Professor Jun XIA

	Address	(Office):	Rm 5445, Academic Building, HKUST
		(Lab):	Rm 6306, Academic Building, HKUST
	Phone	(Office):	(852) 2358-7293
		(Lab):	(852) 2358-7274
	Fax		(852) 2358-1552
	Email		jxia@ust.hk
	Web		http://life-sci.ust.hk/ faculty/Dr.J.Xia/

 

 

 

 

 

 

 

 

Education

	2001	Ph.D.	Johns Hopkins University School of Medicine, USA
	1996	M.Sc.	Chinese Academy of Sciences, China
	1993	B.Med.	Hunan Medical University, China

 

 

 

Position

• Professor, Division of Life Science, Hong Kong University of Science and Technology (HKUST)

 

Research Interests

• Synapses and its role in learning and memory,
• Mechanism of protein trafficking and its implication in brain disorder and diabetes.

 

Representative Publications (*corresponding authors)

• Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, Cheng KKY, Xu A, Lee KM, Jiang L and *Xia J. (2013) PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance. PLOS Biology 11: e1001541.
• Fu AK, Hung KW, Fu WY, Shen C, Chen Y, Xia J, Lai KO and Ip NY. (2011) APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. Nature Neuroscience 14:181-189.
• Xu J, Xiao N and *Xia J. (2010) Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1. Nature Neuroscience 13: 22-24.
• Xiao N, Kam C, Shen C, Jin W, Wang J, Lee KM, Jiang L and *Xia J. (2009) PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. Journal of Clinical Investigation 119: 802-812.
• Cao M, Xu J, Shen C, Kam C, Huganir RL and *Xia J. (2007) PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors. Journal of Neuroscience 27: 12945-12956.
• Pan L, Wu H, Shen C, Shi Y, Jin W, *Xia J and *Zhang M. (2007) Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. EMBO Journal 26: 4576-4587.
• Jin W, Ge W, Xu J, Cao M, Peng L, Yung W, Liao D, Duan S, Zhang M and *Xia J. (2006) Lipid Binding Regulates PICK1’s Synaptic Targeting, AMPA Receptor Trafficking and Synaptic Plasticity. Journal of Neuroscience 26: 2380-2390.
• Long JF, Feng W, Wang R, Chan LN, Ip FC, Xia J, Ip NY and Zhang M. (2005) Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem. Nature Structural and Molecular Biology 12: 722-728.
• Xia J, Chung HJ, Wihler C, Huganir RL and Linden DJ. (2000) Cerebellar Long-Term Depression Requires PKC Regulated Interactions Between GluR2/3 and PDZ Domain-Containing Proteins. Neuron 28: 499-510.
• Xia J, Zhang X, Staudinger J and Huganir RL. (1999) Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.  Neuron 22: 179-187.

#Co-corresponding authors.

 

Research Grants as PC/PI

• 2014-2021, Research Grants Council (RGC) Areas of Excellence Scheme (AoE) Grant “Center for organelle biogenesis and function”, HK$47,250,000;
• 2012-2017, UGC Theme-based Research Scheme “Stem Cell Strategy for Nervous System Disorders”, HK$60,839,000;
• 2012-2015, RGC CRF Grant “EXPO (Exocyst-positive Organelle): Dynamics, Biogenesis and Function in Plants”, HK$8,459,400;
• 2010-2013, RGC GRF Grant “Identify neuroligin associated proteins and investigate their roles in neuroligin-mediated synaptogenesis”, HK$1,600,000;
• 2009-2013, Research Grants Council (RGC) CRF Grant “Protein trafficking: mechanism and diseases”, HK$5,000,000;

 

Awards

• 2008: ASAIHL-Scopus Young Scientist Award in Life Sciences 1st Runner-up, Association of Southeast Asian Institutions of Higher Learning
• 2001: The Paul Ehrlich Young Investigator’s Award, Johns Hopkins University