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Dr. Chuan XIE
MBBS, MD, PhD
Postdoctoral researcher
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong
Research Interests
Helicobacter pylori, Autophagy |
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Publications:
For details about citations arising from my publications and links to online versions of some of the publications, refer to:
https://publons.com/researcher/3991782
(*corresponding author, ^co-first author)
- Xie C, Li N, Wang H, He C, Hu Y, Peng C, Ouyang Y, Wang D, Xie Y, Chen J, Shu X, Zhu Y, Lu N*. Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection. Gut Microbes. 2020 Jun 26:1-23.
- Li N, Lu N, Xie C*. The Hippo and Wnt signalling pathways: crosstalk during neoplastic progression in gastrointestinal tissue. FEBS J. 2019 Jul 25.
- Fu L, Xie C*. A lucid review of Helicobacter pylori-induced DNA damage in gastric cancer. Helicobacter. 2019 Jul 11:e12631.
- Hu Y, Liu JP, Li XY, Cai Y, He C, Li NS, Xie C, Xiong ZJ, Ge ZM, Lu NH*, Zhu Y*. Downregulation of tumor suppressor RACK1 by Helicobacter pylori infection promotes gastric carcinogenesis through the integrin �-1/NF-?B signaling pathway. Cancer Lett. 2019 May 28;450:144-154.
- C Xie^, J Yi^, J Lu^, MW Nie, MF Huang, JF Rong, ZH Zhu, J Chen, XL Zhou, BM Li, HM Chen, NH Lu, Xu Shu*. N-acetylcysteine reduces ROS-mediated oxidative DNA damage and PI3K/Akt pathway activation induced by Helicobacter pylori infection. Oxidative Medicine and Cellular Longevity. 2018 Apr 26;2018:1874985.
- Xu W, Huang Y, Yang Z, Hu Y, Shu X, Xie C, He C, Zhu Y, Lu N*. Helicobacter pylori promotes gastric epithelial cell survival through the PLK1/PI3K/Akt pathway. Onco Targets Ther. 2018 Sep 11;11:5703-5713.
- Xu W, Yang Z, Xie C, Zhu Y, Shu X, Zhang Z, Li N, Chai N, Zhang S, Wu K, Nie Y, Lu N*. PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis. J Exp Clin Cancer Res. 2018 Aug 22;37(1):198.
- Yang Z, Cao X, Xu W, Xie C, Chen J, Zhu Y, Lu N*. Phosphorylation of phosphatase and tensin homolog induced by Helicobacter pylori promotes cell invasion by activation of focal adhesion kinase. Oncol Lett. 2018 Jan;15(1):1051-1057.
- He C, Yang Z, Cheng D, Xie C, Zhu Y, Ge Z, Luo Z, Lu N*. Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice. EBioMedicine.
- Li N, Feng Y, Hu Y, He C, Xie C, Ouyang Y, Artim SC, Huang D, Zhu Y, Luo Z, Ge Z, Lu N*. Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway. J Exp Clin Cancer Res. 2018 Nov 22;37(1):280.
- C Xie^, Z Yang^, Y Hu, XM Cao, J Chen, Y Zhu, NH Lu*. Expression of c-Met and Hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection. Oncol Lett. 2017 Nov;14(5):6151-6155.
- Li N^, Xie C^, Lu NH*. Crosstalk between Hippo signalling and miRNAs in tumour progression. FEBS J. 2017 Apr;284(7):1045-1055. (Co-first authors.)
- Ye JF, Hong JB, Zhu Y, Xie Y, Shu X, Luo LY, Xie C, Zhu ZH, Lu NH*. Evaluation of first-line bismuth-containing 7-day concomitant quintuple therapy for Helicobacter pylori eradication. J Dig Dis. 2017 Dec;18(12):704-708.
- Li N, Xie C^, Lu NH*. p53, a potential predictor of Helicobacter pylori infection-associated gastric carcinogenesis? Oncotarget. 2016 Aug 19.
- Hong J, Shu X, Liu D, Zhu Y, Xie C, Xie Y, Zhang K, Wang A, Xiong H, Zeng H, Yu H, Ma J, Chen Y, Zhu X, Lu N*. Antibiotic resistance and CYP2C19 polymorphisms affect the efficacy of concomitant therapies for Helicobacter pylori infection: an open-label, randomized, single-centre clinical trial. J Antimicrob Chemother. 2016 Aug;71(8):2280-5.
- Xie C, Lu NH*. Clinical management of Helicobacter pylori infection in China. Helicobacter. 2015 Feb;20(1):1-10.
- XG Yuan^, C Xie^, CY Zeng, J Chen, X Shu, Y Xie, KH Zhang, NH Lu*. Seasonal changes in gastric mucosal factors associated with peptic ulcers bleeding. Exp Ther Med. 2015 Jan;9(1):125-130.
- Li NS^, Xie C^, Lu NH*. Transforming growth factor-�: an important mediator in Helicobacter pylori-associated pathogenesis. Front Cell Infect Microbiol. 2015; Nov 4;5:77.
- Yang Z, Xie C, Xu W, et al. Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway. Oncotarget 2015; 6(31): 31916-26.
- Yang Z, Li W, He C, Xie C, Zhu Y, Lu NH*. Potential effect of chronic Helicobacter pylori infection on glucose metabolism of Mongolian gerbils. World journal of gastroenterology 2015; 21(44): 12593-604.
- Xie C, Xu LY, Li W, Yang Z, Lu NH*. Helicobacter pylori infection in Mongolian gerbils does not initiate hematological diseases. World J Gastroenterol. 2014 Sep 14;20(34):12308-12.
- Xie C, Xu LY, Yang Z, Cao XM, Li W, Lu NH*. Expression of ?H2AX in various gastric pathologies and its association with Helicobacter pylori infection. Oncol Lett 2014; 7: 159-163.
- Yu M, Wang Q, Ding JW, Yang Z, Xie C, Lu NH*. Association between raf kinase inhibitor protein loss and prognosis in cancers of the digestive system: A meta-analysis. Cancer Biomarkers 2014; 14(5): 389-400.
- Yu M, Zhang Y, Yang Z, Ding J, Xie C, Lu N*. Association between Helicobacter pylori Infection and Stroke: A Meta-analysis of Prospective Observational Studies. Journal of Stroke & Cerebrovascular Diseases 2014; 23(9): 2233-9.
- Zhu L, Bi W, Liu X, Li J, Wu Y, Du B, Tan Y (2011) Induction of apoptosis by evodiamine involves both activation of mitotic arrest and mitotic slippage. Oncol Rep 26(6):1447-1455.
- Zhu L, Liu X, Tan Y, Li J, Du B, Wu Y (2009) Proliferation-inhibited and apoptosis-induced effects of evodiamine on human hepatoma cell line HepG2. Chinese Pharmacological Bulletin 25(1):68-71.
- Guan H, Liu X, Peng W, Cao R, Ma Y, Chen H, Xu A (2006) Beta-carboline derivatives: novel photosensitizers that intercalate into DNA to cause direct DNA damage in photodynamic therapy. Biochem Biophys Res Commun342(3):894-901.
- Guan H, Chen H, Peng W, Ma Y, Cao R, Liu X, Xu A (2006) Design of beta-carboline derivatives as DNA-targeting antitumor agents. Eur J Med Chem 41(10):1167-79.
- Cao R, Peng W, Chen H, Ma Y, Liu X, Hou X, Guan H, Xu A (2005) DNA binding properties of 9-substituted harmine derivatives. Biochem Biophys Res Commun. 338(3):1557-1563.
- Cao R, Chen H, Peng W, Ma Y, Hou X, Guan H, Liu X, Xu A (2005) Design, synthesis and in vitro and in vivo antitumor activities of novel beta-carboline derivatives. Eur J Med Chem. 40(10):991-1001.
Chairman 
