Mechanically-graded biomaterial for bone-tendon repair. (B) Bone-like and (C) tendon-like tissue patterning on mechanically-graded biomaterial in vivo. Tri, trichrome.

With the combined use of macroscale biomechanical (material stiffness) and biochemical cues (growth factor biopatterning), Prof. Michelle Wang’s group has developed a novel, bio-functionalized, mechanically-graded biomaterial that holds promise for hard-to-soft tissue regeneration such as rotator cuff repair.

  1. Ker DFE*, Wang D*, Behn AW, Wang ETH, Zhang X, Zhou BY, Mercado-Pagan AE, Kim S, Kleimeyer J, Gharaibeh B, Shanjani Y, Nelson D, Safran M, Cheung E, Campbell P, Yang YP. Functionally-Graded, Bone- and Tendon-Like Polyurethane for Rotator Cuff Repair. Advanced Functional Materials. 2018, 28(20): 1707107. *Co-first authors.
  2. Wang D, Xu Y, Lu C, Yang X, Zhang D, Shao L, Wang R. Comparison of fracture strength and fracture modes of zirconia dental ceramics manufactured by four different CAD/CAM systems. Key Engineering Materials. 2012, 492:30-34.