Professor Edwin Ho-yin CHAN

	Address	(Office):	Rm 509B, Mong Man Wai Building, CUHK
		(Lab):	Rm 509A, Mong Man Wai Building, CUHK
	Phone	(Office):	(852) 3943 4021
		(Lab):	(852) 3943 8032
	Fax		(852) 2603 7732
	Email		hyechan@cuhk.edu.hk
	Web		http://www.sls.cuhk.edu.hk/ index.php/faculty-and-staff/ teaching-staff/26-sls/ faculty-and-staff/teaching-staff/ 85-professor-chan-ho-yin-edwin

 

 

 

 

 

 

 

 

 

 

Education

	1999	Ph.D.	University of Cambridge, United Kingdom
	1995	B.Sc.	The Chinese University of Hong Kong (CUHK), Hong Kong

 

 

 

Position

• Associate Professor, School of Life Sciences
• Director, M.Sc. Programme in Biochemical and Biomedical Sciences
• Deputy Director, Natural Sciences Programme, Science Faculty

 

Research Interests

• Cellular, genetic and biochemical analyses of RNA and protein toxicity in neurological diseases
• Human disease modeling

 

Representative Publications (*corresponding author)

• Wong CH, Nguyen L, Peh J, Luu LM, Sanchez JS, Richardson SL, Tuccinardi T, Tsoi H, Chan WY, Chan HYE, Baranger AM, Hergenrother PJ and Zimmerman SC. (2014) Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor. Journal of the American Chemical Society 136: 6355-6361.
• Tsoi H and *Chan HYE. (2014) Roles of the nucleolus in the CAG RNA-mediated toxicity. Biochimica et Biophysica Acta 1842: 779-784.
• Lu JH, Tan JQ, Durairajan SS, Liu LF, Zhang ZH, Ma L, Shen HM, *Chan HYE and Li M. (2012) Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy 8: 98-108.
• Tsoi H, Lau CK, Tsang SY, Lau KF and *Chan HYE. (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proceedings of the National Academy of Sciences of the U.S.A. 109: 13428-13433.
• Tsoi H, Lau CK, Lau KF and *Chan HYE. (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases. Human Molecular Genetics 20: 3787-3797.
• Chan WM, Tsoi H, Wu CC, Wong CH, Cheng TC, Li HY, Lau KF, Shaw PC, Perrimon N and *Chan HYE. (2011) Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Human Molecular Genetics 20: 1738-1750.
• Lam SK, Cai Y, Tse YC, Wang J, Law AHY, Pimpl P, Chan HYE, Xia J and Jiang L. (2009) The BFA-induced compartments from Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells. Plant Journal 60: 865-881.
• Wong SLA, Chan WM and *Chan HYE. (2008) SDS-insoluble polyglutamine oligomers are involved in neuronal degeneration. The FASEB Journal 22: 3348-3357
• Auluck PK, Chan HYE, Trojanowski JQ, Lee VMY and Bonini NM. (2002) Chaperone suppression of a-synuclein toxicity in a Drosophila model for Parkinson’s disease. Science 295: 865-868.
• Warrick JM, Chan HYE, Gray-Board GL, Chai Y, Paulson HL and Bonini NM. (1999) Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nature Genetics 23: 425-428.

 

Research Grants as PC/PI

• 2014-2017, Research Grants Council (RGC) CRF Grant, “Targeting RNA and protein toxicities of polyglutamine diseases using peptidylic inhibitors”, HK$7,044,220;
• 2014-2016, RGC GRF Grant, “Characterization of a novel type of protein nuclear export signal in polyalanine expansion disease proteins”, HK$866,032
• 2013-2015, Health and Medical Research Fund (HMRF) GRF Grant, “An inhibitory peptide approach to simultaneously target RNA and protein toxicities in polyglutamine degeneration”, HK$999,908;
• 2013-2015, RGC GRF Grant, “The role of nucleolin in CAG trinucleotide repeat-mediated RNA toxicity”, HK$790,000;
• 2009-2012, RGC GRF Grant, “Probing the nuclear transport role of the mutant polyglutamine domain in neurodegeneration”, HK$929,247

 

Awards

• 2014: Churchill College Visiting By-Fellowship, University of Cambridge, UK
• 2011: 13th Ju-Chi Li Animal Genetics Prize; “中国遗传学会第十三届李汝祺动物遗传学奖”, Genetics Society of China
• 2009: The Young Researcher Award 2009-10, CUHK
• 2009: Faculty Exemplary Teaching Award 2009, Faculty of Science, CUHK

 

Professional Activities

• Member: Scientific Advisory Board, Society for Research on the Cerebellum
• Member: Asia-Pacific Drosophila Board
• Journal Editorial Board member: Advances in Alzheimer’s Disease, ISRN Entomology
• Ad hoc reviewer: Neurogenetics, Apoptosis, Biochimica et Biophysica Acta – Molecular Basis of Disease, EMBO Reports, EMBO Journal, European Journal of Neuroscience, Human Molecular Genetics, Journal of Cell Science, Journal of Neurochemistry and Neurobiology of Aging

 

Others

• Session Chair (Drosophila models for human diseases), 2nd Asia-Pacific Drosophila Research Conference, Seoul, Korea, 2013
• Chairperson, Scientific and Medical Advisory Committee, Hong Kong Spinocerebellar Ataxia Association (2012-present)