School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

Prof CHAN Hsiao Chang

CHAN Hsiao Chang

Emeritus Professor

B.Sc., Ph.D., 

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  1. Ion channels in spermatogenesis, sperm function, ovarian function, embryo development and implantation;
  2. Epithelial transport mechanisms and transmembrane signaling in health and disease;
  3. Epithelial ion channels in cancer development and as prognosis indicators;
  4. Ion channels in stem cells programming and reprogramming
  1. Guo JH, Chen H, Ruan YC, Zhang XL, Zhang XH, Fok KL, Tsang LL, Yu MK, Huang WQ, Sun X, Chung YW, Jiang X, Sohma Y, Chan HC. (2014) Glucose-induced electrical activities and insulin secretion in pancreatic islet b-cells are modulated by CFTR. Nat Commun. 5:4420. doi: 10.1038/ncomms5420.
  2. Diao R, Fok KL, Chen H, Yu MK, Duan Y, Chung CM, Li Z, Wu H, Li Z, Zhang H, Ji Z, Zhen W, Ng CF, Gui Y, Cai Z, Chan HC. (2014) Deficient human b-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection. Sci Transl Med. 6(249):249ra108. doi: 10.1126/scitranslmed.3009071
  3. Ruan YC, Guo JH, Liu X, Zhang R, Tsang LL, Dong JD, Chen H, Yu MK, Jiang X, Zhang XH, Fok KL, Chung YW, Huang H, Zhou WL, Chan HC (2012) Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation. Nature Medicine 18(7):1112-1118
  4. Lu YC, Chen H, Fok KL, Tsang LL, Yu MK, Zhang XH, Chen J, Jiang X, Chung YW, Ma AC, Leung AY, Huang HF, Chan HC (2012) CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development. Cell Research 22(10):1453-1466
  5. Xie C, Jiang X, Zhang JT, Sun TT, Sanders AJ, Diao RY, Wang Y, Tsang LL, Yu MK, Fok KL, Zhang XH, Chung YW, Ye L, Dong JD, Zhao MY, Guo JH, Xiao ZJ, Lan HY, Ng CF, Cai ZM, Jiang WG, Chan HC (2012) CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer. Oncogene 32(18):2282-91, 2291.e1-7
  6. Liu Y, Jiang X, Zhang X, Chen R, Sun T, Fok KL, Dong J, Tsang LL, Yi S, Ruan Y, Guo J, Yu MK, Tian Y, Chung YW, Yang M, Xu W, Chung CM, Li T, Chan HC (2011) Dedifferentiation-reprogrammed mesenchymal stem cells with improved therapeutic potential. Stem Cells 29(12):2077-89
  7. Xu WM, Shi QX, Chen WY, Zhou CX, Ni Y, Rowlands DK, Yi LG, Zhu H, Ma ZG, Wang XF, Chen ZH, Zhou SC, Dong HS, Zhang XH, Chung YW, Yuan YY, Yang WX, Chan HC (2007) Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility. Proc Natl Acad Sci U S A 104:9816-9821
  8. Zhou CX, Zhang YL, Xiao LQ, Zheng M, Leung KM, Chan MY, Lo PS, Wong HY, Ho LS, Chung YW and Chan HC (2004) An epididymis-specific-defensin involved in initiation of sperm maturation. Nature Cell Biology 6:458-464
  9. Wang XF, Zhou CX, Shi QX, Yuan YY, Yu MK, Ho LS, Ajonuma LC, Lo PS, Lam SY, Tsnag LL, Chan LN, Zhao WC, Chung YW, and Chan HC (2003) Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Nature Cell Biology 5:902-906
  10. Li P, Chan HC, He B, So SC, Chung YW, Shang Q, Zhang YD & Zhang YL (2001) An antimicrobiial peptide gene found in male reproductive system of rats. Science 291:1783-1785