|
Dr. Huarong Chen
PhD
Research Assistant Professor
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong
Research Interests
m6A modification, GI cancer and infectious diseases |
|
Publications:
Total publication number = 49 (25 with IF > 10 and 7 with IF > 20); Total impact factors (IF) = 630; Total SCI citation = 1,073; h-index = 21 (https://www.webofscience.com/wos/author/record/2154268). Of 49 papers, 18 of them I am the first (co-first#) or senior author*. For details about citations arising from my publications and links to online versions of some of the publications, refer to: https://www.researchgate.net/profile/Huarong_Chen
(*corresponding author, ^co-first author)
- Wang Y#, Huarong Chen#, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W. MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target. Theranostics. 2022; 12(15):6509-6526. (IF = 11.6)
- Wang Y#, Huarong Chen#, Yu J, Kang W, To KF. Recent insight into the role and therapeutic potential of YAP/TAZ in gastrointestinal cancers. Biochim Biophys Acta Rev Cancer. 2022 Aug 28;1877(5):188787. (IF = 11.414)
- Huarong Chen, Pan Y, Zhou Q, Liang C, Wong CC, Zhou Y, Huang D, Liu W, Zhai J, Gou H, Su H, Zhang X, Xu H, Wang Y, Kang W, Kei Wu WK, Yu J. METTL3 inhibits anti-tumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer. Gastroenterology. 2022 Oct;163(4):891-907. (IF = 33.883)
- Chen H, Zhang X, Su H, Zeng J, Chan H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV*, Huarong Chen*. Immune dysregulation and RNA N6-methyladenosine modification in sepsis. Wiley Interdiscip Rev RNA. 2022 Sep 23:e1764. (IF = 9.349)
- Zeng J, Xie C, Zhang L, Liu X, Chan MTV, Wu WKK*, Huarong Chen*. Host cell antimicrobial responses against Helicobacter pylori infection: from biological aspects to therapeutic strategies. Int J Mol Sci. 2022 Sep 19;23(18):10941. (IF = 6.208)
- Zhang X, Su H, Chen H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV*, Huarong Chen*. RNA modifications in Gastrointestinal Cancer: Current Status and Future Perspectives. Biomedicines. 2022 Aug 8;10(8):1918. (IF = 4.757)
- Huarong Chen#*, Wang Y#, Su H, Zhang X, Chen H, Yu J*. RNA N6-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness. Front Cell Dev Biol. 2022 Jul 4;10:935224. (IF = 6.081)
- Huang D, Wang X, Huang Z, Liu Y, Liu X, Gin T, Wong SH, Yu J, Zhang L, Chan MTV*, Huarong Chen*, Wu WKK*. 3' Untranslated Regions of Tumor Suppressor Genes Evolved Specific Features to Favor Cancer Resistance. Oncogene. 2022 Jun;41(23):3278-3288. (IF = 8.756)
- Wang X, Zhang L, Liang Q, Wong CC, Chen H, Gou H, Dong Y, Liu W, Li Z, Ji J, Yu J. DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance. Oncogenesis. 2022 Oct 28;11(1):66. (IF = 7.485)
- Chan H, Li Q, Wang X, Liu WY, Hu W, Zeng J, Xie C, Kwong TNY, Ho IHT, Liu X, Huarong Chen, Yu J, Ko H, Chan RCY, Ip M, Gin T, Cheng ASL, Zhang L, Chan MTV, Wong SH, Wu WKK. Vitamin D 3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification. Autophagy. 2022 Sep;18(9):2050-2067.(IF = 13.391)
- Wong CC, Wu JL, Ji F, Kang W, Bian X, Huarong Chen, Chan LS, Luk STY, Tong S, Xu J, Zhou Q, Liu D, Su H, Gou H, Cheung AH, To KF, Cai Z, Shay JW, Yu J. The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer. Nat Commun. 2022 Jul 8;13(1):3971. (IF = 17.694)
- Wang X, Cheng FTF, Lam TYT, Liu Y, Huang D, Liu X, Huarong Chen, Zhang L, Ali Y, Wang MHT, Yu J, Gin T, Chan MTV, Wu WKK, Wong SH. Cardiovascular and Metabolic Risk - Stress hyperglycemia is associated with an increased risk of subsequent development of diabetes mellitus among bacteremic and non-bacteremic patients. Diabetes Care. 2022 Jun 2;45(6):1438-1444. (IF = 17.152)
- Sun X, Liu Y, Huang Z, Xu W, Hu W, Yi L, Liu Z, Chan H, Zeng J, Liu X, Huarong Chen, Yu J, Chan FKL, Ng SC, Wong SH, Wang MH, Gin T, Joynt GM, Hui DSC, Zou X, Shu Y, Cheng CHK, Fang S, Luo H, Lu J, Chan MTV, Zhang L, Wu WKK. SARS-CoV-2 Non-Structural Protein 6 Triggers NLRP3-dependent Pyroptosis by Targeting ATP6AP1. Cell Death Differ. 2022 Jun;29(6):1240-1254. (IF = 12.067)
- Wang X, Hu W, Li X, Huang D, Li Q, Chan H, Zeng J, Xie C, Huarong Chen, Liu X, Gin T, Wang MH, Cheng ASL, Kang W, To KF, Plewczynski D, Zhang Q, Chen X, Chan DCW, Ko H, Wong SH, Yu J, Chan MTV, Zhang L, Wu WKK. Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution. Cancer Res. 2022 Apr 15;82(8):1482-1491. (IF = 13.312)
- Wang S, Gao S, Zeng Y, Zhu L, Mo Y, Wong CC, Bao Y, Su P, Zhai J, Wang L, Soares F, Xu X, Huarong Chen, Hezaveh K, Ci X, He A, McGaha T, O'Brien C, Rottapel R, Kang W, Wu J, Zheng G, Cai Z, Yu J, He HH. N6-methyladenosine reader YTHDF1 promotes ARHGEF2 translation and RhoA signaling in colorectal cancer. Gastroenterology. 2022 Apr;162(4):1183-1196.(IF = 33.883)
- Bai X, Wong CC, Pan Y, Huarong Chen, Liu W, Zhai J, Kang W, Shi Y, Yamamoto M, Tsukamoto T, Nomura S, Chiu P, Yu J, Kwok-Wai Ng E. Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells. J Immunother Cancer. 2022 Feb;10(2):e003663. (IF = 12.469)
- Huarong Chen#, Liu W#, Wang Y, Liu D, Zhao L, Yu J. SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients. EBioMedicine. 2021 Aug;70:103500. (IF = 11.205)
- Huarong Chen, Gao S, Liu W, Wong CC, Wu J, Wu J, Liu D, Gou H, Kang W, Zhai J, Li C, Su H, Wang S, Soares F, Han J, He HH, Yu J. RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target. Gastroenterology. 2021 Mar;160(4):1284-1300. (IF = 33.883) (ESI highly cited paper)
- Zhang J, Zhai J, Wong CC, Huarong Chen, Wang X, Ji J, Yu J. A novel amplification gene PCI Domain Containing 2 (PCID2) promotes colorectal cancer through directly degrading a tumor suppressor Promyelocytic leukemia (PML). Oncogene. 2021 Dec;40(49):6641-6652. (IF = 8.756)
- Gao S, Soares F, Wang S, Wong CC, Huarong Chen, Yang Z, Liu W, Go MYY, Ahmed M, Zeng Y, O'Brien CA, Sung JJY, He HH, Yu J. CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer. Oncogene. 2021 Dec;40(48):6601-6613. (IF =8.756)
- Liu D, Wong CC, Zhou Y, Li C, Huarong Chen, Ji F, Go MYY, Wang F, Su H, Wei H, Cai Z, Wong N, Wong VWS, Yu J. Squalene epoxidase induces nonalcoholic steatohepatitis via binding to carbonic anhydrase and is a therapeutic target. Gastroenterology. 2021 Jun; 160(7):2467-2482.e3.(IF = 33.883)
- Liu W, Zhang X, Xu H, Li S, Lau HC, Chen Q, Zhang B, Zhao L, Huarong Chen, Sung JJ, Yu J. Microbial community heterogeneity within colorectal neoplasia and its correlation with colorectal carcinogenesis. Gastroenterology. 2021 Jun;160(7):2395-2408. (IF = 33.883)
- Chen Y, Cheng WY, Shi H, Huang S, Huarong Chen, Liu D, Xu W, Yu J, Wang J. Classifying gastric cancer using FLORA reveals clinically-relevant molecular subtypes and highlights LINC01614 as a biomarker for patient prognosis. Oncogene. 2021 Apr;40(16):2898-2909. (IF = 8.756)
- Yasi Pan^, Huarong Chen^, Jun Yu. Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives. Biomedicines 2020, 8, 576. (IF = 4.717)
- Yifei Wang^, Huarong Chen^, Jinglin Zhang, Alfred S.L. Cheng, Jun Yu, Ka Fai To, Wei Kang. MCM family in gastrointestinal cancer and other malignancies: from functional characterization to clinical implication. BBA - Reviews on Cancer 2020 Dec;1874(2):188415. (IF = 7.365)
- Chi Chun Wong, Jiaying Xu, Xiqing Bian, Jian-Lin Wu, Wei Kang, Yun Qian, Weilin Li, Huarong Chen, Hongyan Gou, Dabin Liu, Simson TszYat Luk, Qiming Zhou, Fenfen Ji, Lam-Shing Chan, SenjiShirasawa, Joseph JY. Sung, Jun Yu. In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance. Gastroenterology2020. https://doi.org/10.1053/j.gastro.2020.08.016. (IF = 17.373)
- Huarong Chen, Yu J. (2020) Crosstalk of Molecular Signaling in Hepatocellular Carcinoma. In: Radu-Ionita F., Pyrsopoulos N., Jinga M., Tintoiu I., Sun Z., Bontas E. (eds) Liver Diseases. Springer, Cham. (BOOK CHAPTER)
- Huarong Chen, Chi-Chun Wong, Dabin Liu, Minnie Y.Y. Go, Bin Wu, Sui Peng, Ming Kuang, Nathalie Wong, Jun Yu. APLN promotes hepatocellular carcinoma through activating PI3K/Akt pathway and is a druggable target. Theranostics 2019 Jul 9; 9(18):5246-5260. (IF = 8.579)
- Gou H, Liang JQ, Zhang L, Huarong Chen, Zhang Y, Li R, Wang X, Ji J, Tong JH, To KF, Sung JJ, Chan FK, Fang JY, Yu J. TTPAL promotes colorectal tumorigenesis by stabilizing TRIP6 to activate Wnt/�-catenin signaling. Cancer Res. 2019 Jul 1;79(13):3332-3346. (IF = 9.727)
- Chi Chun Wong, Wei Kang, Jiaying Xu, Yun Qian, Simson Tsz Yat Luk, Huarong Chen, Weilin Li, Liuyang Zhao, Xiaoming Zhang, Phlip WY Chiu, Enders KW Ng, Jun Yu. Prostaglandin E-2 induces DNA hypermethylation in gastric cancer in vitro and in vivo. Theranostics 2019; 9(21): 6256�6268. (IF = 8.579)
- Wang X, Liang JQ, Zhang LH, Gou H, Li Z, Huarong Chen, Dong Y, Ji J, Yu J. C8orf76 promotes gastric tumorigenicity and metastasis by directly inducing lncRNA DUSP5P1 and associates with patient outcomes. Clin Cancer Res.2019 May 15;25(10):3128-3140. (IF = 10.107)
- Yujuan Dong, Yanquan Zhang, Wei Kang, Guoping Wang, Huarong Chen, Akira Higashimori, Geicho Natkatsu, Minnie Go, Joanna HM Tong, Shu Zheng, Ka Fai To, Joseph JY Sung, Xiaoyong Yang, Simon SM Ng, Jun Yu. VSTM2A Suppresses Colorectal Cancer and Antagonizes Wnt Signaling Receptor LRP6. Theranostics2019 Aug 21;9(22):6517-6531. (IF = 8.579)
- Zhang L, Li W, Cao L, Xu J, Qian Y, Huarong Chen, Zhang Y, Kang W, Gou H, Wong CC, Yu J. PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53. Oncogene. 2019 Jun;38(23):4590-4604. (IF = 7.971)
- Tang J*, Huarong Chen*, Wong CC, Liu D, Li T, Wang X, Ji J, Sung JJ, Fang JY, Yu J. DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients. Oncogene. 2018 May;37(22):3006-3021. (IF = 7.971)
- Liu D, Wong CC, Fu L, Huarong Chen, Zhao L, Li C, Zhou Y, Zhang Y, Xu W, Yang Y, Wu B, Cheng G, Lai PB, Wong N, Sung JJY, Yu J. Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a direct pharmaceutical target. Sci Transl Med. 2018 Apr 18;10(437). (IF = 16.304)
- Weilin Li, Chi Chun Wong, Xiaoming Zhang, Wei Kang, Geicho Nakatsu, Qinfu Zhao, Huarong Chen, Minnie Yin Yin Go, Philip Wai Yan Chiu, Xiaohong Wang, Jiafu Ji, Xiaona Li, Zongwei Cai, Enders Kwok Wai Ng & Jun Yu. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1a axis to inhibit gastric tumorigenesis. Oncogene. 2018 Dec;37(50):6383-6398. (IF = 7.971)
- Huarong Chen, Cai W, Chu ES, Tang J, Wong CC, Wong SH, Sun W, Liang Q, Fang J, Sun Z, Yu J. Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice. Oncogene. 2017 Aug;36(31):4415-4426. (IF = 7.971)
- Yun Q, Wong CC, Xu J, Huarong Chen, Zhang Y, Kang W, Wang H, Zhang L, Li W, Chu ES, Go MY, Chiu PW, Ng EK, Chan FK, Sung JJ, Si J, Yu J. Sodium channel subunit SCNN1B suppresses gastric cancer growth and metastasis via GRP78 degradation. Cancer Res. 2017 Apr 15;77(8):1968-1982. (IF = 9.727)
- Huarong Chen, Xiaoqiang Sun, Weiting Ge, Yun Qian, Rui Bai, Shu Zheng. A Seven-Gene Signature Predicts Overall Survival of Patients with Colorectal Cancer. Oncotarget. 2016 Aug 1;8(56):95054-95065.
- Wong CC, Qian Y, Li X, Xu J, Kang W, Tong JH, To KF, Jin Y, Li W, Huarong Chen, Go MY, Wu JL, Cheng KW, Ng SS, Sung JJ, Cai Z, Yu J. SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations, and Xenograft Tumor Progression in Mice, via Intracellular Synthesis of Aspartate. Gastroenterology. 2016 Nov;151(5):945-960. (IF = 17.373)
- Qian Y, Wong CC, Lai S, Huarong Chen, He X, Sun L, Wu J, Zhou J, Yu J, Liu W, Zhou D, Si J. A retrospective study of pyogenic liver abscess focusing on Klebsiella pneumoniae as a primary pathogen in China from 1994 to 2015. Sci Rep. 2016 Dec 8; 6: 38587. (IF = 3.998)
- Li Bai, Zubin Yu, Jiawei Zhang, Shuai Yuan, Chen Liao, Prince Jeyabal, Valentina Rubio, Huarong Chen, Yafei Li, Zheng-Zheng Shi. OLA1 contributes to epithelial-mesenchymal transition in lung cancer through the modulation of GSK3�/snail/E-cadherin signaling. Oncotarget. 2016 Mar 1;7(9):10402-13.
- Huarong Chen, Song R, Wang G, Ding Z, Yang C, Zhang J, Zeng Z, Rubio V, Wang L, Zu N, Weiskoff AM, Minze LJ, Jeyabal PV, Mansour OC, Bai L, Merrick WC, Zheng S, Shi ZZ. OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation. Sci Rep. 2015 Aug 18; 5:13241.(IF = 3.998)
- Zhu L*, Huarong Chen*, Zhou D, Li D, Bai R, Zheng S, Ge W. MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility. Med Oncol. 2012, 29(2):1037-43. (IF = 2.834)
- Zhou J, Zhang M, Huang Y, Feng L, Chen H, Hu Y, Huarong Chen, Zhang K, Zheng L, Zheng S. MicroRNA-320b promotes colorectal cancer proliferation and invasion by competing with its homologous microRNA-320a. Cancer Lett. 2015 Jan 28; 356(2 Pt B):669-75.(IF = 7.36)
- Fu Z, Song P, Li D, Yi C, Huarong Chen, Ruan S, Shi Z, Xu W, Fu X, Zheng S. Cancer-associated fibroblasts from invasive breast cancer have an attenuated capacity to secrete collagens. Int J Oncol. 2014 Oct; 45(4):1479-88. (IF = 3.899)
- Jeyabal PV, Rubio V, Huarong Chen, Zhang J, Shi ZZ. Regulation of cell-matrix adhesion by OLA1, the Obg-like ATPase 1. Biochem Biophys Res Commun. 2014 Feb 21; 444(4):568-74. (IF = 2.985)
- Mao RF, Rubio V, Huarong Chen, Bai L, Mansour OC, Shi ZZ. OLA1 protects cells in heat shock by stabilizing HSP70. Cell Death Dis.2013 Feb 14; 4:e491. (IF = 6.304)
- Fu Z, Zuo Y, Li D, Xu W, Li D, Huarong Chen, Zheng S. The crosstalk: Tumor-infiltrating lymphocytes rich in regulatory T cells suppressed cancer-associated fibroblasts. Acta Oncol. 2013, 52(8):1760-70. (IF = 3.701)
- Hu H, Zhang H, Ge W, Liu X, Loera S, Chu P, Huarong Chen, Peng J, Zhou L, Yu S, Yuan Y, Zhang S, Lai LL, Yen Y, Zheng S. Secreted Protein Acidic and Rich in Cysteines-Like 1 Suppresses Aggressiveness and Predicts Better Survival in Colorectal Cancers. Clin Cancer Res. 2012, 18(19):5438-48. (IF = 10.107)
- Zhu L, Bi W, Liu X, Li J, Wu Y, Du B, Tan Y (2011) Induction of apoptosis by evodiamine involves both activation of mitotic arrest and mitotic slippage. Oncol Rep 26(6):1447-1455.
- Zhu L, Liu X, Tan Y, Li J, Du B, Wu Y (2009) Proliferation-inhibited and apoptosis-induced effects of evodiamine on human hepatoma cell line HepG2. Chinese Pharmacological Bulletin 25(1):68-71.
- Guan H, Liu X, Peng W, Cao R, Ma Y, Chen H, Xu A (2006) Beta-carboline derivatives: novel photosensitizers that intercalate into DNA to cause direct DNA damage in photodynamic therapy. Biochem Biophys Res Commun342(3):894-901.
- Guan H, Chen H, Peng W, Ma Y, Cao R, Liu X, Xu A (2006) Design of beta-carboline derivatives as DNA-targeting antitumor agents. Eur J Med Chem 41(10):1167-79.
- Cao R, Peng W, Chen H, Ma Y, Liu X, Hou X, Guan H, Xu A (2005) DNA binding properties of 9-substituted harmine derivatives. Biochem Biophys Res Commun. 338(3):1557-1563.
- Cao R, Chen H, Peng W, Ma Y, Hou X, Guan H, Liu X, Xu A (2005) Design, synthesis and in vitro and in vivo antitumor activities of novel beta-carboline derivatives. Eur J Med Chem. 40(10):991-1001.
Chairman 
