Prof. Zhang Tao, Judy

1

Identification of potential biomarkers and immune infiltration characteristics in recurrent implantation failure using bioinformatics analysis Lai ZZ, Zhang J, Zhou WJ, Shi JW, Yang HL, Yang SL, Wu JN, Xie F, Zhang T, Li MQ Front Immunol. 2023 Jan 26;14:992765

2

A prospective study comparing the inflammation-related cytokine and chemokine profile from the day of blastocyst transfer to 7 weeks of gestation between pregnancies that did or did not result in a miscarriage Zhao Y, Man GCW, Zhang R, Wong CK, Chen X, Chung JP, Wang CC, Laird S, Zhang T, Li TC J Reprod Immunol. 2022 Dec;154:103755

3

An IGF1-expressing endometrial stromal cell population is associated with human decidualization Shi JW, Lai ZZ, Yang HL, Zhou WJ, Zhao XY, Xie F, Liu SP, Chen WD, Zhang T, Ye JF, Zhou XY, Li MQ BMC Biol. 2022 Dec 8;20(1):276

4

Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine Wang H, Chan KYY, Cheng CK, Ng MHL, Lee PY, Cheng FWT, Lam GKS, Chow TW, Ha SY, Chiang AKS, Leung WH, Leung AYH, Wang CC, Zhang T, Zhang XB, So CC, Yuen YP, Sun Q, Zhang C, Xu Y, Cheung JTK, Ng WH, Tang PM, Kang W, To KF, Lee WYW, Wong RSM, Poon ENY, Zhao Q, Huang J, Chen C, Yuen PMP, Li CK, Leung AWK, Leung KT Blood Cancer Discov. 2022 Nov 2;3(6):516-535

5

Pharmacogenomic profiling of pediatric acute myeloid leukemia to identify therapeutic vulnerabilities and inform functional precision medicine. Wang H, Chan KYY, Cheng CK, Ng MHL, Lee PY, Cheng FWT, Lam GKS, Chow TW, Ha SY, Chiang AKS, Leung WH, Leung AYH, Wang CC, Zhang T, Zhang XB, So CC, Yuen YP, Sun QW, Zhang C, Xu YQ, Cheng JTK, Ng WH, Tang PMK, Kang W, To KF, Lee WYW, Wong RS, Poon ENY, Zhao Q, Huang JB, Chen C, Yuen PMP, Li CK, Leung AWK, Leung KT. Blood Cancer Discov. 2022 Nov 2;3(6):516-535.

6

A prospective study comparing inflammation-related cytokine and chemokine profile from the day of blastocyst transfer to 7 weeks of gestation between miscarriage and live birth. Zhao YW, Man GCW, Zhang RZ, Wong CK, Chen XY, Chung JPW, Wang CC, Laird S, Zhang T, Li TC. Journal of Reproductive Immunology. 2022,103755

7

Dynamic changes in maternal immune biomarkers during labor in nulliparous versus multiparous women Ding W, Lau SL, Wang CC, Zhang T, Getsko O, Lee NMW, Chim SSC, Wong CK, Leung TY Am J Obstet Gynecol. 2022 Oct;227(4):627.e1-627.e23

8

Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight Li Y, Hung SW, Zhang R, Man GCW, Zhang T, Chung JPW, Fang L, Wang CC Nutrients. 2022 Oct; 14(19):4087

9

Pathogenic mitochondrial DNA 3243A>G mutation: From genetics to phenotype. Li DY, Liang CM, Zhang T, Marley JL, Zou WW, Lian MQ, Ji DM. Front Genet. 2022 Oct 6;13:951185

10

What we have learned from animal models to understand the etiology and pathology of endometrioma-related infertility. Tan ZYR, Hung SW, Zheng X, Wang CC, Chung JPW, Zhang T Biomedicines. 2022, 10(7), 1483

11

Single-cell transcriptome profiling of the human endometrium of patients with recurrent implantation failure Lai ZZ, Wang Y, Zhou WJ, Liang Z, Shi JW, Yang HL, Xie F, Chen WD, Zhu R, Zhang C, Mei J, Zhao JY, Ye JF, Zhang T, Li MQ Theranostics Sep 2022; 12(15): 6527-6547

12

Systematic review update and meta-analysis of randomized and non-randomized controlled trials of ovarian stimulation versus artifcial cycle for endometrial preparation prior to frozen embryo transfer in women with polycystic ovary syndrome Zhang YY, Wu L, Li TC, Wang CC, Zhang T, Chung PWJ Reprod Biol Endocrinol. 2022 Apr 2;20(1):62

13

A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricing decidual macrophage residence. Yang HL, Lai ZZ, Shi JW, Zhou WJ, Mei J, Ye JF, Zhang T, Wang J, Zhao JY, Li DJ, Li MQ. Autophagy 2022 Feb 27;1-22

14

Insight of autophagy in spontaneous miscarriage. Qin XY, Shen HH, Zhou WJ, Mei J, Lu H, Tan XF, Zhu R, Zhou WH, Li DJ, Zhang T, Ye JF, Li MQ. Int J Biol Sci. 2022 Jan 1; 18(3): 1150-1170

15

Biol Reprod. Metabolic markers of biological fluid in women with reproductive failure: a systematic review of current literature. Zhang YY, Zhang T, Wu L, Li TC, Wang CC, Chung JPW. Biol Reprod 2022, 106(6): 1049-1058

16

Efficacy and safety of Chinese herbal medicine for endometriosis associated pain. Lin YZ, Hou RJ, Zhang T, Chung JPW, Wang CC, RH Zhao. The American Journal of Chinese Medicine 2022, 50(4): 1095-1111

17

The metabolic characteristic of decidual immune cells and its unique properties in pregnancy loss. Zhang T, Shen HH, Qin XY, Li MQ. Immunological Reviews. 2022. 308 (1):168-186

18

Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis. Shen HH, Zhang T, Yang HL, Lai ZZ, Zhou WJ, Mei J, Shi JW, Zhu R, Xu FY, Li DJ, Ye JF, Li MQ. Theranostics. 2021; 11(7): 3512-3526.

19

Association between chronic endometritis and uterine natural killer cell density in women with recurrent miscarriage: clinical implications. Chen XY, Liu YY, Zhao YW, Cheung WC, Zhang T, Qi RF, Chung JPW, Wang CC, Li TC. Journal of Obstetrics and Gynaecology Research. 2020 Jun; 46(6): 858-863.

20

Serial changes in two immune checkpoint receptors and ligands, Tim-3/Gal-9 and PD-1/PD-L1 in peripheral blood prior to miscarriage: Comparison with pregnancies resulting in a live birth Zhang T, Zhao YW, Cheung WC, Gan YH, Huang L, Li MQ, Leung KT, Chung PW, Wang CC, Laird S, Chen XY, Li TC Am J Reprod Immunol. 2022 Feb 7;e13524

21

Auto-immunity and endometriosis: evidence, mechanism and therapeutic potential Zhang T, Li TC, Wang CC In: Immunology of Endometriosis: Pathogenesis and Management

22

Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiation Zhou WJ, Yang HL, Mei J, Chang KK, Lu H, Lai ZZ, Shi JW, Wang XH, Wu K, Zhang T, Wang J, Sun JS, Ye JF, Li DJ, Zhao JY, Jin LP, Li MQ Sci Adv. 2022 Feb 25;8(8):eabj2488.

23

Immunologic Memory in Pregnancy: Focusing on Memory Regulatory T Cells Zhang YJ, She L, Zhang T, Muyayalo KP., Luo J, Mor G, Liao AH Int. J. Biol. Sci. 2022 Mar; 18(6): 2406-2418

24

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage Zhao Y, Man GCW, Chan LKY, Guo X, Liu Y, Zhang T, Kwong J, Wang CC, Chen X, Li TC J Vis Exp. 2021 Aug 4;(174): e62931

25

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review Hung SW, Zhang RZ, Tan ZYR, Chung JPW, Zhang T, Wang CC Med Res Rev. 2021 Jul;41(4):2489-2564

26

Receptor tyrosine kinase inhibitor Sunitinib as novel immunotherapy to inhibit myeloid-derived suppressor cells for treatment of endometriosis He Y, Hung SW, Liang B, Zhang RZ, Gao YT, Chu CY, Xu H, Zhang T, Chung JPW, Wang CC Front. Immunol. 2021 July;12:641206

27

Successful implantation is associated with a transient increase in serum pro-inflammatory cytokine profile, following by a switch to anti-inflammatory cytokine profile prior to confirmation of pregnancy Zhao Y, Zhang T, Guo X, Wong CK, Chen X, Chan YL, Wang CC, Laird S, Li TC Fertil Steril. 2021 Apr;115(4):1044-1053

28

Uterine CD56+ cell density and euploid miscarriage in women with a history of recurrent miscarriage: A clinical descriptive study Chen X, Zhang T, Liu Y, Cheung WC, Zhao Y, Wang CC, Laird S, Li TC Eur J Immunol. 2021 Feb;51(2):487-489

29

The identification of endometrial immune cell densities and clustering analysis in the mid-luteal phase as predictor for pregnancy outcomes after IVF-ET treatment Zhao Y, Man GCW, Wang J, Liu Y, Kwong J, Zhang T, Chung JPW, Wang CC, Chen X, Li TC J Reprod Immunol. 2021 Oct 5;148:103431

30

Therapeutic effects of green tea on endometriosis. Chen X, Man GCW, Hung SW, Zhang T, Fung LWY, Cheung CW, Chung JPW, Li TC, Wang CC. Crit Rev Food Sci Nutr. 2021 Oct 7:1-14

31

Auto-immunity and endometriosis: evidence, mechanism and therapeutic potential. In: Immunology of Endometriosis: Pathogenesis and Management (2021) Zhang T, Li TC, Wang CC. Volume 2 Chapter 6:85-104

32

Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners Lai ZZ, Yang HL, Shi JW, Shen HH, Wang Y, Chang KK, Zhang T, Ye JF, Sun JS, Qiu XM, Li MQ Int J Biol Sci. 2021 May 5;17(8):1878-1894

33

Early transient suppression of immune checkpoint proteins T-cell immunoglobulin mucin-3 and programmed cell death-1 in peripheral blood lymphocytes after blastocyst transfer is associated with successful implantation Zhang T, Zhu W, Zhao Y, Cheung WC, Liu Y, Chen X, Du Y, Leung KT, Chan YL, Wang CC, Laird S, Li TC Fertil Steril. 2020 Aug;114(2):426-435

34

Effects of high progesterone in in-vitro fertilization cycle on DNA methylation and gene expression of adhesion molecules on endometrium during implantation window Xiong Y, Hu L, Zhang T, Wang M, Xu H, Li TC, Sun Y, Wang CC J Assist Reprod Genet. 2020 Jan;37(1):33-43

35

The use of multiplex staining to measure the density and clustering of four endometrial immune cells around the implantation period in women with recurrent miscarriage: comparison with fertile controls Zhao Y, Chen X, Zhang T, Chan LKY, Liu Y, Chung JP, Kwong J, Li TC Journal of Molecular Histology. 2020, Aug; 51: 593-603.

36

Tradition al and molecular chromosomal abnormality analysis of products of conception in spontaneous and recurrent miscarriage Zhang T, Sun Y, Chen Z, Li TC BJOG. 2018 Mar;125(4):414-420

37

The link between immunity, autoimmunity and endometriosis: a literature update Zhang T, De Carolis C, Man GCW, Wang CC Autoimmun Rev 2018 Oct 17 (10) 945-955

38

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review Zhang T, Chen X, Wang CC, Li TC, Kwak KJ Am J Reprod Immunol. 2018 Dec 27:e13077, 12 pages

39

MDSCs drive the process of endometriosis by enhancing angiogenesis and provide a new potential approach for treatment. Zhang T, Zhou JH, Man GCW, Leung KT, Liang B, Xiao B, Ma XT, Huang SY, Huang HX, Hegde VL, Zhong Y, Li YM, Kong GWS, Yiu AKW, Kwong J, Ng PC, Lessey BA, Nagarkatti PS, Nagarkatti M, Wang CC. Eur J Immunol. 2018 Jun; 48(6): 1059-1073.

40

Detection of dendritic cells and related cytokines in follicular fluid of patients with polycystic ovary syndrome. Zhang T, Tian F, Huo R, Tang A, Zeng Y, Duan YG. Am J Reprod Immunol. 2017 Sep; 78(3): e12717.

41

Efficacy of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) for infertile women with thin endometrium: A systematic review and meta-analysis. Xie YR, Zhang T, Tian ZP, Zhang JM, Wang WX, Zhang H, Zeng Y, Ou JP, Yang YH. Am J Reprod Immunol. 2017 Aug; 78(2): e12701.

42

The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy—An immunological perspective Man GCW, Zhang T, Chen X, Wang J, Wu F, Liu Y, Wang CC, Cheong Y, Li TC Am J Reprod Immunol. 2017 Aug;78(2)e12715

43

Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory cells. Diao LH, Li GG, Zhu YC, Tu WW, Huang CY, Lian RC, Chen X, Li YY, Zhang T, Huang Y, Zeng Y. Am J Reprod Immunol. 2017 Mar; 77(3): e12618.

44

Successful treatment with intrauterine delivery of dexamethasone for repeated implantation failure. Zhang T, Huang CY, Du Y, Lian RC, Mo ML, Zeng Y, Mor G. Am J Reprod Immunol. 2017 Dec; 78(6): e12766.

45

Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage. Chen X, Yin B, Lian RC, Zhang T, Zhang HZ, Diao LH, Li YY, Huang CY, Liang DS, Zeng Y. Am J Reprod Immunol. 2016 Dec, 76(6): 432-438.

46

Monochorionic Quadramniotic and Triamniotic Pregnancies following Single Embryo Transfers: Two Case Reports and a Review of the Literature. Saravelos S, Zhang T, Chung JPW, Sun LM, Sun Y, Li TC, Chen ZJ J Assist Reprod Gen Jan 2016;33(1): 27 - 32

47

Prodrug of green tea epigallocatchin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Wang CC, Xu H, Man GCW, Zhang T, Chu KO, Chu CY, Cheng JT, Li G, He YX, Qin L, Lau TS, Kwong J, Chan TH. Angiogenesis 2013 Aug; 16(1): 59-69.

48

Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis. Xu H, Zhang T, Man GCW, May KE, Becker CM, Davis TN, Kung AL, Birsner AE, D’Amato RJ, Wong AW, Wang CC. Angiogenesis 2013 Jul; 16: 541-551.

49

A Novel miR-193a-5p-YY1-APC Regulatory Axis in Human Endometrioid Endometrial Adenocarcinoma. Yang YH, Zhou L, Lu LN, Wang LJ, Li XX, Jiang PY, Chan LKY, Zhang T, Yu J, Kwong J, Cheung TH, Chung TKH, Mak KKL, Sun H, Wang HT Oncogene 2013;32(29): 3432 - 3442

Prof. Zhang Tao, Judy

Qualifications

Research Interests