Associate Professor
Room 243 Science Centre
(852) 3943-0329
Education
| Postdoctoral | University of Chicago, USA | |
| Ph.D. | Iowa State University, USA | |
| B.Sc. (Hons.) | The Chinese University of Hong Kong |
Positions
| Since 2020 | Associate Professor, The Chinese University of Hong Kong |
| 2013-2020 | Associate Professor, Hong Kong Baptist University |
Research Interests
Our group is interested in the study of biomolecular interactions and biomarkers sensing with the aid of fluorescence microscopic methods. Recently, we
| 1. | develop ultrasensitive assays for the detection of potent cancer markers, e.g. microRNA; |
| 2 | study the fibrillogenesis of Alzheimer’s disease-related beta-amyloid peptides and theranostics of Alzheimer’s disease; |
| 3 | develop new imaging contrast agents for early disease diagnosis. |
Honours and Awards
| 2018 | President’s Outstanding Performance in Team Teaching, Hong Kong Baptist University |
| 2016 | The Innovationem Award for the Most Promising Innovation of the Year 2016, Hong Kong Baptist University |
| 2015 | The Hundred Talent of Shanxi Province, China for 2015-2018 |
Representative Publications
| 1. | Zhao Chao, Meng Shuangshuang, Chan Hei-Nga, Wang Xueli, Li Hung-Wing *, Chan Michael C. W. “Saccharide-Functionalized Poly(Zn-salphen)-alt-(m- and p-phenyleneethynylene)s as Dynamic Helical Metallopolymers” Angewandte Chemie International Edition (2022), 61(9) e202115712, doi: 10.1002/anie.202115712 |
| 2. | Iyaswamy Ashok,* Wang Xueli, Krishnamoorthi Senthilkumar, Kaliamoorthy Venkatapathy, Sreenivasmurthy Sravan G., Durairajan Siva Sundara Kumar, Song Ju-Xian, Tong Benjamin Chun-kit, Zhu Zhou, Su Cheng-Fu, Liu Jia, Cheung King-Ho, Lu Jia-Hong, Tan Jie-Qiong, Li Hung-Wing,* Wong Man Shing,, Li Min, “Theranostic F-SLOH mitigates Alzheimer’s disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer’s disease models” Redox Biology (2022), 51, 102280 |
| 3. | Wang, Xueli; Chan, Hei Nga; Desbois, Nicolas; P. Gros, Claude; Bolze, Frederic; Li, Yinhui; Li, Hung-Wing*; Wong, Man Shing. “Multimodal Theranostic Cyanine-Conjugated Gadolinium(III) Complex for In Vivo Imaging of Amyloid-β in an Alzheimer’s Disease Mouse Model”, ACS Applied Materials & Interfaces (2021), 13 (16), 18525-18532. |
| 4. | Wang, Chengke, Wang, Xueli, Chan, Hei‐Nga, Liu, Guifeng, Wang, Zhenxin, Li, Hung-Wing* Wong, Man Shing, “Amyloid‐β Oligomer‐Targeted Gadolinium‐Based NIR/MR Dual‐Modal Theranostic Nanoprobe for Alzheimer’s Disease” Advanced Functional Materials (2020) doi.org/10.1002/adfm.201909529 |
| 5. | Chan, Hei-Nga; He, See-Lok; He, Dinggeng and Li, Hung-Wing*, “Direct and sensitive detection of circulating miRNA in human serum by ligase-mediated amplification”, Talanta (2020), 206, 120217. |
| 6. | Guo, Yahui; Pan, Xinyue; Zhang, Wenya; Hu, Zhigang; Wong, Ka-Wang; He, Zhike and Li, Hung-Wing*, “Label-free probes using DNA-templated silver nanoclusters as versatile reporters”, Biosensors and Bioelectronics (2019), 150, 111926. |
| 7. | He, Dinggeng; Wang, Huizhen; Ho, See-Lok; Chan, Hei-Nga; Hai, Luo; He Xiaoxiaio; Wang, Kemin and Li, Hung-Wing*, “Total Internal Reflection-based Single-Vesicle in situ Quantitative and Stoichiometric Analysis of Tumor-derived Exosomal microRNAs for Diagnosis and Treatment Monitoring” Theranostics (2019), 9(15), 4494-4507. |
| 8. | Chan, Hei-Nga; Xu, Di; Ho, See-Lok; He, Dinggeng; Wong, Man Shing and Li, Hung-Wing*, “Highly Sensitive Quantification of Alzheimer’s Disease Biomarkers by Aptamer-assisted Amplification”, Theranostics (2019), 9(10), 2939-2949. |
| 9. | He, Dinggeng; Ho, See-Lok; Chan, Hei-Nga; Wang, Huizhen; Hai, Luo; He, Xiaoxiao; Wang, Kemin and Li, Hung-Wing*, “Molecular-Recognition-Based DNA Nanodevices for Enhancing the Direct Visualization and Quantification of Single Vesicles of Tumor Exosomes in Plasma Microsamples”, Analytical Chemistry (2019), 91(4), 2768-2775. |
| 10. | Wong, Ka-Wang; Xu, Di; He, Dinggeng; Wong, Man Shing and Li, Hung-Wing*, “Direct Immunomagnetic Detection of Low Abundance Cardiac Biomarker by Aptamer DNA Nanocomplex”, Sensors and Actuators B: Chemical 291 (2019), 291, 200-206. |
| 11. | Li, Yinhui; Xu, Di; Chan, Hei-Nga; Poon, Chung-Yan; Ho, See-Lok; Li, Hung-Wing* and Wong, Man Shing, “Dual-Modal NIR-Fluorophore Conjugated Magnetic Nanoparticle for Imaging Amyloid-β Species in Vivo”, Small (2018), 14(28), 1800901. (Highlighted on Frontispiece Cover) Video Abstract at: https://youtu.be/FzfaLXcJ2Pk |
| 12. | Li, Yinhui; Xu, Di; Sun, Anyang; Ho, See-Lok; Poon, Chung-Yan; Chan, Hei-Nga; Ng, Olivia T. W.; Yung, Ken K. L.; Yan, Hui; Li, Hung-Wing* and Wong, Man Shing, “Fluoro-Substituted Cyanine for Reliable in vivo Labelling of Amyloid‐β Oligomers and Neuroprotection against Amyloid-β Induced Toxicity”, Chemical Science (2017), 8, 8279-8284. |
| 13. | He, Dinggeng; He, Xing; Yang, Xue and Li, Hung-Wing*, “A smart ZnO@polydopamine-nucleic acid nanosystem for ultrasensitive live cell mRNA imaging by the target-triggered intracellular self-assembly of active DNAzyme nanostructures” Chemical Science (2017), 8, 2832-2840. |
Research Grants
1. Hong Kong Research Grants Council: GRF12301020 and GRF12301519
2. The Chinese University of Hong Kong: Direct Grant