The Chinese University of Hong Kong & Prince of Wales Hospital

Department of Obstetrics and Gynaecology

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Prof. Chan Yiu Leung, David

Prof. Chan Yiu Leung, David Assistant Professor
(852) 3505 3199 drdcyl16@cuhk.edu.hk

Qualifications

BSc (Ulster), MPhil (CUHK), DPhil (Oxon), Certified Medical Technologist (American Medical Technologist, AMT)

Biography

Professor CHAN Yiu Leung David earned his bachelor degree in Biotechnology in Ulster University (UK) in 2002 and his MPhil in brain cancer research in The Chinese University of Hong Kong (CUHK) in 2006 respectively. In 2006, he was a Visiting Scholar in University of Pennsylvania to study reproductive cloning. He then obtained his DPhil in chromosome engineering from University of Oxford (UK) in 2011, supported by Clarendon Award and Hong Kong China Oxford scholarships. Professor CHAN had his post-doctoral training in CUHK briefly and then he was trained and practiced in embryology and andrology in University of Hong Kong (HKU), Queen Mary Hospital (QMH) for four and a half years. He joined the Department of Obstetrics and Gynaecology, CUHK in August 2016 and was appointed as Research Assistant Professor in the reproductive medicine team of CUHK.

1
The Sperm Small RNA Transcriptome: Implications beyond Reproductive Disorder Chan SY, Wan CWT, Law TYS, Chan DYL, Fok EKL Int J Mol Sci. 2022 Dec 11;23(24):15716
2
In vitro rescue immature oocytes - a literature review Jie HY, Zhao MP, Alqawasmeh OAM, Chan CPS, Lee TL, Li TC, Chan DYL Hum Fertil (Camb). 2022 Oct;25(4):640-650
3
Common dysmorphic oocytes and embryos in assisted reproductive technology laboratory in association with gene alternations Xu M, Wu W, Zhao M, Chung JPW, Li TC, Chan DYL Int J Biochem Cell Biol. 2022 Sep 16;152:106298
4
Nonoxynol-9 (N-9) on sperm functions: Systematic review and meta-analysis. Xu M, Zhao M, Li RHW, Lin Z, Chung JPW, Li TC, Lee TL, Chan DYL. Effects of Reprod Fertil. 2022 Feb 21;3(1):R19-R33
5
Application of convolutional neural network on early human embryo segmentation during in vitro fertilization. Journal of cellular and molecular medicine, Zhao M, Xu M, Li H, Alqawasmeh O, Chung JPW, Li TC, Lee T, Tang PM, Chan DYL. 2021 Mar;25(5):2633-2644
6
The effects of daily meteorological perturbation on pregnancy outcome: Follow-up of a cohort of young women undergoing IVF treatment. Zhao M, Zhang H, Waters THB, Chung JPW, Li TC, Chan DYL. Environ Health. 2019 Nov 28;18(1):14pages
7
A double-blinded, randomized placebo-controlled trial on the effect of traditional Chinese medicine formula Wuzi Yanzong pill on improving semen qualities in men with suboptimal parameters. Zhao M, Chan CPS, Cheung CWC, Alqawasmeh O, Wang RCC, Wu JCY, Lin ZX, Li TC, Chung JPW, Mak JSM, Law TSM, Chan DYL. Trials. 2019 Aug 29;20(1):540.
8
Development and Validation of a Novel Prognostic Nomogram Combined with Desmoplastic Reaction for Synchronous Colorectal Peritoneal Metastasis Qin X, Zhao M, Deng W, Huang Y, Cheng Z, Chung JPW, Chen X, Yang K, Chan DYL, Wang H Front Oncol. 2022 Mar 11;12:826830
9
Effects of nonoxynol-9 (N-9) on sperm functions: systematic review and meta-analysis Xu M, Zhao M, Li RHW, Lin Z, Chung JPW, Li TC, Lee TL, Chan DYL Reprod Fertil. 2022 Feb 21;3(1):R19-R33
10
Associations between ambient air pollution and IVF outcomes in a heavily polluted city in China Liu J, Zhao M, Zhang H, Zhao J, Kong H, Zhou M, Guan Y, Li TC, Wang X, Chan DYL Reprod Biomed Online. 2022 Jan;44(1):49-62
11
Single-cell RNA sequencing identifies molecular targets associated with poor in vitro maturation performance of oocytes collected from ovarian stimulation Lee AWT, Ng JKW, Liao J, Luk AC, Suen AHC, Chan TTH, Cheung MY, Chu HT, Tang NLS, Zhao MP, Lian Q, Chan WY, Chan DYL, Leung TY, Chow KL, Wang W, Wang LH, Chen NCH, Yang WJ, Huang JY, Li TC, Lee TL Hum Reprod. 2021 Jun 18;36(7):1907-1921
12
Associations between blood metal/ metalloid concentration and human semen quality and sperm function: A cross-sectional study in Hong Kong Shi X, Chan CPS, Man GKY, Chan DYL, Wong MH, Li TC J Trace Elem Med Biol. 2021 May;65:126735
13
Automated and precise recognition of human zygote cytoplasm: A robust image-segmentation system based on a convolutional neural network Zhao M, Li H, Li R, Li Y, Luo X, Li TC, Lee TL, Wang WJ, Chan DYL Biomedical Signal Processing and Control 2021 May;67:102551
14
Kidney Biopsy in Patients with Monoclonal Gammopathy: A Multicenter Retrospective Cohort Study Nie S, Wang M, Wan Q, Kong Y, Ou J, Jia N, Zhang X, Luo F, Liu X, Wang L, Cao Y, Chen R, Zhao M, Chan DYL, Wang G Front Med (Lausanne). 2021 May 24;8:687149
15
Green tea extract as a cryoprotectant additive to preserve the motility and DNA integrity of human spermatozoa Alqawasmeh OAM, Zhao M, Chan CPS, Leung MBW, Chow KC, Agarwal N, Mak JSM, Wang CC, Pang CP, Li TC, Chu WK, Chan DYL Asian J Androl. Mar-Apr 2021;23(2):150-156
16
Application of convolutional neural network on early human embryo segmentation during in vitro fertilization Zhao MP, Xu MR, Li HH, Alqawasmeh O, Chung JPW, Li TC, Lee TL, Tang PMK, Chan DYL J Cell Mol Med. 2021 Mar;25(5):2633-2644
17
Effectiveness of a childbirth massage programme for labour pain relief in nulliparous pregnant women at term: a randomised controlled trial Lai CY, Wong MKW, Tong WH, Chu SY, Lau KY, Tan AML, Hui LL, Lao TTH, Leung TY Hong Kong Med J. 2021 Dec;27(6):405-412
18
CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia Chen H, Shi X, Li XF, Diao RY, Ma Q, Jin J, Qiu ZL, Li CL, Yu MK, Wang CQ, Li XX, Li FH, Chan DYL, Zhao AZJ, Cai ZM, Sun F, Fok KL Mol Ther Nucleic Acids. 2021 Nov 10;26:1374-1386
19
The predictive value of endometrial thickness in 3117 fresh IVF/ICSI cycles for ectopic pregnancy Fang T, Chen M, Yu W, Ma T, Su Z, Chan DYL, Zhao M, Zheng Q, Wang W J Gynecol Obstet Hum Reprod. 2021 Jan 25;50(8):102072
20
Early transient suppression of immune checkpoint proteins T-cell immunoglobulin mucin-3 and programmed cell death-1 in peripheral blood lymphocytes after blastocyst transfer is associated with successful implantation Zhang T, Zhu W, Zhao Y, Cheung WC, Liu Y, Chen X, Du Y, Leung KT, Chan YL, Wang CC, Laird S, Li TC Fertil Steril. 2020 Aug;114(2):426-435
21
TILT: Time-Lapse Imaging Trial-a pragmatic, multi-centre, three-arm randomised controlled trial to assess the clinical effectiveness and safety of time-lapse imaging in in vitro fertilisation treatment Bhide P, Srikantharajah A, Lanz D, Dodds J, Collins B, Zamora J, Chan DYL, Thangaratinam S, Khan KS Trials. 2020 Jul 1;21(1):600
22
Time-Lapse Imaging Trial: A pragmatic, multi-centre, three-arm randomised controlled trial to assess the clinical effectiveness and safety of time-lapse imaging in in-vitro fertilisation treatment Bhide P, Srikantharajah A, Lanz D, Dodds J, Collins B, Zamora J, Chan DYL, Thangaratinam S, Khan KS Trials. 2020 Jul 1;21(1):600
23
Influence of the Period of Abstinence on Semen Quality in a Patient with Systemic Lupus Erythematosus: A Case Report and Review of the Literature Waters THB, Chan CPS, Li TC, Chan DYL Case Rep Rheumatol. 2020 Mar 7;2020:9296858
24
Multigene human artificial chromosome vector delivery with herpes simplex virus 1 amplicons Chan DYL, Moralli D, Wheatley L, Jankowska JD, Monaco ZL Exp Cell Res. 2020 Mar 15;388(2):111840 (5 pages)
25
A double-blinded, randomized placebo-controlled trial on the effect of traditional Chinese medicine formula Wuzi Yanzong pill on improving semen qualities in men with suboptimal parameters Zhao M, Chan CPS, Cheung CWC, Alqawasmeh O, Wang RCC, Wu JCY, Lin ZX, Li TC, Chung JPW, Mak JSM, Law TSM, Chan DYL Trials. 2019 Aug 29;20(1):540 (7 pages)
26
Maternal β-HCG concentrations in early IVF pregnancy: association with the embryo development stage of blastocysts Zhu W, Yeung QSY, Chan DYL, Chi L, Huang J, Wang Q, Chung JPW, Li TC Reprod Biomed Online. 2019 May;38(5):683-690
27
Comparative analysis of single-cell parallel sequencing approaches in oocyte application Qian Y, Liao J, Suen AHC, Lee AWT, Chung HS, Tang NLS, Chow KL, Cao Q, Yip YL, Leung TY, Chan WY, Chan DYL, Li TC, Lee TL Int J Biochem Cell Biol. 2019 Feb;107:1-5
28
The effects of daily meteorological perturbation on pregnancy outcome: Follow-up of a cohort of young women undergoing IVF treatment Zhao M, Zhang H, Waters THB, Chung JPW, Li TC, Chan DYL Environ Health. 2019 Nov 28;18(1):103, 14pages
29
Comparison of DNA fragmentation levels in spermatozoa with different sex chromosome complements Shi X, Chan DYL, Zhao MP, Chan CPS, Huang J, Li TC Reprod Biomed Online. 2019 Jan;38(1):56-65
30
Lifestyle and demographic factors associated with human semen quality and sperm function Shi X, Chan CPS, Waters T, Chi L, Chan DYL, Li TC Syst Biol Reprod Med. 2018 Oct;64(5):358-367
31
The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials Zhao M, Shi X, Kong GWS, Wang CC, Wu JCY, Lin Z, Li TC, Chan DYL Evidence-Based Complementary and Alternative Medicine Jan 2018 (2968025): 1-10
32
Comparison of the external physical damages between laser-assisted and mechanical immobilized human sperm using scanning electronic microscopy Chan DYL, Li TC PLoS One 2017 27;12(11):e0188504
33
Comparison of the external physical damages between laser-assisted and mechanical immobilized human sperm using scanning electronic microscopy. Chan DYL, Li TC. PloS one. 2017;12(11):e0188504. Epub 2017/11/28. doi: 10.1371/journal.pone.0188504. PubMed PMID: 29176855.
34
Human varicella zoster virus is not present in the semen of a man affected by chickenpox during the in vitro fertilisation of his wife. Chan DYL, Lam KKW, Lau EYL, Yeung WSB, Ng EHY Andrologia. 2017. Epub 2017/07/04. doi: 10.1111/and.12822. PubMed PMID: 28670753.
35
Mitochondria Manipulation in Oocytes: A Mini-Review Zhao M, Li TC, Chan DYL Int J Obstet Gynaecol Stud. 2017 1(1) :1-5
36
Mitochondria Manipulation in Oocytes: A Mini-Review. Ming Peng Zhao TCL, Chan DYL* Int J Obstet Gynaecol Study. 2017;1(1).
37
Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells Chan DYL, Moralli D, Khoja S, Monaco ZL Disease Markers. 2017;2017:8. doi: 10.1155/2017/7506976.