Address	(Office): Rm EG01C, Science Centre East Block (Lab): ---
Phone	(Office): (852) 3943 4466 (Lab): ---
Fax	(852) 2603 5646
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	https://www.researchgate.net/profile/Lawrence_Chiu/?ev=prf_act

Education

Position

• Senior Lecturer, School of Life Sciences

Awards 

• Faculty Exemplary Teaching Award 2012
• SCGE Exemplary Teaching Award in General Education 2012

Research Interests

• Cell signaling in apoptosis
• Cancer chemoprevention and chemotherapy with natural products targeting the molecular pathways in carcinogenesis
• Applications of flow cytometry  

Representative Publications

• Ren SX, Cheng AS, To KF, Tong JH, Li MS, Shen J, Wong CC, Zhang L, Chan RL, Wang XJ, Ng SS, Chiu LCM, Marquez VE, Gallo R, Chan FK, Yu J, Sung JJ, Wu WK, Cho CH: Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res 2012, 72:6512-6513.
• Wang H, Chiu LCM, Ooi VEC, Ang P: A potent antitumor polysaccharide from edible brown seaweed Hydroclathrus clathratus. Botanica Marina 2010, 53:265-274.
• Kong CKL, Lam WS, Chiu LCM, Ooi VEC, Sun SSM, Wong YS: A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochem Pharmacol 2009, 77:1487-1496.
• Leung KT, Li K, Sun SSM, Chan PKS, Ooi VEC, Chiu LCM: Activation of the JNK pathway promotes phosphorylation and degradation of BimEL – A novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia. Carcinogenesis 2008, 29:544-551.
• Lam WY, Tang JW, Yeung ACM, Chiu LCM, Sung JJY, Chan PKS: Avian influenza A H5N1 NS1 protein induces apoptosis in human airway epithelial cells. J Virol 2008, 82:2741-2751.
• Li K, Ooi VEC, Chuen CKY, Lam AC, Ooi LSM, Zhang XB, Tsang KS, Chiu LCM , Chan KYY, Li CK, Fok TF, Yuen PMP, Ng PC: The plant mannose-binding lectin NTL preserves cord blood hematopoietic stem/progenitor cells in culture and enhances their ex vivo expansion. Br J Haematol 2008, 140:90-98.
• Lee WYW, Chiu LCM, Yeung JHK: Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation. Food Chem Toxicol 2008, 46:328-338.
• Ho TS, Ho YP, Wong WY, Chiu LCM, Wong YS, Ooi VEC: Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells. Biomed Pharmacother 2007, 61:578-587.
• Shih C-H, Siu S-O, Wong E, Chiu LCM, Chu IK, Lo C: Sorghum 3-deoxyanthocyanidins: Inhibition of cancer cell proliferation and mass spectrometric analysis. J Agric Food Chem 2007, 55:254-259.
• Wong SM, Wong KK, Chiu LCM, Cheung PCK: Non-starch polysaccharides from different developmental stages of Pleurotus tuber-regium inhibited the growth of human acute promyelocytic leukemia HL-60 cells by cell-cycle arrest and/or apoptotic induction. Carbohydr Polym 2007, 68:206-217.
• Chiu LCM, Ho TS, Wong EYL, Ooi VEC: Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-XL expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation. J Ethnopharmacol 2006, 105:263-268.
• Chiu LCM, Zhu W, Ooi VEC: A polysaccharide fraction from medicinal herb Prunella vulgaris downregulates the expression of herpes simplex virus antigen in Vero cells.J Ethnopharmacol 2004, 93:63-68.

Research Grants

• 2009-2012, Teaching Devlopment Grants 2009-12 Triennium, Development of Online Self-learning Systems with Multimedia-enriched Pre-laboratory Talks and Pre-class Tests for Biology Laboratory Courses, $250,000 (Principal Investigator)
• 2009-2012, Teaching Development Grants 2009-12 Triennium, Developing an integrative teaching strategy for large class students to learn cell biology and beyond, $250,000 (Co-investigator)
• 2007-2010, Research Grants Council (Earmarked Grants), Role of the brownish shiitake mycelia exudate on the cell death of leukemia cell line and its role as an antioxidant and a functional food colorant, $920,500 (Co-investigator)
• 2006-2008, Research Fund for the Control of Infectious Diseases, Studies on antiviral activities of Chinese medicine-derived phytochemicals active against SARS-associated coronavirus or avian influenza A (H5N1), $798,930 (Co-investigator)
• 2006-2007, CUHK Research Committee Funding (Direct Grants), Antiproliferative effects of three active compounds isolated from the Chinese medicinal herbs, $54,125 (Co-investigator)
• 2005-2007, CUHK Research Committee Funding (Direct Grants), The cell death induced by SARS-CoV, $54,735 (Co-investigator)
• 2003-2006, Research Grants Council (Earmarked Grants), Molecular cloning of cDNA encoding a novel potent antiviral protein isolated from the Chinese medicinal herb and its transgenic expression in plants, $524,000 (Co-investigator)
• 2003-2005, CUHK Research Committee Funding (Direct Grants), Mechanistic studies of apoptotic cell death induced by respiratory syncytial virus (RSV) in human lung epithelium cells, $22,157
• 2002-2005, Research Grants Council (Earmarked Grants), A mechanistic study of the immunopotentiating and antitumor effects of native and chemically modified nonstarch polysaccharides [(1→3)-β-D-glucans] from mushroom sclerotia, $1,036,000 (Co-investigator)
• 2003-2004, CUHK Research Committee Funding (Direct Grants), Quantitative analysis for antiviral activity of Prunella vulgarisand related medicinal herbs with flow cytometry, $36,853
• 2002-2004, Research Grants Council (Earmarked Grants), In vitro and in vivoanticancer studies of novel polyunsaturated fatty acids (DHA, EPA) purified and characterized from several enriched microalgae, $876,000 (Co-investigator)
• 2001-2004, Research Grants Council (Earmarked Grants), Isolation, characterization and mode of action of novel antiviral agents from seaweeds in Hong Kong, $699,600 (Co-investigator)
• 2001-2003, CUHK Research Committee Funding (Direct Grants), Flow cytometric studies on anticancer and immunomodulatory activities of microalgal DHA and EPA, $80,000 (Co-investigator)

Patents

• Extract of a medicinal mushroom, Polyporus rhinoceros Cooke and composition of the same having antiprofieration of cancer cells and immune enhancing activity. Chinese Patent CN 200510114299.4 (2005 October)

Professional Activities

• Regular Member, American Society for Cell Biology

Others

Community Services

• Interviewee, “Interview with the Scientists” organized by Education and Manpower Bureau
• Mentor, “Cyber Learning and Mentoring Platform (CLAMP), Support Measures for the Exceptionally Gifted Students Scheme” organized by Education and Manpower Bureau and Hong Kong University of Science and Technology
• Advisors and Judges, “Hong Kong Student Science Project Competition” organized by Innovation and Technology Commission, Hong Kong Federation of Youth Groups, and Education and Manpower Bureau

Address	(Office): Rm EG01B, Science Centre, CUHK (Lab): ---
Phone	(Office): (852) 3943 4465 (Lab): ---
Fax	(852) 2603 5646; 2603 5745
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	-

Education

Position

• Lecturer, School of Life Sciences

Research Interests

• Plant cell biology
• Membrane trafficking
• Nitrogen metabolism in plants

Representative Publications

• Chow, C.M., Neto, H., Foucart, C. and Moore, I. (2008) Rab-A2 and -A3 GTPases define a trans-Golgi endosomal membrane domain that contributes substantially to the cell plate. The Plant Cell20: 101-123.
• Lam, H.M., Wong, P., Chan, H.K., Yam, K.M., Chen, L., Chow, C.M., and Coruzzi, G.M. (2003) Overexpression of the ASN1 Gene Enhances Nitrogen Status in Seeds of Arabidopsis. Plant Physiol. 132: 926-935.

Address	(Office): Rm G83, Science Centre South Block
Phone	(Office): (852) 3943 4359
Fax	(852) 2603 7732
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	--

Education

Position

• Lecturer, School of Life Sciences

Research Interests

• Protein Biochemistry
• Metabolic diseases

Representative Publications

• Ng TB, Lam JS, Wong JH, Lam SK, Ngai PH, Wang HX, Chu KT, Chan WY: Differential abilities of the mushroom ribosome-inactivating proteins hypsin and velutin to perturb normal development of cultured mouse embryos. Toxicol In Vitro. 2010, 24(4):1250-7.
• Chan WY, Ng TB, Lam JS, Wong JH, Chu KT, Ngai PH, Lam SK, Wang HX: The mushroom ribosome-inactivating protein lyophyllin exerts deleterious effects on mouse embryonic development in vitro. Appl Microbiol Biotechnol. 2010, 85(4):985-93.
• Wong JH, Ng TB, Cheung RC, Ye XJ, Wang HX, Lam SK, Lin P, Chan YS, Fang EF, Ngai PH, Xia LX, Ye XY, Jiang Y, Liu F: Proteins with antifungal properties and other medicinal applications from plants and mushrooms. Appl Microbiol Biotechnol. 2010, 87(4):1221-35.
• NG TB, NGAI HK, CHEUNG CF, WONG H, WANG HX, YE XJ, FANG F and CHAN YS: White Cabbage (Brassica chinensis) Seeds and Their Health Promoting Activities. Nuts and seeds in health and disease edited by VR Preedy, RR Watson and VB Patel (1st ed.), pp.1159-1163. United States of America: Elsevier Inc., 2011.
• NG TB, LAM SK, CHEUNG CF, WONG H, WANG HX, NGAI HK, YE XJ and FANG F: Therapeutic Use of Caper (Capparis spinosa) Seeds. Nuts and seeds in health and disease edited by VR Preedy, RR Watson and VB Patel (1st ed.), pp. 284-289. United States of America: Elsevier Inc., 2011.

Research Grants

• 2009-2011, Knowledge Transfer Project Fund (KTPF), Development of reagent kits for biotechnology teaching through forensic investigations, $200,000.
• 2009-2011, Knowledge Transfer Project Fund (KTPF), Development of hardware modules for DNA amplification for New Senior Secondary School (NSS) Biology teaching and learning, $200,000.
• 2009-2010, Teaching Development Grants (TDG), Development of a Web-based Teaching Platform for Biochemistry Courses, $200,000.

Professional Activities

• The Hong Kong Society of Biochemistry and Molecular Biology
• Comparative Education Research Center
• Hong Kong Association for Science and Mathematics Education

Address	(Office): Rm 138, Science Centre North Block (Lab): ---
Phone	(Office): (852) 3943 1317 (Lab): ---
Fax	(852) 2603 6510
Email	This email address is being protected from spambots. You need JavaScript enabled to view it.
Web	-

Education

Position

• Lecturer, School of Life Sciences

Research Interests

• Molecular and cellular neuroscience
• Cell signaling and gene regulation 

Representative Publications

• Siow, N.L., Choi, R.C., Xie, H.Q., Kong, L.W., Chu, G.C., Chan, G.K., Simon, J., Barnard, E.A. and Tsim, K.W. (2010) ATP Induces Synaptic Gene Expressions in Cortical Neurons: Transduction and Transcription Control Via P2Y1 Receptors. Mol. Pharmacol.78:1059-1071.
• Doctor, B.P., Tsim, K.W. and Siow, N.L. (2008) The IXth International Meeting on Cholinesterases, Suzhou, People's Republic of China, 6 to 10 May 2007. Chem. Biol. Interact.175:1-2. (Preface of the conference proceedings)
• Xie, H.Q., Choi, R.C., Leung, K.W., Siow, N.L., Kong, L.W., Lau, F.T., Peng, H.B. and Tsim, K.W. (2007) Regulation of a transcript-encoding the proline rich membrane anchor (PRiMA) of globular muscle acetylcholinesterase: the suppressive roles of myogenesis and innervating nerves. J. Biol. Chem.282:11765-75.
• Siow, N.L., Xie, H.Q., Choi, R.C. and Tsim, K.W. (2005) ATP induces the post-synaptic gene expression in neuron-neuron synapses: Transcriptional regulation of AChE catalytic subunit. Chem Biol Interact.157-158:423-426.
• Tung, E.K., Choi, R.C., Siow, N.L., Jiang, J.X., Ling, K.K., Simon, J., Barnard, E.A. and Tsim, K.W. (2004) P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions. Mol. Pharmacol.66:794-806.
• Ling, K.K., Siow, N.L., Choi, R.C., Ting, A.K., Kong, L.W. and Tsim, K.W. (2004) ATP potentiates agrin-induced AChR aggregation in cultured myotubes: activation of RhoA in P2Y1 nucleotide receptor signaling at vertebrate neuromuscular junctions. J. Biol. Chem.279(30):31081-31088.
• Lee, H.H., Choi, R.C., Ting, A.K., Siow, N.L., Jiang, J.X., Massoulie, J. and Tsim KW. (2004) Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promoters. J. Biol. Chem.279(26):27098-27107.
• Jiang, J.X., Choi, R.C., Siow, N.L., Lee, H.H., Wan, D. C. and Tsim, K.W. (2003): Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture: transcriptional regulation mediated by cAMP–dependent signaling. J. Biol. Chem.278:45435-45444.
• Choi, R.C., Siow, N.L., Ling, K.K., Cheng, A.W., Tung, E.K., Simon, J., Barnard, E.A. and Tsim, K.W. (2003): ATP acts through the P2Y1 receptor to enhance the expression of muscle acetylcholinesterase and acetylcholine receptors: transduction pathways and control of transcription. J. Neurosci.23:4445-4456.
• Siow, N.L., Choi, R.C., Cheng, A.W., Jiang, J.X., Wan, D.C., Zhu, S.Q. and Tsim, K.W. (2002) A cyclic AMP-dependent pathway regulates the expression of acetylcholinesterase during myogenic differentiation of C2C12 Cells. J. Biol. Chem. 277: 36129-36136.