School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

Prof JIANG Xiaohua


Jiang XiaohuaAssociate Professor

Telephone:  3943 1229

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Website:  https://jiangcynthia.wixsite.com/website

Address:

 Room 126A, 1/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg., Area 39, CUHK

ORCID: https://orcid.org/0000-0002-7372-4961

 

 

  

Biography

Prof. JIANG Xiaohua (蔣曉華) Prof. JIANG Cynthia Xiaohua (蔣曉華) graduated from Shanghai Second Medical University (currently School of Medicine, Shanghai JiaoTong University), and completed her internship and residency at RuiJin Hospital, Shanghai. She obtained her PhD degree in cell biology at the University of Hong Kong. Prof. JIANG undertook her postdoctoral training at the Department of Medicine, UCLA. Her work focused on the role of protein kinase cascades in cancer development. After that, she joined the University of Southern California and her research focused on understanding the origin and genetics of Ewing sarcoma by using human embryonic stem cells as an innovative model. During her postgraduate study and postdoctoral training, Prof. JIANG received a number of awards including Li Ka Shing Prize, Dr. KP Stephen Chang Gold Medal，California Institute for Regenerative Medicine fellowship, Ruth L. Kirschstein National Research Service award， Edward A Smuckler Memorial Workshop award. In 2013, she established an independent laboratory within School of Biomedical Sciences at CUHK. Her major research interest is in stem cell biology and regenerative medicine, in particular, molecular regulation of stem cells, stem cell microenvironment and stem cell therapy in neurological diseases. Prof. JIANG has published more than 90 peer-reviewed papers, including Nature Medicine, Cell Research, Cell Death and Differentiation, Nature Communication, Theranostics and Stem Cell Reports. 

  1. Molecular regulation of adult stem cells. 
  2. Stem cell therapy in tissue repair and regeneration. 
  3. Crosstalk between stem cells and environment during aging and age-related diseases.
  4. Disease modeling using pluripotent stem cells.
  1. Weng, Z., Lin, J., He, J., Gao, L., Lin, S., Tsang, L. L., Zhang, H., He, X., Wang, G., Yang, X., Zhou, H., Zhao, H., Li, G., Zou, L*., & Jiang, X.* (2022). Human embryonic stem cell-derived neural crest model unveils CD55 as a cancer stem cell regulator for therapeutic targeting in MYCN-amplified neuroblastoma. Neuro Oncol, 24(6),872-885. doi:10.1093/neuonc/noab241.
  2. Bai, S., Lu, X., Pan, Q., Wang, B., Pong, U. K., Yang, Y., Wang, H., Lin, S., Feng, L., Wang, Y., Li, Y., Lin, W., Wang, Y., Zhang, X., Li, Y., Li, L., Yang, Z., Wang, M., Lee, W. Y., Jiang, X., & Li, G*. (2022). Cranial Bone Transport Promotes Angiogenesis, Neurogenesis, and Modulates Meningeal Lymphatic Function in Middle Cerebral Artery Occlusion Rats.Stroke, 53(4), 1373-1385. doi:10.1161/STROKEAHA.121.037912.
  3. Huang J, U KP, Yang F, Ji Z, Lin J, Weng Z, Tsang LL, Merson TD, Ruan YC, Wan C, Li G, & Jiang, X.* (2022). Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal stromal cells after hypoxic-ischaemic brain damage. Theranostics, 12(1), 143-166. doi:10.7150/thno.57234.
  4. Niu, B., Liu, J., Lv, B., Lin, J., Li, X., Wu, C., Jiang, X., Zeng, Z., Zhang, X. K., & Zhou, H. (2021). Interplay between transforming growth factor-beta and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis. Nat Commun, 12(1), 2809, doi:10.1038/s41467-021-23048-5.
  5. Liu, H., Huang, B., Xue, S., U, K.P., Tsang, L.L., Zhang, X., Li, G., & Jiang, X. (2020). Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs. Stem Cell Res Ther, 11(1), 279, doi:10.1186/s13287-020-01798-1.
  6. Huang, B., Wang, B., Lee, Y.W., U, K.P., Leung, K.T., Li, X., Liu, Z., Chen, R., Lin, J.C., Tsang, L.L., Liu, B., Ruan, Y.C., Chan, H.C., Li, G., & Jiang, X. (2019). KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization. iScience, 21, 375-390, doi:10.1016/j.isci.2019.10.041.
  7. Chen, J.J., Xiao, Z.J., Meng, X., Wang, Y., Yu, M.K., Huang, W.Q., Sun, X., Chen, H., Duan, Y.G., Jiang, X., Wong, M.P., Chan, H.C., Zou, F., & Ruan, Y.C. (2019). MRP4 sustains Wnt/beta-catenin signaling for pregnancy, endometriosis and endometrial cancer. Theranostics, 9(17), 5049-5064, doi:10.7150/thno.32097.
  8. Yin, C., Wen, G., Liu, C., Yang, B., Lin, S., Huang, J., Zhao, P., Wong, S.H.D., Zhang, K., Chen, X., Li, G., Jiang, X., Huang, J., Pu, K., Wang, L., & Bian, L. (2018). Organic Semiconducting Polymer Nanoparticles for Photoacoustic Labeling and Tracking of Stem Cells in the Second Near-Infrared Window. ACS Nano, 12(12), 12201-12211, doi:10.1021/acsnano.8b05906.
  9. Liu, S., U, K.P., Zhang, J., Tsang, L.L., Huang, J., Tu, S.P., & Jiang, X. (2018). R-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cells. Cancer Cell International, 18, 156, doi:10.1186/s12935-018-0655-3.
  10. Sun, X., Guo, J.H., Zhang, D., Chen, J.J., Lin, W.Y., Huang, Y., Chen, H., Huang, W.Q., Liu, Y., Tsang, L.L., Yu, M.K., Chung, Y.W., Jiang, X., Huang, H., Chan, H.C., & Ruan, Y.C. (2018). Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor. EMBO Molecular Medicine, 10(10 doi:10.15252/emmm.201808868.
  11. Yang, F.Y., Chen, R., Zhang, X., Huang, B., Tsang, L.L., Li, X., & Jiang, X. (2018). Preconditioning Enhances the Therapeutic Effects of Mesenchymal Stem Cells on Colitis Through PGE2-Mediated T-Cell Modulation. Cell Transplantation, 27(9), 1352-1367, doi:10.1177/0963689718780304.
  12. Li, X., Fok, K.L., Guo, J., Wang, Y., Liu, Z., Chen, Z., Wang, C., Ruan, Y.C., Yu, S.S., Zhao, H., Wu, J., Jiang, X.*, & Chan, H.C.* (2018). Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR. Biochim Biophys Acta Mol Cell Res, 1865(4), 605-615, doi:10.1016/j.bbamcr.2018.01.005.
  13. Chen, K., Liu, Q., Tsang, L.L., Ye, Q., Chan, H.C., Sun, Y., & Jiang, X. (2017). Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/β-catenin/Slug pathway. Cell Death Dis, 8(5), e2819, doi:10.1038/cddis.2017.138.
  14. Chen, R., Lee, W.Y.W., Zhang, X.H., Zhang, J.T., Lin, S., Xu, L.L., Huang, B., Yang, F.Y., Liu, H.L., Wang, B., Tsang, L.L., Willaime-Morawek, S., Li, G., Chan, H.C., & Jiang X. (2017). Epigenetic Modification of the CCL5/CCR1/ERK Axis Enhances Glioma Targeting in Dedifferentiation-Reprogrammed BMSCs. Stem Cell Reports, 8(3), 743-757, doi:10.1016/j.stemcr.2017.01.016.
  15. Liu, Z., Guo, J., Wang, Y., Weng, Z., Huang, B., Yu M.K., Zhang, X., Yuan, P., Zhao, H., Chan, W.Y., Jiang, X.*, & Chan, H.C.* (2017). CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development. Cell Death Diff, 24(1), 98-110, doi:10.1038/cdd.2016.118.
  16. Meng, F., Xu, L., Huang, S., Liu ,Y., Hou, Y., Wang, K., Jiang, X.*, & Li, G.* (2016). Small nuclear ribonucleoprotein polypeptide N (Sm51) promotes osteogenic differentiation of bone marrow mesenchymal stem cells by regulating Runx2. Cell and Tissue Research, 366(1), 155-162, doi:10.1007/s00441-016-2411-0.
  17. Zhang, J.T., Weng, Z.H., Tsang, K.S., Tsang, L.L., Chan, H.C., & Jiang, X. (2016). MycN is critical for the maintenance of human embryonic stem cell-derived neural crest stem cells. PLoS One, 11(1), e0148062, doi:10.1371/journal.pone.0148062.
  18. Rui, Y., Xu, L., Chen, R., Zhang, T., Lin, S., Hou, Y., Liu, Y., Meng, F., Liu, Z., Ni, M., Tsang, K.S., Yang, F., Wang, C., Chan, H.C., Jiang, X.*, & Li G.* (2015). Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells. Scientific Reports, 5, 11056, doi:10.1038/srep11056.
  19. Huang, B., Li, G., & Jiang X. (2015). Fate determination in mesenchymal stem cells: a perspective from histone-modifying enzymes. Stem Cell Research & Therapy , 6(1), 35, doi:10.1186/s13287-015-0018-0.
  20. Ruan, Y.C., Guo, J.H., Liu, X., Zhang, R., Tsang, L.L., Dong, J.D., Chen, H., Yu, M.K., Jiang, X., Zhang, X.H., Fok, K.L., Chung, Y.W., Huang, H., Zhou, W.L., & Chan, H.C. (2012). Activation of the epithelial Na+ channel triggers prostaglandin E(2) release and production required for embryo implantation. Nature Medicine, 18(7), 1112-1117, doi:10.1038/nm.2771.

    * Co-corresponding author 
    # Co-first author
  1. RGC - General Research Fund [PI; 01-Jan-23 to 31-Dec-25]: "Functional and mechanistic characterisation of the role of R-spondin3/LGR5 axis in oligodendrocyte development and white matter repair" (HK$1,378,723).
  2. ITSP Tier 3 [PI; 01-Jan-20 to 30-Oct-21]: "Development of nanoparticles encapsulating stem cell secretion for nose-to-brain delivery to promote brain injury repair" (HK$1,396,971).
  3. RGC - General Research Fund [PI; 01-Jan-20 to 31-Dec-22]: "Jmjd1a regulates mitochondrial function of adult neural stem cells and brain aging via PI3K/AKT/mTOR pathway" (HK$1,114,025).
  4. RGC - General Research Fund [PI; 01-Sep-17 to 31-Aug-20]: "Epigenetic and functional characterization of histone demethylases Jmjd1a and Jmjd2c in MSC senescence" (HK$961,571).
  5. RGC - General Research Fund [PI; 01-Jan-17 to 31-Dec-19]: "Role of CFTR in embryonic stem cells and early embryo development: possible regulation of the Wnt/β-catenin signaling" (HK$1,056,150).
  6. Health and Medical Research Fund [PI; 01-Sep-16 to 31-Aug-18]: "Neural Crest Stem Cells: a Novel Source of Cell Therapy for Neontal Hypoxic-ischemic Brain Damage" (HK$1,195,440).
  7. RGC - General Research Fund [PI; 01-Jan-14 to 31-Dec-16]: "CFTR promotes glioma progression via suppression of p53/miR-34a pathway" (HK$840,051).
  8. Health and Medical Research Fund [PI; 01-Jan-14 to 30-Jun-16]: "Rescuing Neonates from Hypoxic-ischemic Brain Injury with Dedifferentiation-resprogrammed Mesenchymal Stem Cells" (HK$1,000,000).
  9. RGC - General Research Fund [PI; 01-Jan-12 to 31-Dec-13]: " CFTR as a tumor suppressor in breast cancer progression/metastasis" (HK$747,500).
  10. RGC - General Research Fund [PI; 01-Jan-11 to 31-Dec-13]: " Human embryonic stem cells as tools to investigate the oncogenic basis of MYCN in neuroblastoma " (HK$1,390,000).