Professor and Department Chairman
Room G56 Science Centre
(852) 3943 6257
Education
| 2003 | Postdoc., Department of Chemistry, Massachusetts Institute of Technology (MIT), USA |
| 2000 | Ph.D., Department of Chemistry, The Chinese University of Hong Kong |
| 1996 | B.Sc., Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University |
Position
| Since 2021 | Chairman, Department of Chemistry, The Chinese University of Hong Kong |
| Since 2018 | Director, Shenzhen Municipal Key Laboratory of Chemical Synthesis of Medicinal Organic Molecules Shenzhen Centre of Novel Functional Molecules, The Chinese University of Hong Kong Shenzhen Research Institute (新颖功能分子研究中心, 深圳市药用有机小分子化学合成重点实验室, 香港中文大学深圳研究院) |
| Since 2017 | Professor, Department of Chemistry, The Chinese University of Hong Kong |
| 2016-2017 | Associate Head, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University |
| 2014-2017 | Professor, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University |
| 2010-2014 | Associate Professor, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University |
| 2004-2010 | Lecturer/ Assistant Professor Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University |
Professional Activities
| Since 2020 | Elected Member, The Hong Kong Young Academy of Sciences (香港青年科學院院士) |
| Since 2019 | Committee Member on Science Education, Curriculum Development Council (課程發展議會科學教育委員會委員) |
Research Interests
Our research group has broad interests in synthetic organic chemistry and organometallics chemistry. Current areas of focus include:
| 1. | Design, preparation of new phosphine ligands: Applications in cross-coupling reactions |
| 2. | Development of new transition metal-catalyzed C-H functionalization for carbon-carbon and carbon-heteroatom bond formation |
| 3. | Organocatalysis / Cross-Dehydrogenative-Coupling methodologies |
| 4. | Enantioselective reactions |
Honours and Awards
| 2021 | Faculty Exemplary Teaching Award The Chinese University of Hong Kong |
| 2019 | Asian Core Program Lectureship Award The Asian Core Program (China) |
| 2019 | The Distinguished Lectureship Award, The CSJ Asian International Symposium The Chemical Society of Japan |
| 2016 | Asian Core Program/ Advanced Research Network Lectureship Award The Asian Core Program (Japan) |
| 2014 | Higher Education Outstanding Scientific Research Output Awards (Science and Technology) Second-class Award in Natural Science Ministry of Education, PR China (教育部高等學校科學研究優秀成果獎自然科學二等獎) |
| 2014 | Rising Star Award 41st International Conference on Coordination Chemistry |
| 2013 | Asian Core Program Lectureship Award The Asian Core Program (Korea) |
| 2013 | The Croucher Senior Fellowship The Croucher Foundation, Hong Kong |
| 2012 | The President’s Awards on Excellent Achievement in Research & Scholarly Activities The Hong Kong Polytechnic University |
| 2012 | Asian Core Program Lectureship Award The Asian Core Program (Thailand) |
| 2011 | Asian Core Program Lectureship Award The Asian Core Program (China) |
| 2010 | Asian Core Program Lectureship Award The Asian Core Program (Japan) |
| 2010 | Asian Core Program Lectureship Award The Asian Core Program (Singapore) |
| 2001 | Croucher Postdoctoral Fellowship The Croucher Foundation, Hong Kong |
Representative Publications
Representative Publications (Full List of Publications)
| 1. | Man Ho Tse, Pui Ying Choy, Fuk Yee Kwong* “Facile Assembly of Modular-Type Phosphines for Tackling Modern Arylation Processes” Acc. Chem. Res. 2022, 55, 3688-3705. (chosen as Cover Art) |
| 2. | Xinwei He,* Ruxue Li, Pui Ying Choy, Jiahui Duan, Zhenzhen Yin, Keke Xu, Qiang Tang, Rong-Lin Zhong, Yongjia Shang*, Fuk Yee Kwong* “An expeditious FeCl3-catalyzed cascade 1,4-conjugate addition/annulation/1,5–H shift sequence for modular access of all-pyrano-moiety-substituted chromenes” Chem. Sci. 2022, 13, 13617-13622. |
| 3. | Kin Boon Gan; Rong-Lin Zhong*; Zhen-Wei Zhang*; Fuk Yee Kwong* “ Atropisomeric Phosphine Ligands Bearing C–N Axial Chirality: Applications in Enantioselective Suzuki–Miyaura Cross-Coupling Towards the Assembly of Tetra-ortho-Substituted Biaryls” J. Am. Chem. Soc. 2022, 144, 14864-14873. (Highlighted in “Spotlights on Recent JACS Publications” and X-mol) |
| 4. | Wai Chung Fu, Fuk Yee Kwong* “A denitrogenative palladium-catalyzed cascade for regioselective synthesis of fluorenes” Chem. Sci. 2020, 11, 1411-1417. |
| 5. | Mingliang Li, Fuk Yee Kwong* “Cobalt-Catalyzed Tandem C–H Activation/C–C Cleavage/C–H Cyclization of Aromatic Amides with Alkylidenecyclopropanes” Angew. Chem., Int. Ed. 2018, 57, 6512-6516. (chosen as Front-Cover Picture) |
| 6. | Qingyang Zhao, Wai Chung Fu, Fuk Yee Kwong* “Palladium-Catalyzed Regioselective Aromatic Extension of Internal Alkynes through a Norbornene-Controlled Reaction Sequence” Angew. Chem., Int. Ed. 2018, 57, 3381-3385. |
| 7. | Wai Chung Fu, Zheng Wang, Wesley Ting Kwok Chan, Zhenyang Lin, Fuk Yee Kwong* “Regioselective Synthesis of Polycyclic and Heptagon-embedded Aromatic Compounds through a Versatile π-Extension of Aryl Halide.” Angew. Chem., Int. Ed. 2017, 56, 7166-7170. |
| 8. | On Ying Yuen, Chau Ming So, Ho Wing Man, Fuk Yee Kwong* “A General Palladium-Catalyzed Hiyama Cross-Coupling Reaction of Aryl and Heteroaryl Chlorides” Chem. –Eur. J. 2016, 22, 6471-6476. (chosen as HOT paper and Inside Back Cover) |
| 9. | Bao-Min Fan*, Qing-jing Yang, Jun Hu, Cai-ling Fan, Si-feng, Li, Lu Yu, Chao Huang, Wing Wai Tsang, Fuk Yee Kwong* “Asymmetric Hydroalkynylation of Norbornadienes Promoted by Chiral Iridium Catalysts” Angew. Chem., Int. Ed. 2012, 51, 7821-7824. |
| 10. | Chau Ming So, Fuk Yee Kwong* “Palladium-catalyzed cross-coupling reactions of aryl mesylates” Chem. Soc. Rev. 2011, 40, 4963-4872. |
| 11. | Wei Liu, Hao Cao, Hua Zhang, Heng Zhang, Kin Ho Chung, Chuan He, Haibo Wang, Fuk Yee Kwong*, Aiwen Lei* “Organocatalysis in Cross-Coupling: DMEDA-Catalyzed Direct C-H Arylation of Unactivated Benzene” J. Am. Chem. Soc. 2010, 132, 16737-16740. (Top 1% highly cited paper in 2015-2019) |
| 12. | Pui Yee Yeung, Chau Ming So, Chak Po Lau, Fuk Yee Kwong* “A General and Efficient Palladium-Catalyzed Cyanation of Aryl Mesylates in Water or Water/t-BuOH Medium” Angew. Chem., Int. Ed. 2010, 49, 8918-8922. (chosen as HOT paper) |
| 13. | Hang Wai Lee, Fuk Loi Lam, Chau Ming So, Chak Po Lau, Albert S. C. Chan, Fuk Yee Kwong* “Palladium-Catalyzed Cross-Coupling of Aryl Halides Using Organotitanium Nucleophiles” Angew. Chem., Int. Ed. 2009, 48, 7436-7439. (chosen as HOT paper) |
| 14. | Chau Ming So, Chak Po Lau, Fuk Yee Kwong* “A general palladium-catalyzed Suzuki-Miyaura coupling of aryl mesylates” Angew. Chem., Int. Ed. 2008, 47, 8059-8063. |
| 15. | Chau Ming So, Chak Po Lau, Fuk Yee Kwong* “Palladium-Catalyzed Amination of Aryl Mesylates” Angew. Chem., Int. Ed. 2008, 47, 6402-6406. |
Representative Book Chapters (Full List of Book Chapters)
| 1. | Man Pan Leung, Yi Ling Tsang, Pui Ying Choy, and Fuk Yee Kwong* “Recent Advances in Palladium-Based Cross-Dehydrogenative-Coupling (CDC) with C(sp2)–H/C(sp2)–H Bond to Form New C(sp2)–C(sp2) Bond” in Handbook of C–H Functionalization, Debabrata Maiti (Ed) Elsevier (2022), doi: 10.1002/9783527834242.chf0157. |
| 2. | Pui Ying Choy, Xinwei He and Fuk Yee Kwong* “Palladacycles as Precatalysts for Heck and Sonogashira Cross-Coupling Reactions” in Palladacycles: Catalysis and Beyond, Anant R. Kapdi and Debabrata Maiti (Eds) Elsevier (2019), pp. 21-173 |
| 3. | Shun Man Wong, and Fuk Yee Kwong* “Nondirected C-H Bond Functionalizations of (Hetero)arenes” in Strategies for Palladium-Catalyzed Non-Directed and Directed C-H Bond Functionalization, Anant R. Kapdi and Debabrata Maiti (Eds) Elsevier (2017), pp. 49-116. |
| 4. | Shun Man Wong, Chau Ming So and Fuk Yee Kwong* “Ligand-Enabled Palladium-Catalyzed C-N and C-O Bond Formations from Aryl Halides, Tosylates and Mesylates” in Applied Homogeneous Catalysis with Organometallic Compounds, Boy Cornils, Wolfgang A. Hermann, Matthias Beller and Rocco Paciello (Eds) Wiley-VCH: Weinheim (2017), pp. 411-464. |
| 5. | Pengfei Li, Jun Wang and Fuk Yee Kwong* “Asymmetric Michael addition and related reactions” in Stereoselective Synthesis of Drugs and Natural Products, Vasyl Andrushko and Natalia Andrushko (Eds) John Wiley & Sons (2013), pp. 249-270. |
| 6. | Yinuo Wu, Jun Wang and Fuk Yee Kwong* “C-C Cross-Couplings of Acidic C-H Nucleophiles” in Cross-Coupling and Heck-Type Reactions Vol. 1-3, Gary A. Molander and John P. Wolfe (Eds) Georg Thieme (2012), Ch. 2.7.2. |
| 7. | Fuk Loi Lam, Hang Wai Lee, Jun Wang and Fuk Yee Kwong* “Recent Advancement of Catalytic Pauson-Khand-type Reactions” in The Pauson-Khand Reaction: Scope, Variations and Applications, Ramon Rios Torres (Eds) John Wiley & Sons, (2012), pp. 181-210. |
Representative Patents (Full List of Patents)
| 1. | 邝福儿*; 傅伟聪; 杜尚俊; 苏秋铭; 蔡珮盈 “咔唑基磷配体、及其制备方法和应用” 中国专利, 2021, CN106588983B. |
| 2. | 邝福儿*; 李东昇; 蔡珮盈 “苯并咪唑-吲哚骨架的膦配体及其制备方法和应用” 中国专利, 2020, CN107459533B. |
| 3. | 邝福儿*; 苏秋铭; 周永健; 原安莹 “一种吲哚骨架的膦配体及其制备方法和应用” 中国专利, 2020, CN107445989B. |
| 4. | Fuk Yee Kwong*, Shun Man Wong, Chung Chiu Yeung “Novel phosphines, synthesis thereof and their use in catalysis” US Patent, 2018, US10093692B2. |
| 5. | 邝福儿*; 蔡珮盈; 苏秋铭; 原安莹 “(2-二取代膦苯基)-1-烷基-吲哚膦配体及其合成方法和应用” 中国专利, 2018, CN104945434B. |
| 6. | Fuk Yee Kwong*, Pui Ying Choy, Yinuo Wu, Qingjing Yang “Synthesis of Phosphine Ligands Bearing Tunable Linkage: Methods of Their Use in Catalysis” World Patent, 2017, WO 2017/193288. |
| 7. | Fuk Yee Kwong*, Shun Man Wong “Novel benzimidazolyl phosphines as ligands for transition metal-catalyzed coupling and amination reactions” World Patent, 2015, WO 2015/039606. |
| 8. | Fuk Yee Kwong*, Chau Ming So “Ligand for transition metals and methods of use” US Patent, 2012, US 8212056. |
Major On-going HK Research Grant (PI)
| 1. | General Research Fund – Research Grant Council of Hong Kong, “Rational design of pi-extended phosphine ligands: Fundamental investigations of Pd-arene-walking and attributive applications in highly steric hindered coupling processes”, HK$1,165,720, 1 Jan 2023-31 Dec 2025 |
| 2. | General Research Fund – Research Grant Council of Hong Kong, “Exploration of new phosphine ligands for ligand-enabled Pd-catalyzed cross-coupling: Fundamental investigation of aromatic C-O bond functionalization of Aryl Carboxylates”, HK$946,015, 1 Jan 2022-31 Dec 2024 |
| 3. | General Research Fund – Research Grant Council of Hong Kong, “Design and Exploration of Highly Tunable Phosphine Ligands Towards Palladium-Catalyzed Cross-Coupling and Relevant Direct C-H Arylation Processes”, HK$999,769, 1 Jan 2021-31 Dec 2023 |
| 4. | General Research Fund – Research Grant Council of Hong Kong, “Rational Design of Highly Tunable Phosphine Ligands Towards Palladium-Catalyzed Cross-Coupling of Aryl Acetates”, HK$837,408, 1 Jan 2020-31 Dec 2022 |