1. R&D of a Novel Bone Targeting Delivery System Carrying Bone-forming Phytomolecule Icaritin for Prevention of Osteonecrosis (HK$997,540)
   Sponsors: Health and Medical Research Fund
   Principal investigator: Prof. Qin Ling (Department of Orthopaedics and Traumatology)
2. A Randomized Controlled Trial Comparing the Efficacy and Safety between Pattern Laser Trabeculoplasty and Selective Laser Trabeculoplasty (HK$990,518)
   Sponsors: Health and Medical Research Fund
   Principal investigator: Prof. Leung Kai-shun Christopher (Department of Ophthalmology and Visual Sciences)
3. A Study on the Relationship between Maternal Iodine and Thyroid Status, and Autoimmune Thyroid Disease, on Placental Thyroid and Iodide Transport System in Chinese Women (HK$998,976)
   Sponsors: Health and Medical Research Fund
   Principal investigator: Prof. Lao Tzu-hsi Terence (Department of Obstetrics and Gynaecology)
4. Nudges to Influence Influenza Vaccine Uptake in Children: A Randomized Controlled Trial (HK$979,801)
   Sponsors: Health and Medical Research Fund
   Principal investigator: Prof. Nelson Edmund Anthony (Department of Paediatrics)
5. Development of System Using Routine Surveillance Data to Estimate Influenza Vaccine Effectiveness for Hospitalized Hong Kong Children (HK$995,452.5)
   Sponsors: Health and Medical Research Fund
   Principal investigator: Prof. Nelson Edmund Anthony (Department of Paediatrics)
6. Mechanism-guided Design of Tradition Chinese Herbal Formula (Fok Fong) for Prevention and Treatment of Metabolic Syndrome (HK$932,408)
   Sponsors: Health and Medical Research Fund
   Principal investigator: Prof. Lee Sau-tuen Susanna (School of Life Sciences)
7. Investigation on Ataxia Disorder by Using a Novel Genetically-modified Mouse Model (HK$999,880)
   Sponsors: Health and Medical Research Fund
   Principal investigator: Prof. Kwan Kin-ming (School of Life Sciences)
8. Illuminating the Functional Abnormalities of Brain Networks Underlying Social Communication and Repetitive Behaviours in Autism Spectrum Disorder (ASD): Implication on a Neurobiological Treatment of Neurofeedback (HK$754,538)
   Sponsors: Health and Medical Research Fund
   Principal investigator: Prof. Lai Yee-ching Kelly (Department of Psychiatry)
9. The Role of Huperzine A in Treatment of β Amyloid Associated-neuropathology in a Mouse Model of Alzheimer's Disease (HK$722,276)
   Sponsors: Health and Medical Research Fund
   Principal investigator: Dr. Yuan Qiuju (School of Chinese Medicine)
10. Synergism between Tamoxifen and Marmorin, a Ribosome Inactivating Protein from an Edible Medicinal Mushroom, on Breast Cancer in Vitro and in Vivo: A Mechanistic Study (HK$999,128)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Ng Tzi-bun (School of Biomedical Sciences)
11. Psychopathology, Executive Dysfunction and Role Impairment in Chinese Young Adults with a Previous Clinical Diagnosis of Childhood Attention-deficit/Hyperactivity Disorder in Hong Kong (HK$504,020)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Mak Dun-ping Arthur (Department of Psychiatry)
12. Biological Crystal Subunit Vaccines for Mycobacterial Diseases (HK$1,000,000)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Michael Chan (School of Life Sciences)
13. Volumetric Bone Mineral Density and Bone Microarchitecture: A New Population-based Reference Study with High Resolution Peripheral Quantitative Computer Tomography (HK$996,216)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Qin Ling (Department of Orthopaedics and Traumatology)
14. An Investigation into the Therapeutic Potential of Human Fetal Pancreatic Progenitor Cells for Islet Transplantation (HK$995,128)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Leung Po-sing (School of Biomedical Sciences)
15. Molecular Screening for Community-based Cephalosporin-resistant Neisseria Gonorrhoeae in Key Populations in Hong Kong (HK$999,836)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Chan Pui-chung Denise (Stanley Ho Centre for Emerging Infectious Diseases)
16. Electroacupuncture plus Standard Care for Managing Refractory Functional Dyspepsia: Pragmatic Randomized Trial with Economic Evaluation (HK$1,000,000)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Chung Chi-ho Vincent (The Jockey Club School of Public Health and Primary Care)
17. Meteorological Risk Factors for Hospital Admissions among Patients with Diabetes Mellitus in Hong Kong (HK$423,600)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. William B. Goggins (The Jockey Club School of Public Health and Primary Care)
18. The Concordance of KRAS, BRAF, PIK3CA, and PTEN Status between Primary Tumors and Corresponding Metastases in Patients with Colorectal Cancer: A Systematic Review and Meta-analysis (HK$356,664)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Mao Chen (The Jockey Club School of Public Health and Primary Care)
19. Improving Elderly Health Care Voucher Scheme to Incentivise Primary Care in Hong Kong: How has Health Service Utilization Changed (HK$889,732)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Liu Su (The Jockey Club School of Public Health and Primary Care)
20. Evaluation of the Adoption of the Reference Framework for Hypertension in Primary Care: A Mixed Qualitative and Quantitative Study (HK$989,733)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Wong Chi-sang Martin (The Jockey Club School of Public Health and Primary Care)
21. Structure-based Screening for G6PD Stabilizers to Overcome Primaquine-induced Hemolysis in Anti-malaria Treatment (HK$972,276)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Au Wing-ngor Shannon (School of Life Sciences)
22. To Evaluate the Effect of Salvianolic Acid B on Bone Fusion in comparison with Autograft in a Rat Spinal Fusion Model (HK$722,432)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Lee Yuk-wai Wayne (Department of Orthopaedics and Traumatology)
23. The Development of Mechanically Robust Hyaluronic Acid Hydrogels for Joint Cartilage Repair (HK$999,000)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Bian Liming (Department of Mechanical and Automation Engineering)
24. Targeted Drug Discovery for Alzheimer's Disease (HK$727,564)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Chan Man-lok Andrew (School of Biomedical Sciences)
25. Internet-based Mindfulness and Rumination-focused Cognitive Behavioural Therapy as Selective Prevention of Anxiety and Depression: A Randomized Controlled Trial (HK$999,692)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Mak Wing-sze Winnie (Department of Psychology)
26. A Randomized Controlled Trial Evaluating Efficacy of a Psychological Intervention Based on Commonsense Model in Improving Mental Health and Self-care among Type-2 Diabetes Mellitus Patients (HK$999,003.75)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Mo Kit-han Phoenix (The Jockey Club School of Public Health and Primary Care)
27. Rapid Sample-to-answer Smart Lab-on-a-disc Pharmacogenetic Testing Device for Personalized Medicine (HK$988,328)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Ho Ho-pui Aaron (Department of Electronic Engineering)
28. A Randomized Controlled Trial Evaluating Efficacy of an Intervention Which Enhances Social Support and Positive Affect through Online Social Networking in Smoking Cessations (HK$999,904)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Lau Tak-fai Joseph (The Jockey Club School of Public Health and Primary Care)
29. Dysregulation of miR223 and miR431 Expression in Intestinal Tissues of Preterm Infants with Necrotising Enterocolitis: Roles in Altering Enterocyte Gene Expressions and Functions (HK$758,902)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Ng Pak-cheung (Department of Paediatrics)
30. Behavioural Dysexecutive Syndrome after Stroke (HK$1,250,012)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Tang Wai-kwong (Department of Psychiatry)
31. A Randomized Controlled Trial Examining the Effectiveness of a Lifestyle Intervention in Reducing Gestational Diabetes Mellitus in High Risk Chinese Pregnant Women in Hong Kong (HK$989,445.95)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Chan Suk-mei Ruth (Department of Medicine and Therapeutics)
32. Left Ventricular Mass and Clinical Characteristics of Persistent Masked Hypertension in Hong Kong Youth—A Community Cohort Study (HK$995,878)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Yam Man-ching (Department of Paediatrics)
33. Relationship between Chronic Inflammation and Vitamin D Level to Prevalent and Incident Frailty in Older Adults (HK$996,108)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Lee Shun-wah Jenny (Department of Medicine and Therapeutics)
34. Treatment of Parkinsonian Symptoms via Stochastic Stimulation of the Motor Cortex: A Proof-of-principle Study (HK$999,378.5)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Yung Wing-ho (School of Biomedical Sciences)
35. Immunotherapy and Modulatory Mechanisms of Hypoallergen DNA Vaccines for Shellfish Allergy (HK$999,657.6)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Chu Ka-hou (School of Life Sciences)
36. Sulfur Amino Acids as Risk Factors for Obesity and Related Morbidities in Older Chinese People (HK$638,000)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Kwok Chi-yui Timothy (Department of Medicine and Therapeutics)
37. Cellular Mechanisms Underlying the Benefits of Danshen-derived Salvianolic Acid B against Vascular Inflammation and Dysfunction in Diabetes (HK$999,916)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Huang Yu (School of Biomedical Sciences)
38. An Observational Follow Up Study on Pelvic Floor Disorders Related to Three Years after Delivery (HK$221,934)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Chan Shing-chee Symphorosa (Department of Obstetrics and Gynaecology)
39. A Prospective Observational Study to Validate the Reliability of the Early Pregnancy Viability Scoring System (HK$274,822)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Wan Yee-ki Osanna (Department of Obstetrics and Gynaecology)
40. Impact of the Chinese Herbal Medicines on the Combination Therapy with Clopidogrel and Aspirin: Pharmacokinetics and Pharmacodynamics Outcomes and Related Mechanisms in Rats (HK$909,000)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Zuo Zhong (School of Pharmacy)
41. The Effects of an Activity-based Lifestyle Intervention on Moderate Sleep Complaints among Older Adutls: A Sequential Mixed Method Study (HK$818,519.11)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Yu Sau-fung Doris (The Nethersole School of Nursing)
42. An Investigation of Amyloid Precursor Protein in Triple Negative Breast Cancers and its Potential Clinical Value (HK$997,414)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Tse Man-kit Gary (Department of Anatomical and Cellular Pathology)
43. A Randomized Controlled Trial of Combined Physical Exercise-working Memory Training on Slowing Down Cognitive Decline in Elders with Mild Clinical Alzheimer's Disease (HK$956,187)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Lam Chiu-wa Linda (Department of Psychiatry)
44. Tetramethylpyrazine (TMP) as a Novel HIF Activator for Promoting Angiogenesis and Osteogenesis during Skeletal Regeneration (HK$1,000,000)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Wan Chao (School of Biomedical Sciences)
45. Investigation of the Antitussive Effects of a Folk Medicine, Cardiocrinum Seeds (HK$995,128)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Shaw Pang-chui (School of Life Sciences)
46. Randomized Sham-controlled Trial of Augmentative Neuro-navigated Right-dorsolateral Prefrontal Cortex Low-frequency Repetitive Transcranial Magnetic Stimulation for Antidepressant Non-responding Bipolar Depression (HK$977,730)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Mak Dun-ping Arthur (Department of Psychiatry)
47. A Functional Study of Nuclear Receptor LRH-1 and its Targeting in Prostate Cancer (HK$913,304)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Chan Leung Franky (School of Biomedical Sciences)
48. Mast Cells Activities and Osteoporosis—A Novel Research Platform for the Study of Interaction of Herbal and Western Anti-Osteoporosis Agents in Human (HK$998,276)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Lau Hang-yung Alaster (School of Biomedical Sciences)
49. A Pragmatic Randomized Controlled Trial Comparing an Integrated Electroacupuncture Protocol vs Sham-control in Chinese Adults with Generalized Anxiety Disorder and Diarrhea-predominant Irritable Bowel Syndrome (HK$749,630.8)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Mak Dun-ping Arthur (Department of Psychiatry)
50. Investigation of the Effects of Gastrodiae Rhizoma—Containing Herbal Formula (DCXF) in Traumatic Brain Injury Rate Model (HK$957,912)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Ko Chun-hay (Institute of Chinese Medicine)
51. A Randomized Controlled Trial on Perioperative Elderly Patients Undergoing Colorectal Cancer Surgery with Enhanced Geriatric Input (HK$528,414)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Mak Wing-chung Tony (Department of Surgery)
52. Delineation of Therapeutic Potential and the Causal Relationship between Vitamin D and Helicobacter Pylori (HP) Infection and Gastritis (HK$1,000,000)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Wu Che-yuen Justin (Hong Kong Institute of Integrative Medicine)
53. Evaluation of the Effectiveness of Tai Chi versus Brisk Walking in Reducing Cardiovascular Risk Factors: A Randomized Controlled Trial (HK$863,760.5)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Chan Wai-kiu Aileen (The Nethersole School of Nursing)
54. Exploring the Functional Roles of Stromal Leukotrienes in Cancer Development and Treatment (HK$846,408)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Cheung Wing-tai (School of Biomedical Sciences)
55. Adjunctive Light Treatment in Major Depressive Disorder among Evening Chronotype—A Randomized Controlled Trial (HK$839,980)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Wing Yun-kwok (Department of Psychiatry)
56. The Translation of Gastrodia Elata from Laboratory to Clinical Practice: The Study and Treatment of Epilepsy as a Window to Neuroscience (HK$847,414)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Leung Howan (Department of Medicine and Therapeutics)
57. A Randomized Controlled Trial of a New Screening Strategy for Varices Based on Liver and Spleen Stiffness Measurement (LSSM) in Cirrhotic Patients (HK$895,785)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Wong Lai-hung Grace (Department of Medicine and Therapeutics)
58. Effect of Short Course Pulmonary Rehabilitation on the Activity and Frequency of Exacerbations of Patients with Chronic Obstructive Pulmonary Disease (COPD) (HK$789,020)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Ko Wai-san Fanny (Department of Medicine and Therapeutics)
59. Genetic Predictors of Perioperative Myocardial Injury—The GeneVISION Study (HK$999,860.5)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Tony Gin (Department of Anaesthesia and Intensive Care)
60. Familial Aggregation and Biomarkers in REM Sleep Behaviour Disorder: A Case-control Family Study (HK$994,423.5)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Zhang Jihui (Department of Psychiatry)
61. Using a Novel and Noninvasive Cerebral Augmentation Index as Evaluated by External Counterpulsation to Predict Long-term Clinical Outcome after Acute Ischemic Stroke (HK$673,304)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Wong Ka-sing Lawrence (Department of Medicine and Therapeutics)
62. Non-invasive Assessment of Cardiovascular Reserve in Patients with Systemic Autoimmune Diseases (HK$833,148)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Shang Qing (Department of Medicine and Therapeutics)
63. Neural Responses to Pitch in Cantonese-speaking Children with Autism Spectrum Disorders (HK$765,304.8)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Wong Chun-man Patrick (Department of Linguistics and Modern Languages)
64. Effects of Early Life Adversity on the Development of Enteric Neurons (HK$956,432)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Chan Wood-yee (School of Biomedical Sciences)
65. Genetic Susceptibility of Hong Kong Ethnic Chinese to Severe Influenza and RSV Infections (HK$999,823)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Lee Lai-shun Nelson (Department of Medicine and Therapeutics)
66. A Study of Efficacy on the Combination Use of Anti-osteoporosis Drug with Topical Chinese Herbal Paste on Facilitation of Fracture Healing (HK$927,414)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Leung Ping-chung (Institute of Chinese Medicine)
67. Is it Safe to Use Estrogenic Chinese Herbal Medicines in Breast Cancer Patients?—A Preclinical Evaluation (HK$992,288)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Lau Bik-san Clara (Institute of Chinese Medicine)
68. Comparison of Serum Thromboxane B2 and Platelet Function Testing with the Multiple® Device as Measures of Aspirin Resistance in Hong Kong Chinese Patients with Increased Cardiovascular Risk with Stable Coronary Heart Disease or Peripheral Artery Disease (HK$641,474)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Brian Tomlinson (Department of Medicine and Therapeutics)
69. Prevention of Vasovagal Reactions in Blood Donors: A Randomized Double-blinded Controlled Comparison of Efficacy and Haemodynamic Effects of Oral Prehydration Fluids (HK$999,042)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Khaw Kim-sun (Department of Anaesthesia and Intensive Care)
70. Identification of Alterations in Host Genome Methylation Driven by the Human Immunodeficiency Virus Type 1 (HK$999,408)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Tsui Kwok-wing (School of Biomedical Sciences)
71. Association Study of Susceptibility Genes in Wnt Signalling Pathway with Attempted Suicide (HK$940,368)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Waye Miu-yee (School of Biomedical Sciences)
72. The Anti-apoptotic and Anti-proliferative Role of FHL2 Mediated by p53, IL6 and STAT3 (HK$999,408)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Tsui Kwok-wing (School of Biomedical Sciences)
73. Peak Oxygen Uptake in Healthy Chinese Children and Adolescents by Age, Sex and Maturation (HK$999,887.25)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Albert Martin Li (Department of Paediatrics)
74. Role of Platelet-T Cell Interactions in Pathogenesis of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO) (HK$785,000)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Eugene Ponomarev (School of Biomedical Sciences)
75. Molecular Stratification of Lower Grade Gliomas in Routine Practice in Hong Kong (HK$728,624)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Ng Ho-keung (Department of Anatomical and Cellular Pathology)
76. Genetic Studies of Tuberculosis: In-depth Study of Recently GWAS Identified Loci in Chinese Patients (HK$987,414)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Tang Leung-sang Nelson (Department of Chemical Pathology)
77. Therapeutic Treatment against Ocular Inflammation by Green Tea Extract and Catechins in Experimental Uveitis (HK$952,414)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Pang Chi-pui (Department of Ophthalmology and Visual Sciences)
78. Biomedical Effects of Green Tea Extracts on Experimental Age-related Macular Degeneration (HK$997,414)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Ng Tsz-kin (Department of Ophthalmology and Visual Sciences)
79. Novel Treatment of Intermittent Claudication in Patients with Peripheral Arterial Disease Using Danshen Gegen (D&G) Capsule (HK$999,800)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Yan Ping-yen Bryan (Department of Medicine and Therapeutics)
80. Gestational Temporal Behaviour and Cut-off Values of Soluble fms-Like Tyrosine Kinase-1, Placental Growth Factor and its Ratio as a Diagnostic Test for Pre-eclampsia in Chinese (HK$411,000)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Cheng Kwun-yue Yvonne (Department of Obstetrics and Gynaecology)
81. Evaluation of Riboflavin/Ultraviolet-mediated Collagen Crosslinking with Photoactivated Riboflavin (Photoactivated Chromophore for Keratitis [PACK]-CXL) as Adjunctive Treatment for Infectious Keratitis: A Randomized Controlled Trial (HK$402,448.2)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Dr. Vishal Jhanji (Department of Ophthalmology and Visual Sciences)
82. A Randomized Controlled Trial of Rapid Movement Therapy with Real-time Feedback to Improve Balance Recovery for Fall Prevention after Stroke (HK$858,000)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Tong Kai-yu Raymond (Department of Electronic Engineering)
83. Plasma microRNAs as Prognostic Biomarkers for Localized Prostate Cancer (HK$631,408)
    Sponsors: Health and Medical Research Fund
    Principal investigator: Prof. Wang Feng (The Jockey Club School of Public Health and Primary Care)