Demand on your CARE: Combating frailty and sarcopenia
Frailty and sarcopenia become increasingly prevalent with age, leading to a decline in quality of life and loss of independence among older adults. Fortunately, frailty and sarcopenia can be reversed through diet and exercise. Taking this course will help you understand the causes, assessments, nutritional and exercise interventions of frailty and sarcopenia.
Chapter 1
Understanding frailty and sarcopenia
Understanding Frailty
Working Out to Combat Frailty
Brain-training to Combat Frailty
Understanding Sarcopenia
Reverse Sacropenia by Muscle Building Excerise
Preventing Sarcopenia
Frailty and sarcopenia
Content
What is healthy ageing?
What is frailty?
How to identify frailty?
What is sarcopenia?
How to diagnose sarcopenia?
Interventions for frailty and sarcopenia
What is Healthy Ageing?
Process of developing and maintaining functional ability that enables well being of older age (WHO, 2020)
Image source from : https://www.hkhs.com/en/our-business/elderly-housing
The HIGHLIGHT ---- Focus on Functioning
ie. Interactions between individual (intrinsic capacity) and the environment (including physical environment and supporting systems)
Image source from : https://www.futuregen.solutions/2016/08/16/the-shameful-case-of-elder-abuse-in-society/ &
https://thediplomat.com/2019/11/how-does-japans-aging-society-affect-its-economy/
Intrinsic Capacity and function
A-B: denotes impact of environmental factors
C-D: higher baseline level allows more reserve to lose before requiring assistance
E: Accelerated decline because unfavourable lifestyle or disease state
F: restoration / reversal attempts
Healthy Ageing: Building up intrinsic capacity / slow down decline
Modifiable factors
Healthy dieting and good nutrition (cross ref to Chapter 2)
Regular exercise / physical activities (cross ref to Chapter 3)
Maintain mental health
Disease prevention / good disease control
Active life engagement with others and society
Non-modifiable factors
Genetic composition
Sex
Chronological age
From Healthy Ageing to Frailty
Convention scientific approach
Image source from : http://www.intra-lifestyles.eu/intra-supports-bodys-eight-8-biological-systems/
Individual system
Individual disease
One man, one disease model
Linear model (A ➡ B)
Individual disease management
Limitations on use of conventional approach to older adults (1)
No tissue /system is free from ageing (though varies between individual, and among organs of same individual)
With age, increase in multi-system (instead of single disease / system) involvement leading to ➡ function limitation
Limitations on use of conventional approach to older adults (2)
Proper functioning (remember: WHO defines health in term of functioning) depends on multiple systems interacting together
A person may have reduced exercise capacity because of heart problem, lung problem, joint problem, muscle problem, mood problem, or any combinations of each of the problems in variable degree
Convention single disease model has great limitation in older adults
Knowledge from animal studies
Caloric Restriction in mice
• Extended life span by 50%
• Die without apparent diseases
Measurement on number of dysfunctions (irrespective of which) predictive of death
• Deficit accumulation of multiple etiologies
• Reduced reserved (intrinsic capacity)
• Increased vulnerability to stress
Ageing and Frailty
Multi-dimensional aspect of health
Gradual decline over time
High intrinsic capacity / resilience
➡ protect from frailty
➡ healthy aging
Any breakdown
➡ accelerated decline and dependency
Image source from : https://www.hindawi.com/journals/jar/2019/2573239/
Key concepts in Frailty (multiple physiological systems)
Though it may manifest as a physical dimension (e.g. walking problems), underlying issues are multi-dimension and can go across cognitive and social dimension
For research purposes, some authors would like to classify Frailty into
• Physical frailty
• Cognitive frailty
• Social frailty
(Let's focus on healthcare related aspects of frailty)
Image source from : https://www.researchgate.net/figure/fig1_318351153
Key Concepts (decline in reserve)
Image source from : https://link.springer.com/chapter/10.1007/978-981-13-8938-2_1
A decline in intrinsic capacity (reserve) over time (see previous slide)
Implication
• There exists "sub-clinical" ("Pre-frail") with diminishing reserve yet not manifested
➡ allow window time to detect and reverse
Key Concepts in Frailty (Biological but not chronological age)
Although frailty will ultimately set in (unless one dies early), it can be delayed with healthy ageing activities till very old
(see previous slide)
Biological age is more important than chronologic age
Image source from : https://vee-uye.com/
Impacts of Frailty
Image source from : https://vee-uye.com/
It is associated with adverse outcome
• Slower recovery rate
• May not recover to as before
• Excess mortality
Precipitation of geriatric syndrome
• Delirium
• Falls
• Failure to thrive
• Immobility, not coping / dependency
Importance on early identification for
• Preventing complications
• Optimize management plan
(to be discussed later)
Key concept in Frailty (frailty and functioning)
Frailty as "A clinical state of …. decline in reserve and function across multiple physiological systems …."
NOT to be confused with
• Disability / limitation in self care
• Sarcopenia (loss of muscle and loss of function) (to be discussed later)
Disability and Frailty ... Imagine two persons who cannot walk without aids
Person A
• Baseline: independent
• Road traffic accident with below knee amputation (BKA)
• Disability in ambulation: Walks with prothesis or hop with elbow crutches
Person B
• Baseline: osteoarthritis right knee, used to walk slowly
• Now has a cerebrovascular accident with right side lower limb power 4/5
• Sustain fracture hip during acute CVA with leg length discrepancy
• Disability in ambulation: walks with frame
Both cannot walk without aids (similar disability)
• Are the mechanisms leading to the disability similar?
Disability and Frailty...
For A
• Is NOT frail though loss of ambulation (self care limitation, disability) because of single factor involvement (loss of leg as support)
For B
• For each of the risk factor alone (OA knee, CVA, leg length discrepancy) , B may still manage to walk with compensatory mechanism
• Yet, the multiple little impairment in each aspect contribute to the inability to walk (ie. loss of reciprocal compensation)
• B has frailty because lack of reserve and function across multiple physiological system
Key Concepts (frailty ≠ disabilities)
How common is Frailty?
Depends on criteria, setting and groups of subjects chosen
• US (Fried et al., 2012)
9.9%
• Asia Pacific region
3.5 – 27%
• Hong Kong (Woo et al., 2015)
12.5%
• Singapore (Chong et al., 2017)
6%
(Woo et al., 2015) Robust = FRAIL score 0, Prefrail = FRAIL score 1-2, Frail = FRAIL score 3-5
FRAIL score to be discussed at later slides
What to do after diagnosis of Sarcopenia / Frailty
A recap on their relationship
(Cruz-Jentoft et al., 2019)
A recap on their relationship
(Bentov et al., 2019)
What to do after diagnosis of sarcopenia and / or frailty?
Review for possible secondary causes
• Intentional weight loss / dietary restriction
• Review intake and contribution factor (e.g. social isolation with malnutrition, poor denture)
• Review control of medical conditions (e.g. DM)
• Review medication list to avoid iatrogenesis (e.g. hypotension)
• Review lifestyle
• sedentary lifestyle predisposed to accelerated muscle loss
• fatigue from disease (e.g. anemia, hypothyroid, depression)
STRONG Recommendations for primary sarcopenia / frailty
• (Graded) Resistive exercise to improve muscle mass and strength (eg. Vivifrail exercise)
• Protein / caloric supplementation with high protein diet
• To couple with resistive exercise
• Up to 1.2gm/kg/day
• Vitamin D supplement if Vitamin D deficit
Conditional recommendation (preliminary data available but need further studies) on individual nutrient supplements
• Vitamin D if not at deficit state
• B-hydroxy B-methylbutyrate (HMB) (an essential amino acid)
• Whey protein after resistive exercise
The above resistive exercise and high protein diet tackles physical frailty
Psychological frailty, and social frailty need to be addressd
Psychological Frailty
Refers to impairments in various areas, such as mood, cognition and motivational components
A consequence of age-altered brain function
Reduction in cognitive reserve>>>cognitive frailty
Loss of resilience and adaptability in the domain of brain function
Physical frailty has implication in cognitive function
>>> health outcomes
(Fitten, 2015)
Cognitive Frailty
The concept of cognitive frailty
linked to a reduction in cognitive 'reserve';
characterized by the coexistence of physical frailty and cognitive impairment (Clinical Dementia Rating [CDR] = 0.5);
and exclusion of concurrent Alzheimer's disease or other dementias (Kelaiditi et al., 2013)
Social Frailty
A state of being at risk of losing (or having already lost) resources that are essential for meeting one or more basic social demands.
Living alone, not having a friend and family support, socially isolated could have a severe impact on psychological well-being.
Interventions
Aim to improve psychosocial wellbeing concerning emotion, social, mental and spiritual domains
Long term community-based with multidimensional training activities
Cognitive Training
• Enhance attention and information processing, stimulate short-term memory, reasoning and problem-solving abilities
• Gerontecnology e.g. computer games, VR programme etc. Click here for more information
Age-friendly community
• Create supportive environment
• Community resources
Facilitating frail older adults in social participation
Social inclusion and participation
• Paid or unpaid work
• Enhance social connections
Social campaigns
• Arouse public awareness of age-related frailty and pre-frailty
• Early identification and intervention
Improve resilience
• Increase intrinsic capabilities to cope with stressors
Suggest healthy lifestyle to avoid or delay decline
Better still ... to improve resilience
Suggested reading
Professional training materials of Cadenza Training programme
Promoting Psychosocial and Spiritual Well-being of Older People
Reference
Asgar, A. W., Ouzounian, M., Adams, C., Afilalo, J., Fremes, S., Lauck, S., … Webb, J. G. (2019). 2019 Canadian cardiovascular society position statement for Transcatheter aortic valve implantation. Canadian Journal of Cardiology, 35(11), 1437-1448. doi:10.1016/j.cjca.2019.08.011
Bentov, I., Kaplan, S. J., Pham, T. N., & Reed, M. J. (2019). Frailty assessment: From clinical to radiological tools. British Journal of Anaesthesia, 123(1), 37-50. doi:10.1016/j.bja.2019.03.034
Chen, L., Woo, J., Assantachai, P., Auyeung, T., Chou, M., Iijima, K., Jang, H. C., Kang, L., Kim, M., Kim, S., Kojima, T., Kuzuya, M., Lee, J. S., Lee, S. Y., Lee, W., Lee, Y., Liang, C., Lim, J., Lim, W. S., … Arai, H. (2019). Asian working group for Sarcopenia: 2019 consensus update on Sarcopenia diagnosis and treatment. Journal of the American Medical Directors Association, 21(3), 300-307.e2. https://doi.org/10.1016/j.jamda.2019.12.012
Chong, E., Tham, A., Chew, J., Lim, W. S., Tan, H. N., Ang, H., & Chan, M. (2021). Brief aids to guide clinical frailty scale scoring at the front door of acute hospitals. Journal of the American Medical Directors Association, 22(5), 1116-1117.e2. doi:10.1016/j.jamda.2021.02.005
Chong, E., Lim, A., Mah, F., Yeo, L., Ng, S., & Yi, H. (2022). Assessing the psychosocial dimensions of frailty among older adults in Singapore: A community-based cross-sectional study. BMJ Open, 12(2), E047586.
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., & Cederholm, T. (2019). Sarcopenia: Revised European consensus on definition and diagnosis. Age and Ageing, 48(4), 601-601. doi:10.1093/ageing/afz046
Dent, E., Lien, C., Lim, W. S., Wong, W. C., Wong, C. H., Ng, T. P., Woo, J., Dong, B., De la Vega, S., Hua Poi, P. J., Kamaruzzaman, S. B., Won, C., Chen, L., Rockwood, K., Arai, H., Rodriguez-Mañas, L., Cao, L., Cesari, M., Chan, P., … Flicker, L. (2017). The Asia-Pacific clinical practice guidelines for the management of frailty. Journal of the American Medical Directors Association, 18(7), 564-575. https://doi.org/10.1016/j.jamda.2017.04.018
Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Woodhouse, L., Rodríguez-Mañas, L., Fried, L. P., Woo, J., Aprahamian, I., Sanford, A., Lundy, J., Landi, F., Beilby, J., Martin, F. C., Bauer, J. M., Ferrucci, L., Merchant, R. A., Dong, B., Arai, H., Hoogendijk, E. O., …Vellas, B. (2019). Physical frailty: ICFSR international clinical practice guidelines for identification and management. The journal of nutrition, health & aging, 23(9), 771-787. https://doi.org/10.1007/s12603-019-1273-z
Fitten, L. J. (2015). Psychological frailty in the aging patient. Nestlé Nutrition Institute Workshop Series, 45-54. https://doi.org/10.1159/000382060
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., … McBurnie, M. A. (2001). Frailty in older adults: Evidence for a phenotype. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56(3), M146-M157. doi:10.1093/gerona/56.3.m146
Kelaiditi, E., Cesari, M., Canevelli, M., Abellan van Kan, G., Ousset, P. -., Gillette-Guyonnet, S., … Vellas, B. (2013). Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) international consensus group. The journal of nutrition, health & aging, 17(9), 726-734. doi:10.1007/s12603-013-0367-2
Lee, J. S., Auyeung, T., Leung, J., Kwok, T., & Woo, J. (2014). Transitions in frailty states among community-living older adults and their associated factors. Journal of the American Medical Directors Association, 15(4), 281-286. doi:10.1016/j.jamda.2013.12.002
MacLeod, S., Musich, S., Hawkins, K., Alsgaard, K., & Wicker, E. R. (2016). The impact of resilience among older adults. Geriatric Nursing, 37(4), 266-272. https://doi.org/10.1016/j.gerinurse.2016.02.014
Michel, J., & Sadana, R. (2017). "Healthy aging" concepts and measures. Journal of the American Medical Directors Association, 18(6), 460-464. https://doi.org/10.1016/j.jamda.2017.03.008
Mijnarends, D. M. (n.d.). Sarcopenia: A rising geriatric giant. doi:10.26481/dis.20160413dm
Rockwood, K. (2005). A global clinical measure of fitness and frailty in elderly people. Canadian Medical Association Journal, 173(5), 489-495. doi:10.1503/cmaj.050051
Rockwood, K., & Mitnitski, A. (2007). Frailty in relation to the accumulation of deficits. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 62(7), 722-727. doi:10.1093/gerona/62.7.722
Woo, J., Leung, J., & Morley, J. E. (2015). Validating the SARC-F: A suitable community screening tool for Sarcopenia? Journal of the American Medical Directors Association, 15(9), 630-634. doi:10.1016/j.jamda.2014.04.021
Woo, J., Yu, R., Wong, M., Yeung, F., Wong, M., & Lum, C. (2015). Frailty screening in the community using the FRAIL scale. Journal of the American Medical Directors Association, 16(5), 412-419. doi:10.1016/j.jamda.2015.01.087
Xue, Q. (2011). The frailty syndrome: Definition and natural history. Clinics in Geriatric Medicine, 27(1), 1-15. doi:10.1016/j.cger.2010.08.009
Ye, L., Elstgeest, L. E., Zhang, X., Alhambra-Borrás, T., Tan, S. S., & Raat, H. (2021). Factors associated with physical, psychological and social frailty among community-dwelling older persons in Europe: A cross-sectional study of urban health centres Europe (UHCE). BMC Geriatrics, 21(1). https://doi.org/10.1186/s12877-021-02364-x
Yu, R., Tong, C., Ho, F., & Woo, J. (2020). Effects of a Multicomponent frailty prevention program in Prefrail community-dwelling older persons: A randomized controlled trial. Journal of the American Medical Directors Association, 21(2), 294.e1-294.e10. https://doi.org/10.1016/j.jamda.2019.08.024
- End of Chapter 1 -
Chapter 2
Nutrition intervention for frailty and sarcopenia
Sarcopenia and physical frailty share many clinical features, including loss of muscle strength, functional decline, and body shrinking
Similar nutritional strategies can be adopted for the management of sarcopenia and physical frailty
A. Preventing physical frailty and sarcopenia with nutrition
Preventing frailty and sarcopenia with nutrition
1. Adequate energy intake
Food consumed is metabolized to provide energy for organ function and muscle activity
Insufficient energy intake ➡ body fat and muscle are catabolized to provide energy
How do I know if someone's energy intake is (in)adequate?
✔ Any unintentional weight loss?
- % weight change = (current weight – previous weight) / current weight x 100.
- >5% of usual body weight in one month or >10% over a period of six months or longer is considered as severe
- Other visual signs: loose jewellery, baggy clothes, extra notch in belt, prominent bony features
✔ At risk of undernutrition?
- Mini-Nutritional Assessment Short-Form (MNA-SF): widely used tool to assess nutritional status for older adults
- Actions:
• Normal nutritional status (12-14 points): rescreen after an acute event or illness / once per year in community / every 3 months in institutions
• At risk of malnutrition (8-11 points): no weight loss ➡ close weight monitoring, rescreen every 3 months; weight loss ➡ refer to dietitian for in-depth nutritional assessment and intervention
• Malnourished (0-7 points): refer to dietitian for in-depth nutritional assessment and intervention
Strategies to ensure adequate energy intake:
- Encourage three meals regularly + snacks in between meals
- Allow enough time for older adults to eat, offer encouragement
- Follow healthy eating plate to achieve balanced diet
2. Optimal protein intake
Protein is a major regulator of muscle protein metabolism
Old muscle ➡ a reduced muscle protein synthesis (anabolic resistance) ➡ requires larger amounts of amino acids to stimulate muscle anabolism
Higher protein intake ➡ overcome anabolic resistance
Low protein intake ➡ reductions in muscle protein synthesis
Older adults need more dietary protein than do younger people (0.8-1.0g / kg BW / day)
PROT-AGE Study Group: 1.0-1.2g / kg BW / day for healthy older adults to maintain physical function and muscle mass
Older adults with severe kidney disease (GFR<30 mL/min/1.73m2) who are not on dialysis are an exception to the high-protein rule; should consult healthcare professionals
Protein-rich diet
- 1 serving of protein food contains around 7g protein
= 1 tael (兩) of cooked skinless poultry, lean beef, pork and fish (=size of 1 table tennis ball or 1 Mahjong 打牌用的麻雀般大小)
= 1 whole egg
= 1 / 3 piece of hard tofu
= 4 tablespoons cooked legumes
= 1 cup of cooked quinoa
= 1 cup of milk / calcium-fortified soy milk (240ml)
= 30g nuts (1 handful)
- Wholegrains ➡ refined grains e.g. 1 bowl of brown rice (6g protein) vs. 1 bowl of white rice (4g protein)
Consider a spread feeding pattern with at least 25-30g of dietary protein during the main meals (about the size of palm) ➡ better than a single high-protein meal
Examples to increase protein intake:
Breakfast: oats with plain water ➡ oats with milk and eggs
Plain rice porridge + steamed rice roll 白粥+豬腸粉 ➡ rice porridge with pork + steamed rice roll with dried prawns 瘦肉粥+蝦米腸
Lunch: choi sum with rice noodle in soup ➡ choi sum shredded pork with rice noodle in soup
Steamed chicken feet + custard bun 蒸鳳爪+奶皇包 ➡ steamed dace fish ball,
chicken bun and boiled vegetable 蒸鯪魚球, 雞包仔, 烚菜
Dinner: stir fry tri-colored capsicum, steamed pork rib, white rice ➡ stir fry tri-colored capsicum, steamed salmon, white rice with quinoa
Snacks: plain roll 豬仔包 ➡ tuna whole grain sandwich
Biscuit ➡ plain mixed nuts 無鹽非油炸果仁
Chinese dessert e.g. soybean curd dessert, sesame dessert, mixed bean soup 喳咋
3. Vitamin D
No specific intervention studies of the effect of vitamin D supplementation on prevention of physical frailty
No specific guidelines are available regarding the optimal status of 25OHD and recommended dose of vitamin D supplementation to prevent frailty
Evidence shows positive effect of daily doses of 800 IU or more on muscle strength and balance
Recommended intake: 15 µg / 600 IU (≤70y); 20 µg / 800 IU (>70y)
Sources: mostly from sunlight exposure (suggest 15-20 minutes per day)
Food sources: egg yolk, oily fish (salmon, mackerel, tuna), portobello, fortified food such as milk, soymilk and breakfast cereals
4. Omega-3 fatty acid
Anti-inflammatory properties
Growing evidence for the beneficial effect of omega-3 supplementation - increase in muscle mass & improve in physical performance for the older adults, especially when > 2g / day of omega-3 and more than 6 months
Exact dosage, frequency and use (alone or combined) in the treatment and prevention of sarcopenia / physical frailty still need further exploration
General guideline: 2 servings (total ~240g) oily fish per week
5. Mediterranean diet
Rich in vegetables, legumes, fruits, nuts, whole grains, olive oil; moderate intake of fish and seafood, poultry, eggs, dairy; rare intake of red meat, processed meat, and sweets
Older adults with higher adherence to MedDiet were less likely to develop frailty and functional disability
Evidence supports that high adherence to MedDiet reduces the risk of cognitive decline in non-demented older adults (beneficial to the cognitive aspect of frailty)
Examples to incorporate MedDiet in HK food culture:
Green leafy vegetable ➡ 2-3 vegetables of different color per meal
White rice / bread ➡ make at least half the grains as whole grains e.g. add brown rice, quinoa, oats, barley, buckwheat, millet; wholegrain bread and pasta
Cake / egg tart ➡ fruits or yoghurt as snacks
Cracker ➡ nuts as snacks
Chinese restaurant: Steamed chicken feet/ pork rib ➡ steamed dace fish ball (fish or seafood twice a week)
B. Reversing sarcopenia/physical frailty with nutrition
Poor nutrition is related to the occurrence and deterioration of physical frailty
Nutrition intervention as part of the management plan + collaboration with multidisciplinary teams involving geriatricians, physiotherapists, exercise physiologists, social workers, and occupational therapists, caregivers and the patients themselves
1. Maintain a desirable body weight
BMI for Asian older adults
- Older adults with higher body weight seem to be beneficial for those who are frail with or without chronic diseases
- No specific guideline; Normal BMI: 18.5-22.9 for adults ➡ 23.0-24.9 for older adults
- <23 is considered as underweight for older adults vs. <18.5 for adults
- If overweight / obese, any advice on weight loss should be carefully considered, as intentional weight loss is accompanied by muscle and bone loss
Energy requirement: ESPEN recommends 30 kcal / kg body weight/day for older adults, adjusted for gender, nutritional status, disease state and physical activity
Examine treatable causes of unintentional weight loss
- MEALS-ON-WHEELS mnemonic
Strategies to ensure adequate energy intake
- Encourage three meals regularly + snacks in between meals
- Allow enough time for older adults to eat, offer encouragement
- Follow healthy eating plate to achieve balanced diet
- How to deal with loss of appetite / early satiety?
• consider size, timing and frequency of meals (small frequent meals rather than large plates of food)
7:00am
Breakfast
10:00am
Morning tea
12:30pm
Lunch
3:00pm
Afternoon tea
6:00pm
Dinner
8:00pm
Supper
• nutritious snacks (every mouthful count)
• avoid fluid (e.g. soup, water, tea) before and during meals
• eat meat / vegetable and rice first ➡ then soup
• use natural seasoning to enhance the flavor e.g. ginger, garlic, onion, mushroom, herbs…
• changes to enhance mealtime experience e.g. music, presentation of food (colorful), increase food variety
• engage family carers as part of the nutrition care team
• "social facilitation": tend to eat more when dining with others rather than alone
• try to be more physically active to stimulate appetite and help digestion
2. Optimal protein intake
Recommendations from PROT-AGE Study Group:
- 1.2-1.5g / kg body weight / day for older adults who are malnourished or at risk of developing further comorbidities
- 2.0g / kg BW / day for older adults with severe illness, injury or marked malnutrition
- Older adults with severe kidney disease (GFR<30 mL / min / 1.73m2) who are not on dialysis are an exception to the high-protein rule; should consult healthcare professionals
Protein-rich diet
- Refer to previous section re: protein sources
- Protein quality
- some studies showed beneficial effects of animal protein than plant protein on frailty outcomes
- animal-based protein has a higher content of branched-chain amino acids (particularly leucine) ➡ eliciting higher muscle protein synthesis compared with plant- based protein
- animal foods are the primary source of high quality protein, therefore, be the preferred source for frail older adults
Protein-energy / protein supplementation
- Shown to increase physical performance and strength (gait / leg strength)
- Consider when frail older adults report weight loss or undernutrition is diagnosed
- Paired with a physical activity program to have an additive effect
3. Vitamin D
Insufficient evidence to recommend a vitamin D supplementation regime to treat sarcopenia / physical frailty
Supplementation in frail older adults has shown positive results in preventing falls
No consensus regarding the optimal status of 25OHD and recommended dose of vitamin D supplementation to treat frailty
Supplementation is not recommended for the treatment of sarcopenia / physical frailty unless vitamin D deficiency is present
According to some scientific societies, a dose of 800-2000 IU per day should be given to frail elderly to reach the recommended minimal serum 25OHD level of (75 nmol / l)
Clinicians should use their judgement in prescribing vitamin D supplementation
4. Mediterranean diet
Unknown effect for the treatment of already established frailty
Protein food FAQs
Considerations in using oral nutritional supplement
Case study 1
Mr. Chan 70 years old, 60 kg, 160 cm, 2 times Tai Chi per week, no chronic conditions
Is Mr. Chan overweight?
What is his daily protein requirement?
What is the minimum servings of protein food required to meet his protein requirement?
Try to plan the protein food by distributing the protein in three meals and snacks
Answer:
1. BMI 23.4, normal for older adults. Mr. Chan is not overweight.
2. 60 kg x 1-1.2g / kg BW / d = 60-72 g protein
3. 60 / 7 = ~8.5 portion of protein food
4. Breakfast: 2 P (1 egg x 1 / 3 can tuna 吞拿魚炒蛋)
Lunch: 3 P (1 palm size pan-fried salmon)
Snack: 0.5 P (1 bowl of home-made low sugar red bean dessert)
Dinner: 3 P (1 tael prawns, 1 / 3 piece hard tofu + 1 tael minced pork 白焯蝦, 肉碎蒸豆腐)
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., … Boirie, Y. (2013). Evidence-based recommendations for optimal dietary protein intake in older people: A position paper from the PROT-AGE study group. Journal of the American Medical Directors Association, 14(8), 542-559. Doi:10.1016/j.jamda.2013.05.021
Bruyère, O., Cavalier, E., Buckinx, F., & Reginster, J. (2017). Relevance of vitamin D in the pathogenesis and therapy of frailty. Current Opinion in Clinical Nutrition & Metabolic Care, 20(1), 26-29. Doi:10.1097/mco.0000000000000334
Coelho-Junior, H. J., Marzetti, E., Picca, A., Cesari, M., Uchida, M. C., & Calvani, R. (2020). Protein intake and frailty: A matter of quantity, quality, and timing. Nutrients, 12(10), 2915. Doi:10.3390/nu12102915
Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Arai, H., Kritchevsky, S. B., Guralnik, J., … Vellas, B. (2018). International clinical practice guidelines for Sarcopenia (ICFSR): Screening, diagnosis and management. The journal of nutrition, health & aging, 22(10), 1148-1161. Doi:10.1007/s12603-018-1139-9
Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Woodhouse, L., Rodríguez-Mañas, L., Fried, L. P., … Vellas, B. (2019). Physical frailty: ICFSR international clinical practice guidelines for identification and management. The journal of nutrition, health & aging, 23(9), 771-787. Doi:10.1007/s12603-019-1273-z
Huang, Y., Chiu, W., Hsu, Y., Lo, Y., & Wang, Y. (2020). Effects of omega-3 fatty acids on muscle mass, muscle strength and muscle performance among the elderly: A meta-analysis. Nutrients, 12(12), 3739. Doi:10.3390/nu12123739
Kojima, G., Avgerinou, C., Iliffe, S., & Walters, K. (2018). Adherence to Mediterranean diet reduces incident frailty risk: Systematic review and meta-analysis. Journal of the American Geriatrics Society, 66(4), 783-788. Doi:10.1111/jgs.15251
Morley, J. E. (2012). Undernutrition in older adults. Family Practice, 29(suppl 1), i89-i93. Doi:10.1093/fampra/cmr054
Radd-Vagenas, S., Duffy, S. L., Naismith, S. L., Brew, B. J., Flood, V. M., & Fiatarone Singh, M. A. (2018). Effect of the Mediterranean diet on cognition and brain morphology and function: A systematic review of randomized controlled trials. The American Journal of Clinical Nutrition, 107(3), 389-404. Doi:10.1093/ajcn/nqx070
Silva, R., Pizato, N., Da Mata, F., Figueiredo, A., Ito, M., & Pereira, M. G. (2017). Mediterranean diet and musculoskeletal-functional outcomes in community-dwelling older people: A systematic review and meta-analysis. The journal of nutrition, health & aging, 22(6), 655-663. Doi:10.1007/s12603-017-0993-1
Stajkovic, S., Aitken, E. M., & Holroyd-Leduc, J. (2011). Unintentional weight loss in older adults. Canadian Medical Association Journal, 183(4), 443-449. Doi:10.1503/cmaj.101471
Van Duong, T., Chiu, C., Lin, C., Chen, Y., Wong, T., Chang, P. W., & Yang, S. (2020). E-healthy diet literacy scale and its relationship with behaviors and health outcomes in Taiwan. Health Promotion International, 36(1), 20-33. Doi:10.1093/heapro/daaa033
Volkert, D., Beck, A. M., Cederholm, T., Cruz-Jentoft, A., Goisser, S., Hooper, L., … Bischoff, S. C. (2019). ESPEN guideline on clinical nutrition and hydration in geriatrics. Clinical Nutrition, 38(1), 10-47. Doi:10.1016/j.clnu.2018.05.024
Woo, J. (2016). Body mass index and mortality. Age and Ageing, 45(3), 331-333. Doi:10.1093/ageing/afw042
- End of Chapter 2 -
Chapter 3
Exercise intervention for frailty and sarcopenia
Structured exercise programme
increase muscle oxygen content, tolerance, and flexibility
prevent and decrease muscle atrophy
increase muscle mass
enhance muscle strength
improve pace
improve quality of life and confidence
➡ Positive effects on physical functioning, cognition, and psychological well-being
should do at least 150–300 minutes of moderate-intensity aerobic physical activity; or at least 75–150 minutes of vigorous-intensity aerobic physical activity; or an equivalent combination of moderate- and vigorous intensity activity throughout the week, for substantial health benefits.
may increase moderate intensity aerobic physical activity to more than 300 minutes; or do more than 150 minutes of vigorous-intensity aerobic physical activity; or an equivalent combination of moderate- and vigorous intensity activity throughout the week, for additional health benefits.
should also do muscle strengthening activities at moderate or greater intensity that involve all major muscle groups on 2 or more days a week, as these provide additional health benefits.
Strong recommendation, moderate certainty evidence
should do varied multicomponent physical activity that emphasizes functional balance and strength training at moderate or greater intensity, on 3 or more days a week, to enhance functional capacity and to prevent falls.
Strong recommendation, moderate certainty evidence
Image source from : https://www.who.int/publications/i/item/9789240015128/
Your maximum heart rate is about 220 minus your age
Target heart rate during moderate intensity activities is about 50-70% of maximum heart rate, while during vigorous physical activity it's about 70-85% of maximum
Tips for undertaking exercise properly
No-pain rule: if you feel articular or muscular pain, difficulty breathing, dizziness, a rapid heartbeat, etc. during an exercise, stop immediately.
Use an adequate area: eliminate any obstacles that may increase a risk of falling. When doing standing up or balance exercises, you can use objects that will make it safer (chairs, bars, tables, etc.).
Make sure your shoes fit you well: they should have flat soles, be anti-slip and offer good support for your heel.
Wear comfortable clothing.
Do not hold your breathing during the exercises. Breathe normally.
Talk to your doctor if you are not sure if you should do a particular exercise, especially if you have had hip or back surgery.
Stop exercise and seek medical advice immediately if you are not feeling well during exercise.
Vivifrail Exercise
Based on the idea that health in older people should be measured in terms of its function and NOT as a disease
To maintain a level of functionality that maintains the highest degree of autonomy possible in each case
Designed for older adults above 70, that promotes the practice of physical exercise to improve strength, gait ability and balance, while frailty and falls are prevented
Multicomponent exercise programme: Resistance, balance, endurance & coordination training
Reference from: https://vivifrail.com/
Vivifrail test
to determine the most appropriate type of multicomponent physical program regarding the functional capacity and risk of falls of the older adults
consists of assessing functional capacity through the SPPB test and a battery of 4 measures that allow assessing the risk of falls
Casas-Herrero, A., Anton-Rodrigo, I., Zambom-Ferraresi, F., Sáez de Asteasu, M. L., Martinez-Velilla, N., Elexpuru-Estomba, J., Marin-Epelde, I., Ramon-Espinoza, F., Petidier-Torregrosa, R., Sanchez-Sanchez, J. L., Ibañez, B., & Izquierdo, M. (2019). Effect of a multicomponent exercise programme (VIVIFRAIL) on functional capacity in frail community elders with cognitive decline: Study protocol for a randomized multicentre control trial. Trials, 20(1). https://doi.org/10.1186/s13063-019-3426-0
The Government of the Hong Kong Special Administrative Region. (2020). "Create your own exercise programme" - for both elders & caregivers. Elderly Health Service. https://www.elderly.gov.hk/english/ healthy_ageing/exe_leisure_travel/ create_your_own_exercise_program.html
Izquierdo, M., Zambom-Ferraresi, F., Sáez de Asteasu, M. L., Martínez-Velilla, N., Ramirez-Vélez, R., García-Hermoso, A., Casas-Herrero, A., Sinclair, A., & Rodríguez-Mañas, L. (2021, March 6). VIVIFRAIL: A multi-component physical training program to prevent weakness and falls in people over 70 years [web log]. Retrieved January 26, 2022, from https://blogs.bmj.com/bjsm/2021/03/06/vivifrail-a-multi-component-physical-training-program-to-prevent-weakness-and-falls-in-people-over-70-years/
Theou, O., Stathokostas, L., Roland, K. P., Jakobi, J. M., Patterson, C., Vandervoort, A. A., & Jones, G. R. (2011). The effectiveness of exercise interventions for the management of frailty: A systematic review. Journal of Aging Research, 2011, 1-19. https://doi.org/10.4061/2011/569194
World Health Organization. (2020). WHO guidelines on physical activity and sedentary behaviour. Retrieved from https://www.who.int/publications/i/ item/9789240015128
The videos in this course provide information for educational purposes only. The videos do not provide medical recommendations or diagnoses and are not substitutes for medical advice. It is crucial that you talk with your healthcare providers to discuss any questions you may have and seek them for medical advice, before you make any medical decisions. As the videos are only for educational purposes, we will not be responsible for any decisions you will make or consequences you will have based on the information they provide. In no event shall the Funder have any liability of any kind to any person or entity arising from or related to any actions taken or not taken as a result of any of the contents herein.