Prof. CHAN Yiu Leung, David
Current Position:
Assistant Professor
Office Phone:
(852) 3505 3199
Email:
drdcyl16@cuhk.edu.hk
Qualifications:
BSc (Ulster), MPhil (CUHK), DPhil (Oxon)
Certified Medical Technologist (American Medical Technologist, AMT)
Professor CHAN Yiu Leung David earned his bachelor degree in Biotechnology in Ulster University (UK) in 2002 and his MPhil in brain cancer research in The Chinese University of Hong Kong (CUHK) in 2006 respectively. In 2006, he was a Visiting Scholar in University of Pennsylvania to study reproductive cloning. He then obtained his DPhil in chromosome engineering from University of Oxford (UK) in 2011, supported by Clarendon Award and Hong Kong China Oxford scholarships. Professor CHAN had his post-doctoral training in CUHK briefly and then he was trained and practiced in embryology and andrology in University of Hong Kong (HKU), Queen Mary Hospital (QMH) for four and a half years. He joined the Department of Obstetrics and Gynaecology, CUHK in August 2016 and was appointed as Research Assistant Professor in the reproductive medicine team of CUHK.
1 Associations between ambient air pollution and IVF outcomes in a heavily polluted city in China
Liu J, Zhao M, Zhang H, Zhao J, Kong H, Zhou M, Guan Y, Li TC, Wang X, Chan DYL
Reprod Biomed Online. 2022 Jan;44(1):49-62
2 Effectiveness of a childbirth massage programme for labour pain relief in nulliparous pregnant women at term: a randomised controlled trial Lai CY, Wong MKW, Tong WH, Chu SY, Lau KY, Tan AML, Hui LL, Lao TTH, Leung TY
Hong Kong Med J. 2021 Dec;27(6):405-412
3 CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia
Chen H, Shi X, Li XF, Diao RY, Ma Q, Jin J, Qiu ZL, Li CL, Yu MK, Wang CQ, Li XX, Li FH, Chan DYL, Zhao AZJ, Cai ZM, Sun F, Fok KL
Mol Ther Nucleic Acids. 2021 Nov 10;26:1374-1386
4 Kidney Biopsy in Patients with Monoclonal Gammopathy: A Multicenter Retrospective Cohort Study
Nie S, Wang M, Wan Q, Kong Y, Ou J, Jia N, Zhang X, Luo F, Liu X, Wang L, Cao Y, Chen R, Zhao M, Chan DYL, Wang G
Front Med (Lausanne). 2021 May 24;8:687149
5 Automated and precise recognition of human zygote cytoplasm: A robust image-segmentation system based on a convolutional neural network
Zhao M, Li H, Li R, Li Y, Luo X, Li TC, Lee TL, Wang WJ, Chan DYL
Biomedical Signal Processing and Control 2021 May;67:102551
6 Associations between blood metal/ metalloid concentration and human semen quality and sperm function: A cross-sectional study in Hong Kong
Shi X, Chan CPS, Man GKY, Chan DYL, Wong MH, Li TC
J Trace Elem Med Biol. 2021 May;65:126735
7 Successful implantation is associated with a transient increase in serum pro-inflammatory cytokine profile, following by a switch to anti-inflammatory cytokine profile prior to confirmation of pregnancy
Zhao Y, Zhang T, Guo X, Wong CK, Chen X, Chan YL, Wang CC, Laird S, Li TC
Fertil Steril. 2021 Apr;115(4):1044-1053
8 The predictive value of endometrial thickness in 3117 fresh IVF/ICSI cycles for ectopic pregnancy
Fang T, Chen M, Yu W, Ma T, Su Z, Chan DYL, Zhao M, Zheng Q, Wang W
J Gynecol Obstet Hum Reprod. 2021 Jan 25;50(8):102072
9 Application of convolutional neural network on early human embryo segmentation during in vitro fertilization
Zhao MP, Xu MR, Li HH, Alqawasmeh O, Chung JPW, Li TC, Lee TL, Tang PMK, Chan DYL
J Cell Mol Med. 2021 Mar;25(5):2633-2644
10 Green tea extract as a cryoprotectant additive to preserve the motility and DNA integrity of human spermatozoa
Alqawasmeh OAM, Zhao M, Chan CPS, Leung MBW, Chow KC, Agarwal N, Mak JSM, Wang CC, Pang CP, Li TC, Chu WK, Chan DYL
Asian J Androl. Mar-Apr 2021;23(2):150-156
11 Early transient suppression of immune checkpoint proteins T-cell immunoglobulin mucin-3 and programmed cell death-1 in peripheral blood lymphocytes after blastocyst transfer is associated with successful implantation
Zhang T, Zhu W, Zhao Y, Cheung CWC, Liu Y, Chen X, Du Y, Leung KT, Chan DYL, Wang CC, Laird S, Li TC
Fertil Steril. 2020 Aug;114(2):426-435
12 Time-Lapse Imaging Trial: A pragmatic, multi-centre, three-arm randomised controlled trial to assess the clinical effectiveness and safety of time-lapse imaging in in-vitro fertilisation treatment
Bhide P, Srikantharajah A, Lanz D, Dodds J, Collins B, Zamora J, Chan DYL, Thangaratinam S, Khan KS
Trials. 2020 Jul 1;21(1):600
13 Influence of the period of abstinence on semen quality in a patient with systemic lupus erythematosus – A case report and review of the literature
Waters THB, Chan CPS, Li TC, Chan DYL*
Case Rep Rheumatol. 2020 Mar 7;2020:9296858
14 Multigene human artificial chromosome vector delivery with herpes simplex virus 1 amplicons
Chan DYL, Moralli D, Wheatley L, Jankowska JD, Monaco ZL
Exp Cell Res. 2020 Mar 15;388(2):111840 (5 pages)
15 The effects of daily meteorological perturbation on pregnancy outcome: Follow-up of a cohort of young women undergoing IVF treatment
Zhao M, Zhang H, Waters THB, Chung JPW, Li TC, Chan DYL*
Environ Health. 2019 Nov 28;18(1):103, 14pages
16 A double-blinded, randomized placebo-controlled trial on the effect of traditional Chinese medicine formula Wuzi Yanzong pill on improving semen qualities in men with suboptimal parameters
Zhao M, Chan CPS, Cheung CWC, Alqawasmeh O, Wang CC, Wu JCY, Lin ZX, Li TC, Chung JPW, Mak JSM, Law SM, Chan DYL*
Trials. 2019 Aug 29;20(1):540 (7 pages)
17 Maternal β-HCG concentrations in early IVF pregnancy: association with the embryo development stage of blastocysts
Zhu W, Yeung QSY, Chan DYL, Chi L, Huang J, Wang Q, Chung JPW, Li TC
Reprod Biomed Online. 2019 May;38(5):683-690
18 Mitochondria Manipulation in Oocytes: A Mini-Review
Zhao M, Li TC, Chan DYL
Int J Obstet Gynaecol Stud. 2017 1(1) :1-5
19 Comparative analysis of single-cell parallel sequencing approaches in oocyte application
Qian Y, Liao J, Suen AHC, Lee AWT, Chung CHS, Tang NLS, Chow KL, Cao Q, Yip YL, Leung TY, Chan WY, Chan DYL, Li TC, Lee TL
Int J Biochem Cell Biol. 2019 Feb;107:1-5
20 Comparison of DNA fragmentation levels in spermatozoa with different sex chromosome complements
Shi X, Chan DYL, Zhao MP, Chan CPS, Huang J, Li TC
Reprod Biomed Online. 2019 Jan;38(1):56-65
21 Lifestyle and demographic factors associated with human semen quality and sperm function
Shi X, Chan CPS, Waters T, Chi L, Chan DYL, Li TC
Syst Biol Reprod Med. 2018 Oct;64(5):358-367
22 The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials
Zhao M, Shi X, Kong GWS, Wang CC, Wu JCY, Lin Z, Li TC, Chan DYL*
Evidence-Based Complementary and Alternative Medicine. 2018;2018:10. doi: 10.1155/2018/2968025.
23 Mitochondria Manipulation in Oocytes: A Mini-Review.
Ming Peng Zhao TCL, Chan DYL*
Int J Obstet Gynaecol Study. 2017;1(1).
24 Comparison of the external physical damages between laser-assisted and mechanical immobilized human sperm using scanning electronic microscopy.
Chan DYL*, Li TC.
PloS one. 2017;12(11):e0188504. Epub 2017/11/28. doi: 10.1371/journal.pone.0188504. PubMed PMID: 29176855.
25 Human varicella zoster virus is not present in the semen of a man affected by chickenpox during the in vitro fertilisation of his wife.
Chan DYL, Lam KKW, Lau EYL, Yeung WSB, Ng EHY
Andrologia. 2017. Epub 2017/07/04. doi: 10.1111/and.12822. PubMed PMID: 28670753.
26 Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells
Chan DYL, Moralli D, Khoja S, Monaco ZL
Disease Markers. 2017;2017:8. doi: 10.1155/2017/7506976.