Guy LJ CHEN

Research Programmes

1. Molecular genomics and mechanisms of age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV)
2. Molecular genomics and mechanisms of primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG)
3. Investigations and screening for eye diseases in children (Hong Kong Children Eye Study) & investigation of genetic factors of longitudinal development of ocular parameters in children.
4. Molecular genetics of complex eye diseases: high myopia, diabetic macular edema, and uveitis.

Results of Note 

1. Dr CHEN is actively working on ophthalmic researches. His major research interest is ophthalmic genetics, including new gene identification, population genetic association and mutation profiles investigation, genotype-phenotype correlation, genetic prediction model, gene function and disease pathways of major eye diseases, including macular and retinal diseases (e.g., AMD and PCV, diabetic retinopathy, retinitis pigmentosa, etc.), glaucoma, myopia, and corneal dystrophy, etc. He is also working on the genetic profiling of myopia progression in children. Dr CHEN and co-workers have identified a large number of new disease genes/loci, new mutations, new association profiles, and biomarkers for major eye diseases.
2. Dr CHEN is the Principal Investigator (PI) of 6 external competitive research grants, including 1 General Research Fund (GRF) from the Research Grants Council, Hong Kong; 1 Youth Fund of the National Natural Science Foundation of China (NSFC); 3 Health and Medical Research Fund (HMRF) from Food and Health Bureau, Hong Kong; and 1 Research Award from the Global Ophthalmology Awards Program (GOAP) from Bayer, Germany. The total amount of the research funds is over HK$ 5 million
3. Dr CHEN has published over 100 papers in SCI international indexed peer-reviewed journals. He is the first or corresponding author of 40 publications. He has co-authored 1 paper in Lancet Oncology (impact factor [IF] 35.38), 7 papers in Nature Genetics (IF 25.45), 3 in Nature Communication (IF 11.87), 2 in American Journal of Human Genetics (IF 9.92), 1 in PNAS (IF 9.58), 1 in Genetic Medicine (IF 8.68), 1 in Ocular Surface (IF 9.10), 8 in Ophthalmology (IF 7.47), 16 in IOVS (IF 3. 81), and 9 in Br J Ophthalmol (IF 3.61), etc.
4. The H-Index of Dr CHEN is 26 as of May 2019

Representative Publications:

( * co-first author ; # corresponding author )

1. Chen ZJ, Lu SY, Rong SS, Ho M, Ng DS, Chen H, Gong B, Yam JC, Young AL, Brelen M, Tham CC, Pang CP, ^#Chen LJ. Genetic associations of central serous chorioretinopathy: a systematic review and meta-analysis. Br J Ophthalmol. 2021 May 26: doi: 10.1136/bjophthalmol-2021-318953.
2. Chen LJ, Li FF, Lu SY, Zhang XJ, Kam KW, Tang SM, Tam PO, Yip WW, Young AL, Tham CC, Pang CP, Yam JC. Association of polymorphisms in ZFHX1B, KCNQ5 and GJD2 with myopia progression and polygenic risk prediction in children. Br J Ophthalmol. 2021 Dec;105(12):1751-1757.
3. Li FF, Lu SY, Tang SM, Kam KW, Pancy O S T, Yip WWK, Young AL, Tham CC, Pang CP, Yam JC, ^#Chen LJ. Association of multiple gene variants with myopia severities and endophenotypes in children. Br J Ophthalmol. 2021 Aug;105(8):1178-1183.
4. Tang SM, Li FF, Lu SY, Kam KW, Tam PO, Tham CC, Pang CP, Yam JC, #Chen LJ. Association of the ZC3H11B, ZFHX1B and SNTB1 Genes with Myopia of Different Severities. Br J Ophthalmol. 2020 Oct;104(10):1472-1476.
5. Lu SY, Tang SM, Li FF, Kam KW, Pam PO, Yip WK, Young AL, Tham CC, Pang CP, Yam JC, ^#Chen LJ. Association of WNT7B and RSPO1 with Axial Length in School Children. Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):11.
6. Lu SY, Rong SS, Wu Z, Huang C, Matsushita K, Ng TK, Leung CK, Kawashima R, Usui S, Tam PO, Tsujikawa M, Young AL, Zhang M, Wiggs J, Nishida K, Tham CC, Pang CP, ^#Chen LJ. Association of the CAV1-CAV2 locus with Normal Tension Glaucoma in Chinese and Japanese. Clin Exp Ophthalmol. 2020 Jul;48(5):658-665.
7. Chen ZJ, Ma L, Brelen ME, Chen H, Tsujikawa M, Lai TY, Ho M, Sayanagi K, Hara C, Hashida N, Tam PO, Young AL, Nishida K, Tham CC, Pang CP, ^#Chen LJ. Identification of TIE2 as a susceptibility gene for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Br J Ophthalmol. 2020 Mar 9. [Epub ahead of print]
8. Ma L, Ng TK, Chen H, Brelén ME, Lai TYY, Ho M, Tam POS, Young AL, Chen W, Tham CC, Pang CP, ^#Chen LJ. Identification and characterization of a novel promoter variant in placental growth factor for neovascular age-related macular degeneration. Exp Eye Res. 2019 Aug 1;187:107748.
9. Wang YM, Ma L, Lu SY, Chan TCY, Yam JCS, Tang SM, Kam KW, Tam POS, Tham CC, Young AL, Jhanji V, Pang CP, #Chen LJ. Analysis of multiple genetic loci reveals MPDZ-NF1B rs1324183 as a putative genetic marker for keratoconus. Br J Ophthalmol. 2018 Dec;102(12):1736-1741.
10. Tang SM, Ma L, Lu SY, Wang YM, Kam KW, Tam POS, Young AL, Pang CP, Yam JCS, #Chen LJ. Association of the PAX6 gene with extreme myopia rather than lower grade myopias. Br J Ophthalmol. 2018 Apr;102(4):570-574.
11. Tang FY, Ma L, Tam POS, Pang CP, Tham CCY, Chen LJ#. Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus with Primary Angle-Closure Glaucoma in Chinese. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4104-4109.
12. Ma L, Brelen ME, Tsujikawa M, Chen H, Chu WK, Lai TY, Ng DS, Sayanagi K, Hara C, Hashida N, Chan VC, Tam PO, Young AL, Chen W, Nishida K, Pang CP, Chen LJ#. Identification of ANGPT2 as a New Gene for Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the Chinese and Japanese Populations. Invest Ophthalmol Vis Sci. 2017 Feb 1; 58(2):1076-1083.
13. Ma L, Liu K, Tsujikawa M, Chen H, Brelen ME, Chan VC, Lai TY, Sayanagi K, Hara C, Hashida N, Tam PO, Young AL, Chen W, Nishida K, Pang CP, Chen LJ#. Association of ABCG1 with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Chinese and Japanese. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5758-5763.
14. Huang L, Zhang H, Cheng CY, Wen F, Tam PO, Zhao P, Chen H, Li Z, Chen LJ, Tai Z, Yamashiro K, Deng S, Zhu X, Chen W, Cai L, Lu F, Li Y, Cheung CG, Shi Y, Miyake M, Lin Y, Gong B, Liu X, Sim KS, Yang J, Mori K, Zhang X, Cackett PD, Tsujikawa M, Nishida K, Hao F, Ma S, Lin H, Cheng J, Fei P, Lai TY, Tang S, Laude A, Inoue S, Yeo IY, Sakurada Y, Zhou Y, Iijima H, Honda S, Lei C, Zhang L, Zheng H, Jiang D, Zhu X, Wong TY, Khor CC, Pang CP, Yoshimura N, Yang Z. A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy. Nat Genet. 2016 Jun;48(6):640-7.
15. Chen LJ, Ma L, Chu WK, Lai TY, Chen H, Brelén ME, Rong SS, Young AL, Tam PO, Zhang M, Pang CP. Identification of PGF as a New Gene for Neovascular Age-Related Macular Degeneration in a Chinese Population. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):1714-1720.
16. Khor CC*, *Do T, Jia H*, Nakano M*, George R*, Abu-Amero K*, Duvesh R*, Chen LJ*, Li Z, Nongpiur ME, Perera SA, Qiao C, Wong HT, Sakai H, Barbosa de Melo M, Lee MC, Chan AS, Azhany Y, Dao TL, Ikeda Y, Perez-Grossmann RA, Zarnowski T, Day AC, Jonas JB, Tam PO, Tran TA, Ayub H, Akhtar F, Micheal S, Chew PT, Aljasim LA, Dada T, Luu TT, Awadalla MS, Kitnarong N, Wanichwecharungruang B, Aung YY, Mohamed-Noor J, Vijayan S, Sarangapani S, Husain R, Jap A, Baskaran M, Goh D, Su DH, Wang H, Yong VK, Yip LW, Trinh TB, Makornwattana M, Nguyen TT, Leuenberger EU, Park KH, Wiyogo WA, Kumar RS, Tello C, Kurimoto Y, Thapa SS, Pathanapitoon K, Salmon JF, Sohn YH, Fea A, Ozaki M, Lai JS, Tantisevi V, Khaing CC, Mizoguchi T, Nakano S, Kim CY, Tang G, Fan S, Wu R, Meng H, Nguyen TT, Tran TD, Ueno M, Martinez JM, Ramli N, Aung YM, Reyes RD, Vernon SA, Fang SK, Xie Z, Chen XY, Foo JN, Sim KS, Wong TT, Quek DT, Venkatesh R, Kavitha S, Krishnadas SR, Soumittra N, Shantha B, Lim BA, Ogle J, de Vasconcellos JP, Costa VP, Abe RY, de Souza BB, Sng CC, Aquino MC, Kosior-Jarecka E, Fong GB, Tamanaja VC, Fujita R, Jiang Y, Waseem N, Low S, Pham HN, Al-Shahwan S, Craven ER, Khan MI, Dada R, Mohanty K, Faiq MA, Hewitt AW, Burdon KP, Gan EH, Prutthipongsit A, Patthanathamrongkasem T, Catacutan MA, Felarca IR, Liao CS, Rusmayani E, Istiantoro VW, Consolandi G, Pignata G, Lavia C, Rojanapongpun P, Mangkornkanokpong L, Chansangpetch S, Chan JC, Choy BN, Shum JW, Than HM, Oo KT, Han AT, Yong VH, Ng XY, Goh SR, Chong YF, Hibberd ML, Seielstad M, Png E, Dunstan SJ, Chau NV, Bei J, Zeng YX, Karkey A, Basnyat B, Pasutto F, Paoli D, Frezzotti P, Wang JJ, Mitchell P, Fingert JH, Allingham RR, Hauser MA, Lim ST, Chew SH, Ebstein RP, Sakuntabhai A, Park KH, Ahn J, Boland G, Snippe H, Stead R, Quino R, Zaw SN, Lukasik U, Shetty R, Zahari M, Bae HW, Oo NL, Kubota T, Manassakorn A, Ho WL, Dallorto L, Hwang YH, Kiire CA, Kuroda M, Djamal ZE, Peregrino JI, Ghosh A, Jeoung JW, Hoan TS, Srisamran N, Sandragasu T, Set SH, Doan VH, Bhattacharya SS, Ho CL, Tan DT, Sihota R, Loon SC, Mori K, Kinoshita S, Hollander AI, Qamar R, Wang YX, Teo YY, Tai ES, Hartleben-Matkin C, Lozano-Giral D, Saw SM, Cheng CY, Zenteno JC, Pang CP, Bui HT, Hee O, Craig JE, Edward DP, Yonahara M, Neto JM, Guevara-Fujita ML, Xu L, Ritch R, Liza-Sharmini AT, Wong TY, Al-Obeidan S, Do NH, Sundaresan P, Tham CC, Foster PJ, Vijaya L, Tashiro K, Vithana EN, Wang N, Aung T. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2016 May;48(5):556-62.
17. Rong SS, Tang FY, Chu WK, Ma L, Yam JC, Tang SM, Li J, Gu H, Young AL, Tham CC, Pang CP, Chen LJ#. Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-analysis. Ophthalmology. 2016 Jun;123(6):1211-21.
18. Ma L, Li Z, Liu K, Rong SS, Young AL. Kumaramanickavel G, Pang CP, Chen H, Chen LJ#. Association of genetic variants with polypoidal choroidal vasculopathy: a systemic review and updated meta-analysis. Ophthalmology. 2015 Sep;122(9):1854-65.19.
19. *Cheng CY, *Yamashiro K, *Chen LJ, Ahn J, Huang L, Huang L, Cheung CM, Miyake M, Cackett PD, Yeo IY, Laude A, Mathur R, Pang J, Sim KS, Koh AH, Chen P, Lee SY, Wong D, Chan CM, Loh BK, Sun Y, Davila S, Nakata I, Nakanishi H, Akagi-Kurashige Y, Gotoh N, Tsujikawa A, Matsuda F, Mori K, Yoneya S, Sakurada Y, Iijima H, Iida T, Honda S, Lai TY, Tam PO, Chen H, Tang S, Ding X, Wen F, Lu F, Zhang X, Shi Y, Zhao P, Zhao B, Sang J, Gong B, Dorajoo R, Yuan JM, Koh WP, van Dam RM, Friedlander Y, Lin Y, Hibberd ML, Foo JN, Wang N, Wong CH, Tan GS, Park SJ, Bhargava M, Gopal L, Naing T, Liao J, Ong PG, Mitchell P, Zhou P, Xie X, Liang J, Mei J, Jin X, Saw SM, Ozaki M, Mizoguchi T, Kurimoto Y, Woo SJ, Chung H, Yu HG, Shin JY, Park DH, Kim IT, Chang W, Sagong M, Lee SJ, Kim HW, Lee JE, Li Y, Liu J, Teo YY, Heng CK, Lim TH, Yang SK, Song K, Vithana EN, Aung T, Bei JX, Zeng YX, Tai ES, Li XX, Yang Z, Park KH, Pang CP, Yoshimura N, Wong TY, Khor CC. New loci and coding variants confer risk for age-related macular degeneration in East Asians. Nat Commun. 2015 Jan 28; 6:6063.
20. *Liu K, *Chen LJ,, Lai TY, Tam PO, Ho M, Chiang SW, Liu DT, Young AL, Yang Z, Pang CP. Genes in the High-Density Lipoprotein Metabolic Pathway in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. Ophthalmology. 2014 Apr; 121(4):911-6.

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