, Wu WKK (2018) The long non-coding RNA SPRY4-IT1: an emerging player in tumorigenesis and osteosarcoma. Cell Prolif 51(4):e12446.
- Li Z, Li X, Jiang C, Qian W, Tse G, Chan MTV, Wu WKK (2018) Long non-coding RNAs in rheumatoid arthritis. Cell Prolif 51(1):e12404.
- Li Z, Yang B, Weng X, Tse G, Chan MTV, Wu WKK (2018) Emerging roles of microRNAs in osteonecrosis of the femoral head. Cell Prolif 51(1):e12405.
- Yu X, Zheng H, Chan MTV, Wu WKK (2018) Immune consequences induced by photodynamic therapy in non-melanoma skin cancers: a review. Environ Sci Pollut Res 25(21):20569-20574.
- Wu WKK, Zhang L, Chan MTV (2018) Autophagy, NAFLD and NAFLD-related HCC. In: Obesity, Fatty Liver and Liver Cancer, Adv Exp Med Biol pp. 127-138 Singapore: Springer
- Zhang L, Hu W, Ho J, Fitzgerald RJ, Gin T, Chan MTV, Wu WKK (2018) Antimicrobial peptides in the host-microbiota homeostasis. In: Antimicrobial Peptides in Gastrointestinal Diseases pp. 23-33 Elsevier
- Nakatsu G, Zhou H, Wu WKK, Wong SH, Coker OO, Dai Z, Li X, Szeto CH, Sugimura N, Lam TYT, Yu ACS, Wang X, Chen Z, Wong MCS, Ng SC, Chan MTV, Chan PKS, Chan FKL, Sung JJY, Yu J (2018) Alterations in enteric virome associate with colorectal cancer and survival outcomes. Gastroenterology 155(2):529-541.e5.
- Kwong TNY, Wang X, Nakatsu G, Chow TC, Tipoe T, Dai RZW, Tsoi KKK, Wong MCS, Tse G, Chan MTV, Chan FKL, Ng SC, Wu JCY, Wu WKK, Yu J, Sung JJY, Wong SH (2018) Bacteremia from specific microbiota are associated with subsequent colorectal cancer diagnosis. Gastroenterology 155(2):383-390.e8.
- Coker OO, Dai ZW, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WKK, Wong SH, Chen Z, Sung JJY, Yu J (2018) Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut 67(6):1024-1032.
- Huang T, Zhou Y, Zhang J, Wong CC, Li W, Kwan JSH, Yang R, Chan AKY, Dong Y, Wu F, Zhang B, Cheung AHK, Wu WKK, Cheng ASL, Yu J, Wong N, Kang W, To KF (2018) SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis. Oncogene 37(9):1159-1174.
- Li D, Zhou Y, Yu J, Yu H, Xia Y, Zhang L, Wu WKK, Zeng Z, Yao R, Cao Y (2018) Evaluation of a novel prognostic score based on thrombosis and inflammation in patients with sepsis: a retrospective cohort study. Clin Chem Lab Med 56(7):1182-1192.
- Tse G, Du YM, Chan YWF, Liu T, Li G, Bazoukis G, Letsas K, Wu WKK, Tian XY, Wong WT (2018) Quantification of beat-to-beat variability of action potential durations in Langendorff-perfused mouse hearts. Front Physiol 9:1578.
- Li Z, Chen C, Lin Y, Li X, Tan H, Chan MTV, Wu WKK, Zhan S, Cao Q, Shen J (2018) A novel probe for measuring tissue bioelectrical impedance to enhance pedicle screw placement in spinal surgery. Am J Transl Res 10(7):2205-2212.
- Li Z, Jiang C, Ye C, Zhu S, Chen X, Wu WKK, Qian W (2018) miR-10a-5p, miR-99a-5p and miR-21-5p are steroid-responsive circulating microRNAs. Am J Transl Res 10(5):1490-1497.
- To KKW, Wu WKK, Loong HHF (2018) PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy. Eur J Pharmacol 823:19-26.
- Mrkobrada M, Chan MTV, Cowan D, Spence J, Campbell D, Wang CY, Torres D, Malaga G, Sanders RD, Brown C, Sigamani A, Szczeklik W, Dmytriw AA, Agid R, Smith EE, Hill MD, Sharma M, Sharma M, Tsai S, Mensinkai A, Sahlas DJ, Guyatt G, Pettit S, Copland I, Wu WKK, Yu SCH, Gin T, Loh PS, Ramli N, Siow YL, Short TG, Waymouth E, Kumar J, Dasgupta M, Murkin J, Fuentes M, Ortiz-Soriano V, Lindroth H, Simpson S, Sessler D, Devereaux PJ (2018) Rationale and design for the detection and neurological impact of cerebrovascular events in noncardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study. BMJ Open 8:e021521.
- Sun R, Weng H, Men R, Xia X, Chong KC, Wu WKK, Zee BCY, Wang MHT (2018) Gene-methylation epistatic analyses via the W-test identifies enriched signals of neuronal genes in patients undergoing lipid-control treatment. BMC Proc 12(Suppl 9):53.
- Lakhani I, Gong M, Wong WT, Bazoukis G, Lampropoulos K, Wong SH, Wu WKK, Wong MCS, Ong KL, Liu T, Tse G (2018) Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis. Metabolism 83:11-17.
- Tse G, Gong M, Wong SH, Wu WKK, Bazoukis G, Lampropoulos K, Wong WT, Xia Y, Wong MCS, Liu T, Woo J (2018) Frailty and clinical outcomes in advanced heart failure patients undergoing left ventricular assist device implantation: a systematic review and meta-analysis. J Am Med Dir Assoc 19(3):255-261.e1.
- Tse G, Wong CW, Gong M, Wong WT, Bazoukis G, Wong SH, Li G, Wu WKK, Tse LA, Lampropoulos K, Xia YL, Liu T, Baranchuk A; International Health Informatics Study (IHIS) Network (2018) Predictive value of inter-atrial block for new onset or recurrent atrial fibrillation: a systematic review and meta-analysis. Int J Cardiol 250:152-156.
- Tse G, Gong M, Li G, Wong SH, Wu WKK, Wong WT, Roever L, Lee APW, Lip GYH, Wong MCS, Liu T (2018) Genotype-guided warfarin dosing versus conventional dosing strategies: a systematic review and meta-analysis of randomized controlled trials. Br J Clin Pharmacol 84(9):1868-1882
- Li KHC, Dong M, Gong M, Bazoukis G, Wong SH, Li G, Wu WKK, Vassiliou VS, Wong MCS, Letsas KP, Du Y, Yan BP, Chan YS, Xia Y, Liu T, Tse G (2018) Atrial fibrillation recurrence and peri-procedural complication rates in nMARQ versus conventional ablation techniques: a systematic review and meta-analysis. Front Physiol 9:544.
- Ho J, Ngai SPC, Wu WKK, Hou WH (2018) Association between daily life experience and psychological well-being in people living with non-psychotic mental disorders: protocol for a systematic review and meta-analysis. Medicine (Baltimore) 97(4):e9733.
- Tse G, Gong M, Wong CW, Chan C, Georgopoulos S, Chan YS, Yan BP, Li G, Whittaker P, Ciobanu A, Ali-Hasan-Al-Saegh S, Wong SH, Wu WKK, Bazoukis G, Lampropoulos K, Wong WT, Tse LA, Baranchuk AM, Letsas KP, Liu T; International Health Informatics Study (IHIS) Network (2018) Total cosine R-to-T for predicting ventricular arrhythmic and mortality outcomes: A systematic review and meta-analysis. Ann Noninvasive Electrocardiol 23(2):e12495.
- Li KHC, Ho JCS, Recaldin B, Gong M, Ho J, Li G, Liu T, Wu WKK, Wong MCS, Xia Y, Dong M, Tse G; International Health Informatics Study (IHIS) Network (2018) Acute cellular rejection and infection rates in alemtuzumab versus traditional induction therapy agents for lung and heart transplantation: a systematic review and meta-analysis. Transplant Proc 50(10):3723-3731.
- Cheung A, Gong M, Bellanti R, Ali-Hasan-Al-Saegh S, Li G, Roig E, Nunez J, Stamos TD, Yilmaz MB, Hakki K, Wu WKK, Wong SH, Wong WT, Bazoukis G, Lampropoulos K, Tse LA, Zhao J, Lip GYH, Baranchuk A, Wong MCS, Liu T, Tse G (2018) Cancer antigen-125 and atrial fibrillation risk: a systematic review with meta-analysis. Heart Asia 10(1):e010970.
- Tse G, Bazoukis G, Roever L, Liu T, Wu WKK, Wong MCS, Baranchuk A, Korantzopoulos P, Asvestas D, Letsas KP (2018) T-wave indices and atherosclerosis. Curr Atheroscler Rep 20(11):55.
- Leung CS, Lu S, Li J, Wu WKK, Lui KO (2018) Deciphering the role of microRNAs in regulation of immune surveillance, self-tolerance and allograft transplantation. Curr Stem Cell Res Ther 13(5):336-344.
- Wu WKK^, Li X^, Wang X^, Dai RZW, Cheng ASL, Wang MHT, Kwong T, Chow TC, Yu J*, Chan MTV*, Wong SH* (2017) Oncogenes without a neighboring tumor-suppressor gene are more prone to amplification. Mol Biol Evol 34(4):903-907.
- Ho J, Dai RZW, Kwong T, Wang XS, Zhang L, Ip M, Chan RCY, Hawkey PM, Lam Y, Wong M, Tse G, Chan MTV, Chan FKL, Yu J, Ng SC, Lee N, Wu JC, Sung JJY, Wu WKK*, Wong SH* (2017) Disease burden of Clostridium difficile infection in adults from 2006 through 2014: Results from a territory-wide population study in Hong Kong. Emerg Infect Dis 23(10):1671-79.
- Li Z, Shen J, Chan MTV, Wu WKK (2017) MicroRNA-379 suppresses osteosarcoma by targeting PDK1. J Cell Mol Med 21(2):315-323.
- Ho J, He W, Chan MTV, Tse G, Liu T, Wong SH, Leung CCH, Wong WT, Tsang S, Zhang L, Chan RYP, Gin T, Leung J, Lau BWM*, Wu WKK*, Ngai SPC* (2017) Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis. Sci Rep 7(1):13451.
- Chan H, Ho J, Liu X, Zhang L, Wong SH, Chan MTV*, Wu WKK* (2017) Potential and use of bacterial small RNAs to combat drug resistance: a systematic review. Infect Drug Resist 10:521-32.
- Ho J, Zhang L, Liu X, Wong SH, Lau BWM, Ngai SPC, Chan H, Choi G, Leung CCH, Wong WT, Tsang S, Gin T, Yu J, Chan MTV*, Wu WKK* (2017) Pathological role and diagnostic value of endogenous host defense peptides in adult and neonatal sepsis: a systematic review. Shock 47(6):673-679.
- Yu X, Li Z, Zheng H, Ho J, Chan MTV, Wu WKK (2017) Protective roles of melatonin in central nervous system diseases by regulation of neural stem cells. Cell Prolif 50(2):e12323.
- Yu X, Li Z, Zheng H, Chan MTV, Wu WKK (2017) NEAT1: A novel cancer-related long non-coding RNA. Cell Prolif 50(2):e12329.
- Yu X, Li Z, Zheng H, Chan MTV, Wu WKK (2017) CCAT2: a novel oncogenic long non-coding RNA in human cancers. Cell Prolif 50(3):e12342.
- Yu X, Li Z, Zheng H, Ho J, Chan MTV, Wu WKK (2017) Neuro-oncological ventral antigen 1 (NOVA1): Implications in neurological diseases and cancers. Cell Prolif 50(4):e12348.
- Yu X, Zheng H, Chan MTV, Wu WKK (2017) HULC: An oncogenic long non-coding RNA in human cancer. J Cell Mol Med 21(2):410-417.
- Li Z, Shen J, Chan MTV, Wu WKK (2017) The role of microRNAs in intrahepatic cholangiocarcinoma. J Cell Mol Med 21(1):177-184.
- Yu X, Zheng H, Chan MTV, Wu WKK (2017) Modulation of chemoresponsiveness to platinum-based agents by microRNAs in cancer. Am J Cancer Res 7(9):1769-1778.
- Yu X, Zheng H, Chan MTV, Wu WKK (2017) BANCR: a cancer-related long non-coding RNA. Am J Cancer Res 7(9):1779-1787.
- Yu X, Zheng H, Chan MTV, Wu WKK (2017) MicroRNAs: New players in cataract. Am J Transl Res 9(9):3896-3903.
- Chan MTV, Chu MHM, Lam CKM, Jia B, Tsang S, Wu WKK (2017) Deep anesthesia: Too much of a good thing? Can J Anaesth 64(6):574-580.
- Tse G, Liu T, Li G, Keung W, Yeo JM, Chan YWF, Yan BP, Chan YS, Wong SH, Li RA, Zhao J, Wu WKK*, Wong WT* (2017) Effects of pharmacological gap junction and sodium channel blockade on S1S2 restitution properties in Langendorff-perfused mouse hearts. Oncotarget 8(49): 85341-52.
- Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, Zeng B, Chan FKL, Sung JJY, Wei H, Yu J (2017) Gavage of fecal samples from patients with colorectal cancer promotes intestinal carcinogenesis in germ-free and conventional mice. Gastroenterology 153(6):1621-1633.e6.
- Wong SH, Kwong TNY, Chow TC, Luk AKC, Dai DZW, Nakatsu G, Zhang L, Lam TYT, Wu JCY, Chan FKL, Ng SSM, Wong MCS, Ng SC, Wu WKK, Yu J, Sung JJY (2017) Quantitation of faecal Fusobacterium improves performance of faecal immunochemical test in detecting advanced colorectal neoplasia. Gut 66(8):1441-1448.
- Yu J, Feng Q, Wong SH, Liang Q, Qin Y, Tang L, Zhao H, Liang Y, Stenvang J, Wang X, Xu X, Chen N, Wu WKK, Al-Aama J, Nielsen HJ, Kiilerich P, Jensen B, Yau PTO, Lan Z, Jia H, Li J, Xiao L, Lam TYT, Ng SC, Cheng ASL, Wong VWS, Chan FKL, Xu X, Yang H, Madsen L, Datz C, Tilg H, Wang J, Br�nner N, Kristiansen K, Arumugam M, Sung JJY, Wang J (2017) Metagenomic analysis of fecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut 66(1):70-78.
- Li Z, Li X, Chen C, Chan MTV, Wu WKK, Shen J (2017) Melatonin inhibits nucleus pulposus cell proliferation and extracellular matrix remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway. J Pineal Res 63(3):e12435.
- Ren NSX, Ji M, Tokar EJ, Busch EL, Xu X, Lewis D, Li X, Jin A, Zhang Y, Wu WKK, Huang W, Fargo DC, Keku TO, Sandler RS, Li X (2017) Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development. Curr Biol 27(4):483-494.
- Zhang X, Wu WKK, Man K, Wang X, Han J, Leung WY, Wu R, Liu K, Yu J (2017) C-X-C motif chemokine 10 impairs autophagy and autolysosome formation in non-alcoholic steatohepatitis. Theranostics 7(11):2822-2836.
- Wang HT, Weng H, Sun R, Lee J, Chong KC, Wu WKK, Zee B (2017) A Zoom-Focus Algorithm (ZFA) to locate the optimal testing region for rare variant association tests. Bioinformatics 33(15):2330-2336.
- Zhou Y, Huang T, Kang W, Wong CC, Zhang B, Dong Y, Tong JHM, Wu WKK, Cheng ASL, Yu J, To KF (2017) TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. Oncogene 36(47):6518-6530.
- Zhou Y, Huang T, Siu HL, Wong CC, Dong Y, Wu F, Zhang B, Wu WKK, Cheng AS, Yu J, To KF, Kang W (2017) IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis. Mol Cancer 16(1):77.
- Tong WS, Wu WKK, Loong HHF, Cho WCS, To KKW (2017) Drug combination approach to overcome resistance to EGFR tyrosine kinase inhibitors in lung cancer. Cancer Lett 405:100-110.
- Tse G, Gong M, Nunez J, Sanchis J, Li G, Ali-Hasan-Al-Saegh S, Wong WT, Wong SH, Wu WKK, Bazoukis G, Yan GX, Lampropoulos K, Baranchuk AD, Tse LA, Liu T, Woo J; International Health Informatics Study (IHIS) Network (2017) Frailty and mortality outcomes after percutaneous coronary intervention: a systematic review and meta-analysis. J Am Med Dir Assoc 18(12):1097.e1-1097.e10.
- Luo X, Li C, Tan R, Xu X, Wu WKK, Satoh A, Wang T, Yu S (2017) A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C. Oncotarget 8(49): 85415-27.
- Zhao S, Li CM, Luo XM, Siu GK, Gan WJ, Zhang L, Wu WKK, Chan HC, Yu S (2017) Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles. Sci Rep 7:43207.
- Wang HT, Chang B, Sun R, Hu I, Xia X, Wu WKK, Chong KC, Zee BCY (2017) Stratified polygenic risk prediction model with application to CAGI bipolar disorder sequencing data. Hum Mutat 38(9):1235-1239.
- Li Z, Li X, Chan MTV, Wu WKK, Tan D, Shen J (2017) Melatonin antagonizes interleukin-18-mediated inhibition on neural stem cell proliferation and differentiation. J Cell Mol Med 21(9):2163-2171.
- Tse G, Gong M, Wong CW, Wong WT, Georgopoulos S, Letsas KP, Vassiliou VS, To OTL, Chan YS, Yan BP, Wong SH, Li G, Whittaker P, Ali-Hasan-Al-Saegh S, Bhardwaj A, Sawant AC, Wu WKK, Chu A, Xia Y, Baranchuk A, Yan GX, Lui KO, Liu T (2017) Prediction of arrhythmic and mortality outcomes using Tpeak � Tend interval and Tpeak � Tend/QT ratio in long QT syndrome populations: a systematic review and meta-analysis. Heart Rhythm 14(8):1131-1137.
- Wong CCM, Zhang L, Wu WKK, Shen J, Chan RLY, Lu L, Hu W, Li MX, Li FL, Ren SX, Li YF, Li J, Cho CH (2017) Cathelicidin-encoding Lactococcus lactis promotes mucosal repair in murine experimental colitis. J Gastroenterol Hepatol 32(3):609-619.
- Bayoumy A, Gong MQ, Christien Li KH, Wong SH, Wu WKK, Li GP, Bazoukis G, Letsas KP, Wong WT, Xia YL, Liu T, Tse G; International Health Informatics Study (IHIS) Network (2017) Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada Syndrome: an updated systematic review and meta-analysis. J Geriatr Cardiol 14(10):639-643.
- Liu Q, Wang Q, Liu H, Wu WKK, Chan MTV (2017) Warning criteria for intraoperative neurophysiologic monitoring. Curr Opin Anaesthesiol 30(5):557-562.
- Tse G, Wong CW, Gong M, Meng L, Letsas KP, Li G, Whittaker P, Bhardwaj A, Sawant AC, Wu WKK, Wong SH, Shenthar J, Tse LA, Wong MCS, Baranchuk A, Yan GX, Liu T; International Health Informatics Study (IHIS) Network (2017) Meta-analysis of T-wave indices for risk stratification in myocardial infarction. J Geriatr Cardiol 14:776-779.
- Luk KS, Ip C, Gong MQ, Wong SH, Wu WKK, Dong M, Li GP, Chan KP, Du YM, Liu T, Wong MC, Hui DSC, Tse G; International Health Informatics Study (IHIS) Network (2017) A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension. J Geriatr Cardiol 14(12):766-771.
- Li KHC, Kui C, Lee EKM, Ho CS, Wong SH, Wu W, Wong WT, Voll J, Li G, Liu T, Yan B, Chan J, Tse G, Keenan ID (2017) The role of 3D printing in anatomy education and surgical training: A narrative review. MedEdPublish doi:10.15694/mep.2017.000092.
- Li KHC, Bazoukis G, Liu T, Li G, Wu WKK, Wong SH, Wong WT, Chan YS, Wong MCS, Wassilew K, Vassiliou VS, Tse G (2017) Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) in clinical practice. J Arrhythm 34(1):11-22.
- Lai JCL, Tse G, Wu WKK, Gong M, Bazoukis G, Wong WT, Wong SH, Lampropoulos K, Baranchuk A, Tse LA, Xia Y, Li G, Wong MCS, Chan YS, Mu N, Dong M, Liu T; International Health Informatics Study (IHIS) Network (2017) Patent foramen ovale closure versus medical therapy for stroke prevention: A systematic review and meta-analysis of randomized controlled trials. F1000Res 6:2178.
- Lam EKY, Tai EKK, Wu WKK, Yu L, Wong HPS, Shin VY, Cho CH (2017) Differential effects of lipoteichoic acid and lipopolysaccharides on gastric cancer cell proliferation via distinctive involvement of TLR2 signaling mediators. Arch Dig Disord 1(1):22-27.
- Ho J, Yu J, Wong SH, Zhang L, Liu X, Wong WT, Leung CCH, Choi G, Wang MHT, Gin T, Chan MTV*, Wu WKK* (2016) Autophagy in sepsis: degradation into exhaustion? Autophagy 12(7):1073-82.
- Li X, Wu WKK*, Xing R, Wong SH, Liu Y, Fang X, Zhang Y, Wang M, Wang J, Li L, Zhou Y, Tang S, Peng S, Qiu K, Chen L, Chen K, Yang H, Zhang W, Chan MTV, Lu Y, Sung JJY, Yu J* (2016) Distinct subtypes of gastric cancer defined by molecular characterization include novel mutational signatures with prognostic capability. Cancer Res 76(7):1724-32.
- Wu WKK*, Yu J, Chan MTV, To KF, Cheng ASL* (2016) Combinatorial epigenetic deregulation by Helicobacter pylori and Epstein-Barr virus infections in gastric tumorigenesis. J Pathol 239(3):245-9.
- Tsang DPF^, Wu WKK^, Kang W^, Lee YY, Wu F, Yu Z, Xiong L, Chan AW, Tong JH, Yang W, Li MSM, Lau SS, Li X, Lee SD, Yang Y, Lai PBS, Yu DY, Xu G, Lo KW, Chan MTV, Wang H, Lee TL, Yu J, Wong N, Yip KY, To KF, Cheng ASL (2016) Yin Yang 1-mediated epigenetic silencing of tumor-suppressive microRNAs contributes to nuclear factor-?B activation in hepatocellular carcinoma. J Pathol 238(5):651-64.
- Chan MTV, Peyton PJ, Myles PS, Leslie K, Buckley N, Kasza J, Paech MJ, Beattie WS, Sessler DI, Forbes A, Wallace S, Chen Y, Tian Y, Wu WKK; and the Australian and New Zealand College of Anaesthetists Clinical Trials Network for the ENIGMA-II investigators (2016) Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial. Br J Anaesth 117(6):801-811.
- Tang S, Wu WKK*, Li X, Wong SH, Wong N, Chan MTV, Sung JJY, Yu J* (2016) MicroRNAs stratify digestive cancers with different pathological features and survival outcomes. Sci Rep 6:24466.
- Zhang L*, Wu WKK*, Gallo RL, Fang EF, Ling TKW, Shen J, Chan RLY, Lu L, Luo XM, Li MX, Chan KM, Yu J, Wong VWS, Ng SC, Wong SH, Chan FKL, Sung JJY, Chan MTV, Cho CH (2016) Critical role of antimicrobial peptide cathelicidin for controlling Helicobacter pylori survival and infection. J Immunol 196(4):1799-809.
- Ho J^, Chan H^, Wong SH*, Wang MHT, Yu J, Xiao Z, Liu X, Choi G, Leung CCH, Wong WT, Li Z, Gin T, Chan MTV*, Wu WKK* (2016) The involvement of regulatory non-coding RNAs in sepsis: a systematic review. Crit Care 20(1):383.
- Lei D^, Dong C^, Wu WKK^, Dong A, Li T, Chan MTV, Zhou X, Yuan H (2016) Lentiviral delivery of small hairpin RNA targeting connective tissue growth factor blocks profibrotic signaling in Tenon's capsule fibroblasts. Invest Ophthalmol Vis Sci 57(13):5171-5180.
- Yu X, Li Z, Chan MTV, Wu WKK (2016) Circulating epigenetic biomarkers in melanoma. Tumor Biol 37(2):1487-1492.
- Yu X, Li Z, Chan MTV, Wu WKK (2016) The roles of microRNAs in Wilms’ tumors. Tumor Biol 37(2):1445-1450.
- Yu X, Li Z, Chan MTV, Wu WKK (2016) The role of microRNAs in primary central nervous system lymphomas. Cell Prolif 49(2):147-53.
- Yu X, Li Z, Chan MTV, Wu WKK (2016) CCAT1: a pivotal oncogenic long non-coding RNA in human cancers. Cell Prolif 49(3):255-60.
- Li Z, Shen J, Chan MTV, Wu WKK (2016) TUG1: a pivotal oncogenic long non-coding RNA in human cancers. Cell Prolif 49(4):471-5.
- Li Z^, Wong SH^, Shen J, Chan MTV, Wu WKK (2016) The role of microRNAs in ankylosing spondylitis. Medicine 95(14):e3325.
- Wu WKK*, Chan MTV, Cheng ASL* (2016) A transcriptional-microRNA network for �-catenin-driven stemness in hepatocellular carcinoma. Transl Cancer Res 5(Suppl 7):S1408-S1412.
- Cho CH, Yu J, Wu WKK (2016) Identification of pathogenic microRNAs in Helicobacter pylori-associated gastric cancer using a combined approach of animal study and clinical sample analysis. Hong Kong Med J 22(Suppl 6):S13-8.
- Xu L, Li X, Cai M, Chen J, Li X, Wu WKK, Kang W, Tong J, To KF, Guan XY, Sung JJY, Chan FKL, Yu J (2016) Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer. Gut �65(4):635-46.
- Klionsky DJ, et al. Wu WKK, et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222.
- Wong SH, Qao Q, Tsoi KKF, Wu WKK, Tam LS, Lee N, Chan FKL, Wu JC, Sung JJY, Ng SC (2016) Effect of immunosuppressive therapy on interferon gamma release assay in patients with autoimmune diseases: a systematic review and meta-analysis. Thorax 71(1):64-72.
- Yu J, Wu WKK, Liang Q, Zhang N, He J, Li X, Zhang X, Xu L, Chan MTV, Ng SSM, Sung JJY (2016) Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer. Oncogene 35(2):187-195.
- Bai AHC, Wu WKK, Xu L, Wong SH, Go MY, Chan AWH, Harbord M, Zhang S, Chen M, Wu JCY, Chan MWY, Chan MTV, Chan FKL, Sung JJY, Yu J, Cheng ASL, Ng SC (2016) Dysregulated lysine acetyltransferase 2B promotes inflammatory bowel disease pathogenesis through transcriptional repression of interleukin-10. J Crohns Colitis 10(6):726-34.
- Yu L, Wu WKK, Gu C, Zhong D, Kong Y, Zhao X, Lin Q, Chan MTV, Zhou Z, Liu S (2016) Obatocalx impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget 7(12):14693-707.
- Wong SH, Ip M, Hawkey PM, Lo N, Hardy KJ, Manzoor S, Hui W, Choi KW, Wong R, Yung I, Cheung C, Lam K, Kwong T, Wu WKK, Chan FKL, Ng SC, Wu JC, Sung JJY, Lee N (2016) High morbidity and mortality of Clostridium difficile infection and its associations with ribotype 002 in Hong Kong. J Infect 73(2):115-22.
- Shen J, Li ZJ, Li LF, Lu L, Xiao ZG, Wu WKK, Zhang L, Li MX, Hu W, Chan KM, Cho CH (2016) Vascular-targeted TNFa and IFN? inhibits orthotopic colorectal tumor growth. J Transl Med 14(1):187.
- Wang L, Hu T, Shen J, Zhang L, Li LF, Chan RL, Li MX, Wu WKK, Cho CH (2016) Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. Life Sci 151:224-34.
- Sun R, Weng H, Hu I, Guo J, Wu WKK, Zee BCY, Wang MH (2016) A W-test collapsing method for rare-variant association testing in exome sequencing data. Genet Epidemiol 40(7):591-596.
- Chu MH, Tsang S, Wu WKK, Chan M (2016) Anaesthetic implications of mild cognitive impairment. Anaesth Intensive Care 44(5):539-41.
- Lai LML, Wu WKK, Chan MTV (2016) Pharmacology of neurokinin antagonists and novel antiemetics. In: Postoperative Nausea and Vomiting pp. 74-89 Cambridge: Cambridge University Press
- Zhang X, Wu WKK, Yu J (2016) Obesity and cancer. In: Obesity pp. 221-220 Springer
- Yu J^, Wu WKK^, Li X^, He J, Li XX, Ng SM, Yu C, Gao Z, Yang J, Li M, Wang Q, Liang Q, Pan Y, Tong JH, To KF, Wong N, Zhang N, Chen J, Lu Y, Lai PBS, Chan FKL, Li Y, Kung HF, Yang H, Wang J, Sung JJY (2015) Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer. Gut 64(4):636-45.
- Nakatsu G^, Li X^, Zhou H^, Sheng J^, Wong SH^, Wu WKK^, Ng SC, Tsoi H, Dong Y, Zhang N, He Y, Kang Q, Cao L, Wang K, Zhang J, Liang Q, Yu J, Sung JJY (2015) Gut mucosal microbiome across stages of colorectal carcinogenesis. Nat Commun 6:8727.
- Shen J^, Xiao Z^, Wu WKK*, Wang MH, To KF, Chen Y, Yang W, Li MSM, Shin VY, Tong JH, Zhang L, Li M, Wang L, Lu L, Chan RLY, Wong SH, Yu J, Chan MTV, Chan FKL, Sung JJY, Cheng ASL*, Cho CH (2015) Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis. Cancer Res 75(4):754-65.
- Li Z, Yu X, Shen J, Law PTY, Chan MTV, Wu WKK (2015) MicroRNA expression and its implications for diagnosis and therapy of gallbladder cancer. Oncotarget 6(16):13914-24.
- Liu X, Tian Y, Meng Z, Chen Y, Ho IHT, Choy KW, Lichtner P, Wong SH, Yu J, Gin T, Wu WKK#, Cheng CHK#, Chan MTV# (2015) Upregulation of cathepsin G in dorsal horns contributes to pain hypersensitivity: An experimental and clinical genetic study. Anesthesiology 123(4):838-50. (#joint senior authorship)
- Li Z, Shen J, Li Q, Chan MTV, Wu WKK (2015) Drug fever induced by Piperacillin/Tazobactam in a scoliosis patient: A case report. Medicine 94(46):e1875.
- Yu X, Li Z, Chan MTV, Wu WKK (2015) PAQR3: A novel tumor suppressor gene. Am J Cancer Res 5(9):2562-2568.
- Luo MXM, Wong SH, Chan MTV, Yu L, Yu SSB, Wu F, Xiao Z, Wang X, Zhang L, Cheng ASL, Ng SSM, Chan FKL, Cho CH, Yu J, Sung JJY*, Wu WKK* (2015) Autophagy mediates HBx-induced nuclear factor-?B activation and release of IL-6, IL-8 and CXCL2 in hepatocytes. J Cell Physiol 230(10):2382-9.
- Chen X, Dong CG*, Law PT, Chan MTV, Wang S, Su Z, Wu WKK*, Xu H* (2015) MicroRNA-145 targets TRIM2 and exerts tumor-suppressing functions in epithelial ovarian cancer. Gynecol Oncol 139(3):513-19.
- Wang L, Hu T, Shen J, Zhang L, Chan RLY, Lu L, Li MX, Cho CH, Wu WKK (2015) Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer. Phytomedicine 22(12):1079-87.
- Yu X, Li Z, Chan MTV, Wu WKK (2015) MicroRNA deregulation in keloids: An opportunity for clinical intervention? Cell Prolif 48(6):626-30.
- Yu X, Li Z, Yu J, Chan MTV, Wu WKK (2015) MicroRNAs predict and modulate response to chemotherapy in colorectal cancer. Cell Prolif 48(5):503-10.
- Li Z, Yu X, Shen J, Liu Y, Chan MTV, Wu WKK (2015) MicroRNA dysregulation in rhabdomyosarcoma: a new player enters the game. Cell Prolif 48(5):511-6.
- Li Z, Yu X, Shen J, Chan MTV, Wu WKK (2015) MicroRNA in intervertebral disc degeneration. Cell Prolif 48(3):278-83.
- Yu X, Li Z, Chen G, Wu WKK (2015) MicroRNA-10b induces vascular muscle cell proliferation through Akt pathway by targeting TIP30. Curr Vasc Pharmacol 13(5):679-86.
- Yu X, Li Z, Wu WKK (2015) TIP30: A novel tumor-suppressor gene. Oncol Res 22:339-48.
- Cho CH, Yu J, Zhang L, Wu WKK (2015) The role of cathelicidin in control of Helicobacter pylori colonisation in the stomach. Hong Kong Med J 21 Suppl 4:17-9.
- Lu L, Li ZJ, Li LF, Wu WKK, Shen J, Zhang L, Chan RLY, Yu L, Liu YW, Ren SX, Chan KM, Cho CH (2015) Vascular-targeted TNFa enhances vascular function and benefits antitumor immunotherapy in colorectal cancer. J Control Release 210:134-46.
- Li Z, Yu X, Wang Y, Shen J, Wu WKK, Liang J, Feng F (2015) By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth. Oncotarget 6(19):17559-69.
- Liu X, Dong C, Jiang Z, Wu WKK, Chan MTV, Zhang J, Li H, Qin K, Sun X (2015) MicroRNA-10b downregulation mediates acute rejection of renal allografts by derepressing BCL2L11. Exp Cell Res 333(1):155-63.
- Hu T, Wang L, Zhang L, Lu L, Shen J, Chan RLY, Li M, Wu WKK, To KKW, Cho CH (2015) Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity. Phytomedicine 22(5):536-44.
- Li Z, Yu X, Shen J, Wu WKK, Chan MTV (2015) MicroRNA expression and its clinical implications in Ewing’s sarcoma. Cell Prolif 48(1):1-6.
- Chan MTV, Wu WKK, Tang RSY (2015) Optimizing depth of sedation for colonoscopy. Can J Anaesth 62(11):1143-1148.
- Yu C^, Yu J^, Yao X^, Wu WKK^, Lu Y^, Li X, Tang S, Li B, Li X, Hou Y, Wu R, Jian M, Wu H, Chen Y, Xu L, Fan F, He J, Liang Q, Wang H, Hu X, He M, Zhang X, Zheng H, Li Q, Yang X, Zhu S, Chen R, Zhang F, Xu X, Yang H, Wang J, Zhang X, Sung JJY, Li Y, Wang J (2014) Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing. Cell Res 24(6):701-12.
- Zhang L, Sung JJY, Yu J, Ng SC, Wong SH, Cho CH, Ng SSM, Chan FK*, Wu WKK* (2014) Xenophagy in Helicobacter pylori- and Epstein-Barr virus-induced gastric cancer. J Pathol 233(2):103-112.
- Wu WKK*, Sung JJY, Cheng ASL, Chan FK, Ng SSM, To KF, Wang XJ, Yu J, Cho CH* (2014) The Janus face of cathelicidin in tumorigenesis. Curr Med Chem 21(21):2392-400.
- Li Z, Yu X, Liang J, Yu J, Wu WKK, Shen J (2014) Leptin downregulates aggrecan through the p38-ADAMST pathway in human nucleus pulposus cells. PLoS ONE 9(10):e109595.
- Liu H, Zhang G, Zhu W, Wu WKK, Ba Q, Zhang L, Zhang L, Niu N, Ma S, Wang J (2014) Differential proteomic analysis of polyubiquitin-related proteins in chemical hybridization agent-induced wheat (Triticum aestivum L.) male sterility. Acta Physiol Plant 36(6):1473-89.
- Li LF, Chan RLY, Lu L, Shen J, Zhang L, Wu WKK, Wang L, Hu T, Li MX, Cho CH (2014) Cigarette smoking and gastrointestinal diseases: The causal relationship and underlying molecular mechanisms (Review). Int J Mol Med 34(2):372-80.
- Lu L, Chan RLY, Luo XM, Wu WKK, Shin VY, Cho CH (2014) Animal models of gastrointestinal inflammation and cancer. Life Sci 108(1):1-6.
- Cho CH, Wu WKK, Xia J (2014) Current advances in peptides for cancer diagnosis and therapy. Curr Med Chem 21(21):2331.
- Li Z, Liang J, Wu WKK, Yu X, Yu J, Weng X, Shen J (2014) Leptin activates RhoA/ROCK pathway to induce cytoskeleton remodeling in nucleus pulposus cells. Int J Mol Sci 15(1):1176-88.
- Wang C, Wu WKK, Liu X, To KF, Chen GG, Yu J, Ng EKW (2014) Increased serum chemerin level promotes cellular invasiveness in gastric cancer: a clinical and experimental study. Peptides 51:131-138.
- Wong XJ, Yu J*, Wong, SH, Cheng ASL, Chan FKL, Ng SSM, Cho CH, Sung JJY*, Wu WKK* (2013) A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy. Autophagy 9(10):1500-08.
- Wong SH, Sung JJY*, Chan FKL, To KF, Ng SSM, Wang XJ, Yu J*, Wu WKK* (2013) Genome-wide association and sequencing studies on colorectal cancer. Semin Cancer Biol 23(6 Pt B):502-511.
- Wu WKK*, Sung JJY (2013) Focus on gastrointestinal & liver cancers. Semin Cancer Biol 23(6 Pt B):469-470.
- Zhang L, Yu J, Wong CCM, Ling TKW, Li ZJ, Chan KM, Ren SX, Shen J, Chan RLY, Lee CC, Li MSL, Cheng ASL, To KF, Gallo RL, Sung JJY, Wu WKK*, Cho CH* (2013) Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice. Gene Ther 20(7):751-60.
- Tai EKK^, Wu WKK^, Wang XJ, Wong HPS, Yu L, Li ZJ, Lee CW, Wong CCM, Yu J, Sung JJY, Gallo RL, Cho CH (2013) Intrarectal administration of mCRAMP-encoding plasmid reverses exacerbated colitis in Cnlp-/- mice. Gene Ther 20(2):187-93.
- Wu WKK^, Wang XJ^, Cheng ASL, Luo MXM, Ng SSM, To KF, Chan FKL, Cho CH, Sung JJY, Yu J (2013) Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis. Crit Rev Oncol Hematol 86(3):251-77.
- Ren SX, Shen J, Cheng ASL, Lu L, Chan RLY, Li ZJ, Wang XJ, Wong CCM, Zhang L, Ng SSM, Chan FL, Chan FKL, Yu J, Sung JJY, Wu WKK*, Cho CH (2013) FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PLoS ONE 8(5):e63641.
- Dong CG^, Wu WKK^, Feng SY^, Yu J, Shao JF, He GM (2013) Suppressing the malignant phenotypes of glioma cells by lentiviral delivery of small hairpin RNA targeting hypoxia-inducible factor-1a. Int J Clin Exp Pathol 6(11):2323-32.
- Wang L, Yeung JH, Hu T, Lee WY, Lu L, Zhang L, Shen J, Chan RL, Wu WKK, Cho CH (2013) Dihydrotanshinone induces p53 independent but ROS dependent apoptosis in colon cancer cells. Life Sci 93(8):344-51.
- Chow JYC, Li ZJ, Wu WKK, Cho CH (2013) Cathelicidin a potential therapeutic peptide for gastrointestinal inflammation and cancer. World J Gastroenterol 19(18):2731-5.
- Li Z, Shen J, Wu WKK, Yu X, Liang J, Qiu G, Liu J (2013) The role of leptin on the organization and expression of cytoskeleton elements in nucleus pulposus cells. J Orthop Res 31(6):847-57.
- Shen J, Wu WKK, Ren SX, Zhang L, Chan RL, Wong CC, Lu L, Cho CH (2013) miRNAs in Gastrointestinal and Liver Cancers: Their Perspectives and Clinical Applications. Curr Pharm Des 19(7):1301-10.
- Yu X, Li Z, Shen J, Wu WKK, Liang J, Weng X, Qiu G (2013) MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. PLoS ONE 8(12):e83080.
- Ren SX, Cheng ASL, To KF, Tong JHM, Li MS, Shen J, Wong CCM, Zhang L, Chan RLY, Wang XJ, Ng SSM, Chiu LCM, Marquez VE, Gallo RL, Chan FKL, Yu J, Sung JJY, Wu WKK*, Cho CH (2012) Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res 72(24):6512-23.
- Wu WKK*, Coffelt SB, Cho CH, Wang XJ, Lee CW, Chan FKL, Yu J*, Sung JJY* (2012) The autophagic paradox in cancer therapy. Oncogene 31(8):939-53.
- Wu WKK* (2012) Targeting proteasomal protein degradation in cancer-Letter. Clin Cancer Res 18(3):912.
- Wu YC, Wang XJ, Yu L, Chan FKL, Cheng ASL, Yu J, Sung JJY, Wu WKK*, Cho CH (2012) Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells. PLoS ONE 7(5):e37572.
- Wu WKK, Yu J (2012) Dysregulation of cellular signaling in colorectal cancer. In: Signaling, Gene Regulation and Cancer pp. 137-172 Hauppauge: Nova Science Publishers
- Wu WKK, Sung JJY (2012) MicroRNA dysregulations in gastrointestinal Cancers: Pathophysiological and clinical perspectives. Intest Res 10(4):324-331.
- Li Z, Shen J, Wu WKK, Yu X, Liang J, Qiu G, Liu J (2012) Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/Akt and MEK/ERK pathways. PLoS ONE 7(12):e53176.
- Li Z, Shen J, Wu WKK, Wang X, Liang J, Qiu G, Liu J (2012) Vitamin A deficiency induces congenital spinal deformities in rats. PLoS ONE 7(10):e46565.
- Fan Q, He M, Deng X, Wu WKK, Zhao L, Tang J, Wen G, Sun X, Liu Y (2012) Derepression of c-Fos caused by MicroRNA-139 down-regulation contributes to the metastasis of human hepatocellular carcinoma. Cell Biochem Function 30(4):271-8.
- Dong CG, Wu WKK, Feng SY, Wang XJ, Shao JF, Qiao J (2012) Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells. Int J Oncol 41(3):1005-12.
- Klionsky DJ, et al. Wu WKK, et al. (2012) Guides for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4):445-544.
- Feng SY, Dong CG, Wu WKK, Wang XJ, Qiao J, Shao JF (2012) Lentiviral expression of anti-microRNAs targeting miR-27a inhibits proliferation and invasiveness of U87 glioma cells. Mol Med Report 6(2):275-81.
- Wong CCM, Zhang L, Li ZJ, Wu WKK, Ren SX, Chen YC, Ng TB, Cho CH (2012) Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis. J Gastroenterol Hepatol 27(7):1205-12.
- Liu Y, Song F, Wu WKK, He M, Zhao L, Sun X, Li H, Jiang Y, Yang Y, Peng K (2012) Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon. Cell Biochem Function 30(4):271-8.
- Zhang L, Ren JW, Wong CCM, Wu WKK, Ren SX, Shen J, Chan RLY, Cho CH (2012) Effects of cigarette smoke and its active components on ulcer formation and healing in the gastrointestinal mucosa. Curr Med Chem 19(1):63-9.
- Wu WKK^, Law PT^, Lee CW, Cho CH, Fan D, Wu K, Yu J, Sung JJY (2011) MicroRNA in colorectal cancer: from benchtop to bedside. Carcinogenesis 32(3):247-253.
- Wu WKK, Lee CW, Cho CH, Chan FKL, Yu J, Sung JJY (2011) RNA interference targeting raptor inhibits proliferation of gastric cancer cells. Exp Cell Res 317(10):1353-8.�
- Wong HP, Ho JW, Koo MW, Yu L, Wu WKK, Lam EK, Tai EK, Ko JK, Shin VY, Chu KM, Cho CH (2011) Effects of adrenaline in human colon adenocarcinoma HT-29 cells. Life Sci 88(25-26):1108-12.
- Ye CG, Wu WKK, Yeung JHK, Li HT, Li ZJ, Wong CCM, Ren SX, Zhang L, Fung KP, Cho CH (2011) Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein and MRP1 expression. Cancer Lett 304(2):90-6.
- Dong Y, Wu WKK, Wu CW, Sung JJY, Yu J, Ng SSM (2011) MicroRNA dysregulation in colorectal cancer: a clinical perspective. Br J Cancer 104(6):893-8.
- Li X, Wu WKK, Sun B, Cui M, Liu S, Gao J, Lou H (2011) Dihydroptychantol A,a macrocyclic bisbibenzyl derivative,induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells. Toxicol Appl Pharmacol 251(2):146-54.
- Li X, Zhao Y, Wu WKK, Liu S, Cui M, Lou H (2011) Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. Life Sci 88(7-8):314-21.
- Liang J, Feng J, Wu WKK, Wu Z, Han D, Zhu Y, Qiu G (2011) Leptin-mediated cytoskeletal remodeling in chondrocytes via the RhoA/ROCK pathway. J Orthop Res 29(3): 369-374.
- Wu WKK*, Cho CH*, Wu YC, Yu L, Li ZJ, Lee CW, Wong CCM, Li HT, Zhang L, Ren SX, Che CT, Wu K, Fan D, Yu J, Sung JJY* (2010) Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy 6(2):228-238.
- Wu WKK*, Sakamoto KM, Milani M, Aldana-Masankgay G, Fan D, Wu K, Lee CW, Cho CH, Yu J, Sung JJY* (2010) Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy. Drug Resist Updat 13(3):87-92.
- Wu WKK, Lee CW, Cho CH, Fan D, Wu K, Yu J, Sung JJY (2010) MicroRNA dysregulation in gastric cancer: A new player enters the game. Oncogene 29(43):5761-71.
- Wu WKK*, Sung JJY, Lee CW, Yu J, Cho CH* (2010) Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: an update on the molecular mechanisms. Cancer Lett 295(1):7-16.
- Wu WKK*, Cho CH, Lee CW, Fan D, Wu K, Yu J, Sung JJY* (2010) Dysregulation of cellular signaling in gastric cancer. Cancer Lett 295(2):144-153.
- Wu WKK, Cho CH, Lee CW, Wu K, Fan D, Yu J, Sung JJY (2010) Proteasome inhibition: a new strategy to cancer treatment. Cancer Lett 293(1):15-22.
- Wu WKK^*, Wang G^, Coffelt SB^, Betancourt AM, Lee CW, Fan D, Wu K, Yu J, Sung JJY, Cho CH* (2010) Emerging roles of the host defense peptide LL-37 in human cancers and its potential therapeutic applications. Int J Cancer 127(8):1741-7.
- Wu WKK*, Sung JJY, To KF, Yu L, Chu KM, Yu J, Cho CH* (2010) The host defense peptide LL-37 activates the tumor-suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells. J Cell Physiol 223(1):178-86.
- Wu WKK, Wong CC, Li ZJ, Zhang L, Ren SX, Cho CH (2010) Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders. Act Pharmacol Sin 31(9):1118-22.
- Li ZJ, Wu WKK, Ng SS, Yu L, Li HT, Wong CC, Wu YC, Zhang L, Ren SX, Sun XG, Chan KM, Cho CH (2010) A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery. J Control Release 148(3):292-302.
- Tang J, Sun Y, Wu WKK, Zhong T, Liu Y, Xiao J, Tao T, Zhao Z, Gu M (2010) Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats. Biochim Biophys Act - Proteins & Proteomics 1804(9):1895-901.
- Yu J, Ma X, Cheung KF, Li X, Tian L, Wang S, Wu CW, Wu WKK, He ML, Wang M, Ng SS, Sung JJY (2010) Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer. Oncogene 29(49):6464-74.
- Li H, Wu WKK, Li ZJ, Chan KM, Wong CCM, Ye CG, Yu L, Sung JJY, Cho CH, Wang M (2010) 2,3',4,4',5'-Pentamethoxy-trans-stilbene, a resveratrol derivative, inhibits colitis-associated colorectal carcinogenesis in mice. Br J Pharmacol 160(6):1352-61.
- Li H, Wu WKK, Zheng Z, Che CT, Li ZJ, Xu DD, Wong CCM, Ye CG, Sung JJY, Cho CH, Wang M (2010) 3,3',4,5,5'-Pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress. Eur J Pharmacol 637(1-3):55-61.
- Olaleye SB, Wu KK, Cho CH (2010) Catecholamines Inhibit Gastric Epithelial [RGM-1] Cell Proliferation via Beta Adrenoceptors. Niger J Physiol Sci 25(1):5-16.
- Olaleye SB, Onasanwo SA, Ige AO, Wu KK, Cho CH (2010) Anti-inflammatory activities of kolaviron-inhibition of nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha production in activated macrophage-like cell line. Afr J Med Med Sci 39 Suppl: 41-6.
- Wu WKK, Volta V, Cho CH, Wu YC, Li HT, Yu L, Li ZJ, Sung JJY (2009) Repression of protein translation and mTOR signaling by proteasome inhibitor in colon cancer cells. Biochem Biophys Res Commun 386(4):598-601.
- Wu WKK, Sung JJY, Wu YC, Li HT, Yu L, Li ZJ, Cho CH (2009) Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells. Biochem Biophys Res Commun 382(1):79-84.
- Wu YC^, Wu WKK^, Li Y, Yu L, Li ZJ, Wong CC, Li HT, Sung JJY, Cho CH (2009) Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells. Biochem Biophys Res Commun 382(2):541-6.
- Wu WKK, Tse TT, Sung JJ, Li ZJ, Yu L, Cho CH (2009) Expression of ErbB receptors and their cognate ligands in gastric and colon cancer cell lines. Anticancer Res 29(1):229-34.
- Yu L, Wu WKK, Li ZJ, Li HT, Wu YC, Cho CH (2009) Prostaglandin E2 promotes cell proliferation via protein kinase C / extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells. Int J Cancer 125(11):2540-2546.
- Li H, Wu WKK, Zheng Z, Che CT, Yu L, Li ZJ, Wu YC, Cheng KW, Yu J, Cho CH, Wang M (2009) 2,3’,4,4’,5’-Pentamethoxy-trans-stilbene, a resveratrol derivative, is a potent inducer of apoptosis in colon cancer cells via targeting microtubules. Biochem Pharmacol 78(9):1224-32.
- Yu L, Wu WKK, Li ZJ, Liu QC, Li HT, Wu YC, Cho CH (2009) Enhancement of doxorubicin cytotoxicity on human esophageal squamous cell carcinoma cells by indomethacin and SC236 via inhibiting P-glycoprotein activity. Mol Pharmacol 75(6):1364-73.
- Tsoi KK, Pau CY, Wu WKK, Chan FK, Griffiths S, Sung JJY (2009) Cigarette smoking and the risk of colorectal cancer: a meta-analysis of prospective cohort studies. Clin Gastroenterol Hepatol 7(6):682-8.
- Wong HP, Li ZJ, Shin VY, Tai EK, Wu WKK, Yu L, Cho CH (2009) Effects of cigarette smoking and restraint stress on human colon tumor growth in mice. Digestion 80(4):209-14.
- Li P, Wu WKK, Wong HP, Zhang ST, Yu L, Cho CH (2009) Chloroform extract of cigarette smoke induces proliferation of human esophageal squamous-cell carcinoma cells: modulation by beta-adrenoceptors. Drug Chem Toxicol 32(3):175-81.
- Wu WKK, Sung JJY, Wu YC, Li ZJ, Yu L, Cho CH (2008) Bone morphogenetic protein signalling is required for the anti-mitogenic effect of the proteasome inhibitor MG-132 on colon cancer cells. Br J Pharmacol 154(3):632-8.
- Liu X^, Wu WKK^, Yu L, Li ZJ, Sung JJY, Zhang ST, Cho CH (2008) Epidermal growth factor-induced esophageal cancer cell proliferation requires transactivation of beta-adrenoceptors. J Pharmacol Exp Ther 326(1):69-75.
- Liu X^, Wu WKK^, Yu L, Sung JJY, Srivastava G, Zhang ST, Cho CH (2008) Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway. J Cell Biochem 105(1):53-60.
- Wu WKK, Sung JJY, Yu L, Li ZJ, Chu KM, Cho CH (2008) Constitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma. Biochem Biophys Res Commun 373(2):330-4.
- Wu WKK, Sung JJY, Yu L, Cho CH (2008) Proteasome inhibitor MG-132 lowers gastric adenocarcinoma TMK1 cell proliferation via bone morphogenetic protein signaling. Biochem Biophys Res Commun 371(2):209-14.
- Wu WKK, Wu YC, Yu L, Li ZJ, Sung JJY, Cho CH (2008) Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells. Biochem Biophys Res Commun 374(2):258-63.
- Wu WKK, Li GR, Wong TM, Wang JY, Yu L, Cho CH (2008) Involvement of voltage-gated K+ and Na+ channels in gastric epithelial cell migration. Mol Cell Biochem 308(1-2):219-26.
- Yu L, Wu WKK, Li ZJ, Wong HPS, Tai EKK, Li HT, Wu YC, Cho CH (2008) E series of prostaglandin receptor 2-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma. J Pharmacol Exp Ther 327(1):258-67.
- Tai EKK, Wong HPS, Lam EKY, Wu WKK, Yu L, Koo MW, Cho CH (2008) Cathelicidin stimulates colonic mucus synthesis by up-regulating MUC1 and MUC2 expression through a mitogen-activated protein kinase pathway. J Cell Biochem 104(1):251-8.
- Wu WKK, Law PT, Wong HPS, Lam EKY, Tai EKK, Shin VY, Cho CH (2007) Shift of homeostasis from parenchymal regeneration to fibroblast proliferation induced by lipopolysaccharide-activated macrophages in gastric mucosal healing in vitro. Wound Repair Regen 15(2):221-6.
- Tai EKK, Wu WKK, Wong HPS, Lam EKY, Yu L, Cho CH (2007) A new role for cathelicidin in ulcerative colitis in mice. Exp Biol Med 232(6):799-808.
- Lam EK, Tai EK, Koo MW, Wong HP, Wu WKK, Yu L, So WH, Woo PC, Cho CH (2007) Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG. Life Sci 80(23):2128-36.
- Shin VY, Wu WKK, Chu KM, Koo MWL, Wong HPS, Lam EKY, Tai EKK, Cho CH (2007) Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. Toxicol Sci 96(1):21-9.
- Wong HPS, Yu L, Lam EKY, Tai EKK, Wu WKK, Cho CH (2007) Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells. Toxicol Appl Pharmacol 221(3):261-7.
- Lam EKY, Yu L, Wong HPS, Wu WKK, Shin VY, Tai EKK, So WH, Woo PC, Cho CH (2007) Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats. Eur J Pharmacol 565 (1-3):171-9.
- Wong HPS, Yu L, Lam EK, Tai EKY, Wu WKK, Cho CH (2007) Nicotine promotes colon tumor growth and angiogenesis through beta-adrenergic activation. Toxicol Sci 97(2):279-87.
- Liu ES, Ye YN, Shin VY, Wu WKK, Wong BC, Cho CH (2007) Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice. Cancer Invest 25(8):750-7.
- Wu WKK, Li GR, Wong HPS, Hui MKC, Tai EKK, Lam EKY, Shin VY, Ye YN, Li P, Yang YH, Luo JC, Cho CH (2006) Involvement of Kv1.1 and Nav1.5 in proliferation of gastric epithelial cells. J Cell Physiol 207(2):437-44.
- Yang YH^, Wu WKK^, Tai EKK, Wong HPS, Lam EKY, So WHL, Shin VY, Cho CH (2006) The cationic host defense peptide rCRAMP promotes gastric ulcer healing in rats. J Pharmacol Exp Ther 318(2):547-54.
- Wu WKK, Shin VY, Ye YN, Wong HP, Huang FY, Hui MK, Lam EK, Cho CH (2006) Heparin increases human gastric carcinoma cell growth. Anticancer Res 26(1A):439-43.
- Wu WKK, Wong HPS, Yu L, Cho CH (2006) Nicotine and cancer. In: Alcohol, Tobacco, and Cancer pp. 253-267 Basel: Karger
- Hui MK, Wu WKK, Shin VY, So WH, Cho CH (2006) Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice. Int J Med Sci 3(1):1-6.
- Wu WKK^, Wong HPS^, Luo SW, Chan K, Huang FY, Hui MKC, Lam EKY, Shin VY, Ye YN, Yang YH, Cho CH (2005) 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors. Cancer Res 65(12):5272-7.
- Shin VY, Wu WKK, Chu KM, Wong HPS, Lam EKY, Tai EKK, Koo MWL, Cho CH (2005) Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Mol Cancer Res 3(11):607-15.
- Ye YN, Wu WKK, Shin VY, Cho CH (2005) A mechanistic study of colon cancer growth promoted by cigarette smoke extract. Eur J Pharmacol 519(1-2):52-7.
- Liu ES, Shin VY, Ye YN, Luo JC, Wu WKK, Cho CH (2005) Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract. Eur J Pharmacol 518(1):47-55.
- Ye YN, Wu WKK, Shin VY, Bruce IC, Wong BCY, Cho CH (2005) Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. Carcinogenesis 26(4):827-34.
- Luo JC, Shin VY, Yang YH, Wu WKK, Ye YN, So WH, Chang FY, Cho CH (2005) Tumor necrosis factor-alpha stimulates gastric epithelial cell proliferation. Am J Physiol Gastrointest Liver Physiol 288(1):G32-8.
- Wu WKK, Cho CH (2004) The pharmacological actions of nicotine on the gastrointestinal tract. J Pharmacol Sci 94(4):348-58.
- Ye YN, Liu ES, Shin VY, Wu WKK, Cho CH (2004) Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking. Toxicology 203(1-3):179-88.
- Shin VY, Wu WKK, Ye YN, So WHL, Koo MWL, Liu ESL, Luo JC, Cho CH (2004) Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2. Carcinogenesis 25(12):2487-95.
- Ye YN, Liu ES, Shin VY, Wu WKK, Cho CH (2004) The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. J Pharmacol Exp Ther 311(1):123-30.
- Luo JC, Shin VY, Liu ES, Ye YN, Wu WKK, So WH, Chang FY, Cho CH (2004) Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs. Eur J Pharmacol 485(1-3):275-81.
- Ye YN, Liu ES, Shin VY, Wu WKK, Luo JC, Cho CH (2004) Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway. J Pharmacol Exp Ther 308(1):66-72.
- Cho CH, Wu KK, Wu S, Wong TM, So WH, Liu ES, Chu KM, Shin VY, Ye YN, Wong BC (2003) Morphine as a drug for stress ulcer prevention and healing in the stomach. Eur J Pharmacol 460(2-3):177-82.
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