Professor David K. BANFIELD

	Address	(Office):
		(Lab):
	Phone	(Office):	(852)
		(Lab):	(852)
	Fax		(852)
	Email		bodkb@ust.hk
	Web		-

 

 

 

 

 

 

 

Education

	1991	Ph.D.	University of British Columbia, Canada
	1985	B.Sc.	Simon Fraser University, Canada

 

 

Position

• Professor, Division of Life Science, Hong Kong University of Science and Technology (HKUST)

 

Research Interests

• Role of SNARE proteins in the formation of Golgi-derived transport vesicles
• Structure and function studies of Golgi-localized SNAREs and peripheral membrane proteins using NMR and or macromolecular crystallography
• Role of phosphoinositides in the localization of proteins to the Golgi

 

Representative Publications

• Tu L, Chen L and *Banfield DK. (2012) A conserved N-terminal arginine-motif in GOLPH3-family proteins mediated binding to coatomer. Traffic 11: 1496-1507.
• *Banfield DK. (2011) Mechanisms of Protein Retention in the Golgi.  (G. Warren and J. Rothman, Eds.). Cold Spring Harbor Press.
• Tu L and *Banfield DK. (2010) The trafficking and localization of Golgi resident glycosyltransferases. Cellular and Molecular Life Sciences 67: 29-41. (invited review).
• Bubeck J, Langhans M, Scheuring D, Foresti O, *Banfield DK, Denecke J, and Robinson DG. (2008) The syntaxins SYP31 and SYP81 control ER-Golgi trafficking in the plant secretory pathway. Traffic 10: 1629-1652.
• Tu L, Tai WCS, Chen L and *Banfield DK. (2008) Signal-mediated dynamic retention of glycosyltransferases in the Golgi. Science 321: 404-407.
• Wen W, Chen L, Wu H, Sun X, Zhang M and *Banfield DK. (2006). Identification of the Yeast R-SNARE Nyv1p as a Novel Longin Domain-containing Protein. Molecular Biology of the Cell 17: 4282-4299
• Rossi V, Banfield DK, Vacca M, Dietrich LEP, Ungermann C, D’Esposito M, Galli T and *Filippini F. (2004) Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Trends in Biochemical Sciences 29: 682-688.
• Tochio H, Tsui MMK, *Banfield DK and Zhang M. (2001) An Auto-Inhibitory Mechanism for Nonsyntaxin SNARE Proteins Revealed by the Structure of Ykt6p. Science 293: 698-702.
• Tsui MMK, Tai WCS and *Banfield DK. (2001) The Selective Formation of Sed5p-containing SNARE Complexes is Mediated by Combinatorial Binding Interactions. Molecular Biology of the Cell 12: 521-538.
• Tsui MMK and *Banfield DK. (2000) Yeast Golgi SNARE Interactions are Promiscuous. Journal of Cell Science 113: 145-152.

 

Research Grants as PC/PI

• 2014-2021, Research Grants Council (RGC) Areas of Excellence Scheme (AoE) Grant “Center for organelle biogenesis and function”, HK$47,250,000;
• 2011-2014, Research Grants Council (RGC) GRF Grant “Protein signal-mediated and intra-cellular signaling mediated retention of Golgi membrane proteins by Vps74/GOLPH3”, HK$1,250,000;
• 2009-2012, RGC GRF Grant “Characterization of a Novel Longin Domain Containing Protein from Yeast”, HK$944,700;
• 2009-2013, RGC CRF Grant “Protein Trafficking: Mechanism and Diseases”, HK$5,000,000;

 
Awards

• 2011/2012: Croucher Senior Research Fellowship, The Croucher Foundation
• 2003: Award for Excellence in Teaching, HKUST School of Science
• 1998: Short-listed for the 10th Anniversary Outstanding Postdoctoral Fellow Prize, Human Frontier Science Program Organization