An endeavor to investigate the role of hMSCs in regulating hematopoietic stem cell fate and their therapeutic potential to treat lupus nephritis, spinocerebellar ataxia and diabetes in different animal models, and has established clinical trials of systematic administration of MSCs for treatment of osteoarthritis, acute liver failure and spinocerebellar ataxia in patients.

  1. Tsai YA, Liu RS, Lirng JF, Yang BH, Chang CH, Wang YC, Wu YS, Ho JH, Lee OK*, Soong BW*. Mar. 2017. Treatment of spinocerebellar ataxia with mesenchymal stem cells: A phase I-IIa clinical study. Cell Transplantation 26(3):503-512. 
  2. Ji AT, Chang YC, Fu YJ, Lee OK*, Ho JH*. Mar. 2015. Niche-dependent regulations of metabolic balance in high-fat diet induced diabetic mice by mesenchymal stromal cells. Diabetes 64(3):926-36
  3. Chang YK, Chen MH, Chiang YH, Chen YF, Ma WH, Tseng CY, Soong BW, Ho JH*, Lee OK*. Aug. 2011. Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells. J Biomed Sci 18(1):54
  4. Chang JW, Hung SP, Wu HH, Wu WM, Yang AH, Tsai HL, Yang LY, Lee OK*. Feb. 2011. Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis. Cell Transplantation 20(2):245-57