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Prof. Chris Ka-Pun MOK

莫家斌教授

BSc (Chem) (HKUST), MPhil (HKU), PhD (HKU)

Assistant Professor

Email: kapunmok @ cuhk.edu.hk

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ORCID: 0000-0002-0525-6772

Scopus Author ID: 36159732100

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Academic Appointments

  • Associate Editor, Frontier of Immunology

  • Associate Editor, Virology Journal

  • Member of Outbreak Investigation Task Force, Institute Pasteur International Network

  • Honorary Assistant Professor, HKU-Pasteur Research Pole, The University of Hong Kong

Biography

The major objective of our group is to understand the interplay between the host adaptive immunity and the viral determinants of respiratory viruses such as influenza viruses and coronaviruses using a combination of clinical, virological, immunological and structural approaches. We are particularly interested to understand how the adaptive immunity is regulated and sharpen by the evolution of respiratory viruses which will help to further improve the current vaccines.

Research Interests

  • Pathogenicity of zoonotic viruses in human

  • Viral immunology on respiratory diseases

  • Prophylactic and treatment options for respiratory infection

Selected Publications

  1. Cheng SMS*, Mok CKP*, Leung YWY, Ng SS, Chan KCK, Ko FW, Chen C, Yiu K, Lam BHS, Lau EHY, Chan KKP, Luk LLH, Li JKC, Tsang LCH, Poon LLM, Hui DSC, Peiris M. (2022) Neutralizing antibodies against the SARS-CoV-2 Omicron variant following homologous and heterologous CoronaVac or BNT162b2 vaccination. Nat Med. 28(3):486–489 [IF:53.4] (*co-first authors).

  2. Mok CKP, Cheng SMS, Chen C, Yiu K, Chan TO, Lai KC, Ling KC, Sun Y, Ho LL, Peiris M, Hui DS. A Randomized Clinical Trial of a third dose CoronaVac or BNT162b2 vaccine in adults with two doses of CoronaVac. AJRCCM. 205(7):844-847[IF:21.4]

  3. Arunachalam PS*, Wimmers F*, Mok CKP*, Perera M*, Scott M, Hagan T, Sigal N, Feng Y, Bristow L, Tsang OT, Wagh D, Coller J, Pellegrini KL, Kazmin D, Alaaeddine G, Leung WS, Chan JMC, Chik TSH, Choi CYC, Huerta C, McCullough MP, Lv H, Anderson E, Edupuganti S, Upadhyay AA, Bosinger SE, Maecker HT, Khatri P, Rouphael N, Peiris M, Pulendran B. Systems biological assessment of immunity to severe and mild COVID-19 infections. Science. 369:1210-1220. [IF:41] (*co-first authors).

  4. Yuan M, Wu NC, Zhu X, Lee CCD, So RTY, Lv H, Mok CKP*, Wilson IA* (2020) A highly conserved cryptic epitope in the receptor-binding 4 domains of SARS-CoV-2 and SARS-CoV. Science. 368:630-633 [IF:41] (*co-corresponding authors). (Selection by C&EN’s Year in Chemistry 2020)

  5. Mok CKP, Zhu A, Zhao J, Lau EHY, Wang J, Chen Z, Zhuang Z, Wang Y, Wang W, Tan W, Liang W, Oladipo JO, Kuranga SA, Peiris M, Zhao J (2020) Specific T cell responses provide evidence of MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria. Lancet Infect Dis. 6:S1473-3099(20)30599-5. [IF:25.0]

  6. Hachim A, Kavian N, Cohen CA, Chin AWH, Chu DKW, Mok CKP, Tsang OTY, Yeung YC, Perera RAPM, Poon LLM, Peiris JSM, Valkenburg SA (2020) ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection. Nat Immunol. 21(10):1293-1301 [IF:23.5]

  7. Lv H, Wu NC, Tsang OT, Yuan M, Perera RAP, Leung WS, So RT, Chan JMC, Yip GK, Chik TSH, Wang Y, Choi CYC, Lin Y, Ng WW, Zhao J, Poon LLM, Peiris JSM, Wilson IA, Mok CKP (2020) Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections. Cell Rep. 31(9):107725. [IF:9.4] (Best papers in Cell Reports, 2020)

  8. Wu NC, Lv H, Thompson AJ, Wu DC, Ng WWS, Kadam RU, Lin CW, Nycholat CM, McBride R, Liang W, Paulson JC, Mok CKP*, Wilson IA* (2019) Preventing an antigenically disruptive mutation in egg-based H3N2 seasonal influenza vaccines by mutational incompatibility. Cell Host Microbe. 25:836-844 [IF:20.3] (*co-corresponding authors).

  9. Yang ZF*, Mok CK*, Peiris JSM, Zhong NS (2015) Human infection with a novel avian influenza A(H5N6) virus. N Engl J Med. 373:487-489 [IF:70.7] (*co-first author).

  10. Chan MC*, Chan RW*, Chan LL*, Mok CK*, Hui KPY, Fong JHM, Tao KP, Poon LL, Nicholls JM, Guan Y, Peiris JS (2013) Tropism and innate host responses of a novel avian origin influenza A (H7N9) virus in ex vivo and in vitro cultures of the human respiratory tract. Lancet Resp Med. 1:534-542 [IF:23.0] (*co-first author).

Last Updated: 3 May 2021