STAFFS

• Director of Sleep Assessment Unit
• Deputy Director of Centre for Clinical Trials on Chinese Medicine

• Sleep medicine
• Biological and cultural psychiatry
• Neuropsychiatry
• Transcultural psychopharmacology

• Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study
• Striatal dopamine transmission in individuals with isolated rapid eye movement sleep without atonia: a search for precursor biomarker for neurodegeneration
  孤立性快速眼動睡眠肌張力失弛緩的多巴胺轉運：尋找神經退化的生物學標記
• Gut microbiota across early stages of synucleinopathy: from high-risk relatives, REM sleep behavior disorder to early Parkinson’s disease
  早期突觸核蛋白變性疾病與腸道微生物：從高危親屬、快速眼動睡眠行為障礙到早期帕金遜
• Adjunctive light treatment in major depressive disorder among evening chronotype – A randomized controlled trial
  聯合光治療對夜晚型抑鬱症患者的療效：一個隨機對照研究
• Prodromal markers of synucelinopathy neurodegeneration in the first degree relatives of patients with psychiatric disorders comorbid with REM sleep behavior disorder
  突觸核蛋白變性相關神經退化的早期標記與精神障礙伴有快速眼動睡眠行為障礙的一級親屬的關係
• Can we prevent insomnia? A randomized controlled trial of brief cognitive behavioral Insomnia prevention program for high-risk adolescents
  我們是否可以預防失眠？一個針對高危青少年的認知行為治療隨機對照臨床試驗

1. Xu Yingying, Su Sizhen, Jiang Zhendong, Guo Suihuai, Lu Qingdong, Liu Lin, Zhao Yimiao, Wu Ping, Que Jianyu, Shi Le, Deng Jiahui, Meng Shiqiu, Yan Wei, Sun Yankun, Yuan Kai, Lin Xiao, Sun Siwei, Ravindran Arun, Chen Sijing, Wing YK, Tang Xiangdong, Ran Maosheng, Lu Yu, Shi Jie, Huang Guofu, Bao Yanping, Lu Lin.
   Prevalence and risk factors of mental health symptoms and suicidal behavior among university students in Wuhan, China during the COVID-19 pandemic.
   Front Psychiatry. 2021 Jul 13;12:695017.
   doi: 10.3389/fpsyt.2021.695017. eCollection 2021.
2. Li Zhongqi, Chen Xinyi, Vong Joaquim SL, Zhao Lei, Huang Junzhe, Yan Leo YC, Ip Bonaventure, Wing YK, Lai Hei-Ming, Mok Vincent CT, Ko Ho.
   Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner.
   Commun Biol . 2021 Jun 2;4(1):656.
   doi: 10.1038/s42003-021-02208-9.
3. Au CT, Chan KCC, Lee DL, Leung NMW, Chow SM, Wing YK, Li AM,
   Effect of surgical intervention for mild childhood obstructive sleep apnoea on attention and behavioural outcomes: A randomized controlled study.
   Respirology. 2021 Jul;26(7):690-699.
   doi: 10.1111/resp.14050. Epub 2021 Apr 1.
4. Chung Frances, Waseem Rida, Pham Chi, Penzel Thomas, Han Fang, Bjorvatn Bjørn, Morin Charles M., Holzinger Brigitte, Espie Colin A., Benedict Christian, Cedernaes Jonathan, Saaresranta Tarja, Wing YK, Nadorff Michael R., Dauvilliers Yves, De Gennaro Luigi, Plazzi Guiseppe, Merikanto Ilona, Matsui Kentaro, Leger Damien, Sieminski Mariusz, Mota-Rolim Sergio, Inoue Yuichi & Partinen Markku for the International COVID Sleep Study (ICOSS) group
   The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study
   Sleep Breath. 2021 Jun;25(2):849-860.
   doi: 10.1007/s11325-021-02373-5. Epub 2021 Apr 28.
5. Ai Sizhi, Zhang JH, Zhao Guoan, Wang Ningjian, Li Guohua, So Hon-Cheong, Liu Yaping , Chau Steven WH, Chen Jie, Tan Xiao, Jia Fujun, Tang Xiangdong, Shi Jie, Lin Lu, Wing YK.
   Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.
   Eur Heart J. 2021 Sep 7;42(34):3349-3357.
   doi: 10.1093/eurheartj/ehab170.
6. Lei BB, Zhang JH, Chan SJ, Chen J, Yang LL, Ai SZ, Chan NY, Wang J, Dai XJ, Feng HK, Liu YP, Li SX, Jai FJ, Wing YK. Associations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort.
   Sleep. 2021 Aug 13;44(8):zsab053.
   doi: 10.1093/sleep/zsab053
7. Chan NY, Chan JW, Li SX, Wing YK.
   Non-pharmacological Approaches for Management of Insomnia
   Neurotherapeutics. 2021 Jan;18(1):32-43.
   doi: 10.1007/s13311-021-01029-2. Epub 2021 Apr 5.
8. Rao S, Siu CO, Shi M, Zhang J, Lam MHB, Yu M, Wing YK, Waye MMY.
   Associations of Homer Scaffolding Protein 1 gene and psychological correlates with suicide attempts in Chinese: A pilot study of multifactorial risk model.
   Gene. 2018 Dec 30;679:382-388.
9. Liu S, Wing YK, Hao Y, Li W, Zhang J, Zhang B.
   The associations of long-time mobile phone use with sleep disturbances and mental distress in technical college students: a prospective cohort study.
   Sleep. 2018 Nov 3.
10. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK.
    Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.
    Sleep Med. 2018 Sep 24;53:1-8.

• 1981-1998
  Foundation Chairman, Professor of Psychiatry
• 1987-1994
  Foundation Head of Shaw College
• 1992-1998
  Honorary Chief of Service of Department of Psychiatry in Prince of Wales Hospital
• 1996-1998
  Honorary Chief of Service of Department of Psychiatry in Shatin Hospital

• Officer of the Most Excellent Order of the British Empire (OBE) – Appointed by Her Majesty, The Queen of The United Kingdom
• Honorary Fellow (2008), Shaw College, CUHK
• International Distinguished Fellow (since 2012), American Psychiatric Association
• Honorary Fellow (2014), Hong Kong College of Psychiatrists
• Special Contribution Award, Chinese Sleep Research Society
• Emeritus Professorship in 2018

• Past President of International Psychogeriatric Association
• Past President of Pacific Rim College of Psychiatrists
• Past President of the Hong Kong College of Psychiatrists
• Past President of the Hong Kong Psychogeriatric Association
• Chairman of Psychogeriatric Working Group
• Honorary Member of the Hong Kong Alzheimer’s Disease and Brain Failure Association
• Member of Medical and Advisory Panel of the Alzheimer’s Disease International
• Adjunct Professor, Department of Psychiatry, University of Rochester, NY, USA
• Member of Review Sub-committee of Licentiate Committee of the Medical Council of Hong Kong
• Honorary Consultant, the Caritas, Social Work Division
• Co-ordinator of 10/66 Dementia Research Group China and South East Asia Network
• Past Member of Elderly Commission
• Member of Long Term Prison Commission

• Medal of Honor by HKSAR in 1999
• International Psychogeriatric Association Distinguished Service Award in 2011

• Geriatric psychiatry
• Dementia
• Suicide

1. Chiu HFK, Zhong BL, Leung T, Li SW, Chow P, Tsoh J, Yan C, Xiang YT, Wong M.
   Development and validation of a new cognitive screening test: The Hong Kong Brief Cognitive Test (HKBC).
   Int J Geriatr Psychiatry. 2018 Apr 11.
2. Lam Nogueira BOC, Li L, Meng LR, Ungvari GS, Ng CH, Chiu HFK, Kuok KCF, Tran L, Xiang YT.
   Clinical characteristics and quality of life of older adults with cognitive impairment in Macao.
   Psychogeriatrics. 2018 Feb 6
3. Lam Nogueira BOC, Li L, Meng LR, Ungvari GS, Ng CH, Chiu HFK, Kuok KCF, Tran L, Xiang YT.
   Clinical characteristics and quality of life of older adults with cognitive impairment in Macao.
   Psychogeriatrics. 2018 Feb 6.
4. Zhong XM, Wang F, Zhang Q, Ungvari GS, Ng CH, Chiu HFK, Si TM, Sim K, Avasthi A, Grover S, Chong MY, Chee KY, Kanba S, Lee MS, Yang SY, Udomratn P, Kallivayalil RA, Tanra AJ, Maramis MM, Shen WW, Sartorius N, Mahendran R, Tan CH, Shinfuku N, Xiang YT.
   Concurrent benzodiazepine use in older adults treated with Antidepressants in Asia.
   Int Psychogeriatr. 2017 Dec 7:1-7.
5. Bhugra D, Tasman A, Pathare S, Priebe S, Smith S, Torous J, Arbuckle MR, Langford A, Alarcón RD, Chiu HFK, First MB, Kay J, Sunkel C, Thapar A, Udomratn P, Baingana FK, Kestel D, Ng RMK, Patel A, Picker L, McKenzie KJ, Moussaoui D, Muijen M, Bartlett P, Davison S, Exworthy T, Loza N, Rose D, Torales J, Brown M,  Christensen H, Firth J, Keshavan M, Li A, Onnela JP, Wykes T, Elkholy H, Kalra G, Lovett KF, Travis MJ, Ventriglio A. 
   The WPA-Lancet Psychiatry Commission on the Future of Psychiatry.
   Lancet Psychiatry. 2017 Oct;4(10):775-818.
6. Zhong BL, Chan SSM, Liu TB, Jin D, Hu CY, Chiu HFK.
   Mental health of the old-and new-generation migrant workers in China: who are at greater risk for psychological distress?
   Oncotarget. 2017 Mar 7;8(35):59791-59799.
7. Li L, Wang YY, Wang SB, Li L, Lu L, Ng CH, Ungvari GS, Chiu HFK, Hou CL, Jia FJ, Xiang YT.
   Sleep Duration and Sleep Patterns in Chinese University Students: A Comprehensive Meta-Analysis.
   J Clin Sleep Med. 2017 Oct 15;13(10):1153-1162.
8. Li XH, An FR, Ungvari GS, Ng CH, Chiu HFK, Wu PP, Jin X, Xiang YT.
   Prevalence of smoking in patients with bipolar disorder, major depressive disorder and schizophrenia and their relationships with quality of life.
   Sci Rep. 2017 Aug 16;7(1):8430.
9. Li XH, An FR, Ungvari GS, Ng CH, Chiu HFK, Wu PP, Jin X, Xiang YT. Prevalence of smoking in patients with bipolar disorder, major depressive disorder and schizophrenia and their relationships with quality of life.
   Sci Rep. 2017 Aug 16;7(1):8430.
10. Wang S, Wu Y, Ungvari GS, Ng CH, Forester BP, Gatchel JR, Chiu HFK, Kou C, Fu Y, Qi Y, Yu Y, Li B, Xiang YT.
    Sleep duration and its association withdemographics, lifestyle factors, poor mental health and chronic diseases in older Chinese adults.
    Psychiatry Res. 2017 Nov;257:212-218.

• Fellow, The Hong Kong Academy of Medicine, 1994.
  香港醫學專科學院院士 (1994)
• Freeman Foundation Fellowship, Department of Social Medicine, Harvard Medical, School, Boston, USA, 1996-7.
  美國哈佛大學醫學院 社會醫學系Freeman Foundation 訪問學人 (1996 – 1997)
• Fellow, Royal College of Psychiatrists (FRCPsych, UK), 1999.
  英國皇家精神科醫學院榮授院士 (1999)
• Lecturer, Department of Global Health and Social Medicine, Harvard Medical School, USA, 1997-2003.
  美國哈佛大學醫學院 全球健康與社會醫學系講師 (1997 – 2003)
• Advisor to the Eating Disorders Work Group of the DSM-IV (1994), American Psychiatric Association, USA.
  美國精神醫學會 精神疾病的診斷與統計手冊 進食失調症工作組顧問 (1994)
• Advisor to Section on Eating Disorders, DSM-Text Revision (2000) Work Group, American Psychiatric Association, USA
  美國精神醫學會 精神疾病的診斷與統計手冊(修定版)進食失調症工作組顧問 (2000)
• Chairman, Section on classification and diagnostic assessment, World Psychiatric Association (WPA), 1999-2003.
  世界精神病學協會 疾病分類及診斷評估組主席 (1999 – 2003)
• Director, Hong Kong Eating Disorders Center, The Chinese University of Hong Kong, 1999-2019.
  香港中文大學 香港進食失調中心 中心主管 (1999 – 2019)
• Director, Hong Kong Mood Disorders Center, The Chinese University of Hong Kong, 2001-2019.
  香港中文大學 香港健康情緒中心 中心主管 (2001 – 2019)
• Member of the “Somatic Symptom and Related Disorders” workgroup of the DSM-5, American Psychiatric Association, USA, 2006-2013.
  美國精神醫學會 精神疾病的診斷與統計手冊 身體症狀及相關障礙工作組成員 (2006 – 2013)
• Asia-Pacific regional coordinator, World Mental Health Initiative; previously Chief Scientific Advisor, World Mental Health Survey in China (Beijing, Shanghai), organized by Harvard School of Public Health and World Health Organization, since 2000.
  美國哈佛大學公共衛生學院及世界衛生組織主辦 世界精神衛生調查行動 亞太區協調員; 美國哈佛大學公共衛生學院及世界衛生組織主辦 世界精神衛生調查行動 世界心理健康調查(北京及上海)前首席科學顧問 (自2000年起)
• Board member of the Hong Kong Eating Disorders Association.
  香港進食失調康復會董事局成員
  Founding advisor of the Hong Kong FamilyLink Mental Health Advocacy Association.
  香港家連家精神健康倡導協會創始顧問
• Clarivate Analytics “Highly Cited Researchers 2018, 2019, and 2020”
  Clarivate Analytics 「2018, 2019 及 2020 年最廣獲徵引研究人員」

• Assistant Dean (Student support), Faculty of Medicine, CUHK (2016- )  
• Chairman, Graduate School Disciplinary Committee, CUHK (2020- )  
• Chairman, Special Interest Group in Clinical Neuroscience, The Hong Kong College of Psychiatrists 
• Programme Director, Master of Science/Post-graduate Diploma in Mental Health 
• Project Director, Multi-professional Case-management program for case management, Hospital Authority  
• Committee Member, Committee on Complaints against Private Health Care Facilities, Department of Health (2021- )  
• Chairman and convener of the DEC Sub-commitee for MMR, Executive Committee member, The Mental Health Association of Hong Kong (2017- )
• Executive Committee member, HATCH (Hub of Advanced Technology for Child Health), The DH Chen Foundation

• Pacific Rim College of Psychiatrists’ Research Award: Best original research on Mood Disorder 2006 “Elderly Suicide and 2003 SARS Epidemic”
• Faculty Education Award 2021

• Specialists in Psychiatry with the Hong Kong College of Psychiatrists (Fellowship in 2005) and The Royal College of Psychiatrists (UK) (Membership in 2001/ Fellowship in 2015)
• National Institute of Health’s ICOHRTA Fellowship ( Suicide prevention and research) with University of Rochester, USA (2002-03)
• Visiting Fellowship at Martinos Centre for Biomedical Imaging(2012)/Berenson-Allen Center for Non Invasive Brain Stimulation, Harvard Medical School (2013)
• Certified Completion of Training in Psychoanalytic Psychotherapy with The China American Psychoanalytic Alliance (CAPA) (2013-2014)

• Functional brain mapping of mood disorders and neurodevelopmental disorders 
• Network-informed transcranial magnetic stimulation for psychiatric disorders 
• Neuromodulation for cognitive remediation in childhood neurodevelopmental disorders 
• Treatment resistant depression 
• Digital mental health platform 
• Resilience and developmental mental health 
• Suicide prevention 

1. Phase I of the Commissioned Study on Mental Health Survey: Hong Kong Child and Adolescent Psychiatric Epidemiologic Survey: Age 6 to 17
   (Co-I/Executive Director1378, External Grant: FHB-MHS-P1(Part 1)-CUHK)
2. Relationship between social motivation tendency, schizophrenia symptoms, and social functioning
   (Co-I, External Grant: Research Grant Council/ GRF 14605020)
3. Establishing the electro-physiological basis of inner speech deficits in Schizophrenia
   (Co-I, External Grant: Research Grant Council/ GRF 14601122)
4. Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment-refractory depression using neuroimaging biomarkers and machine learning
   (PI, External Grant: Research Grant Council/ GRF 14120322)
5. A mobile-phone-based intervention for caregivers of adolescents – empowerment through mindfulness-based and empathy-guided continuous learning and support programme
   (Co-I, External Grant: Mental Health Initiatives Fund- Phase I/ MH-0068)
6. Double-blind randomized controlled trial with t-DCS on pre-pubertal Autism Spectrum Disorder comorbid with ADHD
   (Project supervisor under HATCH research team) 
7. Microbiome signature in ASD- case-controlled study in pre-pubertal children
   (Project supervisor under HATCH research team) 

1. Chan SSM, Chiu HFK, Lam LCW, Leung VPY.
   Elderly Suicide and the 2003 SARS epidemic in Hong Kong SAR.
   International Journal of Geriatric Psychiatry 2006; 21:113-18.
2. Chan SSM, Lyness JM, Yeates C.
   Do Cerebrovascular Risk Factors Confer Risk for Suicide in Later Life? A Case-control Study.
   American Journal of Geriatric Psychiatry 2007; 15: 541-44
3. Liu J, Ma H, He YL, Xie B, Xu YF, Tang HY, Li M, Hao W, Wang XD, Zhang MY, Ng CH, Goding M, Fraser J, Herrman H, Chiu HFK, Chan SSM, Chiu E, Yu X.
   Mental health system in China: history, recent service reform and future challenges.
   World Psychiatry 2011; 10 (3): 210-16.
4. Chan SSM, Leung PY, Tsoh J, Li SW, Yu CS, Yu KK, Poon TK, Pan PC, Chan WC, Conwell Y, Lam LCW, Chiu HFK.
   Outcomes of a two-tiered multi-faceted elderly suicide prevention program in a Hong Kong Chinese Community.
   American Journal of Geriatric Psychiatry 2011;19: 185-96.
5. So SHW, Chan GHK, Wong CKW, Ching EWK, Lee, SSW, Wong BCW, Chen Z, Sun X, Chung, LKH, Hung AY, Wong JOY, Chan SSM.
   A randomized controlled trial of metacognitive training for psychosis, depression and belief flexibility.
   Journal of Affective Disorders 2020; 279(15): 388-39.
6. Hopman HJ, Choy HY, Ho WS, Lu H, Wong WH, Chan SSM.
   The effects of repetitive transcranial magnetic stimulation antidepressant response on cold cognition: a single-arm prospective longitudinal study.
   Neuropsychiatric Disease and Treatment 2021; 17: 1-12.
7. Hopman HJ (co-first author), Chan SSM (co-first author), Chu CWW, Lu H, Tse CY, Chau SWH, Lam LCW, Mak ADP, Neggers SFW.
   Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment refractory depression using neuroimaging biomarkers and machine learning.
   Journal of Affective Disorders 2021; 290: 261-271.
8. Wong OWH, Lam AMW, Lai KYC, Ma SL, Hung SF, Chan S, Wong S, Leung PWL.
   An elevated anxiety level amongprepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case–control study.
   Autism Research 2021; 14(10): 2131-2142.
9. Chan VKY, Cheung ECL, Chan SSM, Knapp M, Hayes JF, Fan M, Lai FTT, Luo H, Lum T, Wong RSM, Lau LKW, Wan EYF, Wong GHY, Chan EWY, Ip P, Wong ICK, Li X.
   Mortality-causing mechanisms and healthcare resource utilisation of treatment-resistant depression: A six-year population-based cohort study.
   The Lancet Regional Health – Western Pacific 2022;22: 100426
10. Wong OWH, Angela LMW, Or BPN, Lai K, Ma SL, Hung SF, Chan S, Kwong TNH, Wong S, Leung PWL.
    Disentangling the relationship of gut microbiota, functional gastrointestinal disorders and autism: a case-control study on prepubertal Chinese boys.
    Scientific Reports 2022: 12:10659

• Past President, The Hong Kong College of Psychiatrists
• Past Chief Editor, East Asia Archives of Psychiatrists
• Council Member, The Hong Kong College of Psychiatrists
• Founding President, The Chinese Dementia Research Association
• Associate Editor, Editorial Board of International Psychogeriatrics

• Early detection and intervention for Mild Cognitive Impairment and dementia
• Biomarker evaluation for Mild Cognitive Impairment and dementia
• Determinants of Health Aging
• Epidemiology of mental disorders in Hong Kong

1. Wong PCM, Ou J, Pang CWY, Zhang L, Tse CS, Lam LCW.
   Antoniou M.Language Training Leads to Global Cognitive Improvement in Older Adults: A Preliminary Study.
   J Speech Lang Hear Res. 2019 Jul 15;62(7):2411-2424.
2. Ma SL, Tang NLS, Wat KHY, Tang JHY, Lau KH, Law CB, Chiu J, Tam CCW, Poon TK, Lin KL, Kng CPL, Kong HL, Chan TY, Chan WC, Lam LCW.
   Effect of CYP2D6 and CYP3A4 Genotypes on the Efficacy of Cholinesterase Inhibitors in Southern Chinese Patients With Alzheimer’s Disease.
   Am J Alzheimers Dis Other Demen. 2019 Aug;34(5):302-307.
3. Mak AD, Chung VCH, Yuen SY, Tse YK, Wong SYS, Ju Y, Hung SS, Leung KC, You JHS, Lui R, Wong SH, Leung ONW, Lam LCW, Lee S, Wu JCY.
   Noneffectiveness of electroacupuncture for comorbid generalized anxiety disorder and irritable bowel syndrome.
   J Gastroenterol Hepatol. 2019 Mar 19.
4. Lu H, Chan SSM, Lam LCW.
   Localized Analysis of Normalized Distance from Scalp to Cortex and Personalized Evaluation (LANDSCAPE): Focusing on Age- and Dementia-Specific Changes.
   J Alzheimers Dis. 2019;67(4):1331-1341.
5. Ho RTH, Fong TCT, Chan WC, Kwan JSK, Chiu PKC, Yau JCY, Lam LCW.
   Psychophysiological effects of Dance Movement Therapy and physical exercise on older adults with mild dementia: A randomized controlled trial.
   J Gerontol B Psychol Sci Soc Sci. 2018 Nov 28.
6. Ho RTH, Fong TCT, Hon T, Chan WC, Kwan JSK, Chiu PKC, Lam LCW.
   Psychometric validation of Fuld Object Memory Evaluation in older adults with cognitive impairments.
   Aging Ment Health. 2019 Jun;23(6):711-717.
7. Fung AW, Lam LCW.
   Validation of a computerized Hong Kong – vigilance and memory test (HK-VMT) to detect early cognitive impairment in healthy older adults.
   Aging Ment Health. 2018 Oct 1:1-7.
8. Mak ADP, Chan AKW, Chan PKL, Tang CP, Lai K, Wong S, Leung P, Hung SF, Lam LCW, Lee S.
   Diagnostic Outcomes of Childhood ADHD in Chinese Adults.
   J Atten Disord. 2018 Sep 27:1087054718802015.
9. Cheng ST, Lam LCW.
   Improving diagnostic communication in dementia.
   Int Psychogeriatr. 2018 Aug;30(8):1149-1152.
10. Lu H, Ni X, Fung AWT, Lam LCW.
    Mapping the Proxies of Memory and Learning Function in Senior Adults with High-performing, Normal Aging and Neurocognitive Disorders.
    J Alzheimers Dis. 2018;64(3):815-826.

• Honoary Consultant, New Territories East Cluster, Hospital Authority

• Neuropsychiatry in Stroke
• Substance abuse

1. Substance Abuse Clinic Registry.
2. Self Harm in Substance Use Disorders.
3. Adverse Mental Health Effects of a New Psychotropic Substance (Synthetic Cathinones) Use: a Literature Review.
4. Adverse Mental Health Effects of Cannabis Use: A Literature Review and a Prevalence Study in Local Cannabis Abusers.
5. Neuropsychiatric Registry at Acute Stroke Unit at Prince of Wales Hospital.
6. Risk of Self Harm after Transient Ischemic Attack and Subarachnoid Haemorrhage in Kong Kong: a retrospective study.

1. Liang Y, Chen YK, Liu YL, Mok VCT, Ungvari GS, Chu WCW, Tang WK, Kim JS, Kim JM.
   Exploring causal pathways linking cerebral small vessel diseases burden to poststroke depressive symptoms with structural equation model analysis.
   J Affect Disord. 2019 Jun 15;253:218-223.
2. Wong SY, Tang WK, Mak WW, Cheung FM, Mercer S, Griffiths SM, Woo J, Lee DT, Kung K, Lam AT.
   Stepped care programme in primary care to prevent anxiety and depression: a randomised clinical trial.
   Hong Kong Med J. 2019 Feb;25 Suppl 3(1):9-10.
3. Cumming TB, Yeo AB, Marquez J, Churilov L, Annoni JM, Badaru U, Ghotbi N, Harbison J, Kwakkel G, Lerdal A, Mills R, Naess H, Nyland H, Schmid A, Tang WK, Tseng B, van de Port I, Mead G, English C.
   Investigating post-stroke fatigue: An individual participant data meta-analysis.
   J Psychosom Res. 2018 Oct;113:107-112.
4. Tang WK, Wong LK, Mok VC, Chu WC, Wang DF.
   Apathy after stroke: potential risk factors and magnetic resonance imaging markers.
   Hong Kong Med J. 2018 Jun;24 Suppl 3(3):18-20.
5. Liang Y, Chen YK, Mok VC, Wang DF, Ungvari GS, Chu WC, Kang HJ, Tang WK.
   Cerebral Small Vessel Disease Burden Is Associated With Poststroke Depressive Symptoms: A 15-Month Prospective Study.
   Front Aging Neurosci. 2018 Feb 28;10:46.
6. Wong SYS, Sun YY, Chan ATY, Leung MKW, Chao DVK, Li CCK, Chan KKH, Tang WK, Mazzucchelli T, Au AML, Yip BHK.
   Treating Subthreshold Depression in Primary Care: A Randomized Controlled Trial of Behavioral Activation With Mindfulness.
   Ann Fam Med. 2018 Mar;16(2):111-119.
7. Zhang C, Tang WK, Liang HJ, Ungvari GS, Lin SK.
   Other drug use does not impact cognitive impairments in chronic ketamine users.
   Drug Alcohol Depend. 2018 May 1;186:1-8.
8. Liang Y, Chan YL, Deng M, Chen YK, Mok V, Wang F, Ungvari GS, Chu CW, Tang WK.
   Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study.
   J Affect Disord. 2018 Mar 1;228:166-172.
9. Liang Y, Chen YK, Deng M, Mok VCT, Wang DF, Ungvari GS, Chu CW, Kamiya A, Tang WK.
   Association of Cerebral Small Vessel Disease Burden and Health-Related Quality of Life after Acute Ischemic Stroke.
   Front Aging Neurosci. 2017 Nov 13;9:372.
10. Liang Y, Deng M, Chen YK, Mok V, Wang DF, Ungvari GS, Chu CW, Berge E, Tang WK.
    Enlarged perivascular spaces are associated with health-related quality of life in patients with acute ischemic stroke.
    CNS Neurosci Ther. 2017 Dec;23(12):973-979.

• Honorary Secretary, The Hong Kong Society of Sleep Medicine 

• Circadian rhythm and neuropsychiatric disorders
• Clinical application of chronotherapeutic treatments
• Personalized medicin
• Sleep disorders and psychiatric illness

1. A randomized placebo-controlled trial for adjunctive bright light therapy in patients with bipolar depression and eveningness. Funded by General Research Fund, Research Grants Council. Capacity: PI. Study duration: 1/1/2022 – 31/12/2023 
2. Prospective evaluation on the change of chronotype and urinary 6-sulfaltoxymelatonin in hospitalized patients with major depressive episode. Funded by Direct Grant, CUHK. Capacity: PI. Study duration: 30/6/2021 – 29/6/2022 
3. Prevention of insomnia in at-risk youth: A randomised controlled trial comparing cognitive behavioral prevention programme for insomnia with active control condition. Funded by General Research Fund, Research Grants Council. Capacity: Co-I. Study duration: 1/7/2021 – 31/12/2023. 
4. Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study. Funded by General Research Fund, Research Grants Council. Capacity: Co-I. Study duration: 1/1/2022 – 31/12/2024. 
5. Efficacy of group cognitive behavioural therapy for youth anxiety and insomnia: A randomised, assessor blind, parallel-group trial. Funded by General Research Fund, Research Grants Council. Capacity: Co-I. Study duration: 1/1/2022 – 31/12/2024. 
6. Characterizing roles of paired nightshift work schedule and evening chronotype on alleviating sleep disturbance and mental health problems among nurses in Hong Kong. Funded by Health and Medical Research Fund – Advanced Medical Research, Food and Health Bureau. Capacity: Co-I. Study duration: 1/7/2021 – 31/12/2023. 
7. An 18-year follow-up study on obstructive sleep apnoea in a population-based cohort. Funded by Health and Medical Research Fund – Advanced Medical Research, Food and Health Bureau. Capacity: Co-I. Study duration: 1/4/2021 – 31/3/2023. 
8. Understanding the relationship between stress, resilience and sleep problems in adolescents, Funded by Direct grant, CUHK. Capacity: Co-I. Study duration: 30/06/2021 to 29/06/2022.

1. Chan JW, Chan NY, Li SX, Lam SP, Chau SWH, Liu Y, Zhang J, Wing YK.
   Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depression and evening preference.
   J Clin Sleep Med. 2021 Sep 21.
   doi: 10.5664/jcsm.9648. Epub ahead of print. PMID: 34534071. 
2. Chan JW, Lam SP, Li SX, Chau SW, Chan SY, Chan NY, Zhang JH, Wing YK.
   Adjunctive bright light treatment with gradual advance in unipolar major depressive disorder with evening chronotype – A randomized controlled trial.
   Psychol Med. 2020 Sep 14:1-10.
   doi: 10.1017/S0033291720003232. Epub ahead of print. PMID: 32924897. 
3. Chan JW, Li SX, Lam SP, Zhang J, Wing YK.
   Association of Eveningness With Nonremission in Major Depressive Disorder: Reply to Knapen et al.
   Sleep. 2017 Jun 1;40(6) 
4. Chan JW, Lam SP, Li SX, Yu MW, Chan NY, Zhang J, Wing YK.
   Eveningness and insomnia: independent risk factors of nonremission in major depressive disorder.
   Sleep. 2014 May 1;37(5):911-7. 
5. Chan NY, Chan JW, Li SX, Wing YK.
   Non-pharmacological Approaches for Management of Insomnia. Neurotherapeutics. 2021 Jan;18(1):32-43.
6. Chan NY, Li SX, Zhang J, Lam SP, Kwok APL, Yu MWM, Chan JW, Li AM, Morin CM, Wing YK.
   A Prevention Program for Insomnia in At-risk Adolescents: A Randomized Controlled Study.
   Pediatrics. 2021Mar;147(3):e2020006833. 
7. Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MW, Huang B, Li SX, Chau SW, Chan JW, Chen J, Mok V, Wing YK, Zhang J.
   Rest-activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
   Annals Neuro. 2020 Oct 88(4):817-29. 
8. Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MWM, Chan NY, Chan JW, Li SX, Huang B, Feng H, Mok V, Wing YK.
   Residual Injurious Symptoms and Its Association With Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-up Study.
   Mov Disord. 2020 Nov;35(11):2077-2085. 
9. Chan NY, Zhang J, Tsang CC, Li AM, Chan JW, Wing YK, Li SX. The Associations of Insomnia Symptoms and Chronotype with Daytime Sleepiness, Mood Symptoms and Suicide Risk in Adolescents.
   Sleep Med 2020 Oct 74:124-131. 
10. Ling J, Sun W, Chan NY, Zhang J, Lam SP, Li AM, Chan JW, Kyle SD, Li SX.
    Effects of insomnia symptoms and objective short sleep duration on memory performance in youths.
    J Sleep Res.2020, 29(4):e13049

• Psychosomatic medicine
• Affective disorders and anxiety disorders
• Epidemiology and phenomenology of bipolar affective disorders
• Epidemiology of anxiety disorders
• Research on epidemiology, phenomenology, neuroimaging, development and evaluation of treatment modalities for functional gastrointestinal disorders

• American Gastroenterological Association – Digestive Disease Week 2015 -Recognition for Scientific Accomplishment as Early Stage Investigator – “Functional Dyspepsia-Post-Prandial Distress Syndrome is Associated with Increased Glutamate in the Somatosensory Cortex”
• New York Festivals 2017 World’s Best Radio Programs – Bronze Winner – “Madly Musical” – an RTHK4 radio program on the relationship between musical creativity and mental illnesses. (https://goo.gl/oZgVeZ ) (as guest presenter)

For study enquiries please email Dr. Mak directly at: arthurdpmak@cuhk.edu.hk

1. WHO World Mental Survey – International College Students project (coordinator of the WMH-ICS China consortium)
2. Incident mental morbidity and web-based psychological treatment in COVID-19 (a WMH-COVID 19 study).
   HMRF Project No: COVID190212; HKD 2940490; 2020-2022.(wmhsurvey.cuhk.edu.hk)
3. A randomized controlled trial of home-monitored ‘gut-directed’ versus ‘general’ Hatha yoga for adults with constipation-predominant irritable bowel syndrome;
   HMRF Project No.- 15160951; HKD 1086391; 1/8/2018 – 31/7/2020- PI.
4. Transcranial Magnetic Stimulation Treatment for Attention-Deficit
   Hyperactivity Disorder in Young Adults

1. Mak, ADP, Leung, O. N. W., Chou, I. W. Y., Wong, S. L. Y., Chu, W. C., Yeung, D., So, S. H., Ma, S. L., Lam, L. C. W., Leung, C. M. & Lee, S. (2021)
   White matter integrity in young medication-naive bipolar II depressed adults.
   Scientific Reports 11 (1), 1816.
2. So, S. H., Mak, ADP, Chan, P. S., Lo, C. C., Na, S., Leung, M. H., Ng, I. H., Chau, A. K. C. & Lee, S. (2020)
   Efficacy of Phase 1 of Life Goals Programme on symptom reduction and mood stability for bipolar disorder.
   J Affect Disord. 2021 Feb 15;281:949-957.
   doi: 10.1016/j.jad.2020.11.019. Epub 2020 Nov 18.
3. Karyotaki, E., Cuijpers, P., Albor, Y., Alonso, J., Auerbach, R. P., Bantjes, J., Bruffaerts, R., Ebert, D. D., Hasking, P., Kiekens, G., Lee, S., Mclafferty, M., Mak, ADP, Mortier, P., Sampson, N. A., Stein, D. J., Vilagut, G. & Kessler, R. C. (2020)
   Sources of Stress and Their Associations With Mental Disorders Among College Students: Results of the World Health Organization World Mental Health Surveys
   International College Student Initiative.
   Front Psychol. 2020 Jul 30;11:1759.
4. Mak, ADP, Ho, Y. M., Leung, O. N. W., Chou, I. W. Y., Lui, R., Wong, S., Yeung, D. K. W., Chu, W. C. W., Edden, R., Chan, S., Lam, L. & Wu, J. (2020b)
   Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression.
   Front Psychiatry. 2020 Sep 11;11:549749.
5. Mak, ADP, Chan, A. K. W., Chan, P. K. L., Tang, C. P., Lai, K., Wong, S., Leung, P., Hung, S. F., Lam, L. C. W. & Lee, S. (2020)
   Diagnostic Outcomes of Childhood ADHD in Chinese Adults.
   Journal of Attention Disorders 24 (1), 126-135.
6. Chan, Y., Cheong, P. K., Fang, F. F., Cheung, C. K. Y., Lan, L. L., Yuen, K. W. K., Ching, J. Y. L., Mak, ADP, Wu, J. C. (2020)
   A symptom severity questionnaire for patients suffering from functional gastrointestinal disorder: FGI-Checklist.
   Journal of Gastroenterology and Hepatology 35 (7), 1130-1135.
7. Wong KMF, Yuen SSY, Mak ADP.
   Neurocognitive Characteristics of Individuals with Irritable Bowel Syndrome.
   East Asian Arch Psychiatry. 2019 Jun;29(2):48-56.
8. Mak ADP, Wu JCY, Chan Y, Tse YK, Lee S.
   Associations between Gastro-oesophageal Reflux Disease, Generalised Anxiety Disorder, Major Depressive Episodes, and Healthcare Utilisation: a Community-based Study.
   East Asian Arch Psychiatry. 2019 Jun;29(2):41-47.
9. Wu IXY, Wong CHL, Ho RST, Cheung WKW, Ford AC, Wu JCY, Mak ADP, Cramer H, Chung VCH.
   Acupuncture and related therapies for treating irritable bowel syndrome: overview of systematic reviews and network meta-analysis.
   Therap Adv Gastroenterol. 2019 Jan 20;12:1756284818820438.
10. Chan Y, So SH, Mak ADP, Siah KTH, Chan W, Wu JCY.
    The temporal relationship of daily life stress, emotions, and bowel symptoms in irritable bowel syndrome-Diarrhea subtype: A smartphone-based experience sampling study.
    Neurogastroenterol Motil. 2019 Mar;31(3):e13514.

ResearcherID:V-6345-2017
http://www.researcherid.com/rid/V-6345-2017
ORCID:
http://orcid.org/0000-0003-1627-6434
Google Scholar:
https://goo.gl/MFD45t

• Computational modelling of abnormal decision making processes in neuropsychiatric and neurodegenerative disorders
• Data-driven decision making in clinical management of neuropsychiatric and neurodegenerative disorders
• Multi-modal neuroimaging
• Neuropsychiatric disorders associated with Coronavirus (SARS/COVID)
• Novel approach in medical education

1. Prediction of 5-year risk of neurodegeneration in patients with idiopathic REM sleep behavior  disorder from multimodal neurodegenerative markers using deep neural network
2. Decision making in patients with idiopathic REM sleep behavior disorder and its neurobiological correlate

1. Chau, S.W.H., Wong, O.W.H., Ramakrishnan, R. et al.
   History for some or lesson for all? A systematic review and meta-analysis on the immediate and long-term mental health impact of the 2002–2003 Severe Acute Respiratory Syndrome (SARS) outbreak.
   BMC Public Health 2021 Apr 7;21(1):670.
2. Phiri P, Ramahrishnan R, Rathod S, Elliot K, Thayanandan T, Sandle N, Haque N, Chau SWH, Wong OWH, Chan SSM, Wong EKY, Raymont V, Kingdon D, Delanerolle GKE.
   An evaluation of the mental health impact of SARS-Cov-2 on patients, general public and healthcare professionals: A systematic review and meta-analysis.
   EClinicalMedicine.2021 Apr;34:100806.
3. Chau, SWH.
   Antagonistic or inflexible? Exploring the underpinnings of ‘impulse dyscontrol’.
   International Psychogeriatrics, 2021 May 21;1-6.
4. H.J. Hopman, S.M.S. Chan, W.C.W. Chu, H. Lu, C.-Y. Tse, S.W.H. Chau, L.C.W. Lam, A.D.P. Mak, S.F.W. Neggers.
   Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment-refractory depression using neuroimaging biomarkers and machine learning,
   Journal of Affective Disorders, 2021 Jul 1;290:261-271
5. Ai S, Zhang J, Zhao G, Wang N, Li G, So HC, Liu Y, Chau SWH, Chen J, Tan X, Jia F, Tang X, Shi J, Lu Lin, Wing YK.
   Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.
   European Heart Journal. 2021 Sep 7;42(34):3349-3357
6. Feng H, Chen L, Liu, Y, Chen, X, Wang J, Yu MW, Huang B, Li SX, Chau SWH, Chan JW, Chen, J, Mok VC, Wing YK and Zhang J.
   Rest‐activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
   Ann Neurol. 2020 Oct;88(4):817-829
7. Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MWM, Chan NY, Chan JWY, Li SX, Huang B, Feng H, Mok V, Wing YK.
   Residual Injurious Symptoms and Its Association with Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-Up Study.
   Mov Disord. 2020 Nov;35(11):2077-2085
8. Chau SWH, Lewis T, Ng R, Chen JY, Farrell SM, Molodynski A, Bhugra D Wellbeing and mental health amongst medical students from Hong Kong. International Review of Psychiatry, Nov-Dec 2019;31(7-8):626-629
9. Molodynski A, Lewis T, Kadhum M, Farrell SM, Chelieh ML, De Almeida TF, Masri R, Kar A, Volpe U, Moir F, Torales J, Castaldelli-Maia JM, Chau SWH, Wilkes C, Bhugra D (2020).
   Cultural variations in wellbeing, burnout and substance use amongst medical students in twelve countries.
   International Review of Psychiatry, Feb-Mar 2021;33(1-2):37-42
10. Chau SW, Tse CY, So SH, Chan SS
    Attentional Bias Modification Training for Patients with Generalised Anxiety Disorder: a Randomised Controlled Study.
    East Asian Arch Psychiatry, 2019 Mar;29(1):3-9.

• Honorary Associate Consultant, New Territories East Cluster, Hospital Authority
• Vice President, The Chinese Dementia Research Association
• Council member, Hong Kong College of Psychiatrists
• Education Committee member, Hong Kong College of Psychiatrists
• Publications Committee member, Hong Kong College of Psychiatrists
• Editorial Board member, East Asian Archives of Psychiatry (EAAP)

• Best Poster Award, the 15th International Congress of the Asian Society Against Dementia (ASAD), Japan, 2021
• Distinguished Young Fellow, the Hong Kong Academy of Medicine, 2017
• Young Psychiatrists Fellowship Award, the ASEAN Federation of Psychiatry and Mental Health (AFPMH), 2014

• Epidemiology, prevention, early detection, and intervention for neurocognitive disorders
• Determinants of healthy aging
• Associations among physical, mental, and cognitive health

1. Can increasing participation in habitual intellectual activities enhance functional connectivity of default mode network in community-living Chinese adults with subjective cognitive decline? A randomized controlled trial.
   (Funded by Early Career Scheme, RGC 2019/2020. Capacity: PI. Ref. number: 24114519. Funding: $1,190,840. Study duration: 1/1/2020-31/12/2021)
2. Can whole-body vibration treatment optimize cognitive function in older adults who have sarcopenia and are at risk of dementia? A randomized controlled trial
   (Funded by HMRF. Capacity: PI. Reference number: 08190476. Funding: $1,386,977. Study duration: 17/12/2021-16/12/2023)
3. Structured frontal lobe based cognitive stimulation to older adults with subjective cognitive decline and comorbid depressive symptoms
   (Funded by CUHK Direct Grant for Research 2018/2019. Reference number: 2018.076. Capacity: PI. Funding: $149,947. Study duration: 30/6/2019-29/6/2022)
4. Health determinants for late onset dementia and its associated mortality in Hong Kong Chinese older adults.
   (Funded by HMRF Commissioned Study 2018. Ref. number: CFS-CUHK3. Capacity: Co-PI. PI: Linda Lam, Dept of Psychiatry, CUHK. Funding: $7,492,300. Study duration: 1/7/2019-30/6/2022)
5. Small Data Learning for Alzheimer’s Disease: From Digital Biomarker to Early Detection and Intervention
   (Funded by CRF. Capacity: Co-PI. Reference number: C4034-21GF. PI: Professor Guoliang Xing, Department of Information Engineering, CUHK. Funding: $8,230,720. Study duration: 1/1/2022-31/12/2024.)
6. Machine learning technologies for advancing digital biomarkers for Alzheimer’s Disease
   (Funded by the Alzheimer’s Drug Discovery Foundation. Capacity: Co-PI. Reference number: GDADB-201906-2019049. PI: Professor Guoliang Xing, Department of Information Engineering, CUHK. Funding: USD$641,204. Study duration: 1/7/2020-30/6/2023)
7. A 9-year follow-up of the Hong Kong Mental Morbidity Survey (HKMMS) on Chinese adults with depressive and anxiety symptoms.
   (Funded by HMRF Commissioned Study 2018. Ref number: CFS-CUHK4.Capacity: Co-I. PI: Professor Linda Lam, Department of Psychiatry, CUHK. Funding: $7,767,730. Study duration:1/7/2019-31/12/2023)
8. The Hong Kong Mental Morbidity Survey for Older People – MMSOP
   (Funded by HMRF Commissioned Study 2018. Ref. number: MHS-P1(Part 3)-CUHK. Capacity: Co-I. PI: Professor Linda Lam, Department of Psychiatry, CUHK. Funding: $17,289,625. Study duration: 1/1/2019-31/12/2022)
9. Combining mind-body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment: a randomized controlled trial
   (Funded by HMRF 2017. Capacity: Co-I. Reference number: 16170421. PI: Professor Samuel Wong, School of Public Health and Primary Care, CUHK. Funding: $1,499,589. Study duration: 16/9/2019-15/3/2024)
10. Mortality among older persons with schizophrenia in Hong Kong
    (Funded by HMRF. Capacity: Co-I. Reference number: 18192331. PI: Dr. WC Chan, Department of Psychiatry, HKU. Funding: $732,624. Study duration: 3/1/2022-2/1/2024)
11. Circulating cell-free mitochondrial DNA as marker for early detection of cognitive decline in elderly
    (Funded by HMRF. Capacity: Co-I. Reference number: 09200246. PI: Dr. SL Ma, Department of Psychiatry, CUHK. Funding: $1,446,240. Study duration: 15/7/2022-14/7/2025)
12. Novel MRI-based machine learning tool to detect mild cognitive impairment associated with Alzheimer’s disease
    (Funded by HMRF. Capacity: Co-I. Reference number: 08190666. PI: Dr. Ho Ko, CUHK. Funding: $911,140. Study duration: 5/2/2022-4/2/2024)
13. The role of big data in addressing the determinants of non-communicable diseases in the ageing era – collaboration between CUHK and Worldwide Universities Network (WUN) partners
    https://wun.ac.uk/wun/research/view/the-role-of-big-data-in-addressing-the-determinants-of-non-communicable-diseases-in-the-ageing-era

    http://www.oal.cuhk.edu.hk/201909-41-cuhk-wun/

1. Lee ATC, Mok VCT, Lam LCW.
   How do we measure mood and behavioural symptoms across the stages of dementia?
   In Chapter 12 of World Alzheimer Report 2022. Published by Alzheimer’s Disease International in September 2022.
2. Lai VKY, Fung AWT, Lam LCW, Lee ATC.
   Is sleep quality a potential predictor of neurocognitive disorders? A 6-year follow-up study in Chinese older adults.
   International Journal of Geriatric Psychiatry. 2022 Aug;37(8).   
3. Lee ATC, Chiu HFK, Peisah C.
   Clinical considerations when using assessment tools to identify depression in older adults with mild cognitive impairment.
   International Psychogeriatrics. 2022 May;34(5):413-416.
4. Lam LCW, Lee ATC.
   Is cognitive screening useful for long-term prediction of incident dementia?
   The Lancet Healthy Longevity. 2021 July 1;2(7):e387-e388.
5. Lee ATC, Fung AWT, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
   Risk of incident dementia varies with different onset and courses of depression.
   Journal of Affective Disorders. 2021 Mar 1;282:915-920.
6. Lee ATC, Mo FYM, Lam LCW.
   Higher psychogeriatric admissions in COVID-19 than in severe acute respiratory syndrome.
   International Journal of Geriatric Psychiatry. 2020 Dec;35(12):1449-1457.
7. Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
   Higher dementia incidence in older adults with poor visual acuity.
   The Journals of Gerontology: Series A, Biological Sciences and Medical Sciences. 2020 Oct 15;75(11):2162-2168.
8. Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
   Association of daily intellectual activities with lower risk of incident dementia among older Chinese adults.
   JAMA Psychiatry. 2018 Jul 1;75(7):697-703.
9. Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
   Lower risk of incident dementia among Chinese older adults having three servings of vegetables and two servings of fruits a day.
   Age and Ageing. 2017;46(5):773 –779.
10. Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
    Intensity and types of physical exercise in relation to dementia risk reduction in community-living older adults.
    Journal of the American Medical Directors Association. 2015;16(10): 899.e1 –7.

Guest Editor for:

• Age and Ageing
• Alzheimer’s & Dementia
• Alzheimer’s & Dementia: Translational Research & Clinical Interventions
• Behavioral Sleep Medicine
• BJPsych Open
• BMC Geriatrics
• BMJ Open
• Frontiers in Dementia
• Frontiers in Psychiatry
• International Psychogeriatrics
• Stress & Health

Supervised over 10 Master and PhD students at CUHK

Serving as a mentor for GPS Medical Students at CUHK

• Member of Editorial Board, East Asian Archives of Psychiatry (Official Journal of the Hong Kong College of Psychiatrists)
• Member, Special interest group in Clinical Neuroscience, The Hong Kong College of Psychiatrists
• Member, Joint Chinese University of Hong Kong – New Territories East Cluster Clinical Research Ethics Committee
• Member, University Health Service Committee, The Chinese University of Hong Kong

• Autism spectrum disorder
• Child and adolescent mental health
• Microbiota-gut-brain axis
• Neurocognitive function and assessment
• Mobile-phone app base intervention for mental health

1. Hong Kong Child and Adolescent Psychiatric Epidemiologic Survey: Age 6 to 17
   (Funded by HMRF Commissioned Study 2018; Capacity: Co-I; PI: Prof. SF Hung, Department of Psychiatry, CUHK)
2. Gastrointestinal dysbiosis among autism boys without functional gastrointestinal disorder: a metagenomics and case-control study
   (Funded by Funded by CUHK Direct Grant for Research 2020/2021; Capacity: PI)
3. Visualization of clinical psychiatry: development of a series of annotated online teaching videos on mental state examination
   (Funded by Teaching Development and Language Enhancement Grant (TDLEG) for 2019-22; Capacity: Principal Supervisor)
4. Mobile-phone-based Intervention for Caregivers of Adolescents – Empowerment Through Mindfulness-based and Empathy-guided Continuous Learning and Support Programme
   (Funded by Mental Health Initiatives Funding Scheme Phase 1; Capacity: PI)

1. Wong, O. W., Barzilay, R., Lam, A. M., Chan, S., Calkins, M. E., Gur, R. E., & Gur, R. C. (2022).
   Executive function as a generalized determinant of psychopathology and functional outcome in school-aged autism spectrum disorder: a case-control study.
   Psychological Medicine, 1-11.
2. Wong, O. W., Lam, A. M., Or, B. P., Mo, F. Y., Shea, C. K., Lai, K. Y., … & Leung, P. W. (2022)
   Disentangling the relationship of gut microbiota, functional gastrointestinal disorders and autism: a case–control study on prepubertal Chinese boys.
   Scientific reports, 12(1), 1-13.
3. Wong, O. W., Lam, A. M., Lai, K. Y., Ma, S. L., Hung, S. F., Chan, S., Wong, S. Leung, P. W. (2021).
   An elevated anxiety level among prepubertal autistic boys with non‐treatment‐seeking functional gastrointestinal disorders: A case–control study.
   Autism Research,2021 Oct;14(10):2131-2142.
4. Hopman, H. J., Choy, H. Y., Ho, W. S., Lu, H., Wong, W. H. O., Chan, S. M. S. (2021).
   The Effects of Repetitive Transcranial Magnetic Stimulation Antidepressant Response on Cold Cognition: A Single-Arm Prospective Longitudinal Study.
   Neuropsychiatric Disease and Treatment, 2021 May 26;17:1647-1658
5. Chau, S. W., Wong, O. W., Ramakrishnan, R., Chan, S. S., Wong, E. K., Li, P. Y., Raymont, V., Elliot, K., Rathod, S., Delanerolle, G., Phiri, P. (2021).
   History for some or lesson for all? A systematic review and meta-analysis on the immediate and long-term mental health impact of the 2002–2003 Severe Acute Respiratory Syndrome (SARS) outbreak.
   BMC public health, 2021 Apr 7;21(1):670.
6. Wong, O. W., Chan, A., Wong, A., Lau, C. K., Yeung, J. H., Mok, V., Chan, S. (2020).
   Prolonged visual fixation as a surrogate marker of cholinergic deficit in Parkinson’s disease: A 2-year follow-up study. Parkinsonism & Related Disorders, 2020 Dec;81:60-66.
7. Wong, O. W., Fung, G. P., Chan, S. (2019).
   Characterizing the relationship between eye movement parameters and cognitive functions in non-demented Parkinson’s disease patients with eye tracking.
   J Vis Exp. 2019 Sep 26;(151).
8. Wong, O. W., Chan, A. Y., Wong, A., Lau, C. K., Yeung, J. H., Mok, V. C., Lam, L. C., Chan, S. S (2018).
   Eye movement parameters and cognitive functions in Parkinson’s disease patients without dementia.
   Parkinsonism & related disorders, 2018 Jul;52:43-48

• Chemical and molecular biology tools for studying neuropsychiatric diseases
• Molecular and circuitry mechanisms of normal and pathological brain functioning
• Biomarkers for neuropsychiatric diseases
• Neuropsychopharmacology

• 46th International EXhibitions of Inventions Geneva, Switzerland, Gold Medal Award

• Advanced human and animal brain tissue research methods
• Biomarker discovery in psychiatric diseases

1. Thorlabs CMLS-F 4-channel Confocal Microscope
2. MesoSPIM Light Sheet Microscope (https://mesospim.org/setups/#)
3. Neuropixels 1.0 probes
4. Waters ACQUITY Arc Bio High-Performance Liquid Chromatography system

1. Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau JCN, Chan CCY, Chan DCW, Wong TY, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Lam HHN, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H.

Antibody stabilization for thermally accelerated deep immunostaining.

Nature Methods. 2022 Sept 1; 19:1137-1146. Journal IF: 47.990

2. Lai HM, Lu Z, Choi CK, Zhou W, Yau JCN, Tang BZ, Ko H.

Direct room temperature synthesis of α-CsPbI3 perovskite nanocrystals with high photoluminescence quantum yields: implications for lighting and photovoltaic applications.

ACS Applied Nano Materials. 2022 Apr 27;5(9):12366-112373. Journal IF: 6.14

3. Lo HS, Hui K, Lai HM, Khan K, Kaur S, Huang J, Li Z, Chan A, Cheung H, Ng KC, Ho J, Chen YW, Ma B, Cheung P, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok C, Ko H, Aik WS, Chan M, Ng WL.

Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir.

ACS Central Science. 2021 Apr 15;7(5):792-802. Journal IF: 18.728

4. Lee K, Lai HM, Soerensen M, Hui E, Cho W, Ma V, Ho J, Chang RCCC.

Optimized Tissue Clearing Minimizes Distortion and Destruction During Tissue Delipidation.

Neuropathology and Applied Neurobiology. 2020 Dec 2;47(3):441-453. Journal IF: 6.250

5. Lai HM, Liu AKLL, Ng HHM, Goldfinger MH, Chau TW, DeFelice J, Tilley BS, Wong WM, Wu W, Gentleman SM.

Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues.

Nature Communications. 2018 Mar 14;9(1):1066. Journal IF: 17.694

6. Lai HM, Ng WL, Gentleman SM, Wu W.

Chemicals Probes for Visualizing Intact Animal and Human Brain Tissue.

Cell Chemical Biology. 2017 Jun 22;24(6):659-672. Journal IF: 9.039

7. Liu AKLL, Lai HM, Chang RCCC, Gentleman SM.

Free-of-acrylamide SDS-based Tissue Clearing (FASTClear): A novel protocol of tissue clearing for three-dimensional visualisation of human brain tissues.

Neuropathology and Applied Neurobiology. 2017 Jun;43(4):346-351. Journal IF: 6.250

8. Lai HM, Liu AKLL, Ng WL, DeFelice J, Lee WS, Li H, Li W, Ng HHM, Chang RCCC, Lin B, Wu W, Gentleman SM.

Rationalisation and validation of an acrylamide-free procedure in three-dimensional histological imaging.

PLoS One. 2016 Jun 30;11(6):e0158628. Journal IF: 3.752

• Ph.D. in Medical Sciences, Faculty of Medicine, The Chinese University of Hong Kong (2016) 
• Master in Clinical Medicine, Jinan University (2012) 
• Bachelor in Clinical Medicine, Southern Medical University (2009)

• Young Investigator Award. Conference/organization: World Sleep 2017, World Association of Sleep Medicine and World Sleep Federation, Prague, Czech Republic. October 2017.
   
• Best Oral Presentation Award. Conference/organization: CUHK SLEEP 2016, The Chinese University of Hong Kong, Hong Kong. October 2016.

• Determine progression of idiopathic REM sleep behavior disorder towards neurodegenerative diseases and its biomarkers. 
• Examine the potential effective neuroprotective strategies in REM sleep behavior disorder to prevention Parkinson’s disease and dementia.

• 2018-2020 Postdoctoral Visiting Fellow in the Nuffield Department of Clinical Neurosciences, University of Oxford, UK 
• 2016-2018 Postdoctoral Fellow in the Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 
• 2009-2013 Resident in the Department of Psychiatry and Sleep Center, the First Affiliated Hospital, Jinan University, Guangzhou, China 
• 2007-2009 Internship: Internal Medicine, Surgery, Pediatrics and Gynaecology and Obstetrics. The Second Clinical Medical College, Zhujiang Hospital, Southern Medical University, Guangzhou, China

1. PI, Health and Medical Research Fund (08191416). Neural correlates of impulsivity in idiopathic REM sleep behavior disorder and Parkinson’s disease: a functional Magnetic Resonance Imaging case-control study. HK$ 1,122,120. 01/12/2021-30/11/2024. 
2. PI, Knowledge Transfer Project Fund (KPF21GWP26). Risk screening for prodromal Parkinson’s disease in elderly using smartphone. The Chinese University of Hong Kong. HK$ 395,380. 01/04/2021-31/03/2023. 
3. PI, Direct Grant for Research (2020.084). Impact of Long COVID–Neurodegenerative Perspective. CUHK. HK$ 149,000. 30/06/2021-29/06/2022.  
4. Co-PI, Collaborative Research Fund (C4044-21GF). Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alpha-synucleinopathy Neurodegeneration, in a Prospective Family Cohort. HK$ 7,214,620. 01/04/2022-31/03/2025. 
5. Co-PI, Collaborative Research Fund (C4061-21GF). Neuropsychiatric ‘long-COVID’ in adult patients. HK$ 3,251,480. 01/04/2022-31/03/2023. 
6. Co-I, General Research Fund (14108722). Family-based association study in idiopathic rapid eye movement sleep behavior disorder: a two-phase study using whole exome sequencing. HK$ 1,300,000. Start in 2023. 
7. Co-I, Health and Medical Research Fund (18190931). AI-Based Day and Night Digital Phenotyping of Rapid Eye Movement (REM) Sleep Behaviors Disorder (RBD) and its Prediction towards α-Synucleinopathy. HK$ 1,495,330. Start in 2023. 
8. Co-I, Health and Medical Research Fund (09202766). Randomized placebo- and active-controlled trial for assessing the efficacy of bright light therapy for sleep and mood symptoms in patients with Parkinson’s disease.  HK$ 1,413,200. 01/08/2022-31/07/2025. 
9. Co-I, Health and Medical Research Fund (18190221). Gut microbiota in major depressive disorders with and without Rapid Eye Movement Behaviour Disorder: tracing a subtype of depression with underlying neurodegeneration. HK$ 1,104,304. 01/10/2021-31/03/2024. 
10. Co-I, General Research Fund (14116121). Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study. HK$ 1,130,208. 01/01/2022-31/12/2025. 
11. Co-I, Health and Medical Research Fund (06170676). A 7-year prospective study of idiopathic REM sleep behavior disorder cohort in Chinese population: determining the optimal characteristics of prodromal markers to predict neurodegenerative diseases. HK$ 1,250,616. 01/07/2019-30/06/2022. 
12. Co-I, National Natural Science Foundation of China (81471348). Mechanisms of Circadian Rhythms in the Progression of REM sleep behavior disorder towards neurodegeneration. CNY 70,000. 01/01/2015-31/12/2018. 

1. Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK, Liu Y.
   Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder.
   J Sleep Res. 2022:e13791.
2. Liu Y, Zhang J, Chau SW, Man Yu MW, Chan NY, Chan JW, Li SX, Huang B, Wang J, Feng H, Zhou L, Mok V, Wing YK*.
   Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study.
   Neurology. 2022;99(6):e627-e637.
3. Liu Y, Partinen E, Chan NY, Dauvilliers Y, Inoue Y, De Gennaro L, Plazzi G, Bolstad CJ, Nadorff MR, Merikanto I, Bjorvatn B, Han F, Zhang B, Cunha AS, Mota-Rolim S, Léger D, Matsui K, Espie CA, Chung F, Morin CM, Sieminski M, Thomas P, Holzinger B, Partinen M*, Wing YK*.
   Dream-enactment behaviours during the COVID-19 pandemic: an international COVID-19 sleep study.
   J Sleep Res. 2022:10.1111/jsr.13613.
4. Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT*.
   Longitudinal changes in Parkinson’s disease symptoms with and without REM sleep behavior disorder: the Oxford Discovery Cohort study.
   Mov Disord. 2021;36(12):2821-2832.
5. Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MW, Chan NY, Chan JW, Li SX, Huang B, Feng H, Mok VCT, Wing YK*.
   Residual Injurious Symptoms and Its Association with Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-Up Study.
   Mov Disord. 2020;35(11):2077-2085.
6. Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MW, Huang B, Li SX, Chau SWH, Chan JW, Chen J, Mok VCT, Wing YK*, Zhang J*.
   Rest-activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
   Ann Neurol. 2020;88(4):817-829.
7. Liu Y#, Zhang J#, Lam SP, Zhou J, Yu MWM, Li SX, Chan JW, Postuma RB, Mok VCT, Wing YK*.
   A case-control-family study of idiopathic rapid eye movement sleep behavior disorder.
   Ann Neurol. 2019;85(4):582-592.
8. Liu Y, Zhang J*, Lam SP, Yu MW, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan Anne, Mok VCT, Wing YK.
   Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study.
   Sleep Med. 2019;56:128-134.
9. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK*.
   Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.
   Sleep Med. 2018, 24;53:1-8.
10. Liu Y, Zhang J, Lam V, Ho CK, Zhou J, Li SX, Lam SP, Yu MW, Tang X, Wing YK*.
    Altered Sleep Stage Transitions of REM Sleep: A Novel and Stable Biomarker of Narcolepsy.
    J Clin Sleep Med. 2015;11(8):885-94.

• Postdoctoral training at Department of Medicine, Harvard University

• 2005 Sir Edward Youde Memorial Fellowship

• Genetic susceptibility of neurodegenerative disorders, such as mild cognitive impairment and dementia
• Development of genetic markers for early detection of cognitive decline

1. Circulating cell-free mitochondrial DNA as marker for early detection of cognitive decline in elderly.
   (Funded by HMRF 2022; Capacity: PI)
2. Functional study of polymorphisms of inflammasome-related genes in Alzheimer’s disease
   (Funded by CUHK Direct Grant 2022/2023. Capacity: PI)
3. Examining the genetic link of REM sleep behaviour disorder (RBD) and familial aggregation by whole exome sequencing (WES)
   (Funded by CUHK Direct Grant 2021/2022. Capacity: PI)
4. Mapping the Functional Significance of the Human Oxytocin Receptor Gene.
   (Funded by USYD-CUHK Partnership Collaboration Awards. Capacity: PI)
5. Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alpha- synucleinopathy Neurodegeneration, in a Prospective Family Cohort
   (Funded by Collaborative Research Fund 2021/22; Capacity: Co-PI; PI: Prof YK Wing, Department of Psychiatry, CUHK)
6. Hong Kong Child and Adolescent Psychiatric Epidemiologic Survey: Age 6 to 17
   (Funded by HMRF Commissioned Study 2018; Capacity: Co-I; PI: Prof. SF Hung, Department of Psychiatry, CUHK)
7. The Hong Kong Mental Morbidity Survey for Older Persons
   (Funded by HMRF Commissioned Study 2018; Capacity: Co-I. PI: Prof. Linda Lam, Department of Psychiatry, CUHK)
8. Health determinants for late onset dementia and its associated mortality in Hong Kong Chinese older adults.
   (Funded by HMRF Commissioned Study 2018. Capacity: Co-I. PI: Prof. Linda Lam, Dept of Psychiatry, CUHK)

1. Ma SL, Chen LH, Lee CC, Lai KYC, Hung SF, Tang CP, Ho TP, Shea C, Mo F, Mak TSH, Sham PC, Leung PWL.
   Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene.
   Front Neurosci. 2021 Apr 27;15:649588.
2. Ma SL, Wu J, Zhu L, Chan RS, Wang X, Huang D, Tang NL, Woo J.
   Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia.
   Nutrients. 2021 Jul 5;13(7):2313.
3. Ma SL, Tang NLS, Lam LCW.
   Promoter methylation and gene expression of Pin1 is associated to the risk on Alzheimer’s disease in Southern Chinese.
   Curr Alz Res.2020, 17 (13):1232-1237.
4. Lee KY, Leung KS, Ma SL, So HC, Huang D, Tang NLS, Wong MH.
   Genome-wide search for SNP interactions in GWAS data: algorithm, feasibility, replication using schizophrenia datasets.
   Front. Genet. 2020 Aug 28;11:1003.
5. Ma SL, Tang NLS, Wat KHY, Tang JHY, Lau KH, Law CB, Chiu J, Tam CCW, Poon TK, Lin KL, Kng CPL, Kong HL, Chan TY, Chan WC, Lam LCW.
   Effect of CYP2D6 and CYP3A4 genotypes on the efficacy of cholinesterase inhibitors in Southern Chinese patients with Alzheimer’s Disease.
   Am J Alzheimers Dis Other Demen. 2019, 34(5):302-307.
6. Lu H, Ma SL, Wong SW, Tam CW, Cheng ST, Chan SS, Lam LC.
   Aberrant interhemispheric functional connectivity within default mode network and its relationships with neurocognitive features in cognitively normal APOE ε 4 elderly carriers.
   Int Psychogeriatr. 2017;29(5):805-814.
7. Zhou L, Ma SL*, Yeung PKK , Wong YH, Tsim KWK, So KF, Lam LCW and Chung SK,
   Anxiety and depression with neurogenesis defects in Exchange Protein Directly Activated by cAMP (Epac) 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.
   Transl Psychiatry. 2016, 6:e881. *Co-1st author
8. Chen HY, Ma SL*, Huang W, Ji L, Leung VH, Jiang H, Yao X, Tang NL.
   The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model.
   Sci Rep. 2016, 2;6:38225. *Co-1st author

• Visiting Fellow: National Laboratory of Pattern Recognition, Chinese Academy of Sciences
• Honorary Professor: The Affiliated Brain Hospital of Guangzhou Medical University
• Associate Researcher: Shenzhen Research Institute (SZRI) CUHK (By Courtesy)
• Editorial Board Members:
  • BMC Medicine (2021-) (Springer Nature, 5-year IF: 10.249)
  • BMC Psychiatry (2020-) (Springer Nature, 5-year IF: 4.514)
  • General Psychiatry (GPSYCH) (2018-)
• Associate Editor:
  • Journal of Alzheimer’ Disease (2017-) (IOS Press, IF: 3.909)
  • Stroke & Vascular Neurology (2022-) (BMJ Press, IF: 9.211) 

• Individualized non-invasive brain stimulation
• Precise measurement of neurocognitive function
• Mechanisms of cognitive ageing and resilience
• Neuroinformatics approach to brain science in psychiatry

1. Transcranial alternating current stimulation for mild neurocognitive disorders due to Alzheimer’s disease
   Funded by Research Grants Council (RGC)-General Research Fund (GRF). Capacity: PI. Study duration: 01/09/2021-01/09/2023.
2. Developing the geometric model of network-based cortical complexity,
   Funded by National Laboratory of Pattern Recognition, Chinese Academy of Sciences (CAS). Ref. number: 202100034. Capacity: PI. Study duration: 01/2021-12/2022.
3. A novel computational framework for optimizing disease-specific transcranial brain stimulation model (Reference No.: 4054645),
   Funded by CUHK Direct Grant for Research. Capacity: PI. Study duration: 24/06/2021 – 23/06/2022.
4. Decoding the cognitive trajectory of Hong Kong SuperAgers: a six-year follow-up study,
   Funded by CUHK Direct Grant for Research. Ref. number: 4054569. Capacity: PI. Study duration: 25/06/2020-24/06/2021
5. LANDSCAPE 2.0: A Multimodal Neuroimaging Study
   (Funded by CUHK Direct Grant for Research 2018/2019. Ref. number: 4054495. Capacity: PI. Study duration: 24/06/2019-24/06/2020)
6. Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment-refractory depression using neuroimaging biomarkers and machine learning,
   (Funded by Research Grants Council (RGC)-General Research Fund (GRF). Capacity: Co-I. PI: Prof. Sandra Sau Man Chan, CUHK.)
7. Transcranial Direct Current Stimulation in Post-Stroke Fatigue: A Double-blind Randomised Control Trial.
   (Funded by Research Grants Council (RGC)-General Research Fund (GRF). Capacity: Co-I. PI: Prof. Wai Kwong Tang, CUHK.)
8. Can increasing participation in habitual intellectual activities enhance functional connectivity of default mode network in community-living Chinese adults with subjective cognitive decline? A randomized controlled trial.
   (Funded by Early Career Scheme, RGC 2019/2020. Capacity: Co-I. PI: Dr. Allen Lee, CUHK. Ref. number: 24114519. Study duration: 1/1/2020-31/12/2021)

• 2022 Travel Grants, The 63st Annual Meeting of the Japanese Society of Neurology (JSN)
• 2021 Best Paper Awards, China Association of Gerontology and Geriatrics (CAGG)
• 2021 Gold Award on the 19th Asian Oceanian Congress of Neurology (AOCN)
  2021 Fellowship from Japanese Society of Radiology (JSR)
• 2021 Young Education Scholarship (YES) Awards on the 19^th Asian Oceanian Congress of Radiology (AOCR)
• 2020 Travel Grants on the 61st Annual Meeting of the Japanese Society of Neurology (JSN)
• 2019 Best Paper Awards, China Association of Gerontology and Geriatrics (CAGG)
• 2019 Travel Grants on the 60th Annual Meeting of the Japanese Society of Neurology (JSN)
• 2019 Travel Grants on the 3rd International Taiwanese Congress of Neurology (ITCN) & Annual Meeting of Taiwan Neurological Society
• 2019 Training Fellowships from the National Institute for Physiological Sciences (NIPS) (Japan)
• 2018 Champion & Young Investigator Awards on the International Alzheimer’s Disease Conference
• 2018 Young Investigator Awards on The 15th Meeting of the Asian-Pacific Society for Neurochemistry
• 2015 Performance Award on the 22nd International Student Congress of [Bio] Medical Sciences 2015
• 2015 Paper Award on the 15th Congress of Chinese Cerebrovascular Diseases
• 2015 Paper Award on “Putting Aging Research and Clinical Practice in Cultural Context”: US-Hong Kong Conference

1. Lu H*, Li J, Ni X.
   Promoting Resilience in the Age of COVID-19 Pandemic: A New Era of Strategic Foresight.
   Aging and Disease 2021; 12(1): 1-2.
2. Lu H*.
   Caution of variability: Domain-specific cognition measured by Montreal Cognitive Assessment in normal ageing and prodromal dementia.
   International Journal of Geriatric Psychiatry 2020; 35(6), 686-687.
3. Lu H*, Lam LC.
   Associations between intra-individual variability and Montreal Cognitive Assessment (MoCA) in cognitive ageing and prodromal dementia: A domain-specific perspective.
   Parkinsonism & Related Disorders 2018; 48:102-103.
4. Lu H*, Lam LC.
   Impacts of ‘two-level’ variability on the differential power for Montreal Cognitive Assessment (MoCA) in prodromal dementia.
   Journal of Neurology, Neurosurgery and Psychiatry 2017; 88(2): 186-187.
5. Lu H*, Chan SS, Lam LC.
   ‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD).
   Scientific Reports 2017; 7.
6. Lu H*.
   Intra-and inter-individual variability of information processing speed in adults with neurocognitive disorders.
   F1000 Research 2017; 6.
7. Lu H*, Chan SS, Fung AW, Lam LC.
   Utility of Montreal Cognitive Assessment (Hong Kong Version) in the diagnosis of mild neurocognitive disorders (NCD): NCD due to Alzheimer Disease (NCD-AD) and NCD due to Vascular Disease (NCD-Vascular).
   Journal of the American Medical Directors Association 2016; 17(4): 366
8. Lu H, Fung AW, Chan SS, Lam LC.
   Disturbance of attention network functions in Chinese healthy older adults: an intra-individual perspective.
   International Psychogeriatrics 2016; 28(2): 291-301.
9. Lu H*, Chan SS, Fung AW, Lam LC. Efficiency of attentional components in elderly with mild neurocognitive disorders shown by the attention network test.
   Dementia and Geriatric Cognitive Disorders 2016; 41(1-2): 93-98.
10. Lu H*, Law WY, Fung AW, Lam LC.
    Evaluating the Montreal Cognitive Assessment (MoCA) and its subtests for DSM-5 mild neurocognitive disorders (NCD): Does age have an effect on the screening accuracy?
    Journal of Psychosomatic Research 2016; 85: 26-27.
11. Lu H*, Chan SS, Lam LC.
    Associations between intra-Individual variability of reaction time and cognitive function in cognitively normal senior adults: still beyond good or bad?
    Geriatrics 2016; 1(2): 13.
    

1. Li, J.,  Lu, H*.
   MRI‐informed cortical features for brain age prediction in age‐specific adulthoods.
   Human Brain Mapping 2022. (In Press)
2. Lu H*.
   Quantifying Age-Associated Cortical Complexity of Left Dorsolateral Prefrontal Cortex with Multiscale Measurements.
   Journal of Alzheimer’s Disease 2020; 76(2): 505-516.
3. Lu H*, Ma SL, Wong SW, Tam CW, Cheng ST, Chan SS, Lam LC.
   Aberrant interhemispheric functional connectivity within default mode network and its relationships with neurocognitive features in cognitively normal APOE ε 4 elderly carriers.
   International Psychogeriatrics 2017; 29(5): 805-814.
4. Lu H*.
   Mapping the brain: the leading projects of brain science in the era of big data (in Chinese).
   Chinese Journal of Psychiatry 2017; 50(2):157-160.
5. Lu H*, Ma SL, Chan SS, Lam LC.
   The effects of apolipoprotein ε 4 on aging brain in cognitively normal Chinese elderly: a surface-based morphometry study.
   International Psychogeriatrics 2016; 28(9): 1503-1511.
6. Lu H*, Ning YP.
   When neuroscience meets network thinking: new perspective on brain disorders (in Chinese).
   Chinese Journal of Neuromedicine 2014; 13(12): 1292-1296.
7. Lu H*, Ning YP.
   Advances in brain activity mapping (BAM) and brain connectome (in Chinese).
   Chinese Journal of Psychiatry 2014; 47(3): 179-182.
   

1. Lu H, Chan SS, Chan WC, Lin CC, Cheng PW, Lam LC.
   Randomised Controlled Trial of TDCS on Cognition in 201 Seniors with Mild Neurocognitive Disorder.
   Annals of Clinical and Translational Neurology 2019; 6(10): 1938-1948.
2. Lu H*, Lam LC, Ning YP.
   Toward Personalized Brain Stimulation: Advances and Challenges.
   CNS Neuroscience & Therapeutics 2019; 25(11): 1219-1221.
3. Lu H*, Lam LCW.
   Cathodal skin lesions induced by transcranial direct current stimulation (tDCS).
   Neuromodulation: Technology at the Neural Interface 2019; 22(8), 989-991.
4. Lu H*, Chan SS, Lam LC, Cheng CP, Chan WC, He HB, Zhao SH, Ning YP.
   Towards individualized psychiatric practice: the legacy of neurotherapeutics (in Chinese).
   Chinese Science Bulletin 2018; 63: 2592-2598.

1. Lu H*, Xi N, Fung AW, Lam LC.
   Mapping the Proxies of Memory and Learning Function in Senior Adults with High-performing, Normal Aging and Neurocognitive Disorders.
   Journal of Alzheimer’s Disease 2018; 64(3): 815-826.
2. Lu H*, Chan SSM, Fung AWT, Lam LCW.
   Beyond a Differential Diagnosis: Cognitive and Morphometric Decoding of Information Processing Speed in Senior Adults with DSM-5 Mild Neurocognitive Disorders.
   Journal of Alzheimer’s Disease 2017; 58(3):927-937.

1. Lu, H*., Chan, S. S. M., Ma, S., Lin, C., Mok, V. C. T., Shi, L., & Lam, L. C. W.
   Clinical and radiomic features for predicting the treatment response of repetitive transcranial magnetic stimulation in major neurocognitive disorder: Results from a randomized controlled trial.
   Human Brain Mapping 2022. (In Press)
2. Lu, H*.
   Radiomics-informed modeling for transcranial ultrasound stimulation: Age matters.
   Frontiers in Neuroscience 2022, 924.
3. Lu H*.
   MRI-based Geometric Modeling for Personalized Transcranial Magnetic Stimulation in Age-related Neurodegenerative Diseases.
   Frontiers in Neuroscience 2021, 860.
4. Lu H*, Li J, Zhang L, Chan SSM, Lam LCW.
   Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling.
   Journal of NeuroEngineering and Rehabilitation 2021, 18(1): 1-12.
5. Lu H*.
   Developing and aging: A tale of two stages.
   CNS Neuroscience & Therapeutics 2020; 26(2), 281.
6. Lu H*, Chan SS, Lam LC.
   Localized Analysis of Normalized Distance from Scalp to Cortex And Personalized Evaluation (LANDSCAPE): Focusing on Age-and Dementia-specific Changes.
   Journal of Alzheimer’s Disease 2019, 64(7): 1331-1341.
7. Lu H*, Lam LC, Ning YP.
   Scalp to Cortex Distance of Left Primary Motor Cortex and Its Computational Head Model: Implications for Personalized Neuromodulation.
   CNS Neuroscience & Therapeutics 2019; 25(11):1270-1276.

• Committee Member, Brain mapping group, China Image Graphics Society (CSIG), since 11/2021 
• Committee Member, Brain Connects, since 07/2019 
• Member, IEEE Brain, since 05/2020 
• Member, International Neuromodulation Society, since 10/2018 
• Member, International Parkinson and Movement Disorder Society, since 08/2018 
• Member, The Chinese Neuroscience Society, since 09/2017 
• Member, Asian Society Against Dementia, since 09/2016 
• Member, International Psychogeriatric Association, since 09/2015 
• Member, Organization for Human Brain Mapping, since 05/2012 

• Sleep and Psychopathology 
• Psychotherapy for Sleep and Mood Problems 
• Transdiagnostic Approach 
• Digital Mental Health 
• Stepped Care Model 
• Long covid 

• Travel Grant Award for Young Investigators in 2nd Congress of Asian Society of Sleep Medicine, Seoul, Korea, 2018 
• International Pediatric Sleep Association Online Young or New Investigator Poster Award, 2021 
• 3rd Congress of Asian Society of Sleep Medicine Young Investigator Award, 2021

• Motivational Interviewing Network of Trainers

1. Title: Advancing adolescent bedtime by using motivational interviewing and text reminders – A randomized controlled trial. Project period: 1/7/2018 – 30/6/2020
   Funding source: Health and Medical Research Fund
   Position: PI
2. Title: Effects of group-based and digitally delivered cognitive behavioural therapy for insomnia (CBT-I) in youth: a randomised controlled trial.
   Project period: 01/01/2021 – 31/12/2022
   Funding source: GRF
   Position: Co-I
    
3. Title: Randomised controlled study to examine the efficacy of sleep education on extending sleep duration of preschool children. 
   Project period: 01/01/2021 – 31/12/2022
   Funding source: GRF
   Position: Co-I
4. Title: Prevention of insomnia in at-risk youth: A randomized controlled trial comparing cognitive behavioral prevention program for insomnia with active control condition.  
   Study period: 01/01/2022 -31/12-2023
   Funding source: GRF
   Capacity: PI
5. Title: understanding the relationship between stress, resilience and sleep problems in adolescents
   Study period: 30/06/2021 – 29/06/2022
   Funding source: Direct grant
   Capacity: PI
6. Title: Efficacy of group cognitive behavioural therapy for youth anxiety and insomnia: A randomised, assessor blind, parallel-group trial
   Project period: 01/01/2022 – 31/12/2023
   Funding source: GRF
   Position: Co-I
7. Title: Novel strategies to facilitate early detection, prevention and Intervention for long-Term Health problems related to COVID-19 (NovITor-COVID study)
   Project period: 01/04/2021 – 31/03/2026
   Funding source: HMRF Commission research
   Position: Co-I
8. Title: Neuropsychiatric ‘Long COVID’ in adult patients
   Project period: 05/2022 – 05/2023
   Funding source: CRF
   Position: Co-PI  

1. Chen CX, Li TMH, Zhang J, Li SX, Yu MWM, Tsang CC, Chan KCC, Au TC, Li AM, Kong APS, Chan JWY, Wing YK, Chan NY.
   The impact of sleep-corrected social jetlag on mental health, behavioral problems, and daytime sleepiness in adolescents.
   Sleep Medicine, 2022:100, 494-500.
2. Chan NY, Lam SP, Zhang J, Chan JWY, Yu MWM, Suh S, Yang CM, Okajima I, Li AM, Wing YK, Li SX.
   Efficacy of Email-delivered vs. Face-to-face Group Cognitive Behavioral Therapy for Insomnia in Youths: A Randomized Controlled Trial.
   Journal of Adolescent Health, 2022;70: 763-773
3. Chan NY, Li SX, Zhang J, Lam SP, Kwok APL, YU MWM, Chan JWY, Li AM, Morin CM, Wing YK.
   A prevention program for insomnia in at-risk adolescents: a randomized controlled study.
   Pediatrics. 2021;147(3):e2020006833
4. Chan NY, Zhang J, Tsang CC, Li AM, Chan JWY, Wing YK, Li SX.
   The associations of insomnia symptoms and chronotype with daytime sleepiness, mood symptoms and suicide risk in adolescents.
   Sleep Medicine 2020;74:124-31.
5. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK.
   Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.
   Sleep Medicine. 2019; 53: 1-8.
6. Li SX, Chan NY, Man Yu MW, Lam SP, Zhang J, Yan Chan JW, Li AM, Wing YK.
   Eveningness chronotype, insomnia symptoms, and emotional and behavioural problems in adolescents.
   Sleep Medicine. 2018; 47: 93-9
7. Chan NY, Zhang J, Yu MWM, Lam SP, Li SX, Kong APS, Li AM, Wing YK.
   Impact of a modest delay in school start time in Hong Kong school adolescents.
   Sleep Medicine. 2017; 30: 164-70.
8. Zhang J, Chan NY, Lam SP, Li SX, Liu Y, Chan JW, Kong AP, Ma RC, Chan KC, Li AM, Wing YK.
   Emergence of Sex Differences in Insomnia Symptoms in Adolescents: A Large-Scale School-Based Study.
   Sleep. 2015; 39: 1563-70.
9. Chan NY, Lam SP, Zhang J, Yu MWM, Li SX, Li AM, & Wing YK.
   Sleep education in Hong Kong.
   Sleep Biological Rhythm. 2015; 14: 21-5.
10. Wing YK, Chan NY, Yu MWM, Lam SP, Zhang J, Li SX, Kong AP, Li AM.
    A school-based sleep education program for adolescents: a cluster randomized trial.
    Pediatrics. 2015; 13: e635-43.

• Artificial intelligence and digital mental health
• Natural language processing for mental health
• Technology, electronics, and mental health
• Social withdrawal and psychological well-being

• INFORMS ISS Design Science Award 2020

1. An Artificial Intelligence chatbot for sleep education
2. Identifying suicide risk using natural language processing and machine learning of clinical interviews of depression

1. Li, T. M. H., Chan, N. Y., Li, C. T., Chen, J., Chan, J. W., Liu, Y., Li, S. X., Li, A. M., Zhang, J., & Wing, Y. K. (2022).
   The associations of electronic media use with sleep and circadian problems, social, emotional and behavioral difficulties in adolescents.
   Frontiers in Psychiatry, 13, 892583.  
2. Li, T. M. H., & Leung, C. S. Y. (2020)
   Exploring student mental health and intention to use online counselling in Hong Kong during the COVID-19 pandemic. Psychiatry and Clinical Neurosciences, 74(10), 564-565.
3. Chau, M., Li, T. M. H., Wong, P. W. C., Xu, J., Yip, P. S. F., & Chen, H. (2020).
   Finding people with emotional distress in online social media: A design combining machine learning and rule-based classification.
   Management Information Systems Quarterly, 44(2), 933-955.
4. Liu, L. L., Li, T. M. H., Teo, A. R., Kato, T. A., & Wong, P. W. C. (2018).
   Harnessing social media to explore youth social withdrawal in three major cities in China: Cross-sectional web survey.
   JMIR Mental Health, 5(2), e34.
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