張娟 博士

履歷(教育及工作經驗)

教育：

1. 2011 中國安徽中醫藥大學藥學學士
2. 2015 中國雲南中醫藥大學中藥學碩士
3. 2019 中國上海中醫藥大學中藥學博士

工作經驗：

1. 2020至今 博士後研究員 香港中文大學中醫學院
2. 2019-2020 研究助理 香港中文大學中醫學院

科研範圍

1. 中藥及其活性成分抗腫瘤作用（腫瘤細胞凋亡、自噬、轉移、耐藥和防止腫瘤復發）機理研究及抗腫瘤小分子藥物開發

著作及論文（選列）：

1. Xian YF*, Zhang J*, Bian ZX, Zhou H, Zhang ZB, Lin ZX, Xu HX. Bioactive natural compounds against human coronaviruses: a review and perspective. Acta Pharm Sin B, (2020)10(7):1163-1174. (Co-first author)
2. Han L, Xu DQ, Xi ZC, Wu M, Wan Najbah Nik Nabil, Zhang J, Xu HX, et al. The natural compound Oblongifolin C exhibits anticancer activity by inhibiting HSPA8 and Cathepsin B in vitro. Frontiers in pharmacology, (2020)11:564833
3. Ye Y, Wu M, Lao YZ, Fu W, Yang X, Zhang J, Xu HX, Xu G. Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi. Nat Prod Bioprospect, (2020)10(1):1-11.
4. Zhang J, Zheng Z, Wu M, Lao Y, Xu H, et al. The natural compound neobractatin inhibits tumor metastasis by upregulating RNA-binding-protein MBNL2, Cell Death & Disease, (2019)10:554.
5. Zheng Z, Wu M, Zhang J, Fu W, Xu N, Lao YZ, Xu HX. The natural compound neobractatin induces cell cycle arrest by regulating E2F1 and GADD45α. Frontiers in oncology, (2019) 9: 654.
6. Yuan M, Xu L, Zhang J, Kong S, Wu M, Lao YZ, Xu HX. SRC and MEK co-inhibition synergistically enhances the anti-tumor effect in both NSCLC and erlotinib resistant NSCLC cells. Frontiers in oncology, (2019) 9: 586.
7. Duan Y*, Zhang J*, et al. Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi, Tetrahedron Letters, 2018, 59 (2018): 4067–4072 (Co-first author)