Striatal dopamine transmission and prodromal markers of α-synucleinopathy neurodegeneration in recurrent dream enactment behaviors without REM sleep without atonia: a case-control study
Brief description
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a novel and distinct parasomnia characterized by recurrent dream enactment behaviors (DEBs) and REM sleep without atonia (RSWA) during polysomnographic assessment, with a male predominance and typical onset age at early 60’s.
This study is a case-control study, which aims to determine whether recurrent DEBs without sufficient RSWA represents an early stage of α-synucleinopathy.
Study Details
Subjects will undergo a comprehensive survey of neurodegenerative markers, including
- cognitive functions,
- PET scan (striatal dopamine transmission)
- video-polysomnography assessment
- blood test
