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香港中文大學（中大）工商管理學院、工程學院、醫學院生物醫學學院及理學院生命科學學院十二位本科生組成的基因工程隊伍，憑著設計快速辨別流感病毒的方法，在美國波士頓舉行的國際遺傳工程機器設計（International Genetically Engineered Machine，簡稱iGEM）世界賽中榮獲金獎。這是中大第七度在該比賽中奪金，成績驕人。

中大隊伍今年的參賽項目為「快速：核酸適配流感探針檢查器」（RAPID: RNA Aptamer Probe Influenza Detector）。流感等傳染病一直威脅著香港以至全球人類健康，但由於初期症狀如咳嗽、發熱等與傷風相似，很多人將兩者混為一談，未能及時對症下藥。即使醫生診斷為流感，亦須在實驗室測試病毒樣本，才可確定病毒類型（即甲、乙或丙型）及其亞種（如H1N1、H5N1及H7N9等）。大部分病毒樣本測試需時一天或更久，可能錯失控制疫情的黃金時間。中大基因工程隊於是研發一套流感病毒快速測試系統，能夠利用病毒的核糖核酸（Ribonucleic acid，簡稱RNA）分辨其種類，約半小時內便有結果。患者僅需要一部智能手機、一個小巧的探測儀和配件，便可安坐家中自行檢測是否染上流感，及時求醫，減少流感的傳播。

這個測試利用了一款螢光核酸適體（Light-up RNA Aptamer）的設計。當改造過的螢光核酸適體與另一核酸分子相配結合時，它的結構會轉變而導致發出可見的螢光，顯示屬於某種病毒的序列是否存在。這款適體的設計理論上能檢測任何一種核酸分子，包括流感及其他病毒的基因序列。中大基因工程隊設計了一個便攜式螢光探測儀用以檢測適體發出的螢光。隊伍亦基於機器學習的方法設計了一個手機應用程式對檢測結果進行分析。這個設計有望幫助普通市民更加方便快捷的檢測流感病毒。

中大基因工程隊在計劃的初期收集了本地及鄰近國家市民的意見，發現大部分受訪者表示不能分辨流感和感冒的症狀，他們對能自行檢測是否患上流感的裝置感興趣，並樂意付款購買。隊伍又諮詢傳染病專家，專家認同該產品有潛質可幫助市民在家中進行自我測試，而隊伍也根據專家的建議改善產品設計，讓產品更貼近使用者的需要。隊伍亦有訪問家庭醫生，了解現有的快速流感測試，以求令隊伍的產品更有競爭力。

基因工程隊的指導教授之一、中大生命科學學院副教授陳竟明教授表示：「這次比賽，主修不同科目的同學都能夠各自發揮所長，由研究如何開發產品設計，到設計生物零件，均操作實騐，各司其職，亦合作無間。同學們參加這次比賽，亦學會了做報告和演說技巧，與其他來自頂尖大學的學生切磋交流，獲益良多。」

iGEM比賽簡介

今年共有365隊來自世界各地的隊伍參賽，只有114隊奪得金獎。iGEM比賽為國際合成生物學界每年一度的盛事。iGEM由麻省理工學院於2004年創立，旨在促進學生在合成生物學的學習、交流與合作，以培養合成生物學人才。比賽隊伍須利用基本且可交替的生物部件，設計及建立有效的生物系統。參賽作品水平超卓，有效推動解決醫學、食品營養、能源及環境等方面難題的硏究。

2018年12月13日

 

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>>Press Release

>>Team Members

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Mission

In the 20th century, chemical synthesis was the major driving force for generating new compounds and materials. These chemical compounds could be used for multiple applications including dyes, antibiotics, and catalysts. In the 21st century, advances in cloning and bioengineering technologies have made the production and study of biomaterials, a new frontier for the generation of substances with novel properties. We propose to create a Center of Novel Biomaterials at CUHK to provide a platform to bring scientists with expertise in creating new biomaterials with biologists with the expertise to apply these biomaterials to important problems.


Goals

  • To bring scientists from different departments to establish an interdisciplinary team at CUHK in the area of novel biomaterials
  • To develop new technologies to produce novel biomaterials
  • To explore the use of novel biomaterials in specific applications

Core Members

 MC


Prof. Michael K. CHAN

Professor & Center Director

 Office: Room 603B Mong Man Wai Bldg.

 Tel: (852) 3943 1487

 Fax: (852) 2603 5646

 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
 SA


Prof. Shannon AU

Associate Professor

 Office: Room 178 Science Center

 Tel: (852) 3943 4170

 Fax: (852) 2603 7246

 Email:  This email address is being protected from spambots. You need JavaScript enabled to view it.
 LB


Prof. Liming BIAN

Associate Professor

 Office: Room 207 William M W Mong Eng. Bldg.

 Tel: (852) 3943 8342

 Fax: (852) 3942 1024

 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
 JC


Prof. Jonathan CHOI

Assistant Professor

 Office: Room 411 Ho Sin Hang Eng. Bldg.

 Tel: (852) 3943 8469

 Fax: (852) 3942 1024

 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
 MH


Prof. Megan HO

Associate Professor

 Office: Room 208 Ho Sin Hang Eng. Bldg.

 Tel: (852) 3943 4340

 Fax: (852) 3942 1024

 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
 BHK


Prof. Byung Ho KANG

Associate Professor

 Office: Room E109 Science Center East Block

 Tel: (852) 3943 6101

 Fax: (852) 2603 7246

 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
 JNgo


Prof. Jacky Chi Ki NGO

Assistant Professor

 Office: Room E403 Science Center East Block

 Tel: (852) 3943 6348

 Fax: (852) 2603 7246

 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
 FT


Prof. Faye TSANG

Professor

 Office: Room 607 Mong Man Wai Bldg.

 Tel: (852) 3943 1020

 Fax: (852) 2603 7732

 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
 JX


Prof. Jiang XIA

Associate Professor

 Office: Room 360 Science Centre

 Tel: (852) 3943 6165

 Fax: (852) 2603 5057

 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
 

Dr. Marianne Lee

Research Fellow

 Office: Room 611 Mong Man Wai Bldg.

 Tel: (852) 3943 6363

 Fax: (852) 2603 5646

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Since 2010, our six undergraduate programmes are offered as part of the SCIENCE Broad-based Admission Scheme under the Faulty of Science.


JUPAS Applicants

Local applicants with Hong Kong Diploma of Secondary Education (HKDSE) qualifications must first admit to the Science Broad-based Admission Scheme (JS4601 SCIENCE) before joining one of the six programmes offered by the School of Life Sciences.

Entry requirements for JS4601 SCIENCE can be found on the Faculty of Science website.


Non-JUPAS Applicants

Students who are applying on the strength of qualifications other than the HKDSE are considered as non-JUPAS applicants. These include local students who do not join JUPAS, local students who are sub-degree holders, Mainland applicants (Gao Kao candidates) and international applicants.

More information on non-JUPAS admissions through the Science Broad-based Admission Scheme can be found on the Faculty of Science website.

For detailed information about entrance requirements (including language requirements) for non-JUPAS applicants, please refer to the Office of Admissions and Financial Aid (OAFA) website.

Highlights of our programmes can be found in our Admission Handbook. For further inquiry, please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it..

 Bgimage06    

Present Position:         Professor, Earth System Science Programme
Professor, School of Life Sciences and Director,
         Simon S F Li Marine Science Laboratory
Co-director, Institute of Environment, Energy and Sustainability
The Chinese University of Hong Kong
102A, Simon S F Li Marine Science Laboratory,
Shatin, N.T., Hong Kong
[T: (852) 3943 3268; F: (852) 26035391; E: This email address is being protected from spambots. You need JavaScript enabled to view it.] 
     
 Education: 1985-88 PhD (Wetland Ecology) The University of Hong Kong
1982-85 MPhil (Zoology) The University of Hong Kong
1979-82 BSc (Hons) The University of Hong Kong
     
 Employment: Griffith University, Australia
2017 – Adjunct Professor
2006 – 2017 Professor
2006 – 2014 Deputy Director, Australian Rivers Institute
2002 – 2006 Associate Professor
2003 – 2006 Director, Centre for Aquatic Processes and Pollution
1998 – 2002 Senior Lecturer
1997 – 1998 Lecturer

The University of Hong Kong
1994 – 1997 Associate Professor, Department of Ecology and Biodiversity
1989 – 1994 Lecturer, Department of Zoology

School of Ocean Sciences, University of Wales, Bangor, UK
1989 Croucher Foundation Postdoctoral Fellow
         
Professional: Inaugural John Swire Scholarship in Wetland Ecology (WWFHK-HKU) 1985-88
Croucher Foundation Postdoctoral Fellowship 1989-90
USA International Visitorship 1991
Visiting Scientist, University of Georgia Marine Institute, Sapelo Island 1992-2003
Chartered Fellow, Royal Society of Biology
Chartered Environmentalist, Society of Environment
Panel of Reviewers/reviewer, BBSRC and NERC (UK); RGC and ECF (HK); ARC (Australia);
   Qatar National Research Fund; WOTRO, Netherlands Organisation for Scientific 
   Research, KNAW (The Netherlands); Flanders (Belgium); IFS (Sweden); French
   National Research Agency; NSFC; NOAA; NRF (S Africa)
Editorial Board, Ocean Science Journal, Springer 2016 –
Academic Editor, PLoS One, 2015 –
Review Editor, Frontiers in Forest and Global Change, 2018 –
Co-Chair, Mangrove Specialist Group, IUCN 2013-6; Chair, 2017 –
     

Publications (2011 - )
(Google Scholar: Total # of citations > 8,000; h-index = 47; i10-index = 111;
https://scholar.google.com/citations?user=iHFd3V0AAAAJ&hl=en)
          

Books

Rivera-Monroy, V., Lee S.Y., Kristensen, E., Twilley, R. (eds) 2107. Mangrove Ecosystems: A Global Biogeographic Perspective - Structure, Function and Services. ISBN 9783319622040

(Springer USA. Eleven chapters, 449 pages)

Lee S.Y.  2012. (member of editorial board) The Living Species in China’s Seas. Volumes 1 & 2. China Ocean Press. ISBN 9787502782320

Lee S.Y.  2012. (member of editorial board) An Illustrated Guide to Species in China’s Seas, Volumes 1 - 8.Ocean Press, China.
 

Special issue of international journal

Friess, D., Lee, S.Y., Primavera, J.H., (ed.) 2016. Turning the Tide on Mangrove Loss. Marine Pollution Bulletin. Volume 109, issue 2, pp.673-782. Elsevier.
 

Book chapters

Primavera J.H., Friess, D.A., Van Lavieren, H., Lee S.Y. 2018. Chapter 1. The mangrove Ecosystem. Pp.1- 34 In Sheppard C. (ed) World Seas: an Environmental Evaluation. Second edition. Volume 3: Ecological Issues and Environmental Impacts. Academic Press. ISBN 9780128050521

Rivera-Monroy, V., Lee S.Y., Kristensen, E., Twilley, R.R. 2017. Chapter 1 Introduction. Pp. 1-16. In Rivera-Monroy, V., Lee S.Y., Kristensen, E., Twilley, R.R. (eds) Mangrove Ecosystem Structure and Function: a biogeographic perspective. Springer, New York. ISBN 9783319622040

Lee S.Y., Rivera-Monroy, V., Kristensen, E., Twilley, R.R. 2017. Epilogue. Pp. 383-386. In Rivera-Monroy, V., Lee S.Y., Kristensen, E., Twilley, R.R. (eds) Mangrove Ecosystem Structure and Function: a biogeographic perspective. Springer, New York. ISBN 9783319622040

Lee S.Y., Jones, G., Diele, K., Nordhaus, I., 2017. Biodiversity. Pp. 55-86. In Rivera-Monroy, V., Lee S.Y., Kristensen, E., Twilley, R.R. (eds) Mangrove Ecosystem Structure and Function: a biogeographic perspective. Springer, New York. ISBN 9783319622040

Primavera, J.H., Lee S.Y. 2015. The Magical Mangroves of KII. Pp.322-330 In: Hegan, A. (Ed.). (2015). No More Endings: Saving Species One Story at a Time. Melbourne, Florida: Motivational Press.

Lee S.Y. 2015. Chapter 9, Ecology of Brachyura. Pp.469-543. In Castro, P., Davie, P., Guinot, D., Schram, F., J.C. von Vaupel Klein (Eds) Treatise in Zoology. The Crustacea. Brill, Leiden, the Netherlands. ISBN 9789004188730

Hutchison, J., Philipp, D.P., Claussen, J.E., Aburto-Oropeza, O., Carrasquilla-Henao, M., Castellanos- Galindo, G.A., Costa, M.T., Daneshgar, P.D., Hartmann, H.J., Juanes, F., Khan, M.E., Knowles, L., Knudsen, E., Lee S.Y., Murchie, K.J., Tiedemann, J.,     zu Ermgassen, P., Spalding, M. 2015. Building an expert judgment-based model of mangrove fisheries. Pp. 17-42 In: Mangrove as Fish Habitat. (eds) Murchie, K.J., Daneshgar, P.P. American Fisheries Society. ISBN-13: 9781934874424
 

Refereed journal papers

Pitt K.A., Lee S.Y., Connolly R.M., Bui, THH, Doriean N. 2018. Sources and fates of organic matter in constructed versus natural coastal waterways. Marine Pollution Bulletin 135:505-513

Adame, M.F., Rozainah M.Z., Fry B., Chong V.C., Then Y.H.A., Brown C.J., Lee S.Y. 2018. Loss and recovery of carbon and nitrogen after mangrove clearing. Ocean and Coastal Management 161:117- 126

Natin P., Lee S.Y. 2018. Estuarine caridean shrimp (Palaemon debilis Dana, 1852) (Decapoda: Caridea) can differentiate olfactory cues from different mangrove species for microhabitat selection. Journal of Experimental Marine Biology and Ecology 501:99-108

Henderson C.J., Stevens T.F., Gilby B., Lee S.Y. 2018. Spatial conservation of large mobile elasmobranchs requires an understanding of spatio-temporal seascape utilisation. ICES Journal of Marine Science 75: 553-561.

Ouyang, X., Lee S.Y., Connolly, R.M. 2018. Partitioning of sources of CO2 efflux in establishing mangrove ecosystems using experimental isotope labelling of seedlings. Limnology and Oceanography 63: 731- 340. DOI: 10.1002/lno.10663

Ouyang, X., Lee S.Y., Connolly, R.M., Kainz, M. 2018. Spatially explicit valuation of wetlands for cyclone mitigation in Australia and China. Scientific Reports 8:3035. DOI:10.1038/s41598-018-21217-z, 9pp.

Peng, Y.S., Zhang, M., Lee S.Y. 2017. Food availability and reduced predation risk drive the distributional patterns of two pulmonate gastropods in a mangrove-saltmarsh transitional habitat. Marine Environmental Research 130:21-29

Henderson, C.J., Gilby, B., Lee S.Y., Stevens, T.F. 2017. Contrasting effects of habitat complexity and connectivity on biodiversity in seagrass meadows. Marine Biology 164:117 DOI 10.1007/s00227-017-3149-2

Kamal, S., Warnken, J., Bakhtiyari, M., Lee S.Y.* 2017. Sediment distribution in shallow estuaries at fine scale: in situ evidence of 3D structural complexity effects by mangrove pneumatophores. Hydrobiologia 803:121-132. DOI: 10.1007/s10750-017-3178-3

Kristensen, E., Lee S.Y., Mangion, P., Quintana, C.O., Valdemarsen, T. 2017. Trophic fractionation of stable isotopes and food source partitioning by leaf-eating crabs in mangrove environments. Limnology and Oceanography 62:2097-2112. DOI: 10.1002/lno.10553

Henderson, C.J., Olds, A., Lee S.Y., Gilby, B.L., Maxwell, P.S., Connolly, R.M. and Stevens, T.F. 2017. Marine reserves and seascape context shape fish assemblages in seagrass. Marine Ecology Progress Series 566:135-144.

Ouyang, X., Lee S.Y., Connolly, R.M. 2017. Global patterns of root decomposition rates and the fate of root carbon production in mangroves and saltmarsh. Earth Sciences Reviews 166:53-63.

Lee S.Y.*, Khim, J.-S. 2017. Hard science is essential to restoring soft-sediment intertidal habitats in East Asia. Chemosphere 168:765-776

Abudullah, M.M., Lee S.Y. 2017. Structure of mangrove meiofaunal assemblages driven by local sediment conditions in subtropical southeast Australia. Estuarine Coastal and Shelf Science http://dx.doi.org/10.1016/j.ecss.2016.10.039

Spencer D.M., Brown I.W., Lee S.Y., Lemckert C.J. 2017. Physical oceanographic processes affecting spanner crab (Ranina ranina) catchability – a review. Fisheries Research 186:248-257.

Ouyang, X., Lee S.Y., Connolly, R.M. 2017. Structural equation modelling unravels factors regulating sediment carbon stock and CO2 flux in a subtropical mangrove. Science of the Total Environment 578:513-522

Kwon, B.-O., Lee Y., Park, J., Ryu, J., Hong, J., Son, H., Lee S.Y., Nam, J., Koh, C-H., Khim, J.S. 2016. Temporal dynamics and spatial heterogeneity of microalgal biomass in the intertidal flats of the Saemangeum area, Korea. J Sea Research 116:1-11.

Werry, J.M., Sumpton, W., Otway, N., Lee S.Y.*, Mayer, D. 2016. Rainfall: a key driver for movement of bull shark, Carcharhinus leucas, into beach areas. Global Ecology and Conservation. (In revision)

Friess, D., Lee S.Y., Primavera, J.H. 2016. Turning the tide on mangrove loss. Marine Pollution Bulletin 109:673-675.

Henderson, C.J., Stevens, T., Lee S.Y. 2016. Assessing the suitability of a non-lethal biopsy punch for sampling fish muscle tissue.     Fish Physiology and Biochemistry 42:1521-1526

Peng, Y., Zheng, M., Zheng Z., Wu, G., Chen, Y., Xu, H., Tian, G., Peng, S., Chen, G., Lee S.Y. 2016. Virtual increase or latent loss? A reassessment of mangrove populations and their conservation in Guangdong, southern China. Marine Pollution Bulletin 109:691-699.

Harada, Y., Lee S.Y.* 2016. Opportunistic leaf foraging behavior in the mangrove sesarmid crab (Neosarmatium trispinosum) maximizes nutrient intake in a low-quality food environment. Estuarine, Coastal and Shelf Science 174:41-48.

Peng Y., Diao J., Zheng M., Guan D., Zhang R., Chen G., Lee S.Y. 2016. Early growth adaptability of four mangrove species under the canopy of an introduced mangrove plantation: implications for restoration. Forest Ecology and Management 373:179-188

Van de Merwe, J.P., Lee S.Y., Connolly, R.M., Pitt, K., Steven, A. 2016. Assessing temporal and spatial trends in estuarine nutrient dynamics using a multi-species stable isotope approach. Ecological Indicators 67:338-345

M.M. Abdullah, Lee S.Y. 2016 Meiofauna and depositing crabs: is the interaction physical or trophic? Journal of Experimental Marine Biology and Ecology 479:69-75.

Lee S.Y.* 2016. From blue to black: anthropogenic forcing of carbon and nitrogen influx in mangrove-lined estuaries in the South China Sea. Marine Pollution Bulletin 109:682-690.

Alberts-Hubatsch, Lee S.Y., H., Nordhaus, I., Diele, K., Meynecke, J.-O., Wolff, M. 2016. Life-history, movement and habitat use of Scylla serrata – current knowledge and future challenges. Hydrobiologia 763:5-21. DOI 10.1007/s10750-015-2393-z.

Bui, H.T.H., Lee S.Y.* 2015. Potential contributions of gut microbiota to the nutrition of the detritivorous sesarmid crab Parasesarma erythodactyla. Marine Biology 162: 1969-1981 (DOI: 10.1007/s00227- 015-2723-8)

Morris, C., Lee S.Y.*, van de Merwe, J. 2015. δ15N of estuarine fishes as a quantitative indicator of urbanization. Ecological Indicators 56:41-49

Bui, H., Lee S.Y. 2015. Endogenous cellulase production in the leaf litter foraging mangrove crab, Parasesarma erythodactyla. Comparative Biochemistry and Physiology B. 179:27-36

Ouyang, X., Lee S.Y. 2014. Updated estimates of carbon accumulation rates in coastal marsh sediments. Biogeosciences 11: 5057-5071. Doi:10.5194/bg-11-5057-2014.

Alberts-Hubatsch, Lee S.Y., H., Diele, K., Mattias, W., Nordhaus, I. 2014. Microhabitat use of early benthic stage mud crabs (Scylla serrata Forskål, 1775) in eastern Australia. Journal of Crustacean Biology 34:604-610.

Spencer, D., Lemckert, C., Yu, Y., Gustafson, J., Lee S.Y., Zhang, H. 2014. Quantifying dispersion in an estuary: A Lagrangian drifter approach. Journal of Coastal Research SI70:29-34

Kamal, S., Lee S.Y.*, Warnken, J. 2014. Investigating three-dimensional meso-scale habitat complexity and its ecological implications using low-cost RGB-D sensor technology. Methods in Ecology and Evolution 5:845-853.– featured on journal web page and blog+video; ‘Editor’s pick’, short-listed for the Robert May prize in Ecology).

Lee S.Y.*, Primavera J.H., Dahdouh-Geubas F., McKee, K., Bosire J.O., Cannicci, S., Diele, K., Koedam, N., Marchand C., Mendelssohn, I., Mukherjee, N., Record, S. 2014. Ecological role and services of tropical mangrove ecosystems: a reassessment. Global Ecology and Biogeography 23:726-743.

Bui, T.H.H. and Lee S.Y.* 2014. Does ‘you are what you eat’ apply to mangrove grapsid crabs? PLoS One 9(2) : M. Doi :10.1371/journal.pone.0089074 (IF 4.489) 12pp.

Clua, E., Chauvet, C., Read, T., Werry, J., Lee S.Y. 2013. Behavioural patterns of a Tiger Shark (Galeocerdo cuvier) feeding aggregation on a whale carcass in Prony bay, New Caledonia. Marine & Freshwater Behaviour and Physiology 46:1-20.

Werry, J.M., Lee S.Y., Lemckert, C.J., Otway, N. 2012. Natural or artificial? Habitat use by the bull shark Carcharhinus leucas. PLoS One. 7(11):e49796 doi:10.1371/journal.pone.0049796. 17pp.

Lee, K.M., Lee S.Y., Connolly, R.M. 2012. Combining process indices from network analysis with structural population measures to indicate response of estuarine trophodynamics to pulse organic enrichment. Ecological Indicators 18: 652-658.

Meynecke, J.O., Grubert, M., Arthur, J.M., Boston, R. Lee S.Y. 2012. The influence of the La Niña-El Niño cycle on giant mud crab (Scylla serrata) catches in northern Australia. Estuarine, Coastal and Shelf Science 100:93-101

Werry, J.M., Lee S.Y., Otway, N., Hu, Y., Sumpton, W. 2011. A multi-faceted approach for quantifying the estuarine-nearshore transition in the life cycle of the bull shark, Carcharhinus leucas. Marine and Freshwater Research 62: 1421-1431.

Noriega, R., Werry, J.M., Sumpton, W., Mayer, D., Lee S.Y. 2011. Trends in annual CPUE and evidence of sex and size segregation of Sphyrna lewini: management implications in coastal waters of northeastern Australia. Fisheries Research 110: 472-477.

Meynecke, J.-O., Lee S.Y.    2011. Climate-coastal fisheries relationships and their spatial variation in Queensland, Australia. Fisheries Research 110: 365-376.

Lee, K.M., Lee S.Y., Connolly, R.M. 2011. Short-term response of estuarine sandflat trophodynamics to pulse anthropogenic physical disturbance – support for the Intermediate Disturbance Hypothesis. Estuarine, Coastal and Shelf Science 92:639-648.

Lee, K.M., Lee S.Y., Connolly, R.M. 2011. Combining stable isotope enrichment, compartmental modelling and ecological network analysis for quantitative measurement of food web dynamics. Methods in Ecology and Evolution 2: 56-65.

* corresponding author; underlined names are research students with me as principal supervisor

July 2018