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Address

(Office): Rm 603A, Mong Man Wai Building
(Lab): Rm 619, Mong Man Wai Building

 People CLM
 

Phone

(Office): (852) 3943 6378
(Lab): (852) 3943 1298
Fax (852) 2603 7732
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -
 

 

Education

  • 1988    Ph.D. University of Liverpool
  • 1983    M.Phil. The Chinese University of Hong Kong
  • 1981    B.Sc. The Chinese University of Hong Kong


Position 

  • Adjunct Associate Professor, School of Life Sciences
  • Ex-officio member, Committee on Campus Sustainability
  • Member, Campus Landscape Enhancement Committee
  • Member, Committee on Minor Works
  • Member, Green Campus Working Group, Green University Consortium
  • College Representative, Senate
  • Fellow, College Assembly, United College


Research Interests

  • Industrial Ecology
  • Restoration Ecology
  • Urban Ecology
  • Pollution Studies 


Representative Publications

  • Pan, M. & Chu, L.M. (2016) Adsorption and degradation of antibiotics in agricultural soil.  Science of the Total Environment 545-546: 48-56
  • Pan, L. & Chu, L.M. (2015) Life cycle assessment and energy saving potential of a vertical greenery system in Hong Kong. Building and Environment DOI: 10.1016/j.buildenv.2015.06.033
  • Zhang, H. & Chu, L.M. (2015) Seed rain and seedling survival are major factors limiting vegetation regeneration on rehabilitated quarries. Landscape and Ecological Engineering 11: 29-38
  • Pan, M., Wong, C.K.C. & Chu, L.M. (2014) Distribution of antibiotics in wastewater-irrigated soils and their accumulation in vegetable crops in the Pearl River Delta, southern China.  Journal of Agricultural and Food Chemistry 62: 11062-11069
  • Kong, L., Shi, Z. & Chu, L.M. (2014) Carbon emission and sequestration of urban turfgrass systems in Hong Kong.  Science of the Total Environment 473-474: 132-138
  • Zhou, D. & Chu, L.M. (2014) Do avian communities vary with season in highly urbanized Hong Kong?  Wilson Journal of Ornithology 126: 69-80
  • Zhang, H., Zhuang, X. & Chu, L.M. (2013) Plant recruitment in early development stages on rehabilitated quarries in Hong Kong. Restoration Ecology 21: 166-173
  • Zhang, H. & Chu, L.M. (2013) Changes in soil seed bank composition during early succession of rehabilitated quarries. Ecological Engineering 55: 43-50
  • Ng, C.W.W., Woon, K.X., Leung, A.K., & Chu, L.M. (2013) Experimental investigation of induced suction distribution in a grass-covered soil. Ecological Engineering 52: 219-223
  • Zhou, D., Fung, T. & Chu, L.M. (2012) Avian community structure of urban parks in developed and new growth areas: A landscape-scale study from Southeast Asia. Landscape and Urban Planning 108: 91-102


Research Grants

  • 2015-2017, Environment and Conservation Fund, Population status and ecology of yellow-crested cockatoo (Cacatua sulphurea) in Hong Kong, $499,940 (PI)
  • 2014-2015, Environment and Conservation Fund, Value of Hermetia illucens (black soldier fly) for food waste conversion in Hong Kong, $499,500 (PI)
  • 2013-2016, Research Grants Council (RGC) Collaborative Research Fund, Green Slope Engineering: Bioengineered, Live Cover Systems for Man-made Fill Slopes and Landfill Capillary Barriers in Hong Kong, $8,000,000 (Co-I)
  • 2011-2013, Environment and Conservation Fund, The contribution of vertical greening on human climate and carbon footprint in built environment, $1,500,400 (PI)
  • 2011-2012, CUHK Knowledge Transfer Project Fund, UGC, An electronic tree identification encyclopedia, $180,000 (PI)
  • 2010-2013, Research Grants Council (RGC) Collaborative Research Fund, Green slope engineering for Hong Kong, $5,800,000 (Co-I)
  • 2010-2012, Guangdong Provincial Funding, R&D on the key technology for resource-conserving urban greenery, Guangzhou Institute of Landscape Gardening (RMB200,000) Provincial Funding for International Collaboration (Co-I)
  • 2008-2011, Environmental Conservation Fund, Ecological sustainability of vegetated steep soil cutslopes, $788,600
  • 2003-2005, Quality Education Fund, Multi-school collaboration in the information technology for Hong Kong flora and vegetation, $1,938,000 (Co-I)
  • 2001-2002, Quality Education Fund, A web-based databases and training for Hong Kong flora and vegetation, $1,500,000 (Co-I)
  • 2000-2004, Research Grants Council (RGC) Earmarked Grants, Revegetation of newly restored landfills: Site environmental conditions and the role of native species, $650,000
  • 1996-1999, Research Grants Council (RGC) Earmarked Grants, Ecological studies of completed landfills for enhancing natural succession on the man-made habitats $692,000 (PI)
  • 1994-1997, Research Grants Council (RGC) Earmarked Grants Reclamation of fly ash lagoons: an ecological and microbiological approach, $653,000 (PI)
  • 1990-1992, Research Grants Council (RGC) Earmarked Grants, Advanced studies of sanitary landfills: restoration, leachate treatment and methane generation, $850,000 (Co-I)


Professional Activities

Government committees
9/2011-8/2015 Chairman, Country Parks Committee, Agriculture, Fisheries and Conservation Department
9/2009-8/2015 Member, Country and Marine Parks Board, Agriculture, Fisheries and Conservation Department
9/2009-8/2011 Member, Country Parks Committee, Agriculture, Fisheries and Conservation Department
9/2009-8/2011 Member, Marine Parks Education Subcommittee, Agriculture, Fisheries and Conservation Department
10/2008-9/2014 Member, Endangered Species Advisory Committee, Agriculture, Fisheries and Conservation Department
10/2006-10/2010 Member, Environment and Conservation Fund Committee, Environmental Protection Department
9/2005-8/2009 Member, Marine Mammal Conservation Working Group, Agriculture, Fisheries and Conservation Department
10/2004-10/2006 Member, Research Projects Vetting Subcommittee, Environment and Conservation Fund, Environmental Protection Department

Other organizations
10/2007-present Member, Advisory Committee, Environment & Hygiene Committee, Heung Yee Kuk

NGOs
2012-present Advisor, Hong Kong Organic Waste Recycling Center
2008-present Founding member and executive council member, Hong Kong Institute of Horticultural Science
9/2009-present Dean, Academy of Nature and Culture Education, Fung Yuen Butterfly Reserve Advisory Committee, Tai Po Environmental Association
8/2004-present Advisor, Fung Yuen Butterfly Reserve Advisory Committee, Tai Po Environmental Association

Editorial board
International Journal of Ecology, Hindawi Publishing Corporation
International Journal of Recycling of Organic Waste in Agriculture, Springer
Guest reviewers for Applied Soil Ecology, Applied Vegetation Science, Building and Environment,  Ecotoxicology and Environmental Safety, Environmental and Experimental Botany, Environmental Toxicology, Environmental Toxicology and Chemistry, Environmental Geochemistry and Health, Journal of Environmental Management, Land Degradation and Development, Restoration Ecology, Urban Forestry and Urban Greening, Waste Management


Others

Conference Presentations

  1. Chau, N.L. & Chu, L.M.  A rainfall simulation study on the erosion-reducing potential of ferns on soil slopes.  Ecological Society of Australia Annual Conference 2015, 29 Nov 2015 - 3 Dec 2015. Adelaide, Australia (oral presentation)
  2. Kong, L. & Chu, L.M. Carbon dioxide fluxes of turfgrass species in urban turfs in Hong Kong. 9th International Conference on Urban Climate (ICUC9). 20-24 July 2015, International Association for Urban Climate and American Meteorological Society, Toulouse, France. (oral presentation)
  3. Ho, Y., Wang S. & Chu, L.M.  Feeding ecology of Yellow-rested Cockatoo (Cacatua sulphurea) in Hong Kong. Annual International Conference on Ecology, Biodiversity and Environment (CEBE 2014), GSTF, 15-16 Dec 2014, Singapore. (oral presentation) (Best Research Paper)
  4. Chu, L.M. Vertical greening – Efforts and hurdles.  Eco Asia Conference, Eco Expo Asia 2014. Messe Frankfurt and Hong Kong Trade Development Council, 31 Oct 2014, AsiaWorld-Expo, Hong Kong. (oral presentation)
  5. Chu, L.M. Vertical greening in a subtropical city – System and species selection. 1st International Conference on Green Wall – Meeting the Challenge of a Sustainable Urban Future: the Contribution of Green Walls. 4-5 Sept 2014, Staffordshire University, Stoke-on-Trent, UK. (oral presentation)
  6. Pan, M. & Chu, L.M. Distribution and translocation of erythromycin in wastewater irrigated soils and vegetable crops. 2014 International Symposium on Environment and Health, 4-5 July 2014, Beijing, China. (oral presentation)
  7. Zhou, D. & Chu, L.M. Avian diversity of urban parks in Hong Kong: Effects of size, age and human disturbances. Second World Biodiversity Congress, 8-11 September 2011, Kuching, Sawarak. (poster presentation)
  8. Zhou, D. and Chu, L.M.  Does urbanization affect avian community structure of urban parks in Hong Kong?  11th National Conference of the Chinese Ornithological Society, 8-15 August 2011, Lanzhou, China. (oral presentation)
  9. Chu, L.M. Vegitecture: Urban greening for the future (Keynote speech). International Conference on Environment and Industrial Innovations (ICEII2011), 17-19 June 2011, Kuala Lumpur, Malaysia. (oral presentation)
  10. Chu, L.M. & Cheng, C.Y. Living architecture - Vertical planting on facade walls in concrete jungles. Second International Conference on Waste Engineering and Management (ICWEM2010), 13-15 Oct 2010, Tongji University, Shanghai, China. (oral presentation)
  11. Zhang, H. & Chu, L.M. Ecological development of soil microbial communities in rehabilitated quarries. 1stInternational Conference on Structures and Processes of the Initial Ecosystem Development, 20-24 Sept 2010, Cottbus, Germany. (oral presentation)
  12. Chu, L.M. Ecological restoration of quarries (Keynote speech). 2010 International Conference on Environmental Engineering and Applications (ICEEA 2010), 10-12 Sept 2010, Singapore. (oral presentation)
  13. Cheung, K.K.L. & Chu, L.M. Long-term changes in invertebrate communities after hillfire. SERI 2009 World Conference on Ecological Restoration, 23-27 August 2009. Perth, Australia. (oral presentation)
  14. Cheung, K.K.L. & Chu, L.M. Characterization of soil microbial community structure on fire-disturbed sites. SERI 2009 World Conference on Ecological Restoration, 23-27 August 2009, Perth, Australia. (poster presentation)
  15. Zhang, H. & Chu, L.M. Composition and development of aboveground vegetation and soil seed bank in rehabilitated quarries in Hong Kong. SERI 2009 World Conference on Ecological Restoration, 23-27 August 2009, Perth, Australia. (oral presentation)
  16. Chu, L.M., Cheung, K.K.L. & Szeto, S.Y. Spider assemblages of rehabilitated quarries in Hong Kong. 10th International Congress of Ecology, 16-21 August 2009, Brisbane, Australia. (oral presentation)
  17. Zhang, H. & Chu, L.M. Soil seed bank composition and development in restored quarries in Hong Kong. Ninth ISSS Conference on Seed Biology, 6-11 July 2008, Olsztyn, Poland. (oral presentation )
  18. So, I.W.Y. & Chu, L.M. Ant assemblages on rehabilitated landfills in Hong Kong. International Conference on Ants and Other Social Hymenoptera, 10-13 Oct 2007, Punjabi University, Patiala, India. (oral presentation)
  19. Chu, L.M., Wong, S.K. & Cheng, C.Y. Toxicity characterization of landfill leachate using multi-species toxicity identification evaluation. SETAC Asia Pacific Conference, 18-21 Sept 2006, Peking University, Beijing, China. (poster presentation)
  20. Chu, L.M. & Hui, M.H. Butterfly communities on restored landfills. The World Conference on Ecological Restoration. Ecological Restoration: A Global Challenge, 12-18 September 2005, Zaragoza, Spain. (oral presentation)
  21. Lau, J.K.W. & Chu, L.M. Species selection for slope revegetation. International Conference on EcoEngineering – The Use of Vegetation to Improve Slope Stability, 13-17 September 2004, Thessaloniki, Greece. (oral presentation)
  22. Chu, L.M. Ecological assessment of a constructed wetland on fly ash disposal lagoon. Seventh Intecol International Wetlands Conference, 26-30 July 2004, Utrecht, The Netherlands. (poster presentation)
  23. Chu, L.M. Nutrient availability as factor affecting ecosystem development on closed landfills. Ninth International Waste Management and Landfill Symposium, 6-10 Oct 2003, Sardinia, Italy. (oral presentation)


Postgraduate Students

Ho Ka Sin (On-going) Yellow mealworm for food waste bioconversion to insect protein (MPhil)
Wang Sifeng (On-going) Ecology of yellow-crested cockatoo in urban Hong Kong (PhD)
Hui Ling Chui (On-going) Bioengineered live cover systems for fill slopes and landfill capillary barriers (MPhil)
Pan Min (On-going) Soil behavior and plant uptake of antibiotics (PhD)
Chau Ngai Lung (On-going) Values of ferns for the bioengineering of soil cutslopes (PhD)
Pan Lan (On-going) Carbon and water footprint of vertical greening (PhD)
Kong Ling (2014) Carbon sequestration and emission of urban turfs in Hong Kong and Shenzhen  (PhD)
Lai Po Ying (2014) Selection of species and systems for water conservation and temperature reduction in vertical greening (MPhil)
Wong Chuk Kwan (2012) Tadpole assemblages in freshwater wetlands and anti-predation responses in aruran tadpoles (MPhil)
Zhou Daqing (2012) Avian community structure of urban parks in Hong Kong: Effect of urbanization and multi-scale habitat characteristics (PhD)
Guan Lijie (2011) Occurrence, fate and effects of selected pharmaceutical in sewage treatment plants (MPhil)
Cheung Kwok Leung (2011) Biodiversity and recovery of faunal communities after fire disturbance in Hong Kong (PhD)
Tsang Kwok On (2011) Is Cuscuta japonica a potential biological control agent for Mikania micrantha? (MPhil)
Zhang Hao (2010) Vegetation and soil development on rehabilitated quarries in Hong Kong (PhD)
So Wai Yan Ivy (2009) Ant communities in natural and man-made habitats in Hong Kong (MPhil)
Zou Huiling (2008) PAHs contamination of roadside soils and vegetation in Hong Kong (MPhil)
Chiu Ming Ho (2007) Soil water supplying capacity as factor affecting revegetation of cutslopes (MPhil)
Wong Man Wing (2007) Soil bioavailability of rare earth elements and their effects on tree growth (MPhil)
Tsang Chin Kan (2006) Landfill leachate irrigation: Evaluation of plant productivity and soil toxicity (MPhil)
Wong Man Shan Michelle (2006) Growth of freshwater emergents under different submergence levels (MPhil)
Yu Chi Cheung (2005) Ecological inventory and faunal communities on restored quarries (MPhil)
Ho So Man (2005) Nutrient cycling on closed landfills (MPhil)
Lau Ka Wah Joyce (2005) Species selection for cutslope revegetation (MPhil)
Cheng Chung Yin Michael (2005) Utilization of landfill leachate as an alternative source of plant nutrients (MPhil)
Chong Chun Wing John (2003) Tree planting on recently restored landfills: A study of native species (MPhil)
Wong Shiu Kai Raymond (2003) Chemical and ecotoxicological characterization of landfill leachate (MPhil)
Wong Cheuk Yuet Chiky (2003) Establishment of native plant species on restored quarries covered by completely decomposed granite in Hong Kong (MPhil)
Tsui Tsz Ki Martin (2002) Aquatic toxicity and environmental fate of glyphosate-based herbicides (MPhil)
Choi Chi Yuen (2000) Ecological studies of the cover soils on completed landfills (MPhil)
Lui Mei Kam Ada (1999) Vegetation development and performance on postclosure landfills (MPhil)
Chan Chik Yu Jack (1998) Revegetation of fly ash lagoons: An ecological approach (MPhil)
Lau Shun Shun Sam (1997) Pollution status and assimilative potential of wetlands at the Mai Po Marshes (MPhil)
Tong Suk Wah Iris (1996) Ecotoxicological and treatability studies on landfill leachate (MPhil)
Ng Ki Chi Renee (1994) Recycling of agro-industrial wastes by vermiculture (MPhil)


Address

(Office): Rm 111, Science Centre East Block
(Lab): Rm LG102 & 104, Sir Run Run Shaw Science Building

 People CHY2
 

Phone

(Office): (852) 3943 6149
(Lab): (852) 3943 1119
Fax (852) 2603 6149
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -
 

 

Education

1994 Ph.D. Louisiana State University, Baton Rouge
1989 M.Sc. University of Hawaii, Manoa
1986 B.Sc. University of Hawaii, Manoa


Position

Associate Professor, School of Life Sciences


Research Interests

  • Food flavor chemistry, analysis and application
  • Natural product, safety, health and application
  • Food evaluation and food product development
  • Soy-based fermented food and seafood


Representative Publications

  • Huang, Waihuan; Kim, Joo-Shin; Chung, Hau Yin. 2011. Antioxidant activity and total phenolic content in shiitake mycelial exudates.Natural Product Communications. (accepted)
  • Kim, Joo-Shin; Lu, Ying; Chung, Hau Yin. 2011. Chemical and textural properties in commercial fermented soybean curds of sufu.Journal of Food Science and Nutrition. 16: 55-61.
  • Su, Miaoxian; Chung, Hau Yin; Li, Yaolan. 2011. 6-O-Angeloylenolin induced cell-cycle arrest and apoptosis in human nasopharyngeal cancer CNE cells.Chemico-Biological Interactions. 189 : 167-176.
  • Guan, Lei; Chung, Hau Yin; Su, Yalun; Jiao, Rui; Peng, Cheng; Chen, Zhen Yu. 2010. Hypocholesterolemic activity of onion is mediated by enhancing excretion of fecal sterols in hamsters.Food & Function. 1: 84-89.
  • Su, Miaoxian; Wu, Peng; Li, Yaolan; Chung, Hau Yin 2010. Antiproliferative effects of volatile oils from Centipeda minima on Human Nasopharyngeal cancer cells.Natural Product Communications. 5(1): 151-156.
  • Su, Miaoxian; Wu, Xia; Chung, Hau Yin; Li, Yaolan; Ye, Wencai 2009. Antiproliferative activities of five Chinese medicinal herbs and active compounds in Elephantopus scaber.Natural Product Communications. 4(8): 1025-1030.
  • Su, Miaoxian; Li, Yaolan; Chung, Hau Yin; Ye, Wencai 2009. 2β-(Isobutyryloxy)florilenalin, a sesquiterpene lactone isolated from the medicinal plant Centipeda minima, induces apoptosis in human nasopharyngeal carcinoma CNE cells.Molecules 14(6): 2134-2146.
  • Ooi, Linda S.M.; Tian, Li;, Su, Miaoxian; Ho, Wing-Shan; Sun, Samuel S.M.; Chung, Hau Yin; Wong, N.C. Henry; Ooi, Vincent E.C. 2008. Isolation, characterization, molecular cloning and modeling of a new lipid transfer protein with antiviral and antiproliferative activities from Narcissus tazetta.Peptides. 29(12): 2101-2109.
  • Kim, Joo-Shin; Ma, Wing Chi Joyce; Chung, Hau Yin. 2007. Enhancement of Bromophenol Content in Cultivated Green Grouper.Journal of Fisheries Science and Technology 10 (3): 113-118.
  • Chung, H.Y.; Yeung, C.W.; Kim, J.-S.; Chen, Feng. 2007. Static headspace analysis-olfactometry (SHA-O) of odor impact components in salted-dried white herring (Ilisha elongate).Food Chemistry 104: 842-851.


Research Grants

  • 2009. 广 东 省自然科学基金/自由申请项目/应用基础研究, co-I (项目编号:9151064101000027), 09-10. “地胆草属草药中倍半萜内酯类化合物的抗鼻咽癌活性研究”, (funded: CNY 100,000).
  • 2008. 国家自然科学基金/专项基金项目/科学部主任基金, co-I (项目编号:30840099), 08-09. “鹅不食草和地胆草的倍半萜内酯类化合物的抗鼻咽癌活性研究”, (funded: CNY 90,000).
  • 2008. Agriculture, Fisheries & Conservation Department, PI, external grant: (Quotation Ref.: AFCD/SQ/71/08), 08-09. “Provision of service to study the use of fish feeds in improving the flavour and quality of locally cultured fish”, (funded: HKD 700,000)
  • 2006. Innovation and Technology Support Fund, PI, external grant, 06-07. "Improving the flavor quality of local cultivated food fish by feed modification", (funded: HKD744,794).
  • 2006. RGC Earmarked, external grant, 06-07. "Role of the brownish shiitake mycelia exudate on the cell death of Leukemia cell line and its role as an antioxidant and a functional food colorant", (funded: HK$920,000).


Patents

  • Chung, H.Y.; Ang, Put O. Jr.; Woo, Y .S.N.; Ma, W. C.J. 2007. Additive composition for feeding aquaculture animals and feed containing the same. US Patent Application Publication. US 2007/0119380 A1.


Professional Activities

  • Member of Hong Kong Food Science and Technology Association
  • Member of Hong Kong Society of Mass Spectrometry
  • Member of Institute of Food Technologists
  • Member of American Chemical Society
  • Member of AOAC

 

 

Email This email address is being protected from spambots. You need JavaScript enabled to view it. People HWS
 
 
 
 

 

Education

1985 Ph.D. State University of New York Buffalo
  M.A. State University of New York Buffalo
  B.Sc. University of Alberta

Position

  • Adjunct Associate Professor, School of Life Sciences

Research Interests

  • Chemical Carcinogenesis
  • Natural products of herbal medicines and cancer
  • Detoxifying Enzymes  

Representative Publications

  • Chen Wen Yang; Ho Wing Shing John; Huang Jian Dong and Watt Rory M
    Functional Characterization of an Alkaline Exonuclease and Single Strand Annealing Protein from the SXT Genetic element of Vibrio Cholerae. BMC Mol Biol 12, 00-15, 2011.
  • Ho, J.W., Lee, N.H.P., Chim, W.O. Effects of oxymatrine from Ku Shen on cancer cells. Anti-cancer Agents Med Chem. 9(8), 823- 828, 2009.
  • Lee N.H. and Ho, J.W. Celastrol and terpenes as anti-infective agents. Anti-infective Agents in Medicinal Chemistry. 7(2), 97-104, 2008.
  • Ho, J.W. and Meng Jie. Pharmacological activity of cardiovascular agents from herbal medicine.
    Cardiovasc and Hematol Agents Med Chem. 5(4), 273 -277, 2007
  • Ho, J.W., Recent advances in protein and peptide chemistry related to cellular regulation. Protein & Peptide Lett. Vol. 13 (5), 533 pages, 2006.
  • Leung, Y.K. and Ho, J.W. Deciphering signaling control by phosphoproteome using mass spectrometry. Prot. & Peptide Lett. 13(5), 467-470, 2006.
  • Ho, J.W. Potential and cytotoxicity of cis-platinum complex with anti-tumor activity in combination therapy. Recent Patents on Anti-Cancer Drug Discovery, 1(1), 129-135, 2006
  • Ho, J.W. Potential and cytotoxicity of cis-platinum complex with anti-tumor activity in combination therapy. Recent Patents on Anti-Cancer Drug Discovery, 1(1), 129-135, 2006
  • Wong, K.F., Ho, J.W. Identification of histidine-60 interaction with copper in activation of chironomidae ferrochelatase Prot. & Peptide Lett. 13(5), 443-446, 2006.
  • Leung, Y.K. and Ho, J.W. Induction of UDP-glucuronosyltransferase 1A8 mRNA by 3-methylcholanthene in rat hepatoma cells. Biochem. Pharmacol. 63(4), 767-775, 2002.

Research Grants

  • 2009 - 2010, ITC, Establishment of platform for R&D of naturally occurring small molecules for liver cancer therapy, $674,268
  • 2009 - 2011 Contract, R&D of Naturally occurring molecules for disorder & cancer therapy, $1,800, 000
  • 2009 – 2011,GRF, Is Adolescent Idiopathic Scoliosis and Its Accompanying Low Bone Mass Associated with Vitamin-D Insufficiency? – A Case-control Study, Co-I, $498,201

Patents

  • Ho, J.W. and Lau, V. Methods for treatment and/or prevention of liver cancer with andrographolide (and) use thereof. US 08C10485.
  • Ho, J.W. A Method and composition for treatment and/or prevention of gastric ulceration and use thereof . US patent no. 08C10484US.
  • Ho, J.W., Meng, J. Compositions and Methods for treating cancer. CN2008_000460.

Awards

  • Leung Y. K. and Ho, J.W. Effects of licorice on the expression of UGT1A isozymes in rat hepatoma cells.
    FASEB J. 14(8), May 11, 2000. Boston, Annual Meeting of American Society for Biochemistry and Molecular Biology [ASBMB]
  • Leung, Y.K. and Ho, J.W. Induced expression of UDP-glucuronosyltransferase 1A8 in rat liver cells by aqueous licorice root extract.
    15th Symposium of the Protein Society, Philadelphia, July 28-Aug. 1, 2001.

Professional Activities

  • Guest Editor, Protein & Peptide Letters
  • Editor Board member,
    1. Chinese Journal of Medicine;
    2. Anti-Cancer Agents in Medicinal Chemistry;
    3. Recent Patents on Anti-Cancer Drug Discovery.
  • Reviewer, Analytical Chemistry (73 papers have been reviewed)

 

 

 

 

 

 

 

Address

(Office): Room EG03, Science Center East Block

(Lab): Room G96, Science Center South Block

 People KKM
 

Phone

(Office): (852) 3943 1008

(Lab): (852) 3943 6287
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web -
 

 

Education

1997 Ph. D. Department of Biochemistry, The University of Hong Kong, Hong Kong
1990 B. Sc. (Biochemistry), The University of Hong Kong, Hong Kong


Position

  • Associate Professor, School of Life Sciences


Research Interests

  • Genetic manipulation by transgenic and gene knockout technology
  • Study of Organogenesis and Tumorigensis using mouse as model organism
  • Neural development and neuronal cell biology
  • Stem cell research

Representative Publications 

  • Vong KI, Ma TC, Li B, Leung TCN, Nong W, Ngai SM, Hui JHL, Jiang L, Kwan KM. (2021) SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity. Proc Natl Acad Sci U S A. 118(6):e2009568118. doi: 10.1073/pnas.2009568118.
  • Dong X, Kwan KM. (2020) Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Mol Brain. 13(1):104. doi: 10.1186/s13041-020-00643-z
  • Ma TC, Vong KI,Kwan KM. (2020) Spatiotemporal Decline of BMP Signaling Activity in Neural Progenitors Mediates Fate Transition and Safeguards Neurogenesis. Cell Rep. 30(11): 3616-3624.e4. doi: 10.1016/j.celrep.2020.02.089.
  • Lui NC, Tam WY, Gao C, Huang JD, Wang CC, Jiang L, Yung WH, Kwan KM. (2017) Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin. Nat Commun. 8:15079. doi: 10.1038/ncomms15079.
  • Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KK, Tong KK, Kwan KM, Wang N, Chiu JJ, Zhu Y, Huang Y. (2016). Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. doi: 10.1038/nature20602.
  • Zhu J, Kwan KM, Mackem S. (2016) Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT. Proc Natl Acad Sci U S A. 113(14), 3820-3825.
  • Vong KI, Leung CK, Behringer RR, Kwan KM. (2015). Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain. 8, 25.
  • Tong KK, Kwan KM (2013). Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development. Mol Cell Biol. 33(10), 1925-1937.
  • Wong YL, Behringer RR, Kwan KM (2012). Ventral limb ectoderm Smad1/Smad5 signaling functions redundantly and is required in interdigital programmed cell death. Dev Biol. 363(1), 247-257.
  • Tam WY, Leung CK, Tong KK, Kwan KM (2011). Foxp4 is essential in maintenance of Purkinje cell dendritic arborization in the mouse cerebellum. Neuroscience. 172, 562-571.
  • Zhao Y*, Kwan KM*, Mailloux CM, Lee WK, Grinberg A, Wurst W, Behringer RR and Westphal H (2007). LIM-homeodomain proteins Lhx1, Lhx5, and their cofactor Ldb1 control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A. 104, 13182-13186. * equal contribution as first author
  • Kwan KM. (2002). Conditional alleles in mice: practical considerations for tissue-specific knockouts. Genesis. 32, 49-62.
  • Kwan KM, Pang MK, Zhou S, Cowan SK, Kong RY, Pfordte T, Olsen BR, Sillence DO, Tam PP and Cheah KS. (1997). Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function. J Cell Biol. 136, 459-471.


Research Grants

Research Grants Council (RGC) Hong Kong: General Research Fund

  • 2019-2021, Functional analysis of Sox9 in choroid plexus development and regulation of cerebrospinal fluid secretion – HKD$ 971,368 (as PI)
  • 2013-2015, Functional analysis of Foxp4 in exocrine pancreas development and homeostasis in mouse - HKD$ 850,000 (as PI)
  • 2011-2013, GRF, Functional analysis of Foxp4 in Purkinje neurons of cerebellum in mice, HKD$ 1,133,900 (as PI)
  • 2010-2012, GRF, Functional analysis of Sox9 in neural progenitor cells of cerebellum in mice, HKD$ 1,195,046 (as PI)
  • 2009-2011, GRF, Functional analysis of Smad genes in granule neurons of cerebellum in mice, HKD$ 1,064,049 (as PI)
  • 2008-2010, GRF, Functional analysis of Lhx1 and Lhx5 in Purkinje neurons of cerebellum in mice, HKD$ 1,146,611 (as PI)


Research Grants Council (RGC) Hong Kong: Collaborative Research Fund

  • 2020-2023, The First Integrated State-of-the-Art Sample Preparation System for Cryo-Electron Microscopy/Tomography Analysis to Promote Advanced Cellular and Structural Biology Research in Hong Kong – HKD$ 7,439,308 (as Co-I)
  • 2017-2020, The First Integrated cyco-EM and cryo-ET Shared Facility for Life Sciences Research in Hong Kong – HKD$ 9,500,000 (as Co-I)
  • 2014-2017, Targeting RNA and protein toxicities of polyglutamine diseases using peptidylic inhibitors - HKD$ 7,044,220 (as Co-I)
  • 2013-2016, Physical Exercise Promotes Vascular Health: Impact of Mechano-Transduction and Novel endothelium-derived Regulators - HKD$ 7,700,000 (as Co-I)
  • 2012-2015, EXPO (Exocyst-positive Organelle): Dynamics, Biogenesis and Function in Plants - HKD$ 8,459,400 (as Co-I)

Research Grants Council (RGC) Hong Kong: Area of Excellence

  • 2014-2020, Center for Organelle Biogenesis and Function - HKD$ 47,250,000 (as Co-I)


Health and Medical Research Fund (HMRF)

  • 2015-2017, Investigation on ataxia disorder by using a novel genetically-modified mouse model - HKD$ 999,880 (as PI)


Awards

  • 2009 and 2013 Science Faculty Exemplary Teaching Award, The Chinese University of Hong Kong
  • 2008 The Young Researcher Award 2008, The Chinese University of Hong Kong
  • 1991-1994 The Croucher Foundation Scholarship, Hong Kong

 

 

 

Address

(Office): Rm 291, Science Centre South Block
(Lab): Rm 294, Science Centre South Block

 People LKF 

Phone

(Office): (852) 3943 1106
(Lab): (852) 3943 6119
Fax (852) 2603 7246
Email This email address is being protected from spambots. You need JavaScript enabled to view it.
Web
   

Education

1999 Ph.D., Chinese University of Hong Kong
1994 M.Phil., Chinese University of Hong Kong
1992 B.Sc., Hong Kong Baptist University


Position

  • Associate Professor, School of Life Sciences
  • Program Director, MSc Programme in Biochemical and Biomedical Sciences, CUHK


Research Interests

  • Amyloid precursor protein interacting proteins in Alzheimer’s disease and neurodegenerative disorders
  • Amyloid precursor protein and its interacting proteins in neurodevelopment 
  • Protein Kinases in neurodegenerative disorders


Representative Publications

  • Chau DDL, Li W, Chan WWR, Sun JKI, Zhai Y, Chow HM and Lau KF (2022) Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signalling. FASEB J. 36, e22594
  • Zhai Y, Chan WWR, Li W and Lau KF (2022) ARNO is recruited by the neuronal adaptor FE65 to potentiate ARF6-mediated neurite outgrowth. Open Biol (The Royal Society) 12, 220071.
  • Chan WWR, Li W, Chang RCC, and Lau KF (2020) ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1. FASEB J. 34, 16397-16413.
  • Chan WWR, Chau DLD, Li W and Lau KF (2019) Proximity Ligation Assay for the Investigation of the Intramolecular Interaction of ELMO1. Bio-protocol 9(23): e3449. DOI: 10.21769/BioProtoc.3449.
  • Chau DDL, Yung KWY, Chan WWL, An Y, Hao Y, Chan HYE, Ngo JCK and Lau KF (2019) Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35. FASEB J. 33, 12019-12035
  • Chan WW, Li W, Chau D L and Lau KF (2019) An Enhanced Green Fluorescence Protein-based Assay for Studying Neurite Outgrowth in Primary Neurons. J Vis Exp. (152), e60031, doi:10.3791/60031
  • Li W, Chan, Chan WWR, Ngo JCK and Lau KF (2018) Emerging roles of neural adaptor FE65 in neurite outgrowth. Neural Regen Res. 13, 2085-2086.
  • Li W, Tam KMV, Chan WWR, Koon AC, Ngo JCK, Chan HYE and Lau KF (2018) Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. J Biol Chem. 293, 7674-7688.
  • Lee YS, Chow WNV and Lau KF (2017) Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing. Scientific Reports 7(1):12456. doi: 10.1038/s41598-017-12334-2.
  • Chiu WY, Koon A, Ngo JCK, Chan HYE and Lau KF (2017) GULP1/CED-6 ameliorates Amyloid-β toxicity in a Drosophila model of Alzheimer's disease. Oncotarget 8, 99274-99283. doi.org/10.18632/oncotarget.20062.
  • Lee CW, Stankowski, JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW and Petrucelli L (2017) The lysosomal protein cathepsin L is a progranulin protease. Molecular Neurodegeneration 12(1):55. doi: 10.1186/s13024-017-0196-6.
  • Chow WNV, Ngo JCK, Li W, Chen YW, Tam KMV, Chan HYE, Miller CCJ and Lau KF (2015) Phosphorylation of FE65 Serine-610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer’s disease amyloid precursor protein processing. Biochemical Journal 470, 303-317.
  • Chow WNV, Cheung HNM, Li Wen and Lau KF (2015) FE65: roles beyond amyloid precursor protein processing. Cellular & Molecular Biology Letters 20, 66-87.
  • Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho R, Lau KF, Vizcay-Barrena G, Lin WL, Xu F, Lewis J, Dickson D, Petrucelli L, Mitchell J, Shaw CE and Miller CCJ (2014) ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by FTD/ALS-associated TDP-43. Nature Communications 5, 3996. doi:10.1038/ncomms4996.
  • Cheung HN, Dunbar C, Mórotz GM, Cheng WH, Chan HY, Miller CC, Lau KF (2014) FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J 28, 337-349.
  • Chow WNV, Luk HW, Chan HYE and Lau KF (2012). Degradation of mutant huntingtin via ubiquitin-proteasome system is modulated by FE65. Biochemical Journal 443, 681-689.
  • Tsoi H, Lau TC, Tsang SY, Lau KF and Chan HY (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc Natl Acad Sci USA 109, 13428-13433.
  • Li M, Choi ST, Tsang KS, Shaw PC and Lau KF (2012) DNA Microarray Expression Analysis of Baicalin-induced Differentiation of C17.2 Neural Stem Cells. Chembiochem 18, 1286-1290.
  • Tsoi H, Lau CK, Lau KF and Chan HY (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases 1. Human Molecular Genetics 20, 3787-3797.
  • Hao Y, Perkinton MS, Chan WW, Chan HYE, Miller CC and Lau KF (2011) GULP1 is a novel APP interacting protein that alters APP processing. Biochemical Journal 436, 631-639.
  • Li M, Tsang KS, Choi ST, Li K, Shaw PC and Lau KF (2011) Neuronal Differentiation of C17.2 Neural Stem Cells Induced by a Natural Flavonoid, Baicalin. Chembiochem 12, 449-456.
  • Lau KF* (*corresponding author), Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM and Miller CC (2008) Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein dependent transcription. Journal of Biological Chemistry 283, 34728-34737.


Research Grants

  • 2022-2025 Collaborative Research Equipment Grant (Co-PI)
  • 2021-2024 Health and Medical Research Fund (PI)
  • 2020-2023 RGC General Research Fund (Co-I)
  • 2019-2021 RGC General Research Fund (PI)
  • 2016-2018 Health and Medical Research Fund (PI)
  • 2015-2017 Health and Medical Research Fund (Co-I)
  • 2015-2017 RGC General Research Fund (Co-I)
  • 2014-2016 Health and Medical Research Fund (PI)
  • 2013-2015 RGC General Research Fund (PI)
  • 2013-2015 Health and Medical Research Fund (Co-I)
  • 2013-2015 Health and Medical Research Fund (Co-I)
  • 2013-2014 Research Fund for the Control of Infectious Diseases (Co-I)
  • 2012-2014 RGC General Research Fund (Co-I)
  • 2011-2013 RGC General Research Fund (PI)
  • 2007-2010 RGC General Research Fund (PI)
  • 2005-2009 Motor Neurone Disease Association UK

 
Awards

  • Science Faculty Exemplary Teaching Award 2013/2014; 2018/2019
  • Croucher Foundation Fellowship 1999-2001

Professional Activities

  • Associate Editor: Frontiers in Molecular Neuroscience
  • Editorial board member: International Journal of Brain Science; SOJ Biochemistry, International Journal of Neurology Research; American Journal of Psychiatry and Neuroscience