Dr. Yaping LIU
Assistant Professor (Non-clinical)

Doctor LIU Yaping
Assistant Professor (Non-clinical)

PhD (CUHK)

Fax: (852) 2667-5464
Email: yaping.liu@cuhk.edu.hk
ORCID: 0000-0002-2015-8775

PROFESSIONAL QUALIFICATION
  • Ph.D. in Medical Sciences, Faculty of Medicine, The Chinese University of Hong Kong (2016) 
  • Master in Clinical Medicine, Jinan University (2012) 
  • Bachelor in Clinical Medicine, Southern Medical University (2009)
AWARDS
  • Young Investigator Award. Conference/organization: World Sleep 2017, World Association of Sleep Medicine and World Sleep Federation, Prague, Czech Republic. October 2017.
     
  • Best Oral Presentation Award. Conference/organization: CUHK SLEEP 2016, The Chinese University of Hong Kong, Hong Kong. October 2016.
RESEARCH INTERESTS
  • Determine progression of idiopathic REM sleep behavior disorder towards neurodegenerative diseases and its biomarkers. 
  • Examine the potential effective neuroprotective strategies in REM sleep behavior disorder to prevention Parkinson’s disease and dementia.
TRAINING
  • 2018-2020 Postdoctoral Visiting Fellow in the Nuffield Department of Clinical Neurosciences, University of Oxford, UK 
  • 2016-2018 Postdoctoral Fellow in the Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 
  • 2009-2013 Resident in the Department of Psychiatry and Sleep Center, the First Affiliated Hospital, Jinan University, Guangzhou, China 
  • 2007-2009 Internship: Internal Medicine, Surgery, Pediatrics and Gynaecology and Obstetrics. The Second Clinical Medical College, Zhujiang Hospital, Southern Medical University, Guangzhou, China
CURRENT PROJECTS
  1. PI, Health and Medical Research Fund (08191416). Neural correlates of impulsivity in idiopathic REM sleep behavior disorder and Parkinson’s disease: a functional Magnetic Resonance Imaging case-control study. HK$ 1,122,120. 01/12/2021-30/11/2024. 
  2. PI, Knowledge Transfer Project Fund (KPF21GWP26). Risk screening for prodromal Parkinson’s disease in elderly using smartphone. The Chinese University of Hong Kong. HK$ 395,380. 01/04/2021-31/03/2023. 
  3. PI, Direct Grant for Research (2020.084). Impact of Long COVID–Neurodegenerative Perspective. CUHK. HK$ 149,000. 30/06/2021-29/06/2022.  
  4. Co-PI, Collaborative Research Fund (C4044-21GF). Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alpha-synucleinopathy Neurodegeneration, in a Prospective Family Cohort. HK$ 7,214,620. 01/04/2022-31/03/2025. 
  5. Co-PI, Collaborative Research Fund (C4061-21GF). Neuropsychiatric ‘long-COVID’ in adult patients. HK$ 3,251,480. 01/04/2022-31/03/2023. 
  6. Co-I, General Research Fund (14108722). Family-based association study in idiopathic rapid eye movement sleep behavior disorder: a two-phase study using whole exome sequencing. HK$ 1,300,000. Start in 2023. 
  7. Co-I, Health and Medical Research Fund (18190931). AI-Based Day and Night Digital Phenotyping of Rapid Eye Movement (REM) Sleep Behaviors Disorder (RBD) and its Prediction towards α-Synucleinopathy. HK$ 1,495,330. Start in 2023. 
  8. Co-I, Health and Medical Research Fund (09202766). Randomized placebo- and active-controlled trial for assessing the efficacy of bright light therapy for sleep and mood symptoms in patients with Parkinson’s disease.  HK$ 1,413,200. 01/08/2022-31/07/2025. 
  9. Co-I, Health and Medical Research Fund (18190221). Gut microbiota in major depressive disorders with and without Rapid Eye Movement Behaviour Disorder: tracing a subtype of depression with underlying neurodegeneration. HK$ 1,104,304. 01/10/2021-31/03/2024. 
  10. Co-I, General Research Fund (14116121). Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study. HK$ 1,130,208. 01/01/2022-31/12/2025. 
  11. Co-I, Health and Medical Research Fund (06170676). A 7-year prospective study of idiopathic REM sleep behavior disorder cohort in Chinese population: determining the optimal characteristics of prodromal markers to predict neurodegenerative diseases. HK$ 1,250,616. 01/07/2019-30/06/2022. 
  12. Co-I, National Natural Science Foundation of China (81471348). Mechanisms of Circadian Rhythms in the Progression of REM sleep behavior disorder towards neurodegeneration. CNY 70,000. 01/01/2015-31/12/2018. 
SELECTED PUBLICATIONS
  1. Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK, Liu Y.
    Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder.
    J Sleep Res. 2022:e13791.
  2. Liu Y, Zhang J, Chau SW, Man Yu MW, Chan NY, Chan JW, Li SX, Huang B, Wang J, Feng H, Zhou L, Mok V, Wing YK*.
    Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study.
    Neurology. 2022;99(6):e627-e637.
  3. Liu Y, Partinen E, Chan NY, Dauvilliers Y, Inoue Y, De Gennaro L, Plazzi G, Bolstad CJ, Nadorff MR, Merikanto I, Bjorvatn B, Han F, Zhang B, Cunha AS, Mota-Rolim S, Léger D, Matsui K, Espie CA, Chung F, Morin CM, Sieminski M, Thomas P, Holzinger B, Partinen M*, Wing YK*.
    Dream-enactment behaviours during the COVID-19 pandemic: an international COVID-19 sleep study.
    J Sleep Res. 2022:10.1111/jsr.13613.
  4. Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT*.
    Longitudinal changes in Parkinson’s disease symptoms with and without REM sleep behavior disorder: the Oxford Discovery Cohort study.
    Mov Disord. 2021;36(12):2821-2832.
  5. Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MW, Chan NY, Chan JW, Li SX, Huang B, Feng H, Mok VCT, Wing YK*.
    Residual Injurious Symptoms and Its Association with Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-Up Study.
    Mov Disord. 2020;35(11):2077-2085.
  6. Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MW, Huang B, Li SX, Chau SWH, Chan JW, Chen J, Mok VCT, Wing YK*, Zhang J*.
    Rest-activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
    Ann Neurol. 2020;88(4):817-829.
  7. Liu Y#, Zhang J#, Lam SP, Zhou J, Yu MWM, Li SX, Chan JW, Postuma RB, Mok VCT, Wing YK*.
    A case-control-family study of idiopathic rapid eye movement sleep behavior disorder.
    Ann Neurol. 2019;85(4):582-592.
  8. Liu Y, Zhang J*, Lam SP, Yu MW, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan Anne, Mok VCT, Wing YK.
    Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study.
    Sleep Med. 2019;56:128-134.
  9. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK*.
    Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.
    Sleep Med. 2018, 24;53:1-8.
  10. Liu Y, Zhang J, Lam V, Ho CK, Zhou J, Li SX, Lam SP, Yu MW, Tang X, Wing YK*.
    Altered Sleep Stage Transitions of REM Sleep: A Novel and Stable Biomarker of Narcolepsy.
    J Clin Sleep Med. 2015;11(8):885-94.
 
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