Biography:

Professor Hao Sun is currently an assistant professor at the Li Ka Shing Institute of Health Sciences (LiHS) and the Department of Chemical Pathology. He also serves as the Director of Biomedical Computing Centre at LiHS. He received his Ph.D. in the field of Environmental Chemistry from Nanjing University, China in 1998 and a M.S. degree in Computer Science from The University of Akron, USA in 2002. Before he joined The Chinese University of Hong Kong in 2009, he worked as a Co-Director of the Bioinformatics Core Facility in Wistar Institute at Philadelphia, USA during 2008 to 2009 and as a Research Scientist/Adjunct Assistant Professor in the Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine and Public Health, at The Ohio State University, USA from 2001 to 2008. His research interests focus on genomics and bioinformatics. Specifically, he is working on to understand the fundamental aspects of transcriptional regulation of both coding and noncoding RNAs using integrated genomic and bioinformatics approaches. In addition, his interests also cover the development of bioinformatics approaches for non-invasive genetic diagnosis and novel biomarker discovery.  

Specialised Research Area(s):

Bioinformatics, Genomics.

1.   Jiang, P., Sun, K., Lun, F. M., Guo, A. M., Wang, H., Chan, K. C., Chiu, R. W., Lo, Y. M., & Sun, H. (2014). Methy-Pipe: An integrated bioinformatics pipeline for whole genome bisulfite sequencing data analysis. PLoS One. In press.

2.   Sun, K., Zhao, Y., Wang, H., & Sun, H. (2014). Sebnif: An Integrated Bioinformatics Pipeline for the Identification of Novel Large Intergenic Noncoding RNAs (lincRNAs) -Application in Human Skeletal Muscle Cells. PLoS One, 9(1), e84500.

3.   Yang, Y., Zhou, L., Lu, L., Wang, L., Li, X., Jiang, P., Chan, L. K., Zhang, T., Yu, J., Kwong, J., Cheung, T. H., Chung, T., Mak, K., Sun, H.*, & Wang, H*. (2013). A novel miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adenocarcinoma. Oncogene, 32(29), 3432-3442.

4.   Chan, K. C., Jiang, P., Chan, C. W., Sun, K., Wong, J., Hui, E. P., Chan, S. L., Chan, W. C., Hui, D. S., Ng, S. S., Chan, H. L., Wong, C. S., Ma, B. B., Chan, A. T., Lai, P. B., Sun, H., Chiu, R. W., & Lo, Y. M. (2013). Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing, Proceedings of the National Academy of Sciences, 110, 18761-18768.

5.   Lun, F. M., Chiu, R. W., Sun, K., Leung, T. Y., Jiang, P., Chan, K. C., Sun, H., & Lo, Y. M. (2013). Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA, Clinical Chemistry, 59(11), 1583-1594.

6.   Sun, K., Chen, X., Jiang, P., Song, X., Wang, H., & Sun, H. (2013). iSeeRNA: identification of long intergenic non-coding RNA transcripts from transcriptome sequencing data, BMC Genomics, 14 Suppl 2, S7.

7.   Guo, A. M., Sun, K., Su, X., Wang, H., & Sun, H. (2013). YY1TargetDB: an integral information resource for Yin Yang 1 target loci, Database (Oxford), bat007.

8.   Lu, L., Sun, K., Chen, X., Zhao, Y., Wang, L., Zhou, L., Sun, H.^*, & Wang, H.^* (2013). Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis, EMBO Journal, 32(19), 2575-2588.

9.   Lu, L., Zhou, L., Chen, E. Z., Sun, K., Jiang, P., Wang, L., Su, X., Sun, H. ^*, & Wang, H. ^* (2012). A Novel YY1-miR-1 regulatory circuit in skeletal myogenesis revealed by genome-wide prediction of YY1-miRNA network, PLoS One 7(2), e27596.

10. Jiang, P., Chan, K. C., Liao, G. J., Zheng, Y. W., Leung, T. Y., Chiu, R. W., Lo, Y. M., & Sun, H. (2012). FetalQuant: deducing fractional fetal DNA concentration from massively parallel sequencing of DNA in maternal plasma, Bioinformatics, 28, 2883-2890.

11. Diao, Y., Guo, X., Li, Y., Sun, K., Lu, L., Jiang, L., Fu, X., Zhu, H., Sun, H., & Wang, H. (2012). Pax3/7BP Is a Pax7-and Pax3-Binding Protein that Regulates the Proliferation of Muscle Precursor Cells by an Epigenetic Mechanism. Cell Stem Cell, 11(2), 231-241.

12. Chiu, R. W. , Akolekar, R., Zheng, Y. W., Leung, T. Y., Sun, H., Chan, K. C., Lun, F. M., Go, A. T., Lau, E. T., & To, W. W. (2011). Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study.  British Medical Journal. 342, c7401. 

13. Chen, E. Z., Chiu, R. W., Sun, H., Akolekar, R., Chan, K. C., Leung, T. Y., Jiang, P., Zheng, Y. W., Lun, F. M., Chan, L. Y., Jin, Y., Go, A. T., Lau, E. T., To, W. W., Leung, W. C., Tang, R. Y., Au-Yeung, S. K., Lam, H., Kung, Y. Y., Zhang, X., van Vugt, J. M., Minekawa, R., Tang, M. H., Wang, J., Oudejans, C. B., Lau, T. K., Nicolaides, K. H., & Lo, Y. M. (2011). Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing. PLoS One, 6(7), e21791.

14. Sun, H., Wu, J., Wickramasinghe, P., Pal, S., Gupta, R., Bhattacharyya, A., Agosto-Perez, F. J., Showe, L. C., Huang, T. H., & Davuluri, R. V. (2010). Genome-wide mapping of RNA Pol-II promoter usage in mouse tissues by ChIP-seq, Nucleic Acids Research, 39(1), 190-201.

15. Lo, Y. M., Chan, K. C., Sun, H., Chen, E. Z., Jiang, P., Lun, F. M., Zheng, Y. W., Leung, T. Y., Lau, T. K., Cantor, C. R., & Chiu, R. W. (2010). Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus, Science Translational Medicine, 2(61), 61ra91.

16. Wang, H., Garzon, R., Sun, H., Ladner, K. J., Singh, R., Dahlman, J., Cheng, A., Hall, B. M., Qualman, S. J., & Chandler, D. S. (2008). NF-[kappa] B-YY1-miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma, Cancer Cell, 14(5), 369-381.